HPCAL1 is a novel driver of autophagy-dependent ferroptosis

Liwen WANG; Li QIN; Huimei LIU; Lanfang LI

doi:10.1631/jzus.B2300241

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Correspondence | Updated：2024-12-02

HPCAL1 is a novel driver of autophagy-dependent ferroptosis
HPCAL1 is a novel driver of autophagy-dependent ferroptosis
海马钙素样1是一种新的自噬依赖性铁死亡驱动因子
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 24, Issue 11, Pages: 1053-1056(2023)
Affiliations：

1.Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang 421001, China
2.Hengyang Medical School, University of South China, Hengyang 421001, China
Funds：
DOI：10.1631/jzus.B2300241
CLC：
CSTR：
Published： 15 November 2023 ，

Received： 10 April 2023 ，

Revised： 18 June 2023 ，
Accepted：

王丽雯,李琴,刘惠美等.海马钙素样1是一种新的自噬依赖性铁死亡驱动因子[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(11):1053-1056.

LIWEN WANG, LI QIN, HUIMEI LIU, et al. HPCAL1 is a novel driver of autophagy-dependent ferroptosis. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2023, 24(11): 1053-1056.
王丽雯,李琴,刘惠美等.海马钙素样1是一种新的自噬依赖性铁死亡驱动因子[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2023,24(11):1053-1056. DOI： 10.1631/jzus.B2300241.

LIWEN WANG, LI QIN, HUIMEI LIU, et al. HPCAL1 is a novel driver of autophagy-dependent ferroptosis. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2023, 24(11): 1053-1056. DOI： 10.1631/jzus.B2300241.

摘要

Abstract

自噬是细胞内一种高度保守的生理过程，可通过溶酶体系统降解过量或受损的细胞器、有毒的蛋白聚集体和病原体等。最新研究表明，海马钙素样1（HPCAL1）可作为特异性自噬受体和铁死亡的正调节因子。HPCAL1可选择性降解钙粘素2（CDH2），加速脂质过氧化，促进癌细胞铁死亡。iHPCAL1是抑制HPCAL1的小分子化合物，可抑制Erastin诱导的肿瘤细胞铁死亡。此外，它还可以抑制铁死亡诱导的急性胰腺炎。本文通过对HPCAL1在铁死亡中的具体作用机制进行概述，为HPCAL1作为铁死亡相关疾病的潜在治疗靶点提供新思路和理论依据。

关键词

自噬铁死亡脂质过氧化海马钙素样1（HPCAL1）钙粘素2（CDH2）

Keywords

references

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