Commensal bacteria play a fundamental role in maintaining gut immune homeostasis

Shuyu TU; Yanan ZHANG; Li ZHANG; Shu Jeffrey ZHU

doi:10.1631/jzus.B2400431

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Correspondence | Updated：2026-01-27

Commensal bacteria play a fundamental role in maintaining gut immune homeostasis
Commensal bacteria play a fundamental role in maintaining gut immune homeostasis
肠道菌群在维系肠道免疫稳态中的重要作用
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 1, Pages: 101-104(2026)
Affiliations：

1.Department of Cardiology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China
2.Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
Funds：
DOI：10.1631/jzus.B2400431
CLC：
CSTR：
Received：20 August 2024，

Revised：2025-01-05，

Published Online：22 December 2025，

Published：27 January 2026
Accepted：

涂舒谕,张雅楠,张莉等.肠道菌群在维系肠道免疫稳态中的重要作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(01):101-104.

Shuyu TU, Yanan ZHANG, Li ZHANG, et al. Commensal bacteria play a fundamental role in maintaining gut immune homeostasis[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 101-104.
涂舒谕,张雅楠,张莉等.肠道菌群在维系肠道免疫稳态中的重要作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(01):101-104. DOI： 10.1631/jzus.B2400431.

Shuyu TU, Yanan ZHANG, Li ZHANG, et al. Commensal bacteria play a fundamental role in maintaining gut immune homeostasis[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 101-104. DOI： 10.1631/jzus.B2400431.

摘要

肠道中种类庞杂的微生物群落统称为肠道菌群，其与宿主间相互影响，形成了复杂的共生体系统。肠道菌群与动物健康关系密切，具有消化、合成维生素以及合成其他重要代谢物和神经递质的功能。多项研究表明，菌群相关代谢产物可通过直接或间接方式调节宿主的生理功能和免疫反应，以维持局部及全身的稳态平衡。我们利用葡聚糖硫酸钠诱导的结肠炎小鼠模型证实，肠道共生细菌纽约杜伯氏菌及其人类同源菌无害梭菌，可通过产生短链脂肪酸（特别是丙酸）和赖氨酸调节免疫耐受，从而缓解结肠炎。赖氨酸可通过芳烃受体激活树突状细胞中的吲哚胺2

3-双加氧酶1（IDO1），诱导调节性T淋巴细胞（Treg）产生免疫抑制的肠道微环境，该研究可为炎症性肠病提供一种潜在的治疗策略。

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references

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