Neuroscientific therapies for subjective tinnitus

Peng LIU; Xinmiao XUE; Zhixin ZHANG; Hanwen ZHOU; Cong XU; Lijun ZHANG; Zhen LI; Yongqing ZHOU; Shanwei SONG; Yameng TIAN; Fangyuan WANG; Xiaoming LI; Shiming YANG

doi:10.1631/jzus.B2400579

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Review | Updated：2026-04-23

Neuroscientific therapies for subjective tinnitus
Neuroscientific therapies for subjective tinnitus
主观性耳鸣的神经调控治疗
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 4, Pages: 343-358(2026)
Affiliations：

1.Department of Otolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang 050011, China
2.Department of Otolaryngology, Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing 100853, China
3.School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300380, China
Funds：
DOI：10.1631/jzus.B2400579
CLC：
CSTR：
Received：19 November 2024，

Revised：2025-03-02，

Online First：13 March 2026，

Published：23 April 2026
Accepted：

刘鹏,薛鑫淼,张志鑫等.主观性耳鸣的神经调控治疗[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):343-358.

Peng LIU, Xinmiao XUE, Zhixin ZHANG, et al. Neuroscientific therapies for subjective tinnitus[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 343-358.
刘鹏,薛鑫淼,张志鑫等.主观性耳鸣的神经调控治疗[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(04):343-358. DOI： 10.1631/jzus.B2400579.

Peng LIU, Xinmiao XUE, Zhixin ZHANG, et al. Neuroscientific therapies for subjective tinnitus[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(4): 343-358. DOI： 10.1631/jzus.B2400579.

摘要

耳鸣作为一种常见的听觉障碍，显著影响患者的生活质量。尽管其病理生理机制和治疗策略已被广泛研究，目前仍缺乏明确有效的治疗药物。随着生物医学工程的发展，神经调控技术已成为与药物和手术等传统策略并重的治疗方法。该技术通过侵入性或非侵入性方式，利用磁、电和光等多种物理刺激，实现对神经功能的调节。神经调控技术不仅推动了基本理论的进展，也促进了临床应用的优化。作为一种新兴且前景广阔的治疗手段，神经调控丰富了基础神经科学的研究工具，并拓宽了中枢神经系统疾病（包括耳鸣）的临床治疗途径。本文简要回顾了耳鸣的发病机制，讨论了不同神经调控技术的特点及其在耳鸣治疗方面的应用现状，并对未来的发展前景进行展望。

Abstract

Tinnitus

a prevalent auditory symptom

can significantly impair quality of life

yet no definitive pharmacological interventions exist despite extensive ongoing research into its pathophysiology and treatments. The advent of biomedical engineering has introduced neuromodulation as a pivotal therapeutic approach alongside conventional strategies such as pharmacotherapy and surgery. Through the deployment of invasive and non-invasive techniques

using various modalities including magnetic

electronic

and optical means

neuromodulation aims to regulate neural functions. This has not only led to the refinement of fundamental theories but has also enhanced the optimization of clinical applications. As an emerging and promising intervention

neuromodulation enriches the toolkit available for basic neuroscience inquiry and broadens the spectrum of clinical therapies for conditions affecting the central nervous system

including tinnitus. In this paper

we succinctly review the current understanding of tinnitus mechanisms

discuss the features of diverse neuromodulation technologies

explore their application in tinnitus management

and contemplate prospects for their development in treating tinnitus.

关键词

Keywords

references

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