依赖于微生物的肠脑通路治疗伴有胃肠道症状抑郁症的新视角：从实验室到临床

刘梦琳; 樊根豪; 孟令凯; 杨阔; 刘华一

doi:10.1631/jzus.B2300343

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依赖于微生物的肠脑通路治疗伴有胃肠道症状抑郁症的新视角：从实验室到临床

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Review | Updated：2025-04-21

依赖于微生物的肠脑通路治疗伴有胃肠道症状抑郁症的新视角：从实验室到临床
New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside
浙江大学学报（英文版）（B辑：生物医学和生物技术） 2025年26卷第1期页码：1-25
Affiliations：

1.The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Brain Disease Regional Diagnosis and Treatment Center, Zhengzhou450000, China
2.Tianjin University of Traditional Chinese Medicine, Tianjin301600, China
3.Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin300131, China
4.The First Affiliated Hospital of Zhengzhou University, Department of Geriatrics, Zhengzhou450052, China
Funds：

the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;the Scientific Research Projects in Key Areas of Traditional Chinese Medicine of Tianjin Municipal Health and Health Commission(2023004)
DOI：10.1631/jzus.B2300343
中图分类号：
CSTR：
收稿日期：2023-07-09，

修回日期：2023-08-29，

网络出版日期：2024-10-21，

纸质出版日期：2025-01-15
Accepted：

刘梦琳,樊根豪,孟令凯等.依赖于微生物的肠脑通路治疗伴有胃肠道症状抑郁症的新视角：从实验室到临床[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(01):1-25.

Menglin LIU, Genhao FAN, Lingkai MENG, et al. New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(1): 1-25.
刘梦琳,樊根豪,孟令凯等.依赖于微生物的肠脑通路治疗伴有胃肠道症状抑郁症的新视角：从实验室到临床[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(01):1-25. DOI： 10.1631/jzus.B2300343.

Menglin LIU, Genhao FAN, Lingkai MENG, et al. New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(1): 1-25. DOI： 10.1631/jzus.B2300343.

摘要

与普通人群相比，抑郁症患者更易出现慢性胃肠道症状，但这些症状仅被视为抑郁症的躯体症状而缺少特别关注。长期以来，对伴有胃肠道症状的抑郁症患者缺乏适当诊断和有效治疗，因此研究抑郁症与胃肠道疾病间的关联对临床治疗极为重要。越来越多的证据表明，抑郁症与消化道中的微生物群密切相关，而微生物群-肠-脑轴则为抑郁症与胃肠道疾病之间的关联开创了一个新的视角。识别和治疗胃肠道疾病可能预防抑郁症的发作，也可能改善难治性抑郁症的治疗效果。目前抑郁症和微生物相关的肠-脑轴的研究缺乏对胃肠道功能的关注。本综述结合临床前和临床证据，归纳了微生物调控的肠-脑轴在情绪和胃肠道功能中的作用，并总结了潜在治疗策略，为抑郁症伴胃肠道症状的病理机制研究和诊治提供参考。

Abstract

Patients with depression are more likely to have chronic gastrointestinal (GI) symptoms than the general population

but such symptoms are considered only somatic symptoms of depression and lack special attention. There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression accompanied by GI symptoms

and studying the association between depression and GI disorders (GIDs) is extremely important for clinical management. There is growing evidence that depression is closely related to the microbiota present in the GI tract

and the microbiota-gut-brain axis (MGBA) is creating a new perspective on the association between depression and GIDs. Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression. Current studies on depression and the microbially related gut-brain axis (GBA) lack a focus on GI function. In this review

we combine preclinical and clinical evidence to summarize the roles of the microbially regulated GBA in emotions and GI function

and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.

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Keywords

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