Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用

周琦惠; 岑盼盼; 陈智; 金洁

doi:10.1631/jzus.B2400053

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Review | Updated：2025-11-04

Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用
Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第10期页码：972-994
Affiliations：

1.Department of Infectious Diseases, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou 310006, China
2.Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Funds：

the Medical Science and Technology Project of Zhejiang Province(2018KY566)
DOI：10.1631/jzus.B2400053
中图分类号：
CSTR：
收稿：2024-02-26，

修回：2024-06-05，

网络出版：2025-08-28，

纸质出版：2025-10-20
Accepted：

周琦惠,岑盼盼,陈智等.Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):972-994.

Qihui ZHOU, Panpan CEN, Zhi CHEN, et al. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of zhejiang university-science b, 2025, 26(10): 972-994.
周琦惠,岑盼盼,陈智等.Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(10):972-994. DOI： 10.1631/jzus.B2400053.

Qihui ZHOU, Panpan CEN, Zhi CHEN, et al. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of zhejiang university-science b, 2025, 26(10): 972-994. DOI： 10.1631/jzus.B2400053.

摘要

核因子E2相关因子2（Nrf2）是一种细胞内转录因子，在病理条件下有助于保护不同类型细胞免受氧化应激。线粒体参与机体内多种代谢过程，包括氧化还原反应、脂质代谢和细胞死亡等。线粒体自噬是自噬的一种特殊形式，专门负责清除受损的线粒体，在肝脏疾病病理生理机制中起着重要作用。本综述详细阐述了Nrf2信号通路和线粒体自噬在各种肝脏疾病（非酒精性脂肪性肝病、病毒性肝炎、酒精性肝病、药物性肝损伤、自身免疫性肝炎、肝缺血再灌注损伤和肝癌）中的作用及其相互关系，同时提供了一些临床应用相关的潜在见解和治疗方法。

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles that function in diverse metabolic processes in the body

including redox reactions

lipid metabolism

and cell death. Mitophagy

a specific form of autophagy for damaged mitochondria

plays a critical role in the pathophysiology of liver diseases. In this review

we explain in detail the roles of the Nrf2 signaling pathway and mitophagy

and the relationship between them

in various hepatic diseases (nonalcoholic fatty liver disease

viral hepatitis

alcoholic liver disease

drug-induced liver injury

autoimmune hepatitis

hepatic ischemia‒reperfusion injury

and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.

关键词

Keywords

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