ABC转运蛋白的结构及其在细菌致病过程中的作用

Shu Sian HOW; Sylvia CHIENG; Sheila NATHAN; Su Datt LAM

doi:10.1631/jzus.B2300641

Your Location：

Home >

Browse articles >

ABC转运蛋白的结构及其在细菌致病过程中的作用

Scan QR Code

文章被引用时，请邮件提醒。

Submit

Reviews | Updated：2025-04-21

ABC转运蛋白的结构及其在细菌致病过程中的作用
ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第1期页码：58-75
Affiliations：

1.Department of Biological Sciences & Biotechnology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
2.Department of Applied Physics, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Funds：

the Universiti Kebangsaan Malaysia under the Research University Grant(GUP-2020-030);awarded to Sylvia CHIENG
DOI：10.1631/jzus.B2300641
中图分类号：
CSTR：
收稿日期：2023-09-12，

修回日期：2023-12-17，

网络出版日期：2024-10-21，

纸质出版日期：2025-01-15
Accepted：

Shu Sian HOW,Sylvia CHIENG,Sheila NATHAN等.ABC转运蛋白的结构及其在细菌致病过程中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(01):58-75.

Shu Sian HOW, Sheila NATHAN, Su Datt LAM, et al. ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(1): 58-75.
Shu Sian HOW,Sylvia CHIENG,Sheila NATHAN等.ABC转运蛋白的结构及其在细菌致病过程中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(01):58-75. DOI： 10.1631/jzus.B2300641.

Shu Sian HOW, Sheila NATHAN, Su Datt LAM, et al. ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(1): 58-75. DOI： 10.1631/jzus.B2300641.

摘要

腺苷三磷酸结合盒转运蛋白（ATP-binding cassette transporter proteins，ABC转运蛋白）具有向外和向内两种转运方式，能通过克服浓度梯度协助多种底物分子在磷脂双分子层中运输。这些转运蛋白具有两个高度保守的核苷酸结合区域（NBDs）和两个跨膜结构域（TMDs）。与ABC向外转运蛋白不同，原核生物的ABC向内转运蛋白还需额外的底物结合蛋白（SBP）作为特定底物转运的识别位点。大量研究发现在细菌致病体中存在许多ABC转运蛋白，提示这些转运蛋白对细菌感染的建立至关重要。现有研究证实，ABC转运蛋白在细菌生长、致病和毒力方面发挥作用，包括导入细胞活动所需的必要营养物质，以及输出与外膜相关的毒力因子和抗微生物物质等。本文对ABC转运蛋白的经典结构和最新分类进行综述，以便全面了解与细菌毒力和致病性相关的ABC转运蛋白在细菌感染期间的活动与作用。

Abstract

Adenosine triphosphate (ATP)-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer

against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Unlike ABC exporters

prokaryotic ABC importers require an additional substrate-binding protein (SBP) as a recognition site for specific substrate translocation. The discovery of a large number of ABC systems in bacterial pathogens revealed that these transporters are crucial for the establishment of bacterial infections. The existing literature has highlighted the roles of ABC transporters in bacterial growth

pathogenesis

and virulence. These roles include importing essential nutrients required for a variety of cellular processes and exporting outer membrane-associated virulence factors and antimicrobial substances. This review outlines the general structures and classification of ABC systems to provide a comprehensive view of the activities and roles of ABC transporters associated with bacterial virulence and pathogenesis during infection.

关键词

Keywords

references

Abril AG , Quintela-Baluja M , Villa TG , et al. , 2022 . Proteomic characterization of virulence factors and related proteins in Enterococcus strains from dairy and fermented food products . Int J Mol Sci , 23 ( 18 ): 10971 . https://doi.org/10.3390/ijms231810971 https://doi.org/10.3390/ijms231810971

Akhtar AA , Turner DPJ , 2022 . The role of bacterial ATP-binding cassette (ABC) transporters in pathogenesis and virulence: therapeutic and vaccine potential . Microb Pathog , 171 : 105734 . https://doi.org/10.1016/j.micpath.2022.105734 https://doi.org/10.1016/j.micpath.2022.105734

Alav I , Sutton JM , Rahman KM , 2018 . Role of bacterial efflux pumps in biofilm formation . J Antimicrob Chemother , 73 ( 8 ): 2003 - 2020 . https://doi.org/10.1093/jac/dky042 https://doi.org/10.1093/jac/dky042

Alcalde-Rico M , Hernando-Amado S , Blanco P , et al. , 2016 . Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence . Front Microbiol , 7 : 1483 . https://doi.org/10.3389/fmicb.2016.01483 https://doi.org/10.3389/fmicb.2016.01483

Allan RN , Skipp P , Jefferies J , et al. , 2014 . Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae . PLoS ONE , 9 ( 9 ): e107015 . https://doi.org/10.1371/journal.pone.0107015 https://doi.org/10.1371/journal.pone.0107015

Allison DG , 2003 . The biofilm matrix . Biofouling , 19 ( 2 ): 139 - 150 . https://doi.org/10.1080/0892701031000072190 https://doi.org/10.1080/0892701031000072190

Alteri CJ , Mobley HLT , 2012 . Escherichia coli physiology and metabolism dictates adaptation to diverse host microenvironments . Curr Opin Microbiol , 15 ( 1 ): 3 - 9 . https://doi.org/10.1016/j.mib.2011.12.004 https://doi.org/10.1016/j.mib.2011.12.004

Amblar M , Zaballos Á , de la Campa AG , 2022 . Role of PatAB transporter in efflux of levofloxacin in Streptococcus pneumoniae . Antibiotics , 11 ( 12 ): 1837 . https://doi.org/10.3390/antibiotics11121837 https://doi.org/10.3390/antibiotics11121837

Antelo GT , Vila AJ , Giedroc DP , et al. , 2021 . Molecular evolution of transition metal bioavailability at the host-pathogen interface . Trends Microbiol , 29 ( 5 ): 441 - 457 . https://doi.org/10.1016/j.tim.2020.08.001 https://doi.org/10.1016/j.tim.2020.08.001

Baylay AJ , Piddock LJV , 2015 . Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator . J Antimicrob Chemother , 70 ( 3 ): 670 - 679 . https://doi.org/10.1093/jac/dku449 https://doi.org/10.1093/jac/dku449

Beceiro A , Tomás M , Bou G , 2013 . Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev , 26 ( 2 ): 185 - 230 . https://doi.org/10.1128/CMR.00059-12 https://doi.org/10.1128/CMR.00059-12

Begg SL , 2019 . The role of metal ions in the virulence and viability of bacterial pathogens . Biochem Soc Trans , 47 ( 1 ): 77 - 87 . https://doi.org/10.1042/BST20180275 https://doi.org/10.1042/BST20180275

Beis K , 2015 . Structural basis for the mechanism of ABC transporters . Biochem Soc Trans , 43 ( 5 ): 889 - 893 . https://doi.org/10.1042/BST20150047 https://doi.org/10.1042/BST20150047

Berntsson RPA , Smits SHJ , Schmitt L , et al. , 2010 . A structural classification of substrate-binding proteins . FEBS Lett , 584 ( 12 ): 2606 - 2617 . https://doi.org/10.1016/j.febslet.2010.04.043 https://doi.org/10.1016/j.febslet.2010.04.043

Bi YC , Mann E , Whitfield C , et al. , 2018 . Architecture of a channel-forming O-antigen polysaccharide ABC transporter . Nature , 553 ( 7688 ): 361 - 365 . https://doi.org/10.1038/nature25190 https://doi.org/10.1038/nature25190

Bilsing FL , Anlauf MT , Hachani E , et al. , 2023 . ABC transporters in bacterial nanomachineries . Int J Mol Sci , 24 ( 7 ): 6227 . https://doi.org/10.3390/ijms24076227 https://doi.org/10.3390/ijms24076227

Biondo C , 2023 . Bacterial antibiotic resistance: the most critical pathogens . Pathogens , 12 ( 1 ): 116 . https://doi.org/10.3390/pathogens12010116 https://doi.org/10.3390/pathogens12010116

Boël G , Orelle C , Jault JM , et al. , 2019 . ABC systems: structural and functional variations on a common theme . Res Microbiol , 170 ( 8 ): 301 - 303 . https://doi.org/10.1016/j.resmic.2019.10.006 https://doi.org/10.1016/j.resmic.2019.10.006

Bogomolnaya LM , Andrews KD , Talamantes M , et al. , 2013 . The ABC-type efflux pump MacAB protects Salmonella enterica serovar Typhimurium from oxidative stress . mBio , 4 ( 6 ): e00630-13 . https://doi.org/10.1128/mBio.00630-13 https://doi.org/10.1128/mBio.00630-13

Casadevall A , Pirofski LA , 2000 . Host-pathogen interactions: basic concepts of microbial commensalism, colonization, infection, and disease . Infect Immun , 68 ( 12 ): 6511 - 6518 . https://doi.org/10.1128/IAI.68.12.6511-6518.2000 https://doi.org/10.1128/IAI.68.12.6511-6518.2000

Chen L , Hou WT , Fan T , et al. , 2020 . Cryo-electron microscopy structure and transport mechanism of a wall teichoic acid ABC transporter . mBio , 11 ( 2 ): e02749-19 . https://doi.org/10.1128/mBio.02749-19 https://doi.org/10.1128/mBio.02749-19

Choi CC , Ford RC , 2021 . ATP binding cassette importers in eukaryotic organisms . Biol Rev , 96 ( 4 ): 1318 - 1330 . https://doi.org/10.1111/brv.12702 https://doi.org/10.1111/brv.12702

Crow A , Greene NP , Kaplan E , et al. , 2017 . Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily . Proc Natl Acad Sci USA , 114 ( 47 ): 12572 - 12577 . https://doi.org/10.1073/pnas.1712153114 https://doi.org/10.1073/pnas.1712153114

Cui LQ , Wang XR , Huang DY , et al. , 2020 . CRISPR- cas3 of Salmonella upregulates bacterial biofilm formation and virulence to host cells by targeting quorum-sensing systems . Pathogens , 9 : 53 . https://doi.org/10.3390/pathogens9010053 https://doi.org/10.3390/pathogens9010053

Cuthbertson L , Kos V , Whitfield C , 2010 . ABC transporters involved in export of cell surface glycoconjugates . Microbiol Mol Biol Rev , 74 ( 3 ): 341 - 362 . https://doi.org/10.1128/MMBR.00009-10 https://doi.org/10.1128/MMBR.00009-10

Davidson AL , Chen J , 2004 . ATP-binding cassette transporters in bacteria . Annu Rev Biochem , 73 : 241 - 268 . https://doi.org/10.1146/annurev.biochem.73.011303.073626 https://doi.org/10.1146/annurev.biochem.73.011303.073626

Davidson AL , Dassa E , Orelle C , et al. , 2008 . Structure, function, and evolution of bacterial ATP-binding cassette systems . Microbiol Mol Biol Rev , 72 ( 2 ): 317 - 364 . https://doi.org/10.1128/MMBR.00031-07 https://doi.org/10.1128/MMBR.00031-07

Dawson RJP , Locher KP , 2007 . Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP . FEBS Lett , 581 ( 5 ): 935 - 938 . https://doi.org/10.1016/j.febslet.2007.01.073 https://doi.org/10.1016/j.febslet.2007.01.073

de Boer M , Gouridis G , Vietrov R , et al. , 2019 . Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers . eLife , 8 : e44652 . https://doi.org/10.7554/eLife.44652 https://doi.org/10.7554/eLife.44652 .

de la Torre LI , Vergara Meza JG , Cabarca S , et al. , 2021 . Comparison of carbohydrate ABC importers from Mycobacterium tuberculosis . BMC Genomics , 22 : 841 . https://doi.org/10.1186/s12864-021-07972-w https://doi.org/10.1186/s12864-021-07972-w

Delepelaire P , 2019 . Bacterial ABC transporters of iron containing compounds . Res Microbiol , 170 ( 8 ): 345 - 357 . https://doi.org/10.1016/j.resmic.2019.10.008 https://doi.org/10.1016/j.resmic.2019.10.008

Delmar JA , Su CC , Yu EW , 2014 . Bacterial multidrug efflux transporters . Annu Rev Biophys , 43 : 93 - 117 . https://doi.org/10.1146/annurev-biophys-051013-022855 https://doi.org/10.1146/annurev-biophys-051013-022855

Doerrler WT , Reedy MC , Raetz CRH , 2001 . An Escherichia coli mutant defective in lipid export . J Biol Chem , 276 ( 15 ): 11461 - 11464 . https://doi.org/10.1074/jbc.C100091200 https://doi.org/10.1074/jbc.C100091200

Dong HH , Zhang ZY , Tang XD , et al. , 2017 . Structural and functional insights into the lipopolysaccharide ABC transporter LptB 2 FG . Nat Commun , 8 : 222 . https://doi.org/10.1038/s41467-017-00273-5 https://doi.org/10.1038/s41467-017-00273-5

Du XJ , Wang F , Lu XN , et al. , 2012 . Biochemical and genetic characteristics of Cronobacter sakazakii biofilm formation . Res Microbiol , 163 ( 6-7 ): 448 - 456 . https://doi.org/10.1016/j.resmic.2012.06.002 https://doi.org/10.1016/j.resmic.2012.06.002

Eitinger T , Rodionov DA , Grote M , et al. , 2011 . Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions . FEMS Microbiol Rev , 35 ( 1 ): 3 - 67 . https://doi.org/10.1111/j.1574-6976.2010.00230.x https://doi.org/10.1111/j.1574-6976.2010.00230.x

el Garch F , Lismond A , Piddock LJV , et al. , 2010 . Fluoroquinolones induce the expression of patA and patB , which encode ABC efflux pumps in Streptococcus pneumoniae . J Antimicrob Chemother , 65 ( 10 ): 2076 - 2082 . https://doi.org/10.1093/jac/dkq287 https://doi.org/10.1093/jac/dkq287

Fahmy A , Srinivasan A , Webber MA , 2016 . The relationship between bacterial multidrug efflux pumps and biofilm formation. In : Li XZ, Elkins CA, Zgurskaya HI (Eds .), Efflux-Mediated Antimicrobial Resistance in Bacteria . Adis, Cham, p. 651 - 663 . https://doi.org/10.1007/978-3-319-39658-3_25 https://doi.org/10.1007/978-3-319-39658-3_25

Fan CC , Kaiser JT , Rees DC , 2020 . A structural framework for unidirectional transport by a bacterial ABC exporter . Proc Natl Acad Sci USA , 117 ( 32 ): 19228 - 19236 . https://doi.org/10.1073/pnas.2006526117 https://doi.org/10.1073/pnas.2006526117

Fiorentino F , Bolla JR , Mehmood S , et al. , 2019 . The different effects of substrates and nucleotides on the complex formation of ABC transporters . Structure , 27 ( 4 ): 651 - 659.e3 . https://doi.org/10.1016/j.str.2019.01.010 https://doi.org/10.1016/j.str.2019.01.010

Ford RC , Beis K , 2019 . Learning the ABCs one at a time: structure and mechanism of ABC transporters . Biochem Soc Trans , 47 ( 1 ): 23 - 36 . https://doi.org/10.1042/BST20180147 https://doi.org/10.1042/BST20180147

Ford RC , Hellmich UA , 2020 . What monomeric nucleotide binding domains can teach us about dimeric ABC proteins . FEBS Lett , 594 ( 23 ): 3857 - 3875 . https://doi.org/10.1002/1873-3468.13921 https://doi.org/10.1002/1873-3468.13921

França A , Gaio V , Lopes N , et al. , 2021 . Virulence factors in coagulase-negative staphylococci . Pathogens , 10 ( 2 ): 170 . https://doi.org/10.3390/pathogens10020170 https://doi.org/10.3390/pathogens10020170

Fu TW , Fan XY , Long QX , et al. , 2017 . Comparative analysis of prophages in Streptococcus mutans genomes . PeerJ , 5 : e4057 . https://doi.org/10.7717/peerj.4057 https://doi.org/10.7717/peerj.4057

Fulyani F , Schuurman-Wolters GK , Žagar AV , et al. , 2013 . Functional diversity of tandem substrate-binding domains in ABC transporters from pathogenic bacteria . Structure , 21 ( 10 ): 1879 - 1888 . https://doi.org/10.1016/j.str.2013.07.020 https://doi.org/10.1016/j.str.2013.07.020

Gao L , Ma YY , Li XT , et al. , 2020 . Research on the roles of genes coding ATP‐binding cassette transporters in Porphyromonas gingivalis pathogenicity . J Cell Biochem , 121 ( 1 ): 93 - 102 . https://doi.org/10.1002/jcb.28887 https://doi.org/10.1002/jcb.28887

Ghanei H , Abeyrathne PD , Lam JS , 2007 . Biochemical characterization of MsbA from Pseudomonas aeruginosa . J Biol Chem , 282 ( 37 ): 26939 - 26947 . https://doi.org/10.1074/jbc.M702952200 https://doi.org/10.1074/jbc.M702952200

Giuliani SE , Frank AM , Corgliano DM , et al. , 2011 . Environment sensing and response mediated by ABC transporters . BMC Genomics , 12 ( S1 ): S8 . https://doi.org/10.1186/1471-2164-12-S1-S8 https://doi.org/10.1186/1471-2164-12-S1-S8

Gomes AC , Moreira AC , Mesquita G , et al. , 2018 . Modulation of iron metabolism in response to infection: twists for all tastes . Pharmaceuticals , 11 ( 3 ): 84 . https://doi.org/10.3390/ph11030084 https://doi.org/10.3390/ph11030084

Guffick C , Hsieh PY , Ali A , et al. , 2022 . Drug‐dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from Streptococcus pneumoniae . FEBS J , 289 ( 13 ): 3770 - 3788 . https://doi.org/10.1111/febs.16366 https://doi.org/10.1111/febs.16366

Gupta P , Sarkar S , Das B , et al. , 2016 . Biofilm, pathogenesis and prevention—a journey to break the wall: a review . Arch Microbiol , 198 ( 1 ): 1 - 15 . https://doi.org/10.1007/s00203-015-1148-6 https://doi.org/10.1007/s00203-015-1148-6

Hernando-Amado S , Blanco P , Alcalde-Rico M , et al. , 2016 . Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials . Drug Resist Updates , 28 : 13 - 27 . https://doi.org/10.1016/j.drup.2016.06.007 https://doi.org/10.1016/j.drup.2016.06.007

Hicks G , Jia ZC , 2018 . Structural basis for the lipopolysaccharide export activity of the bacterial lipopolysaccharide transport system . Int J Mol Sci , 19 ( 9 ): 2680 . https://doi.org/10.3390/ijms19092680 https://doi.org/10.3390/ijms19092680

Higgins CF , Linton KJ , 2004 . The ATP switch model for ABC transporters . Nat Struct Mol Biol , 11 ( 10 ): 918 - 926 . https://doi.org/10.1038/nsmb836 https://doi.org/10.1038/nsmb836

Holland IB , 2019 . Rise and rise of the ABC transporter families . Res Microbiol , 170 ( 8 ): 304 - 320 . https://doi.org/10.1016/j.resmic.2019.08.004 https://doi.org/10.1016/j.resmic.2019.08.004

Honsa ES , Johnson MDL , Rosch JW , 2013 . The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae . Front Cell Infect Microbiol , 3 : 92 . https://doi.org/10.3389/fcimb.2013.00092 https://doi.org/10.3389/fcimb.2013.00092

Huang LL , Wu CR , Gao HJ , et al. , 2022 . Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview . Antibiotics , 11 ( 4 ): 520 . https://doi.org/10.3390/antibiotics11040520 https://doi.org/10.3390/antibiotics11040520

Ilari A , Pescatori L , di Santo R , et al , 2016 . Salmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporter . Biochim Biophys Acta (BBA) Gen Subj , 1860 ( 3 ): 534 - 541 . https://doi.org/10.1016/j.bbagen.2015.12.006 https://doi.org/10.1016/j.bbagen.2015.12.006

Immadisetty K , Hettige J , Moradi M , 2019 . Lipid-dependent alternating access mechanism of a bacterial multidrug ABC exporter . ACS Cent Sci , 5 ( 1 ): 43 - 56 . https://doi.org/10.1021/acscentsci.8b00480 https://doi.org/10.1021/acscentsci.8b00480

Izoré T , Contreras-Martel C , el Mortaji L , et al. , 2010 . Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae . Structure , 18 ( 1 ): 106 - 115 . https://doi.org/10.1016/j.str.2009.10.019 https://doi.org/10.1016/j.str.2009.10.019

Jeckelmann JM , Erni B , 2020 . Transporters of glucose and other carbohydrates in bacteria . Pflügers Arch Eur J Physiol , 472 ( 9 ): 1129 - 1153 . https://doi.org/10.1007/s00424-020-02379-0 https://doi.org/10.1007/s00424-020-02379-0

Jenul C , Horswill AR , 2019 . Regulation of Staphylococcus aureus virulence . In: Fischetti VA, Novick RP, Ferretti JJ, et al. (Eds.), Gram-Positive Pathogens, 3rd Ed . American Society for Microbiology , Washington , p. 669 - 686 . https://doi.org/10.1128/9781683670131.ch41 https://doi.org/10.1128/9781683670131.ch41

Jiang RJ , Xiang MY , Chen WT , et al. , 2021 . Biofilm characteristics and transcriptomic analysis of Haemophilus parasuis . Vet Microbiol , 258 : 109073 . https://doi.org/10.1016/j.vetmic.2021.109073 https://doi.org/10.1016/j.vetmic.2021.109073

Kadaba NS , Kaiser JT , Johnson E , et al. , 2008 . The high-affinity E . coli methionine ABC transporter : structure and allosteric regulation. Science , 321 ( 5886 ): 250 - 253 . https://doi.org/10.1126/science.1157987 https://doi.org/10.1126/science.1157987

Kalita A , Hu J , Torres AG , 2014 . Recent advances in adherence and invasion of pathogenic Escherichia coli . Curr Opin Infect Dis , 27 ( 5 ): 459 - 464 . https://doi.org/10.1097/QCO.0000000000000092 https://doi.org/10.1097/QCO.0000000000000092

Kanonenberg K , Spitz O , Erenburg IN , et al. , 2018 . Type I secretion system—it takes three and a substrate . FEMS Microbiol Lett , 365 ( 11 ): fny094 . https://doi.org/10.1093/femsle/fny094 https://doi.org/10.1093/femsle/fny094

Khan F , Pham DTN , Tabassum N , et al. , 2020 . Treatment strategies targeting persister cell formation in bacterial pathogens . Crit Rev Microbiol , 46 ( 6 ): 665 - 688 . https://doi.org/10.1080/1040841X.2020.1822278 https://doi.org/10.1080/1040841X.2020.1822278

Klein RD , Hultgren SJ , 2020 . Urinary tract infections: microbial pathogenesis, host‒pathogen interactions and new treatment strategies . Nat Rev Microbiol , 18 ( 4 ): 211 - 226 . https://doi.org/10.1038/s41579-020-0324-0 https://doi.org/10.1038/s41579-020-0324-0

Kolich LR , Chang YT , Coudray N , et al. , 2020 . Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation . eLife , 9 : e60030 . https://doi.org/10.7554/eLife.60030 https://doi.org/10.7554/eLife.60030

Konishi H , Hio M , Kobayashi M , et al. , 2020 . Bacterial chemotaxis towards polysaccharide pectin by pectin-binding protein . Sci Rep , 10 : 3977 . https://doi.org/10.1038/s41598-020-60274-1 https://doi.org/10.1038/s41598-020-60274-1

Lee M , Kim HL , Song S , et al. , 2013 . The α-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC . J Microbiol , 51 ( 2 ): 154 - 159 . https://doi.org/10.1007/s12275-013-2699-3 https://doi.org/10.1007/s12275-013-2699-3

Lee Y , Song S , Sheng LL , et al. , 2018 . Substrate binding protein DppA1 of ABC transporter DppBCDF increases biofilm formation in Pseudomonas aeruginosa by inhibiting Pf5 prophage lysis . Front Microbiol , 9 : 30 . https://doi.org/10.3389/fmicb.2018.00030 https://doi.org/10.3389/fmicb.2018.00030

Leisico F , Godinho LM , Gonçalves IC , et al. , 2020 . Multitask ATPases (NBDs) of bacterial ABC importers type I and their interspecies exchangeability . Sci Rep , 10 : 19564 . https://doi.org/10.1038/s41598-020-76444-0 https://doi.org/10.1038/s41598-020-76444-0

Lewinson O , Livnat-Levanon N , 2017 . Mechanism of action of ABC importers: conservation, divergence, and physiological adaptations . J Mol Biol , 429 ( 5 ): 606 - 619 . https://doi.org/10.1016/j.jmb.2017.01.010 https://doi.org/10.1016/j.jmb.2017.01.010

Lewinson O , Orelle C , Seeger MA , 2020 . Structures of ABC transporters: handle with care . FEBS Lett , 594 ( 23 ): 3799 - 3814 . https://doi.org/10.1002/1873-3468.13966 https://doi.org/10.1002/1873-3468.13966

Lewis VG , Ween MP , McDevitt CA , 2012 . The role of ATP-binding cassette transporters in bacterial pathogenicity . Protoplasma , 249 ( 4 ): 919 - 942 . https://doi.org/10.1007/s00709-011-0360-8 https://doi.org/10.1007/s00709-011-0360-8

Li J , Liu DH , Ding T , 2021 . Transcriptomic analysis reveal differential gene expressions of Escherichia coli O157:H7 under ultrasonic stress . Ultrason Sonochem , 71 : 105418 . https://doi.org/10.1016/j.ultsonch.2020.105418 https://doi.org/10.1016/j.ultsonch.2020.105418

Li YY , Orlando BJ , Liao MF , 2019 . Structural basis of lipopolysaccharide extraction by the LptB 2 FGC complex . Nature , 567 ( 7749 ): 486 - 490 . https://doi.org/10.1038/s41586-019-1025-6 https://doi.org/10.1038/s41586-019-1025-6

Lin MF , Lin YY , Tu CC , et al. , 2017 . Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance . J Microbiol Immunol Infect , 50 ( 2 ): 224 - 231 . https://doi.org/10.1016/j.jmii.2015.04.004 https://doi.org/10.1016/j.jmii.2015.04.004

Liu B , Zheng DD , Zhou SY , et al. , 2022 . VFDB 2022: a general classification scheme for bacterial virulence factors . Nucleic Acids Res , 50 ( D1 ): D912 - D917 . https://doi.org/10.1093/nar/gkab1107 https://doi.org/10.1093/nar/gkab1107

Liu WJ , Huang LX , Su YQ , et al. , 2017 . Contributions of the oligopeptide permeases in multistep of Vibrio alginolyticus pathogenesis . MicrobiologyOpen , 6 ( 5 ): e00511 . https://doi.org/10.1002/mbo3.511 https://doi.org/10.1002/mbo3.511

Locher KP , 2016 . Mechanistic diversity in ATP-binding cassette (ABC) transporters . Nat Struct Mol Biol , 23 ( 6 ): 487 - 493 . https://doi.org/10.1038/nsmb.3216 https://doi.org/10.1038/nsmb.3216

Locher KP , Borths E , 2004 . ABC transporter architecture and mechanism: implications from the crystal structures of BtuCD and BtuF . FEBS Lett , 564 ( 3 ): 264 - 268 . https://doi.org/10.1016/S0014-5793(04)00289-3 https://doi.org/10.1016/S0014-5793(04)00289-3

Low DE , 2004 . Quinolone resistance among pneumococci: therapeutic and diagnostic implications . Clin Infect Dis , 38 ( S4 ): S357 - S362 . https://doi.org/10.1086/382694 https://doi.org/10.1086/382694

Luo QS , Yang X , Yu S , et al. , 2017 . Structural basis for lipopolysaccharide extraction by ABC transporter LptB 2 FG . Nat Struct Mol Biol , 24 ( 5 ): 469 - 474 . https://doi.org/10.1038/nsmb.3399 https://doi.org/10.1038/nsmb.3399

Maqbool A , Horler RSP , Muller A , et al. , 2015 . The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity . Biochem Soc Trans , 43 ( 5 ): 1011 - 1017 . https://doi.org/10.1042/BST20150135 https://doi.org/10.1042/BST20150135

Mi W , Li YY , Yoon SH , et al. , 2017 . Structural basis of MsbA-mediated lipopolysaccharide transport . Nature , 549 ( 7671 ): 233 - 237 . https://doi.org/10.1038/nature23649 https://doi.org/10.1038/nature23649

Miryala SK , Ramaiah S , 2019 . Exploring the multi-drug resistance in Escherichia coli O157:H7 by gene interaction network: a systems biology approach . Genomics , 111 ( 4 ): 958 - 965 . https://doi.org/10.1016/j.ygeno.2018.06.002 https://doi.org/10.1016/j.ygeno.2018.06.002

Mitra A , Ko YH , Cingolani G , et al. , 2019 . Heme and hemoglobin utilization by Mycobacterium tuberculosis . Nat Commun , 10 : 4260 . https://doi.org/10.1038/s41467-019-12109-5 https://doi.org/10.1038/s41467-019-12109-5

Murdoch CC , Skaar EP , 2022 . Nutritional immunity: the battle for nutrient metals at the host‒pathogen interface . Nat Rev Microbiol , 20 ( 11 ): 657 - 670 . https://doi.org/10.1038/s41579-022-00745-6 https://doi.org/10.1038/s41579-022-00745-6

Murphy TF , Brauer AL , Johnson A , et al. , 2016 . ATP-binding cassette (ABC) transporters of the human respiratory tract pathogen, Moraxella catarrhalis : role in virulence . PLoS ONE , 11 ( 7 ): e0158689 . https://doi.org/10.1371/journal.pone.0158689 https://doi.org/10.1371/journal.pone.0158689

Naoe Y , Nakamura N , Doi A , et al. , 2016 . Crystal structure of bacterial haem importer complex in the inward-facing conformation . Nat Commun , 7 : 13411 . https://doi.org/10.1038/ncomms13411 https://doi.org/10.1038/ncomms13411

Neville SL , Sjöhamn J , Watts JA , et al. , 2021 . The structural basis of bacterial manganese import . Sci Adv , 7 ( 32 ): eabg3980 . https://doi.org/10.1126/sciadv.abg3980 https://doi.org/10.1126/sciadv.abg3980

Ohashi H , Hasegawa M , Wakimoto K , et al. , 2015 . Next-generation technologies for multiomics approaches including interactome sequencing . Biomed Res Int , 2015 : 104209 . https://doi.org/10.1155/2015/104209 https://doi.org/10.1155/2015/104209

Oldham ML , Chen SS , Chen J , 2013 . Structural basis for substrate specificity in the Escherichia coli maltose transport system . Proc Natl Acad Sci USA , 110 ( 45 ): 18132 - 18137 . https://doi.org/10.1073/pnas.1311407110 https://doi.org/10.1073/pnas.1311407110

Owens TW , Taylor RJ , Pahil KS , et al. , 2019 . Structural basis of unidirectional export of lipopolysaccharide to the cell surface . Nature , 567 ( 7749 ): 550 - 553 . https://doi.org/10.1038/s41586-019-1039-0 https://doi.org/10.1038/s41586-019-1039-0

Paci V , Krasteva I , Orsini M , et al. , 2020 . Proteomic analysis of Brucella melitensis and Brucella ovis for identification of virulence factor using bioinformatics approachs . Mol Cell Probes , 53 : 101581 . https://doi.org/10.1016/j.mcp.2020.101581 https://doi.org/10.1016/j.mcp.2020.101581

Paludan SR , Pradeu T , Masters SL , et al. , 2021 . Constitutive immune mechanisms: mediators of host defence and immune regulation . Nat Rev Immunol , 21 ( 3 ): 137 - 150 . https://doi.org/10.1038/s41577-020-0391-5 https://doi.org/10.1038/s41577-020-0391-5

Patel S , Mathivanan N , Goyal A , 2017 . Bacterial adhesins, the pathogenic weapons to trick host defense arsenal . Biomed Pharmacother , 93 : 763 - 771 . https://doi.org/10.1016/j.biopha.2017.06.102 https://doi.org/10.1016/j.biopha.2017.06.102

Pier GB , 2007 . Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity . Int J Med Microbiol , 297 ( 5 ): 277 - 295 . https://doi.org/10.1016/j.ijmm.2007.03.012 https://doi.org/10.1016/j.ijmm.2007.03.012

Piercey MJ , Hingston PA , Truelstrup Hansen L , 2016 . Genes involved in Listeria monocytogenes biofilm formation at a simulated food processing plant temperature of 15 ℃. Int J Food Microbiol , 223 : 63 - 74 . https://doi.org/10.1016/j.ijfoodmicro.2016.02.009 https://doi.org/10.1016/j.ijfoodmicro.2016.02.009

Pietrocola G , Campoccia D , Motta C , et al. , 2022 . Colonization and infection of indwelling medical devices by Staphylococcus aureus with an emphasis on orthopedic implants . Int J Mol Sci , 23 ( 11 ): 5958 . https://doi.org/10.3390/ijms23115958 https://doi.org/10.3390/ijms23115958

Rahman A , Amirkhani A , Chowdhury D , et al. , 2022 . Proteome of Staphylococcus aureus biofilm changes significantly with aging . Int J Mol Sci , 23 ( 12 ): 6415 . https://doi.org/10.3390/ijms23126415 https://doi.org/10.3390/ijms23126415

Rempel S , Stanek WK , Slotboom DJ , 2019 . ECF-type ATP-binding cassette transporters . Annu Rev Biochem , 88 : 551 - 576 . https://doi.org/10.1146/annurev-biochem-013118-111705 https://doi.org/10.1146/annurev-biochem-013118-111705

Ribet D , Cossart P , 2015 . How bacterial pathogens colonize their hosts and invade deeper tissues . Microbes Infect , 17 ( 3 ): 173 - 183 . https://doi.org/10.1016/j.micinf.2015.01.004 https://doi.org/10.1016/j.micinf.2015.01.004

Rice AJ , Alvarez FJD , Schultz KM , et al. , 2013 . EPR spectroscopy of MolB 2 C 2 -A reveals mechanism of transport for a bacterial type II molybdate importer . J Biol Chem , 288 ( 29 ): 21228 - 21235 . https://doi.org/10.1074/jbc.M113.483495 https://doi.org/10.1074/jbc.M113.483495

Rice AJ , Park A , Pinkett HW , 2014 . Diversity in ABC transporters: type I, II and III importers . Crit Rev Biochem Mol Biol , 49 ( 5 ): 426 - 437 . https://doi.org/10.3109/10409238.2014.953626 https://doi.org/10.3109/10409238.2014.953626

Rodríguez-Arce I , Al-Jubair T , Euba B , et al. , 2019 . Moonlighting of Haemophilus influenzae heme acquisition systems contributes to the host airway-pathogen interplay in a coordinated manner . Virulence , 10 ( 1 ): 315 - 333 . https://doi.org/10.1080/21505594.2019.1596506 https://doi.org/10.1080/21505594.2019.1596506

Rosa LT , Bianconi ME , Thomas GH , et al. , 2018 . Tripartite ATP-independent periplasmic (TRAP) transporters and tripartite tricarboxylate transporters (TTT): from uptake to pathogenicity . Front Cell Infect Microbiol , 8 : 33 . https://doi.org/10.3389/fcimb.2018.00033 https://doi.org/10.3389/fcimb.2018.00033

Sansonetti PJ , 1993 . Bacterial pathogens, from adherence to invasion: comparative strategies . Med Microbiol Immunol , 182 ( 5 ): 223 - 232 . https://doi.org/10.1007/BF00579621 https://doi.org/10.1007/BF00579621

Sarowska J , Futoma-Koloch B , Jama-Kmiecik A , et al. , 2019 . Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports . Gut Pathog , 11 : 10 . https://doi.org/10.1186/s13099-019-0290-0 https://doi.org/10.1186/s13099-019-0290-0

Sheldon JR , Heinrichs DE , 2012 . The iron-regulated staphylococcal lipoproteins . Front Cell Infect Microbiol , 2 : 41 . https://doi.org/10.3389/fcimb.2012.00041 https://doi.org/10.3389/fcimb.2012.00041

Shirshikova TV , Sierra-Bakhshi CG , Kamaletdinova LK , et al. , 2021 . The ABC-type efflux pump MacAB is involved in protection of Serratia marcescens against aminoglycoside antibiotics, polymyxins, and oxidative stress . mSphere , 6 ( 2 ): e00033-21 . https://doi.org/10.1128/mSphere.00033-21 https://doi.org/10.1128/mSphere.00033-21

Song S , Wood TK , 2021 . The primary physiological roles of autoinducer 2 in Escherichia coli are chemotaxis and biofilm formation . Microorganisms , 9 ( 2 ): 386 . https://doi.org/10.3390/microorganisms9020386 https://doi.org/10.3390/microorganisms9020386

Song YL , Zhang XL , Cai MH , et al. , 2018 . The heme transporter HtsABC of group A Streptococcus contributes to virulence and innate immune evasion in murine skin infections . Front Microbiol , 9 : 1105 . https://doi.org/10.3389/fmicb.2018.01105 https://doi.org/10.3389/fmicb.2018.01105

Soni DK , Dubey SK , Bhatnagar R , 2020 . ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis : target for drug and vaccine development . Emerging Microbes Infect , 9 ( 1 ): 207 - 220 . https://doi.org/10.1080/22221751.2020.1714488 https://doi.org/10.1080/22221751.2020.1714488

Srikant S , 2020 . Evolutionary history of ATP-binding cassette proteins . FEBS Lett , 594 ( 23 ): 3882 - 3897 . https://doi.org/10.1002/1873-3468.13985 https://doi.org/10.1002/1873-3468.13985

Swier LJYM , Slotboom DJ , Poolman B , 2016 . ABC importers . In: George AM (Ed.), ABC Transporters—40 Years on . Springer , Cham , p. 3 - 36 . https://doi.org/10.1007/978-3-319-23476-2_1 https://doi.org/10.1007/978-3-319-23476-2_1

Swoboda JG , Campbell J , Meredith TC , et al. , 2010 . Wall teichoic acid function, biosynthesis, and inhibition . ChemBioChem , 11 ( 1 ): 35 - 45 . https://doi.org/10.1002/cbic.200900557 https://doi.org/10.1002/cbic.200900557

Tanaka KJ , Song S , Mason K , Pinkett HW , 2018 . Selective substrate uptake: the role of ATP-binding cassette (ABC) importers in pathogenesis . Biochimt Biophys Acta (BBA) Biomembr , 1860 ( 4 ): 868 - 877 . https://doi.org/10.1016/j.bbamem.2017.08.011 https://doi.org/10.1016/j.bbamem.2017.08.011

Thélot F , Orlando BJ , Li YY , et al. , 2020 . High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB 2 FGC . Curr Opin Struct Biol , 63 : 26 - 33 . https://doi.org/10.1016/j.sbi.2020.03.005 https://doi.org/10.1016/j.sbi.2020.03.005

Thomas C , Tampé R , 2018 . Multifaceted structures and mechanisms of ABC transport systems in health and disease . Curr Opin Struct Biol , 51 : 116 - 128 . https://doi.org/10.1016/j.sbi.2018.03.016 https://doi.org/10.1016/j.sbi.2018.03.016

Thomas C , Tampé R , 2020 . Structural and mechanistic principles of ABC transporters . Annu Rev Biochem , 89 : 605 - 636 . https://doi.org/10.1146/annurev-biochem-011520-105201 https://doi.org/10.1146/annurev-biochem-011520-105201

Thomas C , Aller SG , Beis K , et al. , 2020 . Structural and functional diversity calls for a new classification of ABC transporters . FEBS Lett , 594 ( 23 ): 3767 - 3775 . https://doi.org/10.1002/1873-3468.13935 https://doi.org/10.1002/1873-3468.13935

Turlin E , Heuck G , Simões Brandão MI , et al. , 2014 . Protoporphyrin (PPIX) efflux by the MacAB-TolC pump in Escherichia coli . MicrobiologyOpen , 3 ( 6 ): 849 - 859 . https://doi.org/10.1002/mbo3.203 https://doi.org/10.1002/mbo3.203

van Veen HW , 2016 . Bacterial ABC multidrug exporters: from shared proteins motifs and features to diversity in molecular mechanisms . In: George AM (Ed.), ABC Transporters—40 Years on . Springer , Cham , p. 37 - 51 . https://doi.org/10.1007/978-3-319-23476-2_2 https://doi.org/10.1007/978-3-319-23476-2_2

Varela MF , Kumar S , 2019 . Strategies for discovery of new molecular targets for anti-infective drugs . Curr Opin Pharmacol , 48 : 57 - 68 . https://doi.org/10.1016/j.coph.2019.04.015 https://doi.org/10.1016/j.coph.2019.04.015

Vestby LK , Grønseth T , Simm R , et al. , 2020 . Bacterial biofilm and its role in the pathogenesis of disease . Antibiotics , 9 ( 2 ): 59 . https://doi.org/10.3390/antibiotics9020059 https://doi.org/10.3390/antibiotics9020059

Vijayababu P , Samykannu G , Antonyraj CB , et al. , 2018 . Patulin interference with ATP binding cassette transferring auto inducer-2 in Salmonella typhi and biofilm inhibition via quorum sensing . Inf Med Unlocked , 11 : 9 - 14 . https://doi.org/10.1016/j.imu.2018.02.001 https://doi.org/10.1016/j.imu.2018.02.001

Villet RA , Truong-Bolduc QC , Wang Y , et al. , 2014 . Regulation of expression of abcA and its response to environmental conditions . J Bacteriol , 196 ( 8 ): 1532 - 1539 . https://doi.org/10.1128/JB.01406-13 https://doi.org/10.1128/JB.01406-13

Wang QY , Wang PF , Liu PP , et al. , 2022 . Comparative transcriptome analysis reveals regulatory factors involved in Vibrio parahaemolyticus biofilm formation . Front Cell Infect Microbiol , 12 : 917131 . https://doi.org/10.3389/fcimb.2022.917131 https://doi.org/10.3389/fcimb.2022.917131

Wang TL , Fu GB , Pan XJ , et al. , 2013 . Structure of a bacterial energy-coupling factor transporter . Nature , 497 ( 7448 ): 272 - 276 . https://doi.org/10.1038/nature12045 https://doi.org/10.1038/nature12045

Woo JS , Zeltina A , Goetz BA , et al. , 2012 . X-ray structure of the Yersinia pestis heme transporter HmuUV . Nat Struct Mol Biol , 19 ( 12 ): 1310 - 1315 . https://doi.org/10.1038/nsmb.2417 https://doi.org/10.1038/nsmb.2417

Wood DW , Setubal JC , Kaul R , et al. , 2001 . The genome of the natural genetic engineer Agrobacterium tumefaciens C58 . Science , 294 ( 5550 ): 2317 - 2323 . https://doi.org/10.1126/science.1066804 https://doi.org/10.1126/science.1066804

Xu K , Zhang MH , Zhao Q , et al. , 2013 . Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis . Nature , 497 ( 7448 ): 268 - 271 . https://doi.org/10.1038/nature12046 https://doi.org/10.1038/nature12046

Yamagishi A , Nakano S , Yamasaki S , et al. , 2020 . An efflux inhibitor of the MacAB pump in Salmonella enterica serovar Typhimurium . Microbiol Immunol , 64 ( 3 ): 182 - 188 . https://doi.org/10.1111/1348-0421.12765 https://doi.org/10.1111/1348-0421.12765

Yamanaka H , Kobayashi H , Takahashi E , et al. , 2008 . MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II . J Bacteriol , 190 ( 23 ): 7693 - 7698 . https://doi.org/10.1128/JB.00853-08 https://doi.org/10.1128/JB.00853-08

Yang JL , He YP , Jiang J , et al. , 2016 . Comparative proteomic analysis by iTRAQ-2DLC-MS/MS provides in sight into the key proteins involved in Cronobacter sp . biofilm formation. Food Control , 63 : 93 - 100 . https://doi.org/10.1016/j.foodcont.2015.11.029 https://doi.org/10.1016/j.foodcont.2015.11.029

Yang XY , Li N , Xu JY , et al. , 2019 . Lipoprotein SPD_1609 of Streptococcus pneumoniae promotes adherence and invasion to epithelial cells contributing to bacterial virulence . Front Microbiol , 10 : 1769 . https://doi.org/10.3389/fmicb.2019.01769 https://doi.org/10.3389/fmicb.2019.01769

Yoshikai H , Kizaki H , Saito Y , et al. , 2016 . Multidrug-resistance transporter AbcA secretes Staphylococcus aureus cytolytic toxins . J Infect Dis , 213 ( 2 ): 295 - 304 . https://doi.org/10.1093/infdis/jiv376 https://doi.org/10.1093/infdis/jiv376

Zaynab M , Chen HR , Chen YF , et al. , 2021 . Signs of biofilm formation in the genome of Labrenzia sp . PO1. Saudi J Biol Sci , 28 ( 3 ): 1900 - 1912 . https://doi.org/10.1016/j.sjbs.2020.12.041 https://doi.org/10.1016/j.sjbs.2020.12.041

Zheng JX , Lin ZW , Sun X , et al. , 2018 . Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae . Emerg Microbes Infect , 7 ( 1 ): 1 - 11 . https://doi.org/10.1038/s41426-018-0141-y https://doi.org/10.1038/s41426-018-0141-y

Zhou Z , Sun N , Wu SS , et al. , 2016 . Genomic data mining reveals a rich repertoire of transport proteins in Streptomyces . BMC Genomics , 17 ( S7 ): 510 . https://doi.org/10.1186/s12864-016-2899-4 https://doi.org/10.1186/s12864-016-2899-4

浏览量

Downloads

CSCD

工具集

关联资源

暂无数据