Effects of <italic style="font-style: italic">Citrus</italic> on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

Yiyan YANG; Jue ZHOU

doi:10.1631/jzus.B2500127

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Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health
Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health
柑橘对氧化应激和脂质代谢调节的影响及其改善女性生殖健康的潜力
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 8, Pages: 763-777(2025)
Affiliations：

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China
Funds：
DOI：10.1631/jzus.B2500127
CLC：
CSTR：
Received：17 March 2025，

Revised：27 May 2025，

Published Online：08 August 2025，

Published：25 August 2025
Accepted：

杨亦岩,周珏.柑橘对氧化应激和脂质代谢调节的影响及其改善女性生殖健康的潜力[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(08):763-777.

Yiyan YANG, Jue ZHOU. Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(8): 763-777.
杨亦岩,周珏.柑橘对氧化应激和脂质代谢调节的影响及其改善女性生殖健康的潜力[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(08):763-777. DOI： 10.1631/jzus.B2500127.

Yiyan YANG, Jue ZHOU. Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(8): 763-777. DOI： 10.1631/jzus.B2500127.

摘要

柑橘在国际上拥有悠久的食用历史，广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用，这些因素与女性生殖健康密切相关。研究表明，柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激，并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响，旨在为促进女性生殖健康提供新思路。然而，仍需进一步的研究明确其作用机制，且柑橘活性成分的临床治疗潜力仍有待验证。

Abstract

Citrus

which has been consumed internationally for a long time

is widely used as a health food.

Citrus

and its active components exert significant effects on oxidative stress and lipid metabolism

which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1)

and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of

Citrus

on oxidative stress and lipid metabolism

aiming to provide new insights for promoting female reproductive health; however

further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of

Citrus

’s bioactive components in clinical settings.

关键词

Keywords

references

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Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

DOI：10.1631/jzus.B2500127

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