肺硬化性肺细胞瘤伴淋巴结转移及PET/CT <sup>18</sup>FDG高摄取：一例罕见病例报告及文献综述

徐敬峰; 赵艺蕾; 吴秋莉; 陈峰

doi:10.1631/jzus.B2500159

Your Location：

Home >

Browse articles >

肺硬化性肺细胞瘤伴淋巴结转移及PET/CT ¹⁸FDG高摄取：一例罕见病例报告及文献综述

Scan QR Code

文章被引用时，请邮件提醒。

Submit

Correspondence | Updated：2026-02-06

肺硬化性肺细胞瘤伴淋巴结转移及PET/CT ¹⁸FDG高摄取：一例罕见病例报告及文献综述
Pulmonary sclerosing pneumocytoma with lymph node metastasis and high ¹⁸FDG uptake in PET/CT: a rare case report and literature review
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第2期页码：202-206
Affiliations：

1.Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Funds：

the Zhejiang Province Public Welfare Technology Application Research Project(LGF19H220003)
DOI：10.1631/jzus.B2500159
中图分类号：
CSTR：
收稿：2025-03-30，

修回：2025-05-19，

纸质出版：2026-02-06
Accepted：

徐敬峰,赵艺蕾,吴秋莉等.肺硬化性肺细胞瘤伴淋巴结转移及PET/CT ¹⁸FDG高摄取：一例罕见病例报告及文献综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):202-206.

Jingfeng XU, Yilei ZHAO, Qiuli WU, et al. Pulmonary sclerosing pneumocytoma with lymph node metastasis and high ¹⁸FDG uptake in PET/CT: a rare case report and literature review[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 202-206.
徐敬峰,赵艺蕾,吴秋莉等.肺硬化性肺细胞瘤伴淋巴结转移及PET/CT ¹⁸FDG高摄取：一例罕见病例报告及文献综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):202-206. DOI： 10.1631/jzus.B2500159.

Jingfeng XU, Yilei ZHAO, Qiuli WU, et al. Pulmonary sclerosing pneumocytoma with lymph node metastasis and high ¹⁸FDG uptake in PET/CT: a rare case report and literature review[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 202-206. DOI： 10.1631/jzus.B2500159.

摘要

Abstract

硬化性肺细胞瘤（PSP）最初被称为肺硬化性血管瘤（PSH），曾被认为来源于血管丰富的内皮细胞。然而近期相关研究表明，该肿瘤实际来源于肺泡上皮细胞。尽管以往研究普遍认为PSP是一种罕见的良性肺肿瘤，但已有报道显示其可发生肺及淋巴结等部位的转移，提示其具有潜在恶行生物学行为。正电子发射计算机断层显像（PET/CT）可显示出PSP对

F-氟脱氧葡萄（

FDG）的摄取程度不一，最大标准化摄取值（SUV

max

）从背景值到6.4不等。因此，PSP很容易被误诊为其他恶性肿瘤，从而接受不必要的手术切除或不恰当治疗。本文报告了一例罕见的年轻PSP患者病例，其PET/CT显示右肺巨大肿块伴右肺门淋巴结肿大，肿瘤和淋巴结的SUV

max

分别为6.1和5.1，属于已有文献报道中最高的摄取值之一。目前，PSP病灶淋巴结转移和/或

FDG高摄取的原因尚不明确，其是否与肿瘤发生部位、大小、血供以及患者的年龄、性别和吸烟史相关，仍无定论。此外，本研究进一步回顾分析了近十年来PSP淋巴结转移和/或

FDG高摄取的文献，通过统计分析肿瘤大小，淋巴结转移和

FDG摄取等情况，发现淋巴结的转移与和/或

FDG高摄取与肿瘤大小正相关（

=0.642，

=0.454，

0.001）。综上，对于年轻患者，若其影像出现肺部边界清楚的较大肿块，即使伴有淋巴结转移和/或

FDG高摄取，仍需要考虑PSP的可能。

关键词

Keywords

references

Arumugam VG , Joseph LD , Thangavel P , et al. , 2017 . Sclerosing pneumocytoma of the lung: a case report . J Clin Diagn Res , 11 ( 2 ): ED12 - ED14 . https://doi.org/10.7860/JCDR/2017/22279.9271 https://doi.org/10.7860/JCDR/2017/22279.9271

Bae K , Song DH , Jeon KN , et al. , 2019 . Pulmonary sclerosing pneumocytoma presenting a peritumoral halo and an intervening lucent zone on computed tomography: radiology–pathology correlation . Thorac Cancer , 10 ( 5 ): 1295 - 1296 . https://doi.org/10.1111/1759-7714.13069 https://doi.org/10.1111/1759-7714.13069

Chen QY , Wu LJ , Hu HZ , et al. , 2012 . A case of pulmonary sclerosing hemangioma with low 18 FDG uptake in PET . Oncol Lett , 3 ( 3 ): 646 - 648 . https://doi.org/10.3892/ol.2011.5248492317727668 https://doi.org/10.3892/ol.2011.5248492317727668

Cherian SV , Estrada-Y-Martin RM , Irani AD , et al. , 2017 . A 33-year-old woman with a fluorodeoxyglucose-avid left lower lobe mass . Chest , 151 ( 5 ): e119 - e122 . https://doi.org/10.1016/j.chest.2016.10.049 https://doi.org/10.1016/j.chest.2016.10.049

Chien NC , Lin CW , Tzeng JE , 2009 . Sclerosing haemangioma with lymph node metastasis . Respirology , 14 ( 4 ): 614 - 616 . https://doi.org/10.1111/j.1440-1843.2009.01523.x https://doi.org/10.1111/j.1440-1843.2009.01523.x

Cho HJ , Lee JH , Lee GK , et al. , 2017 . Case of sclerosing pneumocytoma combined with a typical carcinoid and pulmonary adenocarcinoma in different lobes . Thorac Cancer , 8 ( 4 ): 372 - 375 . https://doi.org/10.1111/1759-7714.12449 https://doi.org/10.1111/1759-7714.12449

David N , Chandy ST , Benjamin SR , et al. , 2022 . Pulmonary sclerosing pneumocytoma—a case series . Indian J Thorac Cardiovasc Surg , 38 ( 2 ): 167 - 172 . https://doi.org/10.1007/s12055-021-01269-z https://doi.org/10.1007/s12055-021-01269-z

de Luca G , Martucci N , Setola S , et al. , 2015 . Sclerosing hemangioma of the lung mimicking pulmonary metastasis . Lung , 193 ( 3 ): 447 - 448 . https://doi.org/10.1007/s00408-015-9711-0 https://doi.org/10.1007/s00408-015-9711-0

Devouassoux-Shisheboran M , Hayashi T , Linnoila RI , et al. , 2000 . A clinicopathologic study of 100 cases of pulmon ary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. Am J Surg Pathol , 24 ( 7 ): 906 - 916 . https://doi.org/10.1097/00000478-200007000-00002 https://doi.org/10.1097/00000478-200007000-00002

Jiang L , Huang Y , Tang QY , et al. , 2018 . 18 F‑FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma . Oncol Lett , 16 ( 1 ): 660 - 665 . https://doi.org/10.3892/ol.2018.8660 https://doi.org/10.3892/ol.2018.8660

Katakura H , Sato M , Tanaka F , et al. , 2005 . Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node . Ann Thorac Surg , 80 ( 6 ): 2351 - 2353 . https://doi.org/10.1016/j.athoracsur.2004.06.099 https://doi.org/10.1016/j.athoracsur.2004.06.099

Khanna A , Alshabani K , Mukhopadhyay S , et al. , 2019 . Sclerosing pneumocytoma: case report of a rare endobronchial presentation . Medicine , 98 ( 15 ): e15038 . https://doi.org/10.1097/MD.0000000000015038 https://doi.org/10.1097/MD.0000000000015038

Khoo ACH , Hamzah F , Ong CK , 2017 . Incidental sclerosing pneumocytoma detected on bone scintigraphy . Clin Nucl Med , 42 ( 1 ): e77 - e79 . https://doi.org/10.1097/RLU.0000000000001371 https://doi.org/10.1097/RLU.0000000000001371

Kim KH , Sul HJ , Kang DY , 2003 . Sclerosing hemangioma with lymph node metastasis . Yonsei Med J , 44 ( 1 ): 150 - 154 . https://doi.org/10.3349/ymj.2003.44.1.150 https://doi.org/10.3349/ymj.2003.44.1.150

Kim MK , Jang SJ , Kim YH , et al. , 2015 . Bone metastasis in pulmonary sclerosing hemangioma . Korean J Intern Med , 30 ( 6 ): 928 - 930 . https://doi.org/10.3904/kjim.2015.30.6.928 https://doi.org/10.3904/kjim.2015.30.6.928

Kocaman G , Yenigün MB , Ersöz CC , et al. , 2021 . Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis: a case report . Gen Thorac Cardiovasc Surg , 69 ( 1 ): 142 - 146 . https://doi.org/10.1007/s11748-020-01431-1 https://doi.org/10.1007/s11748-020-01431-1

Lee K , Sasaki M , Kakimoto T , et al. , 2019 . Pulmonary sclerosing pneumocytoma demonstrating intratumoral hematoma . Respir Med Case Rep , 28 : 100870 . https://doi.org/10.1016/j.rmcr.2019.100870 https://doi.org/10.1016/j.rmcr.2019.100870

Liebow AA , Hubbell DS , 1956 . Sclerosing hemangioma (histiocytoma, xanthoma) of the lung . Cancer , 9 ( 1 ): 53 - 75 . https://doi.org/10.1002/1097-0142(195601/02)9:1<53::aid-cncr2820090104>3.0.co;2-u https://doi.org/10.1002/1097-0142(195601/02)9:1<53::aid-cncr2820090104>3.0.co;2-u

Lim JH , Lee N , Choi DW , et al. , 2016 . Pulmonary sclerosing pneumocytoma mimicking lung cancer: case report and review of the literature . Thorac Cancer , 7 ( 4 ): 508 - 511 . https://doi.org/10.1111/1759-7714.12341 https://doi.org/10.1111/1759-7714.12341

Maeda H , Kanzaki M , Isaka T , et al. , 2015 . Video-assisted thoracoscopic enucleation after congenital cardiac surgery . J Surg Case Rep , 2015 ( 9 ): rjv123 . https://doi.org/10.1093/jscr/rjv123 https://doi.org/10.1093/jscr/rjv123

Masuda M , Endo S , Natsugoe S , et al. , 2018 . Thoracic and cardiovascular surgery in Japan during 2015 . Gen Thorac Cardiovasc Surg , 66 ( 10 ): 581 - 615 . https://doi.org/10.1007/s11748-018-0968-0 https://doi.org/10.1007/s11748-018-0968-0

Miyagawa-Hayashino A , Tazelaar HD , Langel DJ , et al. , 2003 . Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases . Arch Pathol Lab Med , 127 ( 3 ): 321 - 325 . https://doi.org/10.5858/2003-127-0321-pshwln https://doi.org/10.5858/2003-127-0321-pshwln

Morikawa K , Misumi S , Fukuda T , et al. , 2019 . Pulmonary sclerosing pneumocytoma presenting as slow-growing multiple nodules over a long period . Radiol Case Rep , 14 ( 5 ): 602 - 607 . https://doi.org/10.1016/j.radcr.2019.02.024 https://doi.org/10.1016/j.radcr.2019.02.024

Nguyen XC , Lee WW , Chung JH , et al. , 2007 . FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: correlations and prognostic values . Eur J Radiol , 62 ( 2 ): 214 - 219 . https://doi.org/10.1016/j.ejrad.2006.12.008 https://doi.org/10.1016/j.ejrad.2006.12.008

Pokharel S , Dhillon SS , Ylagan L , et al. , 2016 . Sclerosing pneumocytoma with lymph node metastasis . J Thorac Oncol , 11 ( 10 ): 1802 - 1804 . https://doi.org/10.1016/j.jtho.2016.06.005 https://doi.org/10.1016/j.jtho.2016.06.005

Satoh Y , Tsuchiya E , Weng SY , et al. , 1989 . Pulmonary sclerosing hemangioma of the lung. A type II pneumocytoma by immunohistochemical and immunoelectron microscopic studies . Cancer , 64 ( 6 ): 1310 - 1317 . https://doi.org/10.1002/1097-0142(19890915)64:6<1310::aid-cncr2820640624>3.0.co;2-s https://doi.org/10.1002/1097-0142(19890915)64:6<1310::aid-cncr2820640624>3.0.co;2-s

Sakai T , Miyoshi T , Umemura S , et al. , 2019 . Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report . Oxf Med Case Reports , 2019 ( 7 ): omz066 . https://doi.org/10.1093/omcr/omz066 https://doi.org/10.1093/omcr/omz066

Schiergens TS , Khalil PN , Mayr D , et al. , 2011 . Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case . World J Surg Oncol , 9 : 62 . https://doi.org/10.1186/1477-7819-9-62 https://doi.org/10.1186/1477-7819-9-62

Shiina Y , Sakairi Y , Wada H , et al. , 2018 . Sclerosing pneumocytoma diagnosed by preoperative endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) . Surg Case Rep , 4 : 20 . https://doi.org/10.1186/s40792-018-0429-0 https://doi.org/10.1186/s40792-018-0429-0

Soo IX , Sittampalam K , Lim CH , 2017 . Pulmonary sclerosing pneumocytoma with mediastinal lymph node metastasis . Asian Cardiovasc Thorac Ann , 25 ( 7-8 ): 547 - 549 . https://doi.org/10.1177/021 https://doi.org/10.1177/021

Sun Y , Zhou LX , Zhao M , et al. , 2012 . Histogenesis of pulmonary sclerosing hemangioma . Chin J Pathol , 41 ( 4 ): 239 - 242 (in Chinese) . https://doi.org/10.3760/cma.j.issn.0529-5807.2012.04.006 https://doi.org/10.3760/cma.j.issn.0529-5807.2012.04.006

Tanaka I , Inoue M , Matsui Y , et al. , 1986 . A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis . Jpn J Clin Oncol , 16 ( 1 ): 77 - 86 . https://doi.org/10.1093/oxfordjournals.jjco.a039119 https://doi.org/10.1093/oxfordjournals.jjco.a039119

Travis WD , Brambilla E , Nicholson AG , et al. , 2015 . The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification . J Thorac Oncol , 10 ( 9 ): 1243 - 1260 . https://doi.org/10.1097/JTO.0000000000000630 https://doi.org/10.1097/JTO.0000000000000630

Xu J , Dong YW , Yin GT , et al. , 2019 . 18 F-FDG PET/CT imaging: a supplementary understanding of pulmonary sclerosing pneumocytoma . Thorac Cancer , 10 ( 7 ): 1552 - 1560 . https://doi.org/10.1111/1759-7714.13100 https://doi.org/10.1111/1759-7714.13100

Yano M , Yamakawa Y , Kiriyama M , et al. , 2002 . Sclerosing hemangioma with metastases to multiple nodal stations . Ann Thorac Surg , 73 ( 3 ): 981 - 983 . https://doi.org/10.1016/s0003-4975(01)03122-8 https://doi.org/10.1016/s0003-4975(01)03122-8

浏览量

Downloads

CSCD

工具集

关联资源

暂无数据

肺硬化性肺细胞瘤伴淋巴结转移及PET/CT 18FDG高摄取：一例罕见病例报告及文献综述

Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT: a rare case report and literature review

DOI：10.1631/jzus.B2500159

摘要

Abstract

关键词

Keywords

references

肺硬化性肺细胞瘤伴淋巴结转移及PET/CT ¹⁸FDG高摄取：一例罕见病例报告及文献综述

Pulmonary sclerosing pneumocytoma with lymph node metastasis and high ¹⁸FDG uptake in PET/CT: a rare case report and literature review