Cell proliferation and differentiation during epidermis renewal

Kai LIU; Kaidi REN; Dengwen LI; Yang YANG

doi:10.1631/jzus.B2500085

Your Location：

Home >

Browse articles >

Cell proliferation and differentiation during epidermis renewal

Scan QR Code

Alert me when the article has been cited

Submit

Review | Updated：2026-06-23

Cell proliferation and differentiation during epidermis renewal
Cell proliferation and differentiation during epidermis renewal
表皮更新过程中的细胞增殖与分化
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 6, Pages: 603-614(2026)
Affiliations：

1.Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2.Department of Genetics and Cell Biology, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
3.Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Funds：
DOI：10.1631/jzus.B2500085
CLC：
CSTR：
Received：23 February 2025，

Revised：2025-04-22，

Online First：15 April 2026，

Published：15 June 2026
Accepted：

刘凯,任凯迪,李登文等.表皮更新过程中的细胞增殖与分化[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):603-614.

Kai LIU, Kaidi REN, Dengwen LI, et al. Cell proliferation and differentiation during epidermis renewal[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 603-614.
刘凯,任凯迪,李登文等.表皮更新过程中的细胞增殖与分化[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(06):603-614. DOI： 10.1631/jzus.B2500085.

Kai LIU, Kaidi REN, Dengwen LI, et al. Cell proliferation and differentiation during epidermis renewal[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(6): 603-614. DOI： 10.1631/jzus.B2500085.

摘要

表皮作为皮肤的最外层，由复层鳞状上皮细胞组成，其定期更新对维持屏障功能至关重要。这一过程依赖于基底表皮干细胞的协调增殖与分化，并受到细胞分裂方向的内在调控和外部微环境因素的双重影响。本文综述了表皮更新的关键机制，重点关注对称与非对称细胞命运的平衡以及分化细胞在基底层上的整合。文章还探讨了单细胞组学、活体成像和人工智能（AI）建模技术在揭示表皮更新中细胞增殖与分化分子机制方面的重要作用。

Abstract

Residing at the outermost layer of the skin

the epidermis is composed of stratified squamous epithelial cells. Regular renewal of the epidermis is essential for maintaining its barrier function

which is dependent on the orchestrated proliferation and differentiation of stem cells located in the basal epidermis. This process necessitates precise dual regulation through the intrinsic control of cell division orientation and external microenvironmental influences. In this comprehensive review

we delve into the critical processes underlying epidermis renewal

emphasizing the balance between symmetric and asymmetric cell fate and the integration of differentiated cells into the suprabasal layer. Our paper highlights the pivotal roles of single-cell omics

live imaging

and artificial intelligence (AI)-driven modeling techniques in elucidating the molecular mechanisms governing cell proliferation and differentiation during epidermis renewal.

关键词

Keywords

references

Ali NJA , Dias Gomes M , Bauer R , et al. , 2016 . Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation, and stem cell maintenance . J Invest Dermatol , 136 ( 12 ): 2406 - 2416 . https://doi.org/10.1016/j.jid.2016.07.011 https://doi.org/10.1016/j.jid.2016.07.011

Aragona M , Sifrim A , Malfait M , et al. , 2020 . Mechanisms of stretch-mediated skin expansion at single-cell resolution . Nature , 584 ( 7820 ): 268 - 273 . https://doi.org/10.1038/s41586-020-2555-7 https://doi.org/10.1038/s41586-020-2555-7

Arnaud T , Rodrigues-Lima F , Viguier M , et al. , 2023 . Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis . Tissue Barriers , 11 ( 3 ): 2104085 . https://doi.org/10.1080/21688370.2022.2104085 https://doi.org/10.1080/21688370.2022.2104085

Baba K , Sasaki K , Morita M , et al. , 2020 . Cell jamming, stratification and p63 expression in cultivated human corneal epithelial cell sheets . Sci Rep , 10 : 9282 . https://doi.org/10.1038/s41598-020-64394-6 https://doi.org/10.1038/s41598-020-64394-6

Banjac I , Maimets M , Jensen KB , 2023 . Maintenance of high-turnover tissues during and beyond homeostasis . Cell Stem Cell , 30 ( 4 ): 348 - 361 . https://doi.org/10.1016/j.stem.2023.03.008 https://doi.org/10.1016/j.stem.2023.03.008

Bansaccal N , Vieugue P , Sarate R , et al. , 2023 . The extracellular matrix dictates regional competence for tumour initiation . Nature , 623 ( 7988 ): 828 - 835 . https://doi.org/10.1038/s41586-023-06740-y https://doi.org/10.1038/s41586-023-06740-y

Bergman KA , Meis JF , Horrevorts AM , et al. , 1992 . Acute renal failure in a neonate due to pelviureteric candidal bezoars successfully treated with long-term systemic fluconazole . Acta Paediatr , 81 ( 9 ): 709 - 711 . https://doi.org/10.1111/j.1651-2227.1992.tb12342.x https://doi.org/10.1111/j.1651-2227.1992.tb12342.x

Bergstralh DT , Dawney NS , St Johnston D , 2017 . Spindle orientation: a question of complex positioning . Development , 144 ( 7 ): 1137 - 1145 . https://doi.org/10.1242/dev.140764 https://doi.org/10.1242/dev.140764

Betschinger J , Knoblich JA , 2004 . Dare to be different: asymmetric cell division in Drosophila , C . elegans and vertebrates . Curr Biol , 14 ( 16 ): R674 - R685 . https://doi.org/10.1016/j.cub.2004.08.017 https://doi.org/10.1016/j.cub.2004.08.017

Blanpain C , Simons BD , 2013 . Unravelling stem cell dynamics by lineage tracing . Nat Rev Mol Cell Biol , 14 ( 8 ): 489 - 502 . https://doi.org/10.1038/nrm3625 https://doi.org/10.1038/nrm3625

Christophers E , Laurence EB , 1976 . Kinetics and structural organisation of the epidermis . Curr Probl Dermatol , 6 : 87 - 106 . https://doi.org/10.1159/000399007 https://doi.org/10.1159/000399007

Clayton E , Doupé DP , Klein AM , et al. , 2007 . A single type of progenitor cell maintains normal epidermis . Nature , 446 ( 7132 ): 185 - 189 . https://doi.org/10.1038/nature05574 https://doi.org/10.1038/nature05574

Damen M , Wirtz L , Soroka E , et al. , 2021 . High proliferation and delamination during skin epidermal stratification . Nat Commun , 12 : 3227 . https://doi.org/10.1038/s41467-021-23386-4 https://doi.org/10.1038/s41467-021-23386-4

Dekoninck S , Hannezo E , Sifrim A , et al. , 2020 . Defining the design principles of skin epidermis postnatal growth . Cell , 181 ( 3 ): 604 - 620.e22 . https://doi.org/10.1016/j.cell.2020.03.015 https://doi.org/10.1016/j.cell.2020.03.015

Eyermann CE , Chen X , Somuncu OS , et al. , 2024 . ΔNp63 regulates homeostasis, stemness, and suppression of inflammation in the adult epidermis . J Invest Dermatol , 144 ( 1 ): 73 - 83.e10 . https://doi.org/10.1016/j.jid.2023.07.005 https://doi.org/10.1016/j.jid.2023.07.005

Fuchs E , Green H , 1980 . Changes in keratin gene expression during terminal differentiation of the keratinocyte . Cell , 19 ( 4 ): 1033 - 1042 . https://doi.org/10.1016/0092-8674(80)90094-x https://doi.org/10.1016/0092-8674(80)90094-x

Ghazizadeh S , Taichman LB , 2001 . Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin . EMBO J , 20 ( 6 ): 1215 - 1222 . https://doi.org/10.1093/emboj/20.6.1215 https://doi.org/10.1093/emboj/20.6.1215

Gladden AB , Hebert AM , Schneeberger EE , et al. , 2010 . The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex . Dev Cell , 19 ( 5 ): 727 - 739 . https://doi.org/10.1016/j.devcel.2010.10.008 https://doi.org/10.1016/j.devcel.2010.10.008

Gola A , Fuchs E , 2021 . Environmental control of lineage plasticity and stem cell memory . Curr Opin Cell Biol , 69 : 88 - 95 . https://doi.org/10.1016/j.ceb.2020.12.015 https://doi.org/10.1016/j.ceb.2020.12.015

Haake SM , Rios BL , Pozzi A , et al. , 2024 . Integrating integrins with the hallmarks of cancer . Matrix Biol , 130 : 20 - 35 . https://doi.org/10.1016/j.matbio.2024.04.003 https://doi.org/10.1016/j.matbio.2024.04.003

Hardman MJ , Sisi P , Banbury DN , et al. , 1998 . Patterned acquisition of skin barrier function during development . Development , 125 ( 8 ): 1541 - 1552 . https://doi.org/10.1242/dev.125.8.1541 https://doi.org/10.1242/dev.125.8.1541

Holthaus KB , Eckhart L , 2024 . Development-associated genes of the epidermal differentiation complex (EDC) . J Dev Biol , 12 ( 1 ): 4 . https://doi.org/10.3390/jdb12010004 https://doi.org/10.3390/jdb12010004

Jacob T , Annusver K , Czarnewski P , et al. , 2023 . Molecular and spatial landmarks of early mouse skin development . Dev Cell , 58 ( 20 ): 2140 - 2162.e5 . https://doi.org/10.1016/j.devcel.2023.07.015 https://doi.org/10.1016/j.devcel.2023.07.015

Joost S , Zeisel A , Jacob T , et al. , 2016 . Single-cell transcriptomics reveals that differentiation and spatial signatures shape epidermal and hair follicle heterogeneity . Cell Syst , 3 ( 3 ): 221 - 237.e9 . https://doi.org/10.1016/j.cels.2016.08.010 https://doi.org/10.1016/j.cels.2016.08.010

Khalilgharibi N , Mao YL , 2021 . To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease . Open Biol , 11 ( 2 ): 200360 . https://doi.org/10.1098/rsob.200360 https://doi.org/10.1098/rsob.200360

Kim MK , Jeong W , Lee SM , et al. , 2020 . Decellularized extracellular matrix-based bio-ink with enhanced 3D printability and mechanical properties . Biofabrication , 12 ( 2 ): 025003 . https://doi.org/10.1088/1758-5090/ab5d80 https://doi.org/10.1088/1758-5090/ab5d80

Koblan LW , Erdos MR , Wilson C , et al. , 2021 . In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice . Nature , 589 ( 7843 ): 608 - 614 . https://doi.org/10.1038/s41586-020-03086-7 https://doi.org/10.1038/s41586-020-03086-7

Koren E , Feldman A , Yusupova M , et al. , 2022 . Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis . Nat Commun , 13 : 4628 . https://doi.org/10.1038/s41467-022-31629-1 https://doi.org/10.1038/s41467-022-31629-1

Koster MI , Roop DR , 2004 . The role of p63 in development and differentiation of the epidermis: Tanioku Kihei memorial lecture . J Dermatol Sci , 34 ( 1 ): 3 - 9 . https://doi.org/10.1016/j.jdermsci.2003.10.003 https://doi.org/10.1016/j.jdermsci.2003.10.003

Koster MI , Roop DR , 2007 . Mechanisms regulating epithelial stratification . Annu Rev Cell Dev Biol , 23 ( 1 ): 93 - 113 . https://doi.org/10.1146/annurev.cellbio.23.090506.123357 https://doi.org/10.1146/annurev.cellbio.23.090506.123357

Kraut R , Chia W , Jan LY , et al. , 1996 . Role of inscuteable in orienting asymmetric cell divisions in Drosophila . Nature , 383 ( 6595 ): 50 - 55 . https://doi.org/10.1038/383050a0 https://doi.org/10.1038/383050a0

Lawlor KT , Kaur P , 2015 . Dermal contributions to human interfollicular epidermal architecture and self-renewal . Int J Mol Sci , 16 ( 12 ): 28098 - 28107 . https://doi.org/10.3390/ijms161226078 https://doi.org/10.3390/ijms161226078

Lechler T , Fuchs E , 2005 . Asymmetric cell divisions promote stratification and differentiation of mammalian skin . Nature , 437 ( 7056 ): 275 - 280 . https://doi.org/10.1038/nature03922 https://doi.org/10.1038/nature03922

Liu N , Matsumura H , Kato T , et al. , 2019 . Stem cell competition orchestrates skin homeostasis and ageing . Nature , 568 ( 7752 ): 344 - 350 . https://doi.org/10.1038/s41586-019-1085-7 https://doi.org/10.1038/s41586-019-1085-7

Liu S , Zhang HS , Duan EK , 2013 . Epidermal development in mammals: key regulators, signals from beneath, and stem cells . Int J Mol Sci , 14 ( 6 ): 10869 - 10895 . https://doi.org/10.3390/ijms140610869 https://doi.org/10.3390/ijms140610869

Lotti R , Palazzo E , Quadri M , et al. , 2022 . Isolation of an “early” transit amplifying keratinocyte population in human epidermis: a role for the low affinity neurotrophin receptor CD271 . Stem Cells , 40 ( 12 ): 1149 - 1161 . https://doi.org/10.1093/stmcls/sxac060 https://doi.org/10.1093/stmcls/sxac060

Ma HX , Qi FF , Ji L , et al. , 2022 . NuMA forms condensates through phase separation to drive spindle pole assembly . J Mol Cell Biol , 14 ( 1 ): mjab081 . https://doi.org/10.1093/jmcb/mjab081 https://doi.org/10.1093/jmcb/mjab081

Mascré G , Dekoninck S , Drogat B , et al. , 2012 . Distinct contribution of stem and progenitor cells to epidermal maintenance . Nature , 489 ( 7415 ): 257 - 262 . https://doi.org/10.1038/nature11393 https://doi.org/10.1038/nature11393

Matsui T , 2023 . Epidermal barrier development via corneoptosis: a unique form of cell death in stratum granulosum cells . J Dev Biol , 11 ( 4 ): 43 . https://doi.org/10.3390/jdb11040043 https://doi.org/10.3390/jdb11040043

Matsumura H , Mohri Y , Binh NT , et al. , 2016 . Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis . Science , 351 ( 6273 ): aad4395 . https://doi.org/10.1126/science.aad4395 https://doi.org/10.1126/science.aad4395

Mehrel T , Hohl D , Rothnagel JA , et al. , 1990 . Identification of a major keratinocyte cell envelope protein, loricrin . Cell , 61 ( 6 ): 1103 - 1112 . https://doi.org/10.1016/0092-8674(90)90073-n https://doi.org/10.1016/0092-8674(90)90073-n

Mesa KR , Kawaguchi K , Cockburn K , et al. , 2018 . Homeostatic epidermal stem cell self-renewal is driven by local differentiation . Cell Stem Cell , 23 ( 5 ): 677 - 686.e4 . https://doi.org/10.1016/j.stem.2018.09.005 https://doi.org/10.1016/j.stem.2018.09.005

Morrison SJ , Kimble J , 2006 . Asymmetric and symmetric stem-cell divisions in development and cancer . Nature , 441 ( 7097 ): 1068 - 1074 . https://doi.org/10.1038/nature04956 https://doi.org/10.1038/nature04956

Niessen MT , Scott J , Zielinski JG , et al. , 2013 . aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation . J Cell Biol , 202 ( 6 ): 887 - 900 . https://doi.org/10.1083/jcb.201307001 https://doi.org/10.1083/jcb.201307001

Ouspenskaia T , Matos I , Mertz AF , et al. , 2016 . WNT-SHH antagonism specifies and expands stem cells prior to niche formation . Cell , 164 ( 1-2 ): 156 - 169 . https://doi.org/10.1016/j.cell.2015.11.058 https://doi.org/10.1016/j.cell.2015.11.058

Panteleyev AA , 2022 . Dual nature of mouse periderm structure, function and fate . Exp Dermatol , 31 ( 7 ): 1102 - 1108 . https://doi.org/10.1111/exd.14608 https://doi.org/10.1111/exd.14608

Piperigkou Z , Götte M , Theocharis AD , et al. , 2018 . Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing . Adv Drug Deliv Rev , 129 : 16 - 36 . https://doi.org/10.1016/j.addr.2017.10.008 https://doi.org/10.1016/j.addr.2017.10.008

Poulson ND , Lechler T , 2010 . Robust control of mitotic spindle orientation in the developing epidermis . J Cell Biol , 191 ( 5 ): 915 - 922 . https://doi.org/10.1083/jcb.201008001 https://doi.org/10.1083/jcb.201008001

Poulson ND , Lechler T , 2012 . Asymmetric cell divisions in the epidermis . Int Rev Cell Mol Biol , 295 : 199 - 232 . https://doi.org/10.1016/B978-0-12-394306-4.00012-5 https://doi.org/10.1016/B978-0-12-394306-4.00012-5

Pozzi A , Yurchenco PD , Iozzo RV , 2017 . The nature and biology of basement membranes . Matrix Biol , 57 - 58 : 1 - 11 . https://doi.org/10.1016/j.matbio.2016.12.009 https://doi.org/10.1016/j.matbio.2016.12.009

Prado-Mantilla A , Lechler T , 2023 . Polarity in skin development and cancer . Curr Top Dev Biol , 154 : 317 - 336 . https://doi.org/10.1016/bs.ctdb.2023.02.003 https://doi.org/10.1016/bs.ctdb.2023.02.003

Randles MJ , Humphries MJ , Lennon R , 2017 . Proteomic definitions of basement membrane composition in health and disease . Matrix Biol , 57 - 58 : 12 - 28 . https://doi.org/10.1016/j.matbio.2016.08.006 https://doi.org/10.1016/j.matbio.2016.08.006

Rinnerthaler M , Bischof J , Streubel MK , et al. , 2015 . Oxidative stress in aging human skin . Biomolecules , 5 ( 2 ): 545 - 589 . https://doi.org/10.3390/biom5020545 https://doi.org/10.3390/biom5020545

Roig-Rosello E , Dayan G , Bovio S , et al. , 2024 . Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin . Aging Cell , 23 ( 4 ): e14096 . https://doi.org/10.1111/acel.14096 https://doi.org/10.1111/acel.14096

Rompolas P , Mesa KR , Kawaguchi K , et al. , 2016 . Spatiotemporal coordination of stem cell commitment during epidermal homeostasis . Science , 352 ( 6292 ): 1471 - 1474 . https://doi.org/10.1126/science.aaf7012 https://doi.org/10.1126/science.aaf7012

Rousselle P , Laigle C , Rousselet G , 2022 . The basement membrane in epidermal polarity, stemness, and regeneration . Am J Physiol Cell Physiol , 323 ( 6 ): C1807 - C1822 . https://doi.org/10.1152/ajpcell.00069.2022 https://doi.org/10.1152/ajpcell.00069.2022

Sada A , Tumbar T , 2013 . New insights into mechanisms of stem cell daughter fate determination in regenerative tissues . Int Rev Cell Mol Biol , 300 : 1 - 50 . https://doi.org/10.1016/B978-0-12-405210-9.00001-1 https://doi.org/10.1016/B978-0-12-405210-9.00001-1

Sada A , Jacob F , Leung E , et al. , 2016 . Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin . Nat Cell Biol , 18 ( 6 ): 619 - 631 . https://doi.org/10.1038/ncb3359 https://doi.org/10.1038/ncb3359

Satta JP , Lan Q , Taketo MM , et al. , 2024 . Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis . J Invest Dermatol , 144 ( 6 ): 1223 - 1237.e10 . https://doi.org/10.1016/j.jid.2023.11.018 https://doi.org/10.1016/j.jid.2023.11.018

Schmuth M , Eckmann S , Moosbrugger-Martinz V , et al. , 2024 . Skin barrier in atopic dermatitis . J Invest Dermatol , 144 ( 5 ): 989 - 1000.e1 . https://doi.org/10.1016/j.jid.2024.03.006 https://doi.org/10.1016/j.jid.2024.03.006

Seldin L , Macara I , 2017 . Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions . F1000Res , 6 : 984 . https://doi.org/10.12688/f1000research.11370.1 https://doi.org/10.12688/f1000research.11370.1

Seldin L , Muroyama A , Lechler T , 2016 . NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures . eLife , 5 : e12504 . https://doi.org/10.7554/eLife.12504 https://doi.org/10.7554/eLife.12504

Shin L , Peterson DA , 2013 . Human mesenchymal stem cell grafts enhance normal and impaired wound healing by recruiting existing endogenous tissue stem/progenitor cells . Stem Cells Transl Med , 2 ( 1 ): 33 - 42 . https://doi.org/10.5966/sctm.2012-0041 https://doi.org/10.5966/sctm.2012-0041

Simpson CL , Patel DM , Green KJ , 2011 . Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis . Nat Rev Mol Cell Biol , 12 ( 9 ): 565 - 580 . https://doi.org/10.1038/nrm3175 https://doi.org/10.1038/nrm3175

Smart IHM , 1970 . Variation in the plane of cell cleavage during the process of stratification in the mouse epidermis . Br J Dermatol , 82 ( 3 ): 276 - 282 . https://doi.org/10.1111/j.1365-2133.1970.tb12437.x https://doi.org/10.1111/j.1365-2133.1970.tb12437.x

te Molder L , de Pereda JM , Sonnenberg A , 2021 . Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4 . J Cell Sci , 134 ( 18 ): jcs259004 . https://doi.org/10.1242/jcs.259004 https://doi.org/10.1242/jcs.259004

Ussar S , Wang HV , Linder S , et al. , 2006 . The Kindlins: subcellular localization and expression during murine development . Exp Cell Res , 312 ( 16 ): 3142 - 3151 . https://doi.org/10.1016/j.yexcr.2006.06.030 https://doi.org/10.1016/j.yexcr.2006.06.030

Villeneuve C , Hashmi A , Ylivinkka I , et al. , 2024 . Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture . Nat Cell Biol , 26 ( 2 ): 207 - 218 . https://doi.org/10.1038/s41556-023-01332-4 https://doi.org/10.1038/s41556-023-01332-4

Visscher MO , Carr AN , Narendran V , 2022 . Epidermal immunity and function: origin in neonatal skin . Front Mol Biosci , 9 : 894496 . https://doi.org/10.3389/fmolb.2022.894496 https://doi.org/10.3389/fmolb.2022.894496

Wang XY , Ghasri P , Amir M , et al. , 2013 . Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure . Mol Ther , 21 ( 7 ): 1335 - 1344 . https://doi.org/10.1038/mt.2013.87 https://doi.org/10.1038/mt.2013.87

Weaver VM , Lelièvre S , Lakins JN , et al. , 2002 . β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium . Cancer Cell , 2 ( 3 ): 205 - 216 . https://doi.org/10.1016/s1535-6108(02)00125-3 https://doi.org/10.1016/s1535-6108(02)00125-3

Williams SE , Fuchs E , 2013 . Oriented divisions, fate decisions . Curr Opin Cell Biol , 25 ( 6 ): 749 - 758 . https://doi.org/10.1016/j.ceb.2013.08.003 https://doi.org/10.1016/j.ceb.2013.08.003

Williams SE , Beronja S , Pasolli HA , et al. , 2011 . Asymmetric cell divisions promote Notch-dependent epidermal differentiation . Nature , 470 ( 7334 ): 353 - 358 . https://doi.org/10.1038/nature09793 https://doi.org/10.1038/nature09793

Williams SE , Ratliff LA , Postiglione MP , et al. , 2014 . Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN . Nat Cell Biol , 16 ( 8 ): 758 - 769 . https://doi.org/10.1038/ncb3001 https://doi.org/10.1038/ncb3001

Xu P , Yang LL , Lai S , et al. , 2024 . Effects of EGFR-TKI on epidermal melanin unit integrity: therapeutic implications for hypopigmented skin disorders . Pigment Cell Melanoma Res , 37 ( 4 ): 514 - 529 . https://doi.org/10.1111/pcmr.13171 https://doi.org/10.1111/pcmr.13171

Yan JJ , Zhang K , Guo TM , et al. , 2022 . Par3 regulates the asymmetric division of basal stem cells in psoriasis via the Par3/mInsc/LGN signaling axis . Cell Immunol , 373 : 104496 . https://doi.org/10.1016/j.cellimm.2022.104496 https://doi.org/10.1016/j.cellimm.2022.104496

Yang S , Luo YG , Yang ML , et al. , 2023 . Src inhibition induces mitotic arrest associated with chromosomal passenger complex . Cell Tissue Res , 392 ( 3 ): 733 - 743 . https://doi.org/10.1007/s00441-023-03765-7 https://doi.org/10.1007/s00441-023-03765-7

Yin HX , Hu MZ , Li DW , 2023 . Regulation of epidermal stratification and development by basal keratinocytes . J Cell Physiol , 238 ( 4 ): 742 - 748 . https://doi.org/10.1002/jcp.30978 https://doi.org/10.1002/jcp.30978

Yu F , Yang S , Ni H , et al. , 2023 . O -GlcNAcylation regulates centrosome behavior and cell polarity to reduce pulmonary fibrosis and maintain the epithelial phenotype . Adv Sci , 10 ( 36 ): e2303545 . https://doi.org/10.1002/advs.202303545 https://doi.org/10.1002/advs.202303545

Zhong F , Wang F , Yang HF , 2024 . Composition and structure ana

lysis of different depths in the stratum corneum using confocal Raman microscopy combined with two-dimensional correlation spectroscopy . Talanta , 270 : 125559 . https://doi.org/10.1016/j.talanta.2023.125559 https://doi.org/10.1016/j.talanta.2023.125559

Zhong T , Wu XF , Xie W , et al. , 2022 . ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes . Cell Death Differ , 29 ( 9 ): 1719 - 1729 . https://doi.org/10.1038/s41418-022-00958-5 https://doi.org/10.1038/s41418-022-00958-5

Zhou BH , Lin WL , Long YL , et al. , 2022 . Notch signaling pathway: architecture, disease, and therapeutics . Signal Transduct Target Ther , 7 : 95 . https://doi.org/10.1038/s41392-022-00934-y https://doi.org/10.1038/s41392-022-00934-y

Zhu JW , Wen WY , Zheng Z , et al. , 2011 . LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways . Mol Cell , 43 ( 3 ): 418 - 431 . https://doi.org/10.1016/j.molcel.2011.07.011 https://doi.org/10.1016/j.molcel.2011.07.011

Views

Downloads

CSCD

Tools

Publicity Resources

Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review

Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models

HENMT1: an RNA methyltransferase in biology and disease

Regenerative potential of Schneiderian membrane-derived mesenchymal stem cells in sinus floor elevation model and calvarial defect model

Integrative analytical and statistical framework for optimization of multiplex qPCR detection of TGFBI mutations in refractive surgery candidates

Related Author

Siyi LIN

Xinyu HE

Ying WANG

Yu CHEN

Aifu LIN

Related Institution

College of Medicine, Zhejiang University

College of Life Sciences, Zhejiang University

Cancer Center, Zhejiang University

Key Laboratory for Cell and Gene Engineering of Zhejiang Province

International School of Medicine, International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu

Address：Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou, China Postal code：310027
Tel：+86-571-87952783 Email：cjzhang@zju.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰