儿童炎症性肠病的母子对研究：临床危险因素和肠道菌群特征

张存正; 段汝乔; 代妮妮; 陈俞竹; 李高楠; 李晓盎; 季小琳; 钟雪梅; 李在玲; 段丽萍

doi:10.1631/jzus.B2400330

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儿童炎症性肠病的母子对研究：临床危险因素和肠道菌群特征

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Research Article | Updated：2025-11-04

儿童炎症性肠病的母子对研究：临床危险因素和肠道菌群特征
Pediatric inflammatory bowel disease in mother‒child pairs: clinical risk factors and gut microbiota characteristics
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第10期页码：995-1014
Affiliations：

1.Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
2.Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases, Beijing 100191, China
3.Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China
4.Department of Gastroenterology, Children’s Hospital Capital Institute of Pediatrics, Beijing 100020, China
Funds：

the National Key R&D Program of China(2021YFA1301300;2019YFA0905600;2023YFC2706503);the National Natural Science Foundation of China(82170557;82000510)
DOI：10.1631/jzus.B2400330
中图分类号：
CSTR：
收稿：2024-06-25，

修回：2024-08-26，

网络出版：2025-09-26，

纸质出版：2025-10-20
Accepted：

张存正,段汝乔,代妮妮等.儿童炎症性肠病的母子对研究：临床危险因素和肠道菌群特征[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):995-1014.

Cunzheng ZHANG, Ruqiao DUAN, Nini DAI, et al. Pediatric inflammatory bowel disease in mother‒child pairs: clinical risk factors and gut microbiota characteristics[J]. Journal of zhejiang university-science b, 2025, 26(10): 995-1014.
张存正,段汝乔,代妮妮等.儿童炎症性肠病的母子对研究：临床危险因素和肠道菌群特征[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):995-1014. DOI： 10.1631/jzus.B2400330.

Cunzheng ZHANG, Ruqiao DUAN, Nini DAI, et al. Pediatric inflammatory bowel disease in mother‒child pairs: clinical risk factors and gut microbiota characteristics[J]. Journal of zhejiang university-science b, 2025, 26(10): 995-1014. DOI： 10.1631/jzus.B2400330.

摘要

在儿童炎症性肠病（PIBD）发病中，母子肠道菌群的作用及相关风险因素尚未明确。本研究旨在探究PIBD发病的临床危险因素，分析患儿与母亲的肠道菌群特征，并探讨二者肠道菌群的相关性。研究采用病例-对照设计，纳入54对PIBD患儿及其母亲作为病例组，122对健康儿童及其母亲作为对照组。通过问卷收集家族疾病史、围产期及生命早期事件等信息；采集两组儿童及母亲的粪便样本，进行微生物16S rRNA测序，分析肠道菌群组成及其与PIBD发病的潜在关联。结果显示，自身免疫病家族史、孕期抗生素使用与PIBD发病风险升高相关，而父亲学历较高则与PIBD发病风险降低相关。病例组母子的肠道菌群与对照组存在显著差异，且同组内母亲与子女的肠道菌群具有相似性。此外，母亲的肠道菌群生物标志物可预测其子女患PIBD的风险。综上，PIBD的发病受母源性危险因素影响，患者存在独特的肠道菌群特征；母子肠道菌群的密切关联提示二者间存在菌群传递与相互影响。本研究为阐明PIBD的潜在发病机制提供了依据，并为针对性干预措施的开发奠定了基础。

Abstract

Objective

The risk factors and role of mother‒child gut microbiota in pediatric inflammatory bowel disease (PIBD) remain unclear. We aimed to explore the clinical risk factors associated with PIBD

analyze the characteristics of gut microbiota of children and their mothers

and examine the correlation of the microbial composition in mother‒child pairs.

Methods

We conducted a case-control study including children with PIBD and their mothers as the case group

as well as healthy children and their mothers as the control group. Questionnaires were used to collect information such as family illness history and maternal and early-life events. Fecal samples were collected from the children and mothers for microbiota 16S ribosomal RNA (rRNA) sequencing to analyze the composition and its potential association with PIBD.

Results

A total of 54 pairs of cases and 122 pairs of controls were recruited. A family history of autoimmune disease and antibiotic use during pregnancy were associated with an increased risk of PIBD

and a higher education level of the father was associated with a decreased risk of PIBD. Children with PIBD and mothers exhibited different gut microbiota compared to healthy children and mothers. Similarities were observed in the gut microbiota of mothers and children in the same groups. Some bacterial biomarkers of mothers discovered in this study had the power to predict PIBD in their offspring.

Conclusions

PIBD is influenced by maternal risk factors and has unique gut microbiota characteristics. The mother‒child gut microbiota is closely related

suggesting the transmission and influence of the gut microbiota between mothers and children. This study highlights the potential pathogenesis of PIBD and provides a basis for developing targeted interventions.

关键词

Keywords

references

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