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1.Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830017, China
2.Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Urumqi 830017, China
3.Scientific Research Platform of Xinjiang Medical University Key Laboratory of Neurophysiology and Clinical Translation, Urumqi 830017, China
4.Department of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China
5.Liangzhu Laboratory, Hangzhou 311121, China
收稿:2025-04-22,
修回:2025-11-03,
纸质出版:2026-01-27
刘毅,段福芹,林润鹏等.TRPV1:从结构到功能——多维度治疗靶点的研究进展[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2026,27(01):1-22.
Yi LIU, Fuqin DUAN, Runpeng LIN, et al. TRPV1: from structure to function—a multidimensional target for therapeutic advances[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 1-22.
刘毅,段福芹,林润鹏等.TRPV1:从结构到功能——多维度治疗靶点的研究进展[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2026,27(01):1-22. DOI: 10.1631/jzus.B2500209.
Yi LIU, Fuqin DUAN, Runpeng LIN, et al. TRPV1: from structure to function—a multidimensional target for therapeutic advances[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 1-22. DOI: 10.1631/jzus.B2500209.
瞬时受体电位香草素亚型1(transient receptor potential vanilloid subtype 1,TRPV1)是一种多模态激活的钙离子通透性非选择性阳离子通道蛋白,广泛分布于全身各部位,在伤害感觉神经元中表达显著。该离子通道在生理与病理状态下均发挥关键作用,不仅介导多种刺激的应答反应,还参与维持机体稳态。TRPV1凭借其对温度变化、化学配体及电压波动的独特响应能力,成为理解与调控正常生理功能的关键靶点,同时也为疾病诊断与治疗提供重要依据。本文系统综述了TRPV1的结构、门控机制及其生理和病理作用,强调了其在多种疾病中的潜在治疗价值。本综述全面概述TRPV1的多重功能,旨在为未来研究提供思路,并推动以TRPV1为靶点的新疗法研发,从而助力提升人类健康水平。
Transient receptor potential vanilloid subtype 1 (TRPV1)
a polymodally activated
calcium-permeable non-selective cation channel
is broadly present in all parts of the body
with notable expression in the nociceptive neurons. Both physiological and pathological functions rely heavily on this ion channel
mediating responses to a variety of stimuli and contributing to the maintenance of bodily homeostasis. Its unique ability to respond to temperature changes
chemical ligands
and voltage fluctuations positions TRPV1 as a key target in understanding and modulating normal bodily functions
in addition to diagnosing and treating diseases. This review synthesizes current knowledge on the structure
gating mechanisms
and physiological and pathological roles of TRPV1
highlighting its potential as a therapeutic target across multiple disease states. By providing a comprehensive overview of the multifaceted functions of TRPV1
this review aims to inform and inspire future research
finally contributing to the advancement of new therapeutic techniques focusing on TRPV1 to enhance human health.
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