一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性

林瑾娅; 王仁定; 朱园园; 黄维加; 孙洁

doi:10.1631/jzus.B2300940

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一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性

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Correspondence | Updated：2025-07-25

一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性
A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第7期页码：708-712
Affiliations：

1.Bone Marrow Transplantation Centre, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Funds：

the National Natural Science Foundation of China(82070200)
DOI：10.1631/jzus.B2300940
中图分类号：
CSTR：
收稿日期：2023-12-27，

修回日期：2024-09-12，

网络出版日期：2025-06-24，

纸质出版日期：2025-07-15
Accepted：

林瑾娅,王仁定,朱园园等.一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):708-712.

Jinya LIN, Rending WANG, Yuanyuan ZHU, et al. A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 708-712.
林瑾娅,王仁定,朱园园等.一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):708-712. DOI： 10.1631/jzus.B2300940.

Jinya LIN, Rending WANG, Yuanyuan ZHU, et al. A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 708-712. DOI： 10.1631/jzus.B2300940.

摘要

Abstract

嗜酸性肉芽肿性多血管炎（EGPA）是一种罕见的多系统性疾病，其诊断充满挑战，尤其是在病情复杂且发病率低的情况下。本文报告了一例58岁男性患者，既往有10年哮喘病史和1年特发性嗜酸性粒细胞增多症（I-HES）病史。患者因持续性嗜酸性粒细胞增多并伴随心脏骤停和自发性肾出血（SRH）而住院治疗。经心肺复苏后，患者因肾破裂出血接受了右肾切除术，肾脏活检结果显示血管闭塞及嗜酸性粒细胞浸润，最终确诊为EGPA。患者在糖皮质激素和免疫抑制剂联合治疗后取得显著疗效。本文强调了早期识别和及时干预在EGPA管理中的重要性。

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references

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