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Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT: a rare case report and literature review
Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT: a rare case report and literature review
- 肺硬化性肺细胞瘤伴淋巴结转移及PET/CT 18FDG高摄取：一例罕见病例报告及文献综述
- Journal of Zhejiang University-SCIENCE B Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 2, Pages: 202-206(2026)
- Affiliations：
1.Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
- Funds：
DOI：10.1631/jzus.B2500159
CLC：- CSTR：
Received：30 March 2025，
Revised：2025-05-19，
Published：06 February 2026
- Accepted：
徐敬峰,赵艺蕾,吴秋莉等.肺硬化性肺细胞瘤伴淋巴结转移及PET/CT 18FDG高摄取：一例罕见病例报告及文献综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):202-206.
Jingfeng XU, Yilei ZHAO, Qiuli WU, et al. Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT: a rare case report and literature review[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 202-206.
徐敬峰,赵艺蕾,吴秋莉等.肺硬化性肺细胞瘤伴淋巴结转移及PET/CT 18FDG高摄取：一例罕见病例报告及文献综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):202-206. DOI： 10.1631/jzus.B2500159.
Jingfeng XU, Yilei ZHAO, Qiuli WU, et al. Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT: a rare case report and literature review[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 202-206. DOI： 10.1631/jzus.B2500159.
摘要
Abstract
硬化性肺细胞瘤（PSP）最初被称为肺硬化性血管瘤（PSH），曾被认为来源于血管丰富的内皮细胞。然而近期相关研究表明，该肿瘤实际来源于肺泡上皮细胞。尽管以往研究普遍认为PSP是一种罕见的良性肺肿瘤，但已有报道显示其可发生肺及淋巴结等部位的转移，提示其具有潜在恶行生物学行为。正电子发射计算机断层显像（PET/CT）可显示出PSP对
18
F-氟脱氧葡萄（
18
FDG）的摄取程度不一，最大标准化摄取值（SUV
max
）从背景值到6.4不等。因此，PSP很容易被误诊为其他恶性肿瘤，从而接受不必要的手术切除或不恰当治疗。本文报告了一例罕见的年轻PSP患者病例，其PET/CT显示右肺巨大肿块伴右肺门淋巴结肿大，肿瘤和淋巴结的SUV
max
分别为6.1和5.1，属于已有文献报道中最高的摄取值之一。目前，PSP病灶淋巴结转移和/或
18
FDG高摄取的原因尚不明确，其是否与肿瘤发生部位、大小、血供以及患者的年龄、性别和吸烟史相关，仍无定论。此外，本研究进一步回顾分析了近十年来PSP淋巴结转移和/或
18
FDG高摄取的文献，通过统计分析肿瘤大小，淋巴结转移和
18
FDG摄取等情况，发现淋巴结的转移与和/或
18
FDG高摄取与肿瘤大小正相关（
R
=0.642，
R
2
=0.454，
P
<
0.001）。综上，对于年轻患者，若其影像出现肺部边界清楚的较大肿块，即使伴有淋巴结转移和/或
18
FDG高摄取，仍需要考虑PSP的可能。
关键词
Keywords
references
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