Sporadic Alzheimer’s disease with bipolar-like features: a case report and a brief review of the current research status

Lingzhuo KONG; Yan YANG; Weihua ZHOU; Shaohua HU

doi:10.1631/jzus.B2500307

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Correspondence | Updated：2026-04-23

Sporadic Alzheimer’s disease with bipolar-like features: a case report and a brief review of the current research status
Sporadic Alzheimer’s disease with bipolar-like features: a case report and a brief review of the current research status
具有双相障碍样特征的散发性阿尔茨海默病：病例报告及当前研究现状简述
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 4, Pages: 416-425(2026)
Affiliations：

1.Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.Nanhu Brain-Computer Interface Institute, Hangzhou 310003, China
3.Zhejiang Key Laboratory of Precision Psychiatry, Hangzhou 310003, China
4.MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou 310003, China
5.Brain Research Institute of Zhejiang University, Hangzhou 310003, China
6.Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 310003, China
7.Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou 310003, China
Funds：
DOI：10.1631/jzus.B2500307
CLC：
CSTR：
Received：07 June 2025，

Online First：15 April 2026，

Published：23 April 2026
Accepted：

孔令卓,杨燕,周韦华等.具有双相障碍样特征的散发性阿尔茨海默病：病例报告及当前研究现状简述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):416-425.

Lingzhuo KONG, Yan YANG, Weihua ZHOU, et al. Sporadic Alzheimer’s disease with bipolar-like features: a case report and a brief review of the current research status[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 416-425.
孔令卓,杨燕,周韦华等.具有双相障碍样特征的散发性阿尔茨海默病：病例报告及当前研究现状简述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):416-425. DOI： 10.1631/jzus.B2500307.

Lingzhuo KONG, Yan YANG, Weihua ZHOU, et al. Sporadic Alzheimer’s disease with bipolar-like features: a case report and a brief review of the current research status[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 416-425. DOI： 10.1631/jzus.B2500307.

摘要

近年来，关于阿尔茨海默病（AD）的机制研究不断取得新进展，其与其他神经精神疾病之间共享的病理生理机制也逐渐明晰。然而，对于在疾病早期阶段表现出非典型症状（如情绪调节障碍）的AD患者，临床实践中难以将其与其他神经退行性疾病或情感障碍进行有效鉴别。本研究报告一例75岁女性患者，她出现了进行性记忆衰退及类似情感障碍的情绪与行为表现状态的反复波动。经多次检查和治疗尝试后，最终确诊为早期AD，且在治疗后病情趋于稳定。本个案报道旨在进一步揭示AD和情感障碍之间共同的病理生理机制，以提醒医疗卫生工作人员应关注早期AD以情绪异常为主要表现的非典型症状，并展望未来治疗策略的发展方向。

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