甲基丙二酸生物学功能和分子机制的研究进展

王子昂; 程文荟; 王腾; 张依迪; 史新娥; 吕玉琦; 靳建军

doi:10.1631/jzus.B2400202

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Review | Updated：2026-03-18

甲基丙二酸生物学功能和分子机制的研究进展
Recent research advances in the biological function and molecular mechanism of methylmalonic acid
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2026年27卷第3期页码：225-235
Affiliations：

1.Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
2.College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
Funds：

the Natural Science Foundation of Shanxi Province(2023-JC-QN-0243);the National Natural Science Foundation of China(31900448);the Fundamental Research Funds for the Central Universities(Z1010422004)
DOI：10.1631/jzus.B2400202
中图分类号：
CSTR：
收稿：2024-04-22，

修回：2024-11-02，

网络首发：2025-11-21，

纸质出版：2026-03-18
Accepted：

王子昂,程文荟,王腾等.甲基丙二酸生物学功能和分子机制的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(03):225-235.

Zi’ang WANG, Wenhui CHENG, Teng WANG, et al. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(3): 225-235.
王子昂,程文荟,王腾等.甲基丙二酸生物学功能和分子机制的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(03):225-235. DOI： 10.1631/jzus.B2400202.

Zi’ang WANG, Wenhui CHENG, Teng WANG, et al. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(3): 225-235. DOI： 10.1631/jzus.B2400202.

摘要

甲基丙二酸（MMA）的异常积累是导致甲基丙二酸血症的主要原因，可对大脑、肾脏和心血管系统造成不可逆的损害。此外，已有研究发现血液中MMA的积累与癌症、身体运动受限和生长发育迟缓有关。本综述总结了近年来MMA代谢异常与疾病发生之间关系的研究，涉及脑、肾、心血管系统、癌症和骨骼肌等方面，为进一步研究和治疗与MMA相关的病理生理学变化提供理论依据和参考。

Abstract

The abnormal accumulation of methylmalonic acid (MMA)

the leading cause of methylmalonic acidemia

can cause irreversible damage to the brain

kidney

and cardiovascular system. In addition

the accumulation of MMA in the blood has recently been associated with the occurrence of cancer

restricted bodily movement

and growth retardation. In this review

recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized

concerning the brain

kidney

cardiovascular system

cancer

and skeletal muscles. It provides a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

关键词

Keywords

references

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