表皮更新过程中的细胞增殖与分化

刘凯; 任凯迪; 李登文; 杨阳

doi:10.1631/jzus.B2500085

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Review | Updated：2026-06-23

表皮更新过程中的细胞增殖与分化
Cell proliferation and differentiation during epidermis renewal
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第6期页码：603-614
Affiliations：

1.Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2.Department of Genetics and Cell Biology, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
3.Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Funds：

the National Key R&D Program of China(2021YFA1101001);the National Natural Science Foundation of China(82204389;82470403)
DOI：10.1631/jzus.B2500085
中图分类号：
CSTR：
收稿：2025-02-23，

修回：2025-04-22，

网络首发：2026-04-15，

纸质出版：2026-06-15
Accepted：

刘凯,任凯迪,李登文等.表皮更新过程中的细胞增殖与分化[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):603-614.

Kai LIU, Kaidi REN, Dengwen LI, et al. Cell proliferation and differentiation during epidermis renewal[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 603-614.
刘凯,任凯迪,李登文等.表皮更新过程中的细胞增殖与分化[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):603-614. DOI： 10.1631/jzus.B2500085.

Kai LIU, Kaidi REN, Dengwen LI, et al. Cell proliferation and differentiation during epidermis renewal[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 603-614. DOI： 10.1631/jzus.B2500085.

摘要

表皮作为皮肤的最外层，由复层鳞状上皮细胞组成，其定期更新对维持屏障功能至关重要。这一过程依赖于基底表皮干细胞的协调增殖与分化，并受到细胞分裂方向的内在调控和外部微环境因素的双重影响。本文综述了表皮更新的关键机制，重点关注对称与非对称细胞命运的平衡以及分化细胞在基底层上的整合。文章还探讨了单细胞组学、活体成像和人工智能（AI）建模技术在揭示表皮更新中细胞增殖与分化分子机制方面的重要作用。

Abstract

Residing at the outermost layer of the skin

the epidermis is composed of stratified squamous epithelial cells. Regular renewal of the epidermis is essential for maintaining its barrier function

which is dependent on the orchestrated proliferation and differentiation of stem cells located in the basal epidermis. This process necessitates precise dual regulation through the intrinsic control of cell division orientation and external microenvironmental influences. In this comprehensive review

we delve into the critical processes underlying epidermis renewal

emphasizing the balance between symmetric and asymmetric cell fate and the integration of differentiated cells into the suprabasal layer. Our paper highlights the pivotal roles of single-cell omics

live imaging

and artificial intelligence (AI)-driven modeling techniques in elucidating the molecular mechanisms governing cell proliferation and differentiation during epidermis renewal.

关键词

Keywords

references

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