促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展

胡娴; 徐法伟; 张敏霞; 陈义庆; 蔡佳沁; 马菁晶; 谈伟强; 方青青

doi:10.1631/jzus.B2500261

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促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展

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Review | Updated：2026-08-13

促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展
Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第8期页码：832-855
Affiliations：

Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Funds：

the Zhejiang Provincial Major Medical Science and Technology Plan funded by the National Health Commission of China(WKJ-Z-2530);the Zhejiang Provincial Medical and Healthy Science Foundation of China(2023RC183;2024KY110);the National Natural Science Foundation of China(82172206;82302803)
DOI：10.1631/jzus.B2500261
中图分类号：
CSTR：
收稿：2025-05-18，

修回：2025-07-02，

网络首发：2026-08-13，

纸质出版：2026-08-13
Accepted：

胡娴,徐法伟,张敏霞等.促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(08):832-855.

Xian HU, Fawei XU, Minxia ZHANG, et al. Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(8): 832-855.
胡娴,徐法伟,张敏霞等.促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(08):832-855. DOI： 10.1631/jzus.B2500261.

Xian HU, Fawei XU, Minxia ZHANG, et al. Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(8): 832-855. DOI： 10.1631/jzus.B2500261.

摘要

伤口愈合是一个包括止血、炎症、增殖和重塑四个阶段的复杂生物学过程，瘢痕形成是该过程中的常见问题，尤其是病理性瘢痕如增生性瘢痕和瘢痕疙瘩，严重影响美观与功能。近年来，水凝胶敷料凭借独特的物理化学和生物学特性，可通过提供湿润环境、抗菌、抗炎、促进组织再生以及调控伤口微环境等多重机制，加速愈合并减少瘢痕形成，已成为促进无瘢痕愈合的研究热点。本综述详述了无瘢痕愈合的概念与机制，并探讨了负载抗瘢痕药物、干细胞及细胞外囊泡的水凝胶敷料在无瘢痕伤口愈合中的应用；此外，还对可调节机械信号的水凝胶敷料及光响应、有机生物高分子和纳米颗粒等多种创新型多功能水凝胶的研究进展进行总结。但上述水凝胶敷料在展现出广阔的临床应用前景的同时，仍面临药物递送效率、生物相容性和长期安全性等挑战，未来研究需要进一步聚焦优化水凝胶组成与功能，并探索其在临床中的潜在应用。

Abstract

This review summarizes progress made in research on hydrogel wound dressings in promoting scarless skin healing. Wound healing is a complex biological process that involves four stages: hemostasis

inflammation

proliferation

and remodeling. Scar formation is a common issue during this process

especially pathological scars such as hypertrophic scars and keloids

which severely affect aesthetics and function. In recent years

hydrogel dressings have become a research hotspot for promoting scarless healing due to their unique physicochemical and biological properties. Hydrogels promote wound healing and reduce scar formation through multiple mechanisms

including providing a moist environment

antimicrobial activity

anti-inflammatory effects

promoting tissue regeneration

and regulating the wound microenvironment. This review details the concept and mechanisms of scarless healing and explores the application of hydrogel dressings loaded with anti-scarring drugs

stem cells

and extracellular vesicles (EVs) in scarless wound healing. Additionally

it summarizes progress in research on hydrogel dressings that regulate mechanical signals and innovative multifunctional hydrogel dressings

such as photo-responsive

organic biopolymer

and nanoparticle hydrogels. These hydrogel dressings show great potential for clinical application but still face challenges such as drug delivery efficiency

biocompatibility

and long-term safety. Future research needs to further optimize the composition and functionality of hydrogels and explore their potential applications in clinical settings.

关键词

Keywords

references

Abedanzadeh M , Abolmaali SS , Heidari R , et al. , 2024 . Photo-crosslinked hyaluronic acid hydrogels designed for simultaneous delivery of mesenchymal stem cells and tannic acid: advancing towards scarless wound healing . Int J Biol Macromol , 281 : 136394 . https://doi.org/10.1016/j.ijbiomac.2024.136394 https://doi.org/10.1016/j.ijbiomac.2024.136394

Bai Q , Teng L , Zhang XL , et al. , 2022 . Multifunctional single-component polypeptide hydrogels: the gelation mechanism, superior biocompatibility, high performance hemostasis, and scarless wound healing . Adv Healthc Mater , 11 ( 6 ): 2101809 . https://doi.org/10.1002/adhm.202101809 https://doi.org/10.1002/adhm.202101809

Bainbridge P , 2013 . Wound healing and the role of fibroblasts . J Wound Care , 22 ( 8 ): 407 - 408 , 410 - 412 . https://doi.org/10.12968/jowc.2013.22.8.407 https://doi.org/10.12968/jowc.2013.22.8.407

Bharadia SK , Burnett L , Gabriel V , 2023 . Hypertrophic scar . Phys Med Rehabil Clin N Am , 34 ( 4 ): 783 - 798 . https://doi.org/10.1016/j.pmr.2023.05.002 https://doi.org/10.1016/j.pmr.2023.05.002

Bhattacharya D , Tiwari R , Bhatia T , et al. , 2019 . Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways . Drug Deliv Transl Res , 9 ( 6 ): 1143 - 1158 . https://doi.org/10.1007/s13346-019-00660-z https://doi.org/10.1007/s13346-019-00660-z

Bian J , Bao LH , Gao XK , et al. , 2022 . Bacteria-engineered porous sponge for hemostasis and vascularization . J Nanobiotechnol , 20 : 47 . https://doi.org/10.1186/s12951-022-01254-7 https://doi.org/10.1186/s12951-022-01254-7

Burrington JD , 1971 . Wound healing in the fetal lamb . J Pediatr Surg , 6 ( 5 ): 523 - 528 . https://doi.org/10.1016/0022-3468(71)90373-3 https://doi.org/10.1016/0022-3468(71)90373-3

Chang LK , Xu YL , Wu ZY , et al. , 2023 . Hyaluronic acid methacrylate/laponite hydrogel loaded with BMP4 and maintaining its bioactivity for scar-free wound healing . Regen Biomater , 10 : rbad023 . https://doi.org/10.1093/rb/rbad023 https://doi.org/10.1093/rb/rbad023

Chen MY , Cao MQ , Xu TY , 2024 . Progress in the application of artificial intelligence in skin wound assessment and prediction of healing time . Am J Transl Res , 16 ( 7 ): 2765 - 2776 . https://doi.org/10.62347/myhe3488 https://doi.org/10.62347/myhe3488

Chen Q , Li SY , Li K , et al. , 2024 . A skin stress shielding platform based on body temperature-induced shrinking of hydrogel for promoting scar-less wound healing . Adv Sci , 11 ( 41 ): 2306018 . https://doi.org/10.1002/advs.202306018 https://doi.org/10.1002/advs.202306018

Chen SX , Cheng J , Watchmaker J , et al. , 2022 . Review of lasers and energy-based devices for skin rejuvenation and scar treatment with histologic correlations . Dermatol Surg , 48 ( 4 ): 441 - 448 . https://doi.org/10.1097/dss.0000000000003397 https://doi.org/10.1097/dss.0000000000003397

Chen XH , Song HY , Song K , et al. , 2024 . Temperature-sensitive hydrogel releasing pectolinarin facilitate scarless wound healing . J Cell Mol Med , 28 ( 4 ): e18130 . https://doi.org/10.1111/jcmm.18130 https://doi.org/10.1111/jcmm.18130

Cheng XY , Li YQ , Liang Y , et al. , 2024 . Mechanical biomimetic silk nano fiber-magnesium ion complex/hydroxyethylcellulose/glycerol hydrogel dressing with angiogenic capacity for accelerating scarless diabetic wound healing . J Colloid Interface Sci , 667 : 624 - 639 . https://doi.org/10.1016/j.jcis.2024.03.142 https://doi.org/10.1016/j.jcis.2024.03.142

Childs DR , Murthy AS , 2017 . Overview of wound healing and management . Surg Clin North Am , 97 ( 1 ): 189 - 207 . https://doi.org/10.1016/j.suc.2016.08.013 https://doi.org/10.1016/j.suc.2016.08.013

Deng J , Li JY , Yan LZ , et al. , 2024 . Accelerated, injectable, self-healing, scarless wound dressings using rGO reinforced dextran/chitosan hydrogels incorporated with PDA-loaded asiaticoside . Int J Biol Macromol , 278 : 134424 . https://doi.org/10.1016/j.ijbiomac.2024.134424 https://doi.org/10.1016/j.ijbiomac.2024.134424

Ding JY , Chen MJ , Wu LF , et al. , 2023 . Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges . Mil Med Res , 10 : 36 . https://doi.org/10.1186/s40779-023-00472-w https://doi.org/10.1186/s40779-023-00472-w

Fu DL , Huang JF , Wu XQ , et al. , 2024 . Shape-fixing hydrogel promotes scarless healing of wounds under tension . Acta Biomater , 183 : 173 - 190 . https://doi.org/10.1016/j.actbio.2024.05.036 https://doi.org/10.1016/j.actbio.2024.05.036

Gan DL , Su QY , Su HW , et al. , 2021 . Burn ointment promotes cutaneous wound healing by modulating the PI3K/AKT/mTOR signaling pathway . Front Pharmacol , 12 : 631102 . https://doi.org/10.3389/fphar.2021.631102 https://doi.org/10.3389/fphar.2021.631102

Gope A , Mukhopadhyay A , Mukhopadhyay O , et al. , 2022 . Regenerative repair of full thickness skin wound assisted by dual crosslinking percolative gel casting maneuvered alginate hydrogel embedded with honey ghee blend resembles standard cutaneous properties . J Tissue Viability , 31 ( 4 ): 657 - 672 . https://doi.org/10.1016/j.jtv.2022.07.007 https://doi.org/10.1016/j.jtv.2022.07.007

Govindharaj M , Al Hashimi N , Soman SS , et al. , 2024 . 3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the treatment of deep tunneling wounds . Bio-Des Manuf , 7 ( 6 ): 938 - 954 . https://doi.org/10.1007/s42242-024-00305-2 https://doi.org/10.1007/s42242-024-00305-2

Griffin MF , desJardins-Park HE , Mascharak S , et al. , 2020 . Understanding the impact of fibroblast heterogeneity on skin fibrosis . Dis Model Mech , 13 ( 6 ): dmm044164 . https://doi.org/10.1242/dmm.044164 https://doi.org/10.1242/dmm.044164

Guo S , Dipietro LA , 2010 . Factors affecting wound healing . J Dent Res , 89 ( 3 ): 219 - 229 . https://doi.org/10.1177/0022034509359125 https://doi.org/10.1177/0022034509359125

Han L , Liu ZX , Li M , et al. , 2025 . 3D bioprinting of a dermal scaffold for full-thickness skin tissue regeneration . Bio-Des Manuf , 8 ( 1 ): 68 - 84 . https://doi.org/10.1631/bdm.2400058 https://doi.org/10.1631/bdm.2400058

Hao AL , Dong XY , Gou YN , et al. , 2025 . Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling . Genes Dis , 12 ( 3 ): 101484 . https://doi.org/10.1016/j.gendis.2024.101484 https://doi.org/10.1016/j.gendis.2024.101484

Hassan WU , Greiser U , Wang WX , 2014 . Role of adipose-derived stem cells in wound healing . Wound Repair Regen , 22 ( 3 ): 313 - 325 . https://doi.org/10.1111/wrr.12173 https://doi.org/10.1111/wrr.12173

Hassanshahi A , Moradzad M , Ghalamkari S , et al. , 2022 . Macrophage-mediated inflammation in skin wound healing . Cells , 11 ( 19 ): 295 . https://doi.org/10.3390/cells11192953 https://doi.org/10.3390/cells11192953

He JH , Fang B , Shan SZ , et al. , 2021 . Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1 . Cell Death Dis , 12 ( 3 ): 226 . https://doi.org/10.1038/s41419-021-03481-6 https://doi.org/10.1038/s41419-021-03481-6

Hu HH , Cao G , Wu XQ , et al. , 2020 . Wnt signaling pathway in aging-related tissue fibrosis and therapies . Ageing Res Rev , 60 : 101063 . https://doi.org/10.1016/j.arr.2020.101063 https://doi.org/10.1016/j.arr.2020.101063

Hua YJ , Wang K , Huo YY , et al. , 2023 . Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction . Nat Commun , 14 : 7632 . https://doi.org/10.1038/s41467-023-43421-w https://doi.org/10.1038/s41467-023-43421-w

Huang J , Zhou XB , Xia LL , et al. , 2021 . Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model . Int Wound J , 18 ( 5 ): 598 - 607 . https://doi.org/10.1111/iwj.13561 https://doi.org/10.1111/iwj.13561

Huebener P , Schwabe RF , 2013 . Regulation of wound healing and organ fibrosis by toll-like receptors . Biochim Biophys Acta-Mol Basis Dis , 1832 ( 7 ): 1005 - 1017 . https://doi.org/10.1016/j.bbadis.2012.11.017 https://doi.org/10.1016/j.bbadis.2012.11.017

Indrakumar S , Joshi A , Dash TK , et al. , 2023 . Photopolymerized silk fibroin gel for advanced burn wound care . Int J Biol Macromol , 233 : 123569 . https://doi.org/10.1016/j.ijbiomac.2023.123569 https://doi.org/10.1016/j.ijbiomac.2023.123569

Jeon EY , Choi BH , Jung D , et al. , 2017 . Natural healing-inspired collagen-targeting surgical protein glue for accelerated scarless skin regeneration . Biomaterials , 134 : 154 - 165 . https://doi.org/10.1016/j.biomaterials.2017.04.041 https://doi.org/10.1016/j.biomaterials.2017.04.041

Jere SW , Abrahamse H , Houreld NN , 2017 . The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing . Cytokine Growth Factor Rev , 38 : 73 - 79 . https://doi.org/10.1016/j.cytogfr.2017.10.001 https://doi.org/10.1016/j.cytogfr.2017.10.001

Jin L , Guo XQ , Gao D , et al. , 2022 . An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing . Bioact Mater , 16 : 162 - 172 . https://doi.org/10.1016/j.bioactmat.2022.03.006 https://doi.org/10.1016/j.bioactmat.2022.03.006

Kadota T , Fujita Y , Araya J , et al. , 2021 . Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk . J Extracell Vesicles , 10 ( 10 ): e12124 . https://doi.org/10.1002/jev2.12124 https://doi.org/10.1002/jev2.12124

Kanchanawong P , Calderwood DA , 2023 . Organization, dynamics and mechanoregulation of integrin-mediated cell‒ECM adhesions . Nat Rev Mol Cell Biol , 24 ( 2 ): 142 - 161 . https://doi.org/10.1038/s41580-022-00531-5 https://doi.org/10.1038/s41580-022-00531-5

Karppinen SM , Heljasvaara R , Gullberg D , et al. , 2019 . Toward understanding scarless skin wound healing and pathological scarring . F1000Res , 8 : F1000 . https://doi.org/10.12688/f1000research.18293.1 https://doi.org/10.12688/f1000research.18293.1

Kavanagh F , Rozen W , Seth I , et al. , 2024 . Exploring the efficacy of negative pressure wound therapy in the management of mycobacterium ulcerans wounds: a comprehensive literature review . Plast Aesthet Res , 11 : 43 . https://doi.org/10.20517/2347-9264.2024.26 https://doi.org/10.20517/2347-9264.2024.26

Keykhaee M , Rahimifard M , Najafi A , et al. , 2023 . Alginate/gum arabic-based biomimetic hydrogel enriched with immobilized nerve growth factor and carnosine improves diabetic wound regeneration . Carbohydr Polym , 321 : 121179 . https://doi.org/10.1016/j.carbpol.2023.121179 https://doi.org/10.1016/j.carbpol.2023.121179

Kluwe J , Mencin A , Schwabe RF , 2009 . Toll-like receptors, wound healing, and carcinogenesis . J Mol Med , 87 ( 2 ): 125 - 138 . https://doi.org/10.1007/s00109-008-0426-z https://doi.org/10.1007/s00109-008-0426-z

Knoedler S , Broichhausen S , Guo RJ , et al. , 2023 . Fibroblasts ‒ the cellular choreographers of wound healing . Front Immunol , 14 : 1233800 . https://doi.org/10.3389/fimmu.2023.1233800 https://doi.org/10.3389/fimmu.2023.1233800

Lee HJ , Jang YJ , 2018 . Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids . Int J Mol Sci , 19 ( 3 ): 711 . https://doi.org/10.3390/ijms19030711 https://doi.org/10.3390/ijms19030711

Lee SH , An S , Ryu YC , et al. , 2023 . Adhesive hydrogel patch-mediated combination drug therapy induces regenerative wound healing through reconstruction of regenerative microenvironment . Adv Healthc Mater , 12 ( 18 ): 2203094 . https://doi.org/10.1002/adhm.202203094 https://doi.org/10.1002/adhm.202203094

Lei LJ , Wang XG , Zhu YL , et al. , 2022 . Antimicrobial hydrogel microspheres for protein capture and wound healing . Mater Des , 215 : 110478 . https://doi.org/10.1016/j.matdes.2022.110478 https://doi.org/10.1016/j.matdes.2022.110478

Li AQ , Ma B , Hua SY , et al. , 2024 . Chitosan-based injectable hydrogel with multifunction for wound healing: a critical review . Carbohydr Polym , 333 : 121952 . https://doi.org/10.1016/j.carbpol.2024.121952 https://doi.org/10.1016/j.carbpol.2024.121952

Li J , Chen J , Kirsner R , 2007 . Pathophysiology of acute wound healing . Clin Dermatol , 25 ( 1 ): 9 - 18 . https://doi.org/10.1016/j.clindermatol.2006.09.007 https://doi.org/10.1016/j.clindermatol.2006.09.007

Li MZ , Wang P , Li JT , et al. , 2023 . NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars . Cell Death Discov , 9 : 341 . https://doi.org/10.1038/s41420-023-01635-3 https://doi.org/10.1038/s41420-023-01635-3

Li X , Wang X , Shen T , et al. , 2024 . Advances in photodynamic therapy of pathologic scar . Photodiagnosis Photodyn Ther , 46 : 104040 . https://doi.org/10.1016/j.pdpdt.2024.104040 https://doi.org/10.1016/j.pdpdt.2024.104040

Li Z , Li YN , Liu CR , et al. , 2024 . Research progress of the mechanisms and applications of ginsenosides in promoting bone formation . Phytomedicine , 129 : 155604 . https://doi.org/10.1016/j.phymed.2024.155604 https://doi.org/10.1016/j.phymed.2024.155604

Liang YP , He JH , Guo BL , 2021 . Functional hydrogels as wound dressing to enhance wound healing . ACS Nano , 15 ( 8 ): 12687 - 12722 . https://doi.org/10.1021/acsnano.1c04206 https://doi.org/10.1021/acsnano.1c04206

Liu LT , Ding ZZ , Yang Y , et al. , 2021 . Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration . Biomater Sci , 9 ( 15 ): 5227 - 5236 . https://doi.org/10.1039/d1bm00904d https://doi.org/10.1039/d1bm00904d

Lou JQ , Xiang ZY , Zhu XY , et al. , 2025 . Evaluating the therapeutic efficacy and safety of alginate-based dressings in burn wound and donor site wound management associated with burn surgery: a systematic review and meta-analysis of contemporary randomized controlled trials . BMC Surg , 25 : 215 . https://doi.org/10.1186/s12893-025-02956-z https://doi.org/10.1186/s12893-025-02956-z

Margadant C , Sonnenberg A , 2010 . Integrin-TGF-β crosstalk in fibrosis, cancer and wound healing . EMBO Rep , 11 ( 2 ): 97 - 105 . https://doi.org/10.1038/embor.2009.276 https://doi.org/10.1038/embor.2009.276

Mascharak S , Desjardins-Park HE , Davitt MF , et al. , 2021 . Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring . Science , 372 ( 6540 ): eaba2374 . https://doi.org/10.1126/science.aba2374 https://doi.org/10.1126/science.aba2374

Matsuzaki K , Upton D , 2013 . Wound treatment and pain management: a stressful time . Int Wound J , 10 ( 6 ): 638 - 644 . https://doi.org/10.1111/j.1742-481X.2012.01038.x https://doi.org/10.1111/j.1742-481X.2012.01038.x

Mussbacher M , Derler M , Basílio J , et al. , 2023 . NF-κB in monocytes and macrophages ‒ an inflammatory master regulator in multitalented immune cells . Front Immunol , 14 : 1134661 . https://doi.org/10.3389/fimmu.2023.1134661 https://doi.org/10.3389/fimmu.2023.1134661

Naasani LIS , Pretto L , Zanatelli C , et al. , 2023 . Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model . Biofabrication , 15 : 015012 . https://doi.org/10.1088/1758-5090/ac9ff4 https://doi.org/10.1088/1758-5090/ac9ff4

Negut I , Grumezescu V , Grumezescu AM , 2018 . Treatment strategies for infected wounds . Molecules , 23 ( 9 ): 2392 . https://doi.org/10.3390/molecules23092392 https://doi.org/10.3390/molecules23092392

Nguyen AV , Soulika AM , 2019 . The dynamics of the skin’s immune system . Int J Mol Sci , 20 ( 8 ): 1811 . https://doi.org/10.3390/ijms20081811 https://doi.org/10.3390/ijms20081811

Nowak NC , Menichella DM , Miller R , et al. , 2021 . Cutaneous innervation in impaired diabetic wound healing . Transl Res , 236 : 87 - 108 . https://doi.org/10.1016/j.trsl.2021.05.003 https://doi.org/10.1016/j.trsl.2021.05.003

Ogawa R , Dohi T , Tosa M , et al. , 2021 . The latest strategy for keloid and hypertrophic scar prevention and treatment: the nippon medical school (NMS) protocol . J Nippon Med Sch , 88 ( 1 ): 2 - 9 . https://doi.org/10.1272/jnms.JNMS.2021_88-106 https://doi.org/10.1272/jnms.JNMS.2021_88-106

Ou MY , Tan PC , Xie Y , et al. , 2022 . Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing . Theranostics , 12 ( 12 ): 5470 - 5487 . https://doi.org/10.7150/thno.72317 https://doi.org/10.7150/thno.72317

Peña OA , Martin P , 2024 . Cellular and molecular mechanisms of skin wound healing . Nat Rev Mol Cell Biol , 25 ( 8 ): 599 - 616 . https://doi.org/10.1038/s41580-024-00715-1 https://doi.org/10.1038/s41580-024-00715-1

Pignet AL , Hecker A , Voljc T , et al. , 2024 . The use of acellular fish skin grafts in burns and complex trauma wounds: a systematic review of clinical data . Plast Aesthet Res , 11 : 40 . https://doi.org/10.20517/2347-9264.2024.54 https://doi.org/10.20517/2347-9264.2024.54

Pratsinis H , Mavrogonatou E , Kletsas D , 2019 . Scarless wound healing: from development to senescence . Adv Drug Deliv Rev , 146 : 325 - 343 . https://doi.org/10.1016/j.addr.2018.04.011 https://doi.org/10.1016/j.addr.2018.04.011

Qin BQ , Wu SZ , Dong HX , et al. , 2023 . Accelerated healing of infected diabetic wounds by a dual-layered adhesive film cored with microsphere-loaded hydrogel composite dressing . ACS Appl Mater Interfaces , 15 ( 28 ): 33207 - 33222 . https://doi.org/10.1021/acsami.2c22650 https://doi.org/10.1021/acsami.2c22650

Rabello FB , Souza CD , Farina Júnior JA , 2014 . Update on hypertrophic scar treatment . Clinics , 69 ( 8 ): 565 - 573 . https://doi.org/10.6061/clinics/2014(08)11 https://doi.org/10.6061/clinics/2014(08)11

Rahimi F , Ahmadkhani N , Goodarzi A , et al. , 2023 . Gelatin-based hydrogel functionalized with taurine moieties for in vivo skin tissue regeneration . Bio-Des Manuf , 6 ( 3 ): 284 - 297 . https://doi.org/10.1007/s42242-022-00227-x https://doi.org/10.1007/s42242-022-00227-x

Schuster R , Younesi F , Ezzo M , et al. , 2023 . The role of myofibroblasts in physiological and pathological tissue repair . Cold Spring Harb Perspect Biol , 15 ( 1 ): a041231 . https://doi.org/10.1101/cshperspect.a041231 https://doi.org/10.1101/cshperspect.a041231

Shan JY , Che JY , Song CH , et al. , 2023 . Emerging antibacterial nanozymes for wound healing . Smart Med , 2 ( 3 ): e20220025 . https://doi.org/10.1002/smmd.20220025 https://doi.org/10.1002/smmd.20220025

Sharifi E , Sadati SA , Yousefiasl S , et al. , 2022 . Cell loaded hydrogel containing Ag-doped bioactive glass-ceramic nanoparticles as skin substitute: antibacterial properties, immune response, and scarless cutaneous wound regeneration . Bioeng Transl Med , 7 ( 3 ): e10386 . https://doi.org/10.1002/btm2.10386 https://doi.org/10.1002/btm2.10386

Shen YF , Xu GZ , Huang HX , et al. , 2021 . Sequential release of small extracellular vesicles from bilayered thiolated alginate/polyethylene glycol diacrylate hydrogels for scarless wound healing . ACS Nano , 15 ( 4 ): 6352 - 6368 . https://doi.org/10.1021/acsnano.0c07714 https://doi.org/10.1021/acsnano.0c07714

Shi M , Gao YF , Lee L , et al. , 2022 . Adaptive gelatin microspheres enhanced stem cell delivery and integration with diabetic wounds to activate skin tissue regeneration . Front Bioeng Biotechnol , 10 : 813805 . https://doi.org/10.3389/fbioe.2022.813805 https://doi.org/10.3389/fbioe.2022.813805

Shpichka A , Butnaru D , Bezrukov EA , et al. , 2019 . Skin tissue regeneration for burn injury . Stem Cell Res Ther , 10 : 94 . https://doi.org/10.1186/s13287-019-1203-3 https://doi.org/10.1186/s13287-019-1203-3

Song YT , Hu QX , Liu SH , et al. , 2024 . Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma . Biomed Technol , 8 : 65 - 80 . https://doi.org/10.1016/j.bmt.2024.10.001 https://doi.org/10.1016/j.bmt.2024.10.001

Sorg H , Tilkorn DJ , Hager S , et al. , 2017 . Skin wound healing: an update on the current knowledge and concepts . Eur Surg Res , 58 ( 1-2 ): 81 - 94 . https://doi.org/10.1159/000454919 https://doi.org/10.1159/000454919

Talbott HE , Mascharak S , Griffin M , et al. , 2022 . Wound healing, fibroblast heterogeneity, and fibrosis . Cell Stem Cell , 29 ( 8 ): 1161 - 1180 . https://doi.org/10.1016/j.stem.2022.07.006 https://doi.org/10.1016/j.stem.2022.07.006

Vågesjö E , Öhnstedt E , Mortier A , et al. , 2018 . Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria . Proc Natl Acad Sci USA , 115 ( 8 ): 1895 - 1900 . https://doi.org/10.1073/pnas.1716580115 https://doi.org/10.1073/pnas.1716580115

Velnar T , Bailey T , Smrkolj V , 2009 . The wound healing process: an overview of the cellular and molecular mechanisms . J Int Med Res , 37 ( 5 ): 1528 - 1542 . https://doi.org/10.1177/147323000903700531 https://doi.org/10.1177/147323000903700531

Verdolino DV , Thomason HA , Fotticchia A , et al. , 2021 . Wound dressings: curbing inflammation in chronic wound healing . Emerg Top Life Sci , 5 ( 4 ): 523 - 537 . https://doi.org/10.1042/etls20200346 https://doi.org/10.1042/etls20200346

Wang XJ , Banda J , Qi H , et al. , 2022 . Scarless wound healing: current insights from the perspectives of TGF-β, KGF-1, and KGF-2 . Cytokine Growth Factor Rev , 66 : 26 - 37 . https://doi.org/10.1016/j.cytogfr.2022.03.001 https://doi.org/10.1016/j.cytogfr.2022.03.001

Wang YJ , He G , Tang H , et al. , 2019 . Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway . Cell Prolif , 52 ( 4 ): e12650 . https://doi.org/10.1111/cpr.12650 https://doi.org/10.1111/cpr.12650

Wang ZC , Zhao WY , Cao YY , et al. , 2020 . The roles of inflammation in keloid and hypertrophic scars . Front Immunol , 11 : 603187 . https://doi.org/10.3389/fimmu.2020.603187 https://doi.org/10.3389/fimmu.2020.603187

Weng WQ , Wang L , Fan L , et al. , 2024 . Ordered micro-nano structured biomaterials for wound healing . Biomed Technol , 8 : 104 - 114 . https://doi.org/10.1016/j.bmt.2024.09.001 https://doi.org/10.1016/j.bmt.2024.09.001

Xie JL , Qi SH , Li TZ , et al. , 2009 . Effect of asiaticoside on hypertrophic scar in the rabbit ear model . J Cutan Pathol , 36 ( 2 ): 234 - 239 . https://doi.org/10.1111/j.1600-0560.2008.01015.x https://doi.org/10.1111/j.1600-0560.2008.01015.x

Xing DD , Du YR , Dai K , et al. , 2024 . Polysaccharide-based injectable hydrogel loaded with quercetin promotes scarless healing of burn wounds by reducing inflammation . Biomacromolecules , 25 ( 11 ): 7529 - 7542 . https://doi.org/10.1021/acs.biomac.4c01276 https://doi.org/10.1021/acs.biomac.4c01276

Xing DL , Xia GQ , Tang XD , et al. , 2024 . A multifunctional nanocomposite hydrogel delivery system based on dual-loaded liposomes for scarless wound healing . Adv Healthc Mater , 13 ( 28 ): 2401619 . https://doi.org/10.1002/adhm.202401619 https://doi.org/10.1002/adhm.202401619

Xiong MC , Yang XL , Shi ZW , et al. , 2024 . Programmable artificial skins accomplish antiscar healing with multiple appendage regeneration . Adv Mater , 36 ( 50 ): 2407322 . https://doi.org/10.1002/adma.202407322 https://doi.org/10.1002/adma.202407322

Xu TT , Yang R , Ma XB , et al. , 2019 . Bionic poly(γ-glutamic acid) electrospun fibrous scaffolds for preventing hypertrophic scars . Adv Healthc Mater , 8 ( 13 ): 1900123 . https://doi.org/10.1002/adhm.201900123 https://doi.org/10.1002/adhm.201900123

Xu XY , Wang YW , Han CH , et al. , 2024 . Poison turned panacea: arsenic trioxide loaded hydrogel for inhibiting scar formation in wound healing . ACS Biomater Sci Eng , 10 ( 10 ): 6533 - 6544 . https://doi.org/10.1021/acsbiomaterials.4c01083 https://doi.org/10.1021/acsbiomaterials.4c01083

Yang BW , Lin YM , Huang YB , et al. , 2023 . Extracellular vesicles modulate key signalling pathways in refractory wound healing . Burns Trauma , 11 : tkad039 . https://doi.org/10.1093/burnst/tkad039 https://doi.org/10.1093/burnst/tkad039

Yang CH , Zhang ZK , Gan L , et al. , 2023 . Application of biomedical microspheres in wound healing . Int J Mol Sci , 24 ( 8 ): 7319 . https://doi.org/10.3390/ijms24087319 https://doi.org/10.3390/ijms24087319

Yang GW , Liu LT , Xiao LY , et al. , 2024 . Accelerated scarless wound healing by dynamical regulation of angiogenesis and inflammation with immobilized asiaticoside and magnesium ions in silk nanofiber hydrogels . J Mater Chem B , 12 ( 45 ): 11670 - 11684 . https://doi.org/10.1039/d4tb01584c https://doi.org/10.1039/d4tb01584c

Yang JT , Wu DW , Li JP , et al. , 2024 . An injectable composite hydrogel of verteporfin-bonded carboxymethyl chitosan and oxidized sodium alginate facilitates scarless full-thickness skin regeneration . Macromol Biosci , 24 ( 2 ): 2300165 . https://doi.org/10.1002/mabi.202300165 https://doi.org/10.1002/mabi.202300165

Yang S , Jiang H , Qian M , et al. , 2022 . MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model . Biomed Mater , 17 ( 3 ): 034104 . https://doi.org/10.1088/1748-605X/ac68bc https://doi.org/10.1088/1748-605X/ac68bc

Yang YH , Suo D , Xu TP , et al. , 2024 . Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing . Sci Adv , 10 ( 33 ): eado9479 . https://doi.org/10.1126/sciadv.ado9479 https://doi.org/10.1126/sciadv.ado9479

Yang YL , Zhang JN , Wu SW , et al. , 2024 . Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions . Biomaterials , 308 : 122558 . https://doi.org/10.1016/j.biomaterials.2024.122558 https://doi.org/10.1016/j.biomaterials.2024.122558

Yin JY , Zhang SM , Yang C , et al. , 2022 . Mechanotransduction in skin wound healing and scar formation: potential therapeutic targets for controlling hypertrophic scarring . Front Immunol , 13 : 1028410 . https://doi.org/10.3389/fimmu.2022.1028410 https://doi.org/10.3389/fimmu.2022.1028410

Ying XZ , Yu CC , Yang WT , et al. , 2024 . The transformation of multifunctional bio-patch to hydrogel on skin wounds for efficient scarless wound healing . Mater Today Bio , 24 : 100901 . https://doi.org/10.1016/j.mtbio.2023.100901 https://doi.org/10.1016/j.mtbio.2023.100901

Younesi FS , Miller AE , Barker TH , et al. , 2024 . Fibroblast and myofibroblast activation in normal tissue repair and fibrosis . Nat Rev Mol Cell Biol , 25 ( 8 ): 617 - 638 . https://doi.org/10.1038/s41580-024-00716-0 https://doi.org/10.1038/s41580-024-00716-0

Yu QY , Sun H , Yue ZW , et al. , 2023 . Zwitterionic polysaccharide-based hydrogel dressing as a stem cell carrier to accelerate burn wound healing . Adv Healthc Mater , 12 ( 7 ): 2202309 . https://doi.org/10.1002/adhm.202202309 https://doi.org/10.1002/adhm.202202309

Yuan NN , Shao K , Huang S , et al. , 2023 . Chitosan, alginate, hyaluronic acid and other novel multifunctional hydrogel dressings for wound healing: a review . Int J Biol Macromol , 240 : 124321 . https://doi.org/10.1016/j.ijbiomac.2023.124321 https://doi.org/10.1016/j.ijbiomac.2023.124321

Yue K , Trujillo-de Santiago G , Alvarez MM , et al. , 2015 . Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels . Biomaterials , 73 : 254 - 271 . https://doi.org/10.1016/j.biomaterials.2015.08.045 https://doi.org/10.1016/j.biomaterials.2015.08.045

Zhang AD , Liu Y , Qin D , et al. , 2020 . Research status of self-healing hydrogel for wound management: a review . Int J Biol Macromol , 164 : 2108 - 2123 . https://doi.org/10.1016/j.ijbiomac.2020.08.109 https://doi.org/10.1016/j.ijbiomac.2020.08.109

Zhang DY , Ouyang QQ , Hu Z , et al. , 2021 . Catechol functionalized chitosan/active peptide microsphere hydrogel for skin wound healing . Int J Biol Macromol , 173 : 591 - 606 . https://doi.org/10.1016/j.ijbiomac.2021.01.157 https://doi.org/10.1016/j.ijbiomac.2021.01.157

Zhang J , Zheng YJ , Lee J , et al. , 2021 . A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing . Nat Commun , 12 : 1670 . https://doi.org/10.1038/s41467-021-21964-0 https://doi.org/10.1038/s41467-021-21964-0

Zhang Q , Shi L , He H , et al. , 2022 . Down-regulating scar formation by microneedles directly via a mechanical communication pathway . ACS Nano , 16 ( 7 ): 10163 - 10178 . https://doi.org/10.1021/acsnano.1c11016 https://doi.org/10.1021/acsnano.1c11016

Zhang T , Wang XF , Wang ZC , et al. , 2020 . Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation . Biomed Pharmacother , 129 : 110287 . https://doi.org/10.1016/j.biopha.2020.110287 https://doi.org/10.1016/j.biopha.2020.110287

Zhang YH , Kang J , Chen X , et al. , 2023 . Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds . J Nanobiotechnol , 21 : 435 . https://doi.org/10.1186/s12951-023-02209-2 https://doi.org/10.1186/s12951-023-02209-2

Zhao RL , Liang H , Clarke E , et al. , 2016 . Inflammation in chronic wounds . Int J Mol Sci , 17 ( 12 ): 2085 . https://doi.org/10.3390/ijms17122085 https://doi.org/10.3390/ijms17122085

Zhao Y , Li MX , Mao JY , et al. , 2024 . Immunomodulation of wound healing leading to efferocytosis . Smart Med , 3 ( 1 ): e20230036 . https://doi.org/10.1002/smmd.20230036 https://doi.org/10.1002/smmd.20230036

Zhao YF , Liu J , Sun LX , et al. , 2025 . Zinc-doped curcumin carbon dots promote infected wound healing with photodynamic via the VEGF signaling pathway . J Nanobiotechnol , 23 : 424 . https://doi.org/10.1186/s12951-025-03509-5 https://doi.org/10.1186/s12951-025-03509-5

Zheng X , Ding ZZ , Cheng WN , et al. , 2020 . Microskin-inspired injectable MSC-laden hydrogels for scarless wound healing with hair follicles . Adv Healthc Mater , 9 ( 10 ): 2000041 . https://doi.org/10.1002/adhm.202000041 https://doi.org/10.1002/adhm.202000041

Zou ML , Liu SY , Sun ZL , et al. , 2021 . Insights into the role of adipose-derived stem cells: wound healing and clinical regenerative potential . J Cell Physiol , 236 ( 4 ): 2290 - 2297 . https://doi.org/10.1002/jcp.30019 https://doi.org/10.1002/jcp.30019

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