Small fish making a big difference: beloved star of environmental toxicology research in the current era

Yang JIANG; Zhen SU; Jing ZHENG; Chih-Hung HSU; Ye CHEN

doi:10.1631/jzus.B2500166

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Review | Updated：2025-07-25

Small fish making a big difference: beloved star of environmental toxicology research in the current era
Small fish making a big difference: beloved star of environmental toxicology research in the current era
小鱼大作为：当代环境毒理学研究中的明星生物
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 7, Pages: 613-632(2025)
Affiliations：

1.Department of Genetic and Metabolic Disease, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China
2.College of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou 310058, China
Funds：
DOI：10.1631/jzus.B2500166
CLC：
CSTR：
Received：03 April 2025，

Revised：01 May 2025，

Published：15 July 2025
Accepted：

江阳,苏真,郑静等.小鱼大作为：当代环境毒理学研究中的明星生物[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):613-632.

Yang JIANG, Zhen SU, Jing ZHENG, et al. Small fish making a big difference: beloved star of environmental toxicology research in the current era[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 613-632.
江阳,苏真,郑静等.小鱼大作为：当代环境毒理学研究中的明星生物[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):613-632. DOI： 10.1631/jzus.B2500166.

Yang JIANG, Zhen SU, Jing ZHENG, et al. Small fish making a big difference: beloved star of environmental toxicology research in the current era[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 613-632. DOI： 10.1631/jzus.B2500166.

摘要

斑马鱼凭借其独特的生物学特性和广泛的应用价值，已成为生命科学研究中的重要模式生物。本综述全面概述了斑马鱼在环境毒理学领域的最新研究进展，并重点介绍了利用该物种探究各类污染物的生态影响及其作用机制的代表性成果。这些研究充分印证了斑马鱼作为模式生物在揭示环境污染的生态效应与毒性通路方面的重要潜力。通过融合人工智能、高通量筛选及多组学分析等前沿技术，斑马鱼模型的应用将显著加速毒理学研究进程，推动环境保护实践，助力人类健康保障，并推进可持续发展目标的实现。

Abstract

The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications. This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology

highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms. The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways. By incorporating cutting-edge technologies such as artificial intelligence (AI)

high-throughput screening

and omics approaches

the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations

promote environmental conservation efforts

contribute to safeguarding human health

and advance sustainable development objectives.

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Keywords

references

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