Alamandine通过MrgD介导的HIF-1α/VEGF通路改善病理性视网膜血管新生

赵锟; 姜亚萍; 黄雯; 毛宇康; 陈轶卉; 李鹏; 杨传熙

doi:10.1631/jzus.B2500154

Your Location：

Home >

Browse articles >

Alamandine通过MrgD介导的HIF-1α/VEGF通路改善病理性视网膜血管新生

Scan QR Code

文章被引用时，请邮件提醒。

Submit

Research Article | Updated：2025-11-04

Alamandine通过MrgD介导的HIF-1α/VEGF通路改善病理性视网膜血管新生
Alamandine inhibits pathological retinal neovascularization by targeting the MrgD-mediated HIF-1α/VEGF pathway
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第10期页码：1015-1036
Affiliations：

1.Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
2.Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200082, China
3.Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China
4.Department of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200082, China
Funds：

the National Natural Science Foundation of China(82200379;82300309);the Shanghai Sailing Program(22YF1443100);the Academy Talent Special Fund of The First Affiliated Hospital of Nanjing Medical University(YNRCQN0312;MXJL202208);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB592)
DOI：10.1631/jzus.B2500154
中图分类号：
CSTR：
收稿：2025-03-27，

修回：2025-05-15，

网络出版：2025-10-07，

纸质出版：2025-10-20
Accepted：

赵锟,姜亚萍,黄雯等.Alamandine通过MrgD介导的HIF-1α/VEGF通路改善病理性视网膜血管新生[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):1015-1036.

Kun ZHAO, Yaping JIANG, Wen HUANG, et al. Alamandine inhibits pathological retinal neovascularization by targeting the MrgD-mediated HIF-1α/VEGF pathway[J]. Journal of zhejiang university-science b, 2025, 26(10): 1015-1036.
赵锟,姜亚萍,黄雯等.Alamandine通过MrgD介导的HIF-1α/VEGF通路改善病理性视网膜血管新生[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):1015-1036. DOI： 10.1631/jzus.B2500154.

Kun ZHAO, Yaping JIANG, Wen HUANG, et al. Alamandine inhibits pathological retinal neovascularization by targeting the MrgD-mediated HIF-1α/VEGF pathway[J]. Journal of zhejiang university-science b, 2025, 26(10): 1015-1036. DOI： 10.1631/jzus.B2500154.

摘要

早产儿视网膜病变（ROP）是一种由缺氧导致视网膜血管病理性生长的疾病，威胁患儿的视力健康。本研究探究了肾素-血管紧张素家族中的一种新型七肽—alamandine，对低氧诱导的视网膜血管新生的影响及其潜在生物学机制。液相色谱-串联质谱法（LC-MS/MS）分析结果显示：与对照组相比，氧诱导性视网膜病变（OIR）小鼠血清和视网膜中的alamandine水平显著降低；体内alamandine的补充可显著改善低氧诱导的OIR小鼠视网膜病理性血管新生和生理性的血运重建。体外实验发现，alamandine能通过抑制HIF-1α/VEGF通路，有效抑制VEGF诱导人视网膜微血管内皮细胞（HRMECs）的增殖、迁移和成管。此外，Mas相关G蛋白偶联受体D（MrgD）拮抗剂D-Pro

，具有可逆转alamandine在体内和体外对低氧诱导的病理性血管生成的保护作用。上述研究结果表明，alamandine可通过MrgD介导的HIF-1α/VEGF通路减轻视网膜病理性新生血管的形成，为OIR的临床防治提供潜在方向。

Abstract

Retinopathy of prematurity (ROP) is a vision-threatening disorder that leads to pathological growth of the retinal vasculature due to hypoxia. Here

we investigated the potential effects of alamandine

a novel heptapeptide in the renin-angiotensin system (RAS)

on hypoxia-induced retinal neovascularization and its underlying mechanisms. In vivo

the C57BL/6J mice with oxygen-induced retinopathy (OIR) were injected intravitreally with alamandine (1.0 μmol/kg per eye). In vitro

human retinal microvascular endothelial cells (HRMECs) were utilized to investigate the effects of alamandine (10 μg/mL) on proliferation

apoptosis

migration

and tubular formation under vascular endothelial growth factor (VEGF) stimulation. Single-cell RNA sequencing (scRNA-seq) matrix data from the Gene Expression Omnibus (GEO) database and RAS-related genes from the Molecular Signatures Database (MSigDB) were sourced for subsequent analyses. By integrating scRNA-seq data across multiple species

we identified that RAS-associated endothelial cell populations were highly related to retinal neovascularization. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis revealed a significant decrease in alamandine levels in both the serum and retina of OIR mice compared to those in the control group. Next

alamandine ameliorated hyp

oxia-induced retinal pathological neovascularization and physiologic revascularization in OIR mice. In vitro

alamandine effectively mitigated VEGF-induced proliferation

scratch wound healing

and tube formation of HRMECs primarily by inhibiting the hypoxia-inducible factor-1α (HIF-1α)/VEGF pathway. Further

coincubation with D-Pro

(Mas-related G protein-coupled receptor D (MrgD) antagonist) hindered the beneficial impacts of alamandine on hypoxia-induced pathological angiogenesis both in vivo and in vitro. Our findings suggested that alamandine could mitigate retinal neovascularization by targeting the MrgD-mediated HIF-1α/VEGF pathway

providing a potential therapeutic agent for OIR prevention and treatment.

关键词

Keywords

references

Ahmed NEMB , Murakami M , Kaneko S , et al. , 2016 . The effects of hypoxia on the stemness properties of human dental pulp stem cells (DPSCs) . Sci Rep , 6 : 35476 . https://doi.org/10.1038/srep35476 https://doi.org/10.1038/srep35476

Amraei R , Rahimi N , 2020 . COVID-19, renin-angiotensin system and endothelial dysfunction . Cells , 9 ( 7 ): 1652 . https://doi.org/10.3390/cells9071652 https://doi.org/10.3390/cells9071652

Aouiss A , Anka Idrissi D , Kabine M , et al. , 2019 . Update of inflammatory proliferative retinopathy: ischemia, hypoxia and angiogenesis . Curr Res Transl Med , 67 ( 2 ): 62 - 71 . https://doi.org/10.1016/j.retram.2019.01.005 https://doi.org/10.1016/j.retram.2019.01.005

Au NPB , Ma CHE , 2022 . Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy . Front Immunol , 13 : 860070 . https://doi.org/10.3389/fimmu.2022.860070 https://doi.org/10.3389/fimmu.2022.860070

Boddu SHS , Acharya D , Hala V , et al. , 2023 . An update on strategies to deliver protein and peptide drugs to the eye . ACS Omega , 8 ( 39 ): 35470 - 35498 . https://doi.org/10.1021/acsomega.3c02897 https://doi.org/10.1021/acsomega.3c02897

Brenner M , Messing A , 2021 . Regulation of GFAP expression . ASN Neuro , 13 : 1759091420981206 . https://doi.org/10.1177/1759091420981206 https://doi.org/10.1177/1759091420981206

Broxterman EC , Hug DA , 2016 . Retinopathy of prematurity: a review of current screening guidelines and treatment options . Mo Med , 113 ( 3 ): 187 - 190 .

Chang E , Josan AS , Purohit R , et al. , 2022 . A network meta-analysis of retreatment rates following bevacizumab, ranibizumab, aflibercept, and laser for retinopathy of prematurity . Ophthalmology , 129 ( 12 ): 1389 - 1401 . https://doi.org/10.1016/j.ophtha.2022.06.042 https://doi.org/10.1016/j.ophtha.2022.06.042

Chang RL , Lin JW , Kuo WW , et al. , 2016 . Angiotensin-(1–7) attenuated long-term hypoxia-stimulated cardiomyocyte apoptosis by inhibiting HIF-1α nuclear translocation via Mas receptor regulation . Growth Factors , 34 ( 1-2 ): 11 - 18 . https://doi.org/10.3109/08977194.2016.1155150 https://doi.org/10.3109/08977194.2016.1155150

Checchin D , Sennlaub F , Levavasseur E , et al. , 2006 . Potential role of microglia in retinal blood vessel formation . Invest Ophthalmol Vis Sci , 47 ( 8 ): 3595 - 3602 . https://doi.org/10.1167/iovs.05-1522 https://doi.org/10.1167/iovs.05-1522

Cheng Y , Zhang M , Xu R , et al. , 2024 . P53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6 . Exp Gerontol , 188 : 112391 . https://doi.org/10.1016/j.exger.2024.112391 https://doi.org/10.1016/j.exger.2024.112391

Cheng Y , Zhang M , Li CG , et al. , 2025 . Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling . Nat Commun , 16 : 1332 . https://doi.org/10.1038/s41467-025-55970-3 https://doi.org/10.1038/s41467-025-55970-3

Choręziak-Michalak A , Szpecht D , Chmielarz-Czarnocińska A , et al. , 2023 . Comprehensive analysis of the role of gene variants in matrix metalloproteinases and their tissue inhibitors in retinopathy of prematurity: a study in the Polish population . Int J Mol Sci , 24 ( 20 ): 15309 . https://doi.org/10.3390/ijms242015309 https://doi.org/10.3390/ijms242015309

Connor KM , Krah NM , Dennison RJ , et al. , 2009 . Quantifi cation of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc , 4 ( 11 ): 1565 - 1573 . https://doi.org/10.1038/nprot.2009.187 https://doi.org/10.1038/nprot.2009.187

Dammann O , Hartnett ME , Stahl A , 2023 . Retinopathy of prematurity . Dev Med Child Neurol , 65 ( 5 ): 625 - 631 . https://doi.org/10.1111/dmcn.15468 https://doi.org/10.1111/dmcn.15468

Daruich A , Bremond-Gignac D , Behar-Cohen F , et al. , 2020 . Retinopathy of prematurity: from prevention to treatment . Med Sci (Paris) , 36 ( 10 ): 900 - 907 . https://doi.org/10.1051/medsci/2020163 https://doi.org/10.1051/medsci/2020163

de Carvalho Santuchi M , Dutra MF , Vago JP , et al. , 2019 . Angiotensin-(1–7) and alamandine promote anti-inflammatory response in macrophages in vitro and in vivo . Mediators Inflamm , 2019 : 2401081 . https://doi.org/10.1155/2019/2401081 https://doi.org/10.1155/2019/2401081

de Jesus ICG , Scalzo S , Alves F , et al. , 2018 . Alamandine acts via MrgD to induce AMPK/NO activation against Ang II hypertrophy in cardiomyocytes . Am J Physiol Cell Physiol , 314 ( 6 ): C702 - C711 . https://doi.org/10.1152/ajpcell.00153.2017 https://doi.org/10.1152/ajpcell.00153.2017

de Jesus ICG , Mesquita T , Souza Santos RA , et al. , 2023 . An overview of alamadine/MrgD signaling and its role in cardiomyocytes . Am J Physiol Cell Physiol , 324 ( 3 ): C606 - C613 . https://doi.org/10.1152/ajpcell.00399.2021 https://doi.org/10.1152/ajpcell.00399.2021

Domińska K , Okła P , Kowalska K , et al. , 2018 . Angiotensin 1–7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer . Sci Rep , 8 : 15772 . https://doi.org/10.1038/s41598-018-34049-8 https://doi.org/10.1038/s41598-018-34049-8

Dong LJ , Li WB , Lin TT , et al. , 2021 . PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function . Cell Commun Signal , 19 : 14 . https://doi.org/10.1186/s12964-020-00684-w https://doi.org/10.1186/s12964-020-00684-w

Duan YQ , Beli E , Li Calzi S , et al. , 2018 . Loss of angiotensin-converting enzyme 2 exacerbates diabetic retinopathy by promoting bone marrow dysfunction . Stem Cells , 36 ( 9 ): 1430 - 1440 . https://doi.org/10.1002/stem.2848 https://doi.org/10.1002/stem.2848

Fevereiro-Martins M , Marques-Neves C , Guimarães H , et al. , 2023 . Retinopathy of prematurity: a review of pathophysiology and signaling pathways . Surv Ophthalmol , 68 ( 2 ): 175 - 210 . https://doi.org/10.1016/j.survophthal.2022.11.007 https://doi.org/10.1016/j.survophthal.2022.11.007

Guo Y , Gu RP , Gan DK , et al. , 2020 . Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells . Cell Commun Signal , 18 : 172 . https://doi.org/10.1186/s12964-020-00637-3 https://doi.org/10.1186/s12964-020-00637-3

Hartnett ME , 2023 . Pathophysiology of retinopathy of prematurity . Annu Rev Vis Sci , 9 : 39 - 70 . https://doi.org/10.1146/annurev-vision-093022-021420 https://doi.org/10.1146/annurev-vision-093022-021420

He XM , Wen SY , Tang XX , et al. , 2024 . Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling . Acta Pharm Sin B , 14 ( 6 ): 2613 - 2630 . https://doi.org/10.1016/j.apsb.2024.03.011 https://doi.org/10.1016/j.apsb.2024.03.011

Hu ZZ , Mao XY , Chen MK , et al. , 2022 . Single-cell transcriptomics reveals novel role of microglia in fibrovascular membrane of proliferative diabetic retinopathy . Diabetes , 71 ( 4 ): 762 - 773 . https://doi.org/10.2337/db21-0551 https://doi.org/10.2337/db21-0551

Huang H , 2020 . Pericyte-endothelial interactions in the retinal microvasculature . Int J Mol Sci , 21 ( 19 ): 7413 . https://doi.org/10.3390/ijms21197413 https://doi.org/10.3390/ijms21197413

Karlstetter M , Scholz R , Rutar M , et al. , 2015 . Retinal microglia: just bystander or target for therapy? Prog Retin Eye Res , 45 : 30 - 57 . https://doi.org/10.1016/j.preteyeres.2014.11.004 https://doi.org/10.1016/j.preteyeres.2014.11.004

Lashkari K , Hirose T , Yazdany J , et al. , 2000 . Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity . Am J Pathol , 156 ( 4 ): 1337 - 1344 . https://doi.org/10.1016/s0002-9440(10)65004-3 https://doi.org/10.1016/s0002-9440(10)65004-3

Lautner RQ , Villela DC , Fraga-Silva RA , et al. , 2013 . Discovery and characterization of alamandine: a novel compon ent of the renin–angiotensin system. Circ Res , 112 ( 8 ): 1104 - 1111 . https://doi.org/10.1161/circresaha.113.301077 https://doi.org/10.1161/circresaha.113.301077

Li HG , Horke S , Förstermann U , 2014 . Vascular oxidative stress, nitric oxide and atherosclerosis . Atherosclerosis , 237 ( 1 ): 208 - 219 . https://doi.org/10.1016/j.atherosclerosis.2014.09.001 https://doi.org/10.1016/j.atherosclerosis.2014.09.001

Li N , Gao S , Wang J , et al. , 2019 . Anti-apoptotic effect of interleukin-17 in a mouse model of oxygen-induced retino pathy. Exp Eye Res , 187 : 107743 . https://doi.org/10.1016/j.exer.2019.107743 https://doi.org/10.1016/j.exer.2019.107743

Li P , Chen XR , Xu F , et al. , 2018 . Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways . Life Sci , 206 : 106 - 116 . https://doi.org/10.1016/j.lfs.2018.04.010 https://doi.org/10.1016/j.lfs.2018.04.010

Mintz-Hittner HA , Kennedy KA , Chuang AZ , 2011 . Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity . N Engl J Med , 364 ( 7 ): 603 - 615 . https://doi.org/10.1056/NEJMoa1007374 https://doi.org/10.1056/NEJMoa1007374

Moravski CJ , Skinner SL , Stubbs AJ , et al. , 2003 . The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes: transgenic and interventional studies . Am J Pathol , 162 ( 1 ): 151 - 160 . https://doi.org/10.1016/s0002-9440(10)63806-0 https://doi.org/10.1016/s0002-9440(10)63806-0

Nicosia RF , Ottinetti A , 1990 . Growth of microvessels in serum-free matrix culture of rat aorta . A quantitative assay of angiogenesis in vitro. Lab Invest , 63 ( 1 ): 115 - 122 .

Park BM , Phuong HTA , Yu LM , et al. , 2018 . Alamandine protects the heart against reperfusion injury via the MrgD receptor . Circ J , 82 ( 10 ): 2584 - 2593 . https://doi.org/10.1253/circj.CJ-17-1381 https://doi.org/10.1253/circj.CJ-17-1381

Paul M , Poyan Mehr A , Kreutz R , 2006 . Physiology of local renin-angiotensin systems . Physiol Rev , 86 ( 3 ): 747 - 803 . https://doi.org/10.1152/physrev.00036.2005 https://doi.org/10.1152/physrev.00036.2005

Perelli RM , O'Sullivan ML , Zarnick S , et al. , 2021 . Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development . Development , 148 ( 9 ): dev199418 . https://doi.org/10.1242/dev.199418 https://doi.org/10.1242/dev.199418

Phipps JA , Dixon MA , Jobling AI , et al. , 2019 . The renin-angiotensin system and the retinal neurovascular unit: a role in vascular regulation and disease . Exp Eye Res , 187 : 107753 . https://doi.org/10.1016/j.exer.2019.107753 https://doi.org/10.1016/j.exer.2019.107753

Rathi S , Jalali S , Patnaik S , et al. , 2017 . Abnormal complement activation and inflammation in the pathogenesis of retinopathy of prematurity . Front Immunol , 8 : 1868 . https://doi.org/10.3389/fimmu.2017.01868 https://doi.org/10.3389/fimmu.2017.01868

Rattner A , Williams J , Nathans J , 2019 . Roles of HIFs and VEGF in angiogenesis in the retina and brain . J Clin Invest , 129 ( 9 ): 3807 - 3820 . https://doi.org/10.1172/jci126655 https://doi.org/10.1172/jci126655

Rivera JC , Madaan A , Zhou TE , et al. , 2016 . Review of the mechanisms and therapeutic avenues for retinal and choroidal vascular dysfunctions in retinopathy of prematurity . Acta Paediatr , 105 ( 12 ): 1421 - 1433 . https://doi.org/10.1111/apa.13586 https://doi.org/10.1111/apa.13586

Sabri K , Ells AL , Lee EY , et al. , 2022 . Retinopathy of prematurity: a global perspective and recent developments . Pediatrics , 150 ( 3 ): e2021053924 . https://doi.org/10.1542/peds.2021-053924 https://doi.org/10.1542/peds.2021-053924

Santiago AR , Madeira MH , Boia R , et al. , 2020 . Keep an eye on adenosine: its role in retinal inflammation . Pharmacol Ther , 210 : 107513 . https://doi.org/10.1016/j.pharmthera.2020.107513 https://doi.org/10.1016/j.pharmthera.2020.107513

Schleifenbaum J , 2019 . Alamandine and its receptor MrgD pair up to join the protective arm of the renin-angiotensin system . Front Med (Lausanne) , 6 : 107 . https://doi.org/10.3389/fmed.2019.00107 https://doi.org/10.3389/fmed.2019.00107

Song MA , Dasgupta C , Zhang LB , 2015 . Chronic losartan treatment up-regulates AT 1 R and increases the heart vulnerability to acute onset of ischemia and reperfusion injury in male rats . PLoS ONE , 10 ( 7 ): e0132712 . https://doi.org/10.1371/journal.pone.0132712 https://doi.org/10.1371/journal.pone.0132712

Tual-Chalot S , Allinson KR , Fruttiger M , et al. , 2013 . Whole mount immunofluorescent staining of the neonatal mouse retina to investigate angiogenesis in vivo . J Vis Exp , (77): e 50546. https://doi.org/10.3791/50546 https://doi.org/10.3791/50546

Uemura A , Fruttiger M , D'Amore PA , et al. , 2021 . VEGFR1 signaling in retinal angiogenesis and microinflammation . Prog Retin Eye Res , 84 : 100954 . https://doi.org/10.1016/j.preteyeres.2021.100954 https://doi.org/10.1016/j.preteyeres.2021.100954

Vallée A , Guillevin R , Vallée JN , 2018 . Vasculogenesis and angiogenesis initiation under normoxic conditions through Wnt/β-catenin pathway in gliomas . Rev Neurosci , 29 ( 1 ): 71 - 91 . https://doi.org/10.1515/revneuro-2017-0032 https://doi.org/10.1515/revneuro-2017-0032

Voigt AP , Mullin NK , Stone EM , et al. , 2021 . Single-cell RNA sequencing in vision research: insights into human retinal health and disease . Prog Retin Eye Res , 83 : 100934 . https://doi.org/10.1016/j.preteyeres.2020.100934 https://doi.org/10.1016/j.preteyeres.2020.100934

Wang YH , Fang JW , Niu T , et al. , 2023 . Serum Ang-1/Ang-2 ratio may be a promising biomarker for evaluating severity of diabetic retinopathy . Graefes Arch Clin Exp Ophthalmol , 261 ( 1 ): 49 - 55 . https://doi.org/10.1007/s00417-022-05745-z https://doi.org/10.1007/s00417-022-05745-z

Xu Y , Lu X , Hu YG , et al. , 2018 . Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of HIF-1α-VEGF pathway in oxygen-induced retinopathy mice . J Pineal Res , 64 ( 4 ): e12473 . https://doi.org/10.1111/jpi.12473 https://doi.org/10.1111/jpi.12473

Yang CX , Wu XG , Shen YH , et al. , 2020 . Alamandine attenuates angiotensin II-induced vascular fibrosis via inhibiting p38 MAPK pathway . Eur J Pharmacol , 883 : 173384 . https://doi.org/10.1016/j.ejphar.2020.173384 https://doi.org/10.1016/j.ejphar.2020.173384

Yang XF , Wang JP , Chen C , 2021 . Serum VEGF and Ang-2 levels in infants before and after laser treatment for retinopathy of prematurity . Fetal Pediatr Pathol , 40 ( 5 ): 407 - 413 . https://doi.org/10.1080/15513815.2020.1721625 https://doi.org/10.1080/15513815.2020.1721625

Zhang XZ , Zhang F , Xu X , 2024 . Single-cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy . Clin Transl Med , 14 ( 7 ): e1751 . https://doi.org/10.1002/ctm2.1751 https://doi.org/10.1002/ctm2.1751

Zhao K , Xu TH , Mao YK , et al. , 2022a . Alamandine alleviated heart failure and fibrosis in myocardial infarction mice . Biol Direct , 17 : 25 . https://doi.org/10.1186/s13062-022-00338-6 https://doi.org/10.1186/s13062-022-00338-6

Zhao K , Jiang YP , Zhang J , et al. , 2022b . Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway . Cell Cycle , 21 ( 19 ): 2091 - 2108 . https://doi.org/10.1080/15384101.2022.2087277 https://doi.org/10.1080/15384101.2022.2087277

Zhao K , Hua DX , Yang CX , et al. , 2023 . Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling . Cell Commun Signal , 21 : 181 . https://doi.org/10.1186/s12964-023-01168-3 https://doi.org/10.1186/s12964-023-01168-3

Zhu P , Verma A , Prasad T , et al. , 2020 . Expression and function of Mas-related G protein-coupled receptor D and its ligand alamandine in retina . Mol Neurobiol , 57 ( 1 ): 513 - 527 . https://doi.org/10.1007/s12035-019-01716-4 https://doi.org/10.1007/s12035-019-01716-4

Zimna A , Kurpisz M , 2015 . Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies . Biomed Res Int , 2015 : 549412 . https://doi.org/10.1155/2015/549412 https://doi.org/10.1155/2015/549412

浏览量

Downloads

CSCD

工具集

关联资源

暂无数据