与种植体周炎相关的表观遗传因素：综述

李千慧; 卢洪叶; 章梦媛; 叶雨婷; 陈谦明; 孙平

doi:10.1631/jzus.B2400032

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Review | Updated：2025-07-25

与种植体周炎相关的表观遗传因素：综述
Epigenetic factors associated with peri-implantitis: a review
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第7期页码：657-674
Affiliations：

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China
Funds：

the Basic Public Welfare Research Project of Zhejiang Province(LGF22H140007);the Research and Development Project of Stomatology Hospital Affiliated to Zhejiang University School of Medicine(RD2022JCXK01);the National Natural Science Foundation of China(82301072);the Postdoctoral Science Foundation of China(2021TQ0277;2022M722741)
DOI：10.1631/jzus.B2400032
中图分类号：
CSTR：
收稿日期：2024-01-24，

修回日期：2024-07-09，

网络出版日期：2025-07-04，

纸质出版日期：2025-07-15
Accepted：

李千慧,卢洪叶,章梦媛等.与种植体周炎相关的表观遗传因素：综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):657-674.

Qianhui LI, Hongye LU, Mengyuan ZHANG, et al. Epigenetic factors associated with peri-implantitis: a review[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 657-674.
李千慧,卢洪叶,章梦媛等.与种植体周炎相关的表观遗传因素：综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):657-674. DOI： 10.1631/jzus.B2400032.

Qianhui LI, Hongye LU, Mengyuan ZHANG, et al. Epigenetic factors associated with peri-implantitis: a review[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 657-674. DOI： 10.1631/jzus.B2400032.

摘要

种植体周病是一类以硬组织吸收和软组织炎症为特征的病症。表观遗传学是指不在DNA序列中编码的基因表达的改变，影响免疫反应、炎症和骨代谢在内的多种生理活动。表观遗传修饰导致个体间组织特异性基因表达的差异，可能引发或加剧炎症和疾病易感性，然而其对种植体周炎的影响尚无定论。为了填补这一空白，我们在PubMed、Web of Science、Scopus和Google Scholar上使用“epigenetics”“peri-implantitis”“DNA methylation”和“microRNA”等关键词进行文献搜索，探讨表观遗传机制与种植体周炎之间的关系，并特别关注DNA甲基化和microRNAs（miRNAs或miRs）。DNA甲基化和miRNAs在种植体周围形成了一种动态的表观遗传机制。与炎症和成骨相关的基因表观遗传修饰为理解局部和环境因素如何影响种植体周炎的发病机制提供了新的视角。此外，我们评估了DNA甲基化和miRNAs在种植体周炎预防、诊断和治疗中的潜在应用，旨在为未来探索潜在治疗靶点并开发更有效的管理策略提供基础。这些发现对于理解其他口腔炎症性疾病（如牙周炎）的发病机制也具有更广泛的意义。

Abstract

Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue. Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence

influencing diverse physiological activities

including immune response

inflammation

and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition. However

the impact of these factors on peri-implantitis remains inconclusive. To address this gap

we conducted a comprehensive review to investigate the associations between epigenetic mechanisms and peri-implantitis

specifically focusing on DNA methylation and microRNAs (miRNAs or miRs). We searched for relevant literature on PubMed

Web of Science

Scopus

and Google Scholar with keywords including “epigenetics

” “peri-implantitis

” “DNA methylation

” and “microRNA.” DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants. Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective for understanding how local and environmental factors influence the pathogenesis of peri-implantitis. In addition

we assessed the potential application of DNA methylation and miRNAs in the prevention

diagnosis

and treatment of peri-implantitis

aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition. These findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis.

关键词

Keywords

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