前列腺癌精确诊断与治疗的分子成像探针技术的研究进展

方家杰; Ahmad ALHASKAWI; 董延钊; 程澄; 徐志杰; 田俊杰; Sahar Ahmed ABDALBARY; 卢荟

doi:10.1631/jzus.B2300614

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Review | Updated：2025-02-25

前列腺癌精确诊断与治疗的分子成像探针技术的研究进展
Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第2期页码：124-144
Affiliations：

1.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
2.Department of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
3.Zhejiang Engineering Research Center for Urinary Bladder Carcinoma Innovation Diagnosis and Treatment, Hangzhou 310024, China
4.Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University, Beni Suef 62511, Egypt
5.Biomechanics and Microsurgery Labs, Nahda University, Beni Suef 62511, Egypt
6.Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, Hangzhou 310058, China
Funds：

the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2022RC146);the Zhejiang Provincial Natural Science Foundation of China(LQ22H050003)
DOI：10.1631/jzus.B2300614
中图分类号：
CSTR：
收稿日期：2023-08-29，

网络出版日期：2025-01-15，

纸质出版日期：2025-02-25
Accepted：

方家杰,Ahmad ALHASKAWI,董延钊等.前列腺癌精确诊断与治疗的分子成像探针技术的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):124-144.

Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, et al. Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 124-144.
方家杰,Ahmad ALHASKAWI,董延钊等.前列腺癌精确诊断与治疗的分子成像探针技术的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):124-144. DOI： 10.1631/jzus.B2300614.

Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, et al. Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 124-144. DOI： 10.1631/jzus.B2300614.

摘要

前列腺癌是男性第二常见癌症，在2020年占新发癌症病例的14.1%。前列腺癌的侵袭性高度变异，取决于其在诊断时的分级和分期。尽管近年来前列腺癌治疗有所进步，但仍有一些患者在接受根治性治疗后会出现疾病的复发甚至进展的情况。精确的初始分期和复发监测决定了患者的治疗方案，进而影响患者的预后和生存率。相比传统影像学在前列腺癌的诊断和治疗中的局限性，新型分子探针的使用提高了前列腺癌检测的检出率、特异性和准确性。基于分子探针的影像学方式可以在活体系统中实现分子和细胞水平的生物学过程的可视化和定量测量。对前列腺癌肿瘤生物学的深入理解和新肿瘤生物标志物的发现，使得探索新的分子探针目标成为可能。新型配体的开发和基于纳米的传递技术的进步加速了分子探针的研究和开发。在此，我们总结了分子探针在正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）、磁共振成像（MRI）、光学成像和超声成像中的应用，并简述了前列腺癌中重要的靶分子。

Abstract

Prostate cancer is the second most common cancer in men

accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable

depending on its grade and stage at the time of diagnosis. Despite recent advances in prostate cancer treatment

some patients still experience recurrence or even progression after undergoing radical treatment. Accurate initial staging and monitoring for recurrence determine patient management

which in turn affect patient prognosis and survival. Classical imaging has limitations in the diagnosis and treatment of prostate cancer

but the use of novel molecular probes has improved the detection rate

specificity

and accuracy of prostate cancer detection. Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems. An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets. The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes. Here

we summarize the use of molecular probes in positron emission tomography (PET)

single-photon emission computed tomography (SPECT)

magnetic resonance imaging (MRI)

optical imaging

and ultrasound imaging

and provide a brief overview of important target molecules in prostate cancer.

关键词

Keywords

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MRI-derived radiomics models for diagnosis, aggressiveness, and prognosis evaluation in prostate cancer

Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer