原位5-氨基酮戊酸光动力疗法成功治愈1例53岁的老年原位皮肤鳞状细胞癌女性患者

罗丽敏; 蒋莜凌; 乔建军; 方红; 李军

doi:10.1631/jzus.B2400164

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原位5-氨基酮戊酸光动力疗法成功治愈1例53岁的老年原位皮肤鳞状细胞癌女性患者

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Correspondence | Updated：2025-09-22

原位5-氨基酮戊酸光动力疗法成功治愈1例53岁的老年原位皮肤鳞状细胞癌女性患者
Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第9期页码：915-922
Affiliations：

1.Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Funds：

the the National Natural Science Foundation of China(82003372);the Medical and Health Technology Project of Zhejiang Province(2024KY984)
DOI：10.1631/jzus.B2400164
中图分类号：
CSTR：
收稿日期：2024-03-28，

修回日期：2024-12-09，

纸质出版日期：2025-09-20
Accepted：

罗丽敏,蒋莜凌,乔建军等.原位5-氨基酮戊酸光动力疗法成功治愈1例53岁的老年原位皮肤鳞状细胞癌女性患者[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(09):915-922.

Limin LUO, Xiaoling JIANG, Jianjun QIAO, et al. Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(9): 915-922.
罗丽敏,蒋莜凌,乔建军等.原位5-氨基酮戊酸光动力疗法成功治愈1例53岁的老年原位皮肤鳞状细胞癌女性患者[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(09):915-922. DOI： 10.1631/jzus.B2400164.

Limin LUO, Xiaoling JIANG, Jianjun QIAO, et al. Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(9): 915-922. DOI： 10.1631/jzus.B2400164.

摘要

Abstract

皮肤鳞状细胞癌（cSCC）是非黑色素瘤皮肤癌中最常见的肿瘤之一，根据其临床表现可分为原位、侵袭性和特殊亚型（如角化棘皮瘤、疣状癌等）。原位cSCC好发于中老年人群，常见于头面部和四肢等暴露部位，典型皮损表现为单一的、边界清晰的红色斑块。由于皮肤鳞状细胞癌的发病率和死亡率呈不断升高的趋势，亟需采取新的防治措施。5-氨基酮戊酸光动力疗法（5-ALA PDT）在临床上广泛应用于尖锐湿疣、痤疮、光线性角化病和某些皮肤恶性肿瘤（如浅表型基底细胞癌和原位cSCC等）。然而，5-ALA PDT在原位cSCC治疗中的安全性仍有待阐明。本文报道了1例53岁的原位cSCC女性患者。患者主诉“左侧鼻根皮疹一年余”，皮疹局部伴有轻度疼痛，且逐渐增大。出于美容考虑，患者拒绝行扩大手术切除根治术，并要求保守治疗。因此，作为手术的替代治疗，患者每周接受1次5-ALA PDT，共治疗4周。4次治疗结束后患者皮损消退，疗效显著，未遗留明显瘢痕形成，随访2年未见肿瘤复发。

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