Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing

Xian HU; Fawei XU; Minxia ZHANG; Yiqing CHEN; Jiaqin CAI; Jingjing MA; Weiqiang TAN; Qingqing FANG

doi:10.1631/jzus.B2500261

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Review | Updated：2026-08-13

Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing
Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing
促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 8, Pages: 832-855(2026)
Affiliations：

Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Funds：
DOI：10.1631/jzus.B2500261
CLC：
CSTR：
Received：18 May 2025，

Revised：2025-07-02，

Online First：13 August 2026，

Published：13 August 2026
Accepted：

胡娴,徐法伟,张敏霞等.促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(08):832-855.

Xian HU, Fawei XU, Minxia ZHANG, et al. Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(8): 832-855.
胡娴,徐法伟,张敏霞等.促进皮肤再生：无瘢痕愈合相关水凝胶伤口敷料的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(08):832-855. DOI： 10.1631/jzus.B2500261.

Xian HU, Fawei XU, Minxia ZHANG, et al. Promoting skin regeneration: research progress on hydrogel wound dressings related to scarless healing[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(8): 832-855. DOI： 10.1631/jzus.B2500261.

摘要

伤口愈合是一个包括止血、炎症、增殖和重塑四个阶段的复杂生物学过程，瘢痕形成是该过程中的常见问题，尤其是病理性瘢痕如增生性瘢痕和瘢痕疙瘩，严重影响美观与功能。近年来，水凝胶敷料凭借独特的物理化学和生物学特性，可通过提供湿润环境、抗菌、抗炎、促进组织再生以及调控伤口微环境等多重机制，加速愈合并减少瘢痕形成，已成为促进无瘢痕愈合的研究热点。本综述详述了无瘢痕愈合的概念与机制，并探讨了负载抗瘢痕药物、干细胞及细胞外囊泡的水凝胶敷料在无瘢痕伤口愈合中的应用；此外，还对可调节机械信号的水凝胶敷料及光响应、有机生物高分子和纳米颗粒等多种创新型多功能水凝胶的研究进展进行总结。但上述水凝胶敷料在展现出广阔的临床应用前景的同时，仍面临药物递送效率、生物相容性和长期安全性等挑战，未来研究需要进一步聚焦优化水凝胶组成与功能，并探索其在临床中的潜在应用。

Abstract

This review summarizes progress made in research on hydrogel wound dressings in promoting scarless skin healing. Wound healing is a complex biological process that involves four stages: hemostasis

inflammation

proliferation

and remodeling. Scar formation is a common issue during this process

especially pathological scars such as hypertrophic scars and keloids

which severely affect aesthetics and function. In recent years

hydrogel dressings have become a research hotspot for promoting scarless healing due to their unique physicochemical and biological properties. Hydrogels promote wound healing and reduce scar formation through multiple mechanisms

including providing a moist environment

antimicrobial activity

anti-inflammatory effects

promoting tissue regeneration

and regulating the wound microenvironment. This review details the concept and mechanisms of scarless healing and explores the application of hydrogel dressings loaded with anti-scarring drugs

stem cells

and extracellular vesicles (EVs) in scarless wound healing. Additionally

it summarizes progress in research on hydrogel dressings that regulate mechanical signals and innovative multifunctional hydrogel dressings

such as photo-responsive

organic biopolymer

and nanoparticle hydrogels. These hydrogel dressings show great potential for clinical application but still face challenges such as drug delivery efficiency

biocompatibility

and long-term safety. Future research needs to further optimize the composition and functionality of hydrogels and explore their potential applications in clinical settings.

关键词

Keywords

references

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