超慢体表电位与甲状腺癌的组水平关联

邓博瀚; 张瑞丽; 刘昱绚; 林敬珞; 桂世聪; 魏希浩; 成荫; 郑力; 胡少华; 吕萍萍; 李宇波; 王华芬

doi:10.1631/jzus.B2600040

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超慢体表电位与甲状腺癌的组水平关联

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Correspondence | Updated：2026-04-23

超慢体表电位与甲状腺癌的组水平关联
Infra-slow body-surface potentials show a group-level association with thyroid cancer
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第4期页码：426-430
Affiliations：

1.College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, China
2.Zhejiang Key Laboratory of Intelligent Rehabilitation and Translational Neuroelectronics, Hangzhou 310027, China
3.International Research Center for Information Science and Electronic Engineering, Zhejiang University, Haining 314400, China
4.Department of Nursing, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
5.Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou 310003, China
Funds：

the 2025 Beilun District Health Science and Technology Plan Project(2025BLWSZD001)
DOI：10.1631/jzus.B2600040
中图分类号：
CSTR：
收稿：2026-01-22，

修回：2026-03-02，

纸质出版：2026-04-23
Accepted：

邓博瀚,张瑞丽,刘昱绚等.超慢体表电位与甲状腺癌的组水平关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):426-430.

Bohan DENG, Ruili ZHANG, Yuxuan LIU, et al. Infra-slow body-surface potentials show a group-level association with thyroid cancer[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 426-430.
邓博瀚,张瑞丽,刘昱绚等.超慢体表电位与甲状腺癌的组水平关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):426-430. DOI： 10.1631/jzus.B2600040.

Bohan DENG, Ruili ZHANG, Yuxuan LIU, et al. Infra-slow body-surface potentials show a group-level association with thyroid cancer[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 426-430. DOI： 10.1631/jzus.B2600040.

摘要

既往皮电活动研究多聚焦于0.5 Hz以上的快速瞬变成分，而0.2 Hz以下的超慢频段是否携带与系统性疾病相关的生物电信息，目前尚缺乏充分探索。甲状腺癌兼具内分泌与代谢系统效应，是检验超慢体表电位与机体全身状态之间关系的理想临床模型。本研究通过自研CTP008高阻抗直流耦合采集系统，在321例恶性肿瘤患者（甲状腺癌82例，其他癌种239例）中完整保留了0.025–0.2 Hz超慢频段（Band 1）的振荡与稳态基线信息，并预先指定甲状腺癌组与其他癌种组之间的Band 1能量差异为唯一主要终点。经三阶段自动化质量控制排除5例高伪迹受试者后（最终316例），Mann-Whitney

检验显示甲状腺癌患者的Band 1能量显著高于其他癌种患者（中位数9.23 vs. 6.23，

=0.0014）。在逐步加严伪迹剔除阈值的敏感性分析中，该效应不仅未被削弱，反而略有增强，从而排除了伪迹驱动的解释。值得关注的是，信号采集位点位于手指与手腕，远离甲状腺本身，这一空间分离提示所观测到的差异更可能源于全身性代谢或自主神经状态的改变。本研究为超慢体表电位作为肿瘤系统状态非侵入性标志物提供了初步证据，并揭示了直流耦合生物传感技术在临床转化中的潜在价值。

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references

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