水生态系统中内分泌干扰物对水生生物和人类的影响及检测修复技术进展

Tariq DILDAR; 薛永成; 崔文晓; Mhd IKHWANUDDIN; Muhammad SHAFIQ; 马洪雨

doi:10.1631/jzus.B2500252

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Review | Updated：2026-06-23

水生态系统中内分泌干扰物对水生生物和人类的影响及检测修复技术进展
Endocrine-disrupting chemicals in aquatic ecosystems and their impacts on aquatic organisms and humans with advances in detection and remediation
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第6期页码：561-589
Affiliations：

1.Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, China
2.Agro-Tech Extension Center of Guangdong Province, Guangzhou 511499, China
3.International Joint Research Center for the Development and Utilization of Important Mariculture Varieties Surrounding the South China Sea Region, Shantou University, Shantou 515063, China
4.STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou 515063, China
5.Higher Institute Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, Kuala Nerus 21030, Malaysia
6.Institute of Clinical Pharmacy, Department of Pharmacology, Shantou University Medical College, Shantou 515041, China
Funds：

the Research on Breeding Technology of Candidate Species for Guangdong Modern Marine Ranching(2024-MRB-00-001);the National Natural Science Foundation of China(32473150);the Program of Agricultural and Rural Department of Guangdong Province(2024-SPY-00-013)
DOI：10.1631/jzus.B2500252
中图分类号：
CSTR：
收稿：2025-05-14，

修回：2025-08-15，

纸质出版：2026-06-15
Accepted：

Tariq DILDAR,薛永成,崔文晓等.水生态系统中内分泌干扰物对水生生物和人类的影响及检测修复技术进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):561-589.

Tariq DILDAR, Yongcheng XUE, Wenxiao CUI, et al. Endocrine-disrupting chemicals in aquatic ecosystems and their impacts on aquatic organisms and humans with advances in detection and remediation[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 561-589.
Tariq DILDAR,薛永成,崔文晓等.水生态系统中内分泌干扰物对水生生物和人类的影响及检测修复技术进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):561-589. DOI： 10.1631/jzus.B2500252.

Tariq DILDAR, Yongcheng XUE, Wenxiao CUI, et al. Endocrine-disrupting chemicals in aquatic ecosystems and their impacts on aquatic organisms and humans with advances in detection and remediation[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 561-589. DOI： 10.1631/jzus.B2500252.

摘要

在人口增长及工农业生产加剧的推动下，日益增加的人类活动促使内分泌干扰物（EDCs）被广泛释放到水生态系统中，对环境和人类健康产生了重大影响。已有诸多研究报道了EDCs在水环境中的浓度及其毒理学效应，但关于其检测方法和修复技术的研究仍然较少。本综述旨在系统阐述水生态系统中EDCs的来源、动力学和生物累积特征，并分析其对水生物种和人类健康的毒理学影响。此外，本综述还概述了先进的检测和修复技术。结果发现，EDCs（特别是邻苯二甲酸盐和双酚）常跟随工业废水、生活垃圾和农业径流经人类活动被排放到水体中。EDCs与水生生物的各种毒性效应密切相关，包括生物累积、跨代效应、生长减缓、免疫毒性、DNA损伤和异常激素释放，进而损害水生生物的生殖和发育功能。在检测技术方面，相比于传统方法，生物传感器、表面增强拉曼光谱和核磁共振光谱被认为是水环境中EDCs检测最具前景的三种技术。在新兴修复技术中，混合活性炭系统和氮掺杂碳吸附剂因其高效的去除能力而备受青睐。总之，本综述为促进水生态系统中EDCs的毒性机制研究，以及推动检测和修复技术发展提供了宝贵的参考资料。

Abstract

The increasing anthropogenic burden

driven by population growth and intensified industrial and agricultural practices

has led to the widespread release of endocrine-disrupting chemicals (EDCs) into aquatic ecosystems

with significant implications for both environmental and human health. Many studies have reported the concentrations and toxicological effects of EDCs in aquatic environments

but few have addressed detection methods and remediation techniques. This review aims to highlight the sources

dynamics

and bioaccumulation of EDCs in aquatic ecosystems

along with their toxic effects on aquatic species and associated health risks in humans. Additionally

we provide an overview of advanced detection and remediation techniques. Our review found that EDCs

particularly phthalates and bisphenols

included in industrial effluents

domestic waste

and agricultural runoff

are frequently discharged into aquatic bodies through human activities. EDCs are associated with various toxic effects in aquatic organisms

such as bioaccumulation

transgenerational effects

reduced growth

immunotoxicity

DNA damage

and abnormal hormonal release

which impair reproductive development. Among the detection methods

biosensors

surface-enhanced Raman spectroscopy (SERS)

and nuclear magnetic resonance (NMR) spectroscopy are promising tools for EDC detection relative to conventional analytical methods in aquatic systems. Emerging remediation techniques

such as hybrid activated carbon systems and N-doped carbon-based adsorbents

are recommended for their high removal efficiency. This review serves as a valuable resource for advancing research on EDC toxicity

detection

and remediation technologies.

关键词

Keywords

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