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Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAAR δ subunit expression in the dorsal periaqueductal gray (dPAG) region
Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAAR δ subunit expression in the dorsal periaqueductal gray (dPAG) region
- 舒郁胶囊通过激活dPAG脑区γ-氨基丁酸能神经元和下调GABAA受体δ亚基的表达改善经前烦躁症小鼠动情周期依赖性抑郁样行为
- Journal of Zhejiang University-SCIENCE B Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 1, Pages: 73-88(2026)
- Affiliations：
1.Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education / Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine / Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2.Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
3.Institute of Pharmaceutical Research, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
4.Department of Encephalopathy, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China
5.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
6.Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China
- Funds：
DOI：10.1631/jzus.B2400410
CLC：- CSTR：
Received：08 August 2024，
Revised：2024-11-17，
Published Online：17 December 2025，
Published：27 January 2026
- Accepted：
许佳玲,刘坤,崔雅茹等.舒郁胶囊通过激活dPAG脑区γ-氨基丁酸能神经元和下调GABAA受体δ亚基的表达改善经前烦躁症小鼠动情周期依赖性抑郁样行为[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(01):73-88.
Jialing XU, Kun LIU, Yaru CUI, et al. Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAAR δ subunit expression in the dorsal periaqueductal gray (dPAG) region[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 73-88.
许佳玲,刘坤,崔雅茹等.舒郁胶囊通过激活dPAG脑区γ-氨基丁酸能神经元和下调GABAA受体δ亚基的表达改善经前烦躁症小鼠动情周期依赖性抑郁样行为[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(01):73-88. DOI： 10.1631/jzus.B2400410.
Jialing XU, Kun LIU, Yaru CUI, et al. Shuyu capsule improves estrous cycle-dependent depression-like behavior in premenstrual dysphoric disorder (PMDD) mice by increasing GABAergic neuronal activation and downregulating GABAAR δ subunit expression in the dorsal periaqueductal gray (dPAG) region[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(1): 73-88. DOI： 10.1631/jzus.B2400410.
摘要
经前烦躁症（PMDD）是经前综合征（PMS）的一种亚型，该病的身体和情绪症状会影响患者日常生活和工作，亟需可靠且无副作用的临床干预。舒郁胶囊在临床上是一种可有效治疗PMDD的中药制剂，但其治疗机制尚不清楚。既往研究表明，中脑导水管周围灰质（PAG）中的γ-氨基丁酸能（GABAergic）系统可能在中药治疗PMDD中发挥作用，但缺乏功能验证。本研究旨在揭示舒郁胶囊治疗PMDD的潜在机制。通过聚焦雌性C57BL/6J和Vgat-Cre小鼠背侧中脑导水管周围灰质（dPAG）中的GABAergic系统，以评估舒郁胶囊对PMDD的影响。经强迫游泳测试检测小鼠抑郁样行为，并使用蛋白质印迹法和免疫荧光法检测激活的GABAergic神经元数量和γ-氨基丁酸A型受体δ亚基（GABRD）的表达量；分别使用化学遗传学技术和腺相关病毒载体，特异性地激活GABAergic神经元和敲低GABRD的表达，为舒郁胶囊具备治疗PMDD的神经生物学机制研究提供参考。结果显示，受到强迫游泳应激后，舒郁胶囊干预的PMDD小鼠在动情间期后期（LD）的不动时间缩短，表明舒郁胶囊可以改善PMDD小鼠动情周期依赖性抑郁样行为。此外，应用舒郁胶囊可下调PMDD模型小鼠dPAG脑区中GABRD的表达量，并逆转GABAergic神经元激活下降的趋势。研究还发现，操控二者中的单个靶点足以改善PMDD模型小鼠的抑郁样行为。本研究还建立了GABRD敲除的转基因小鼠，并通过行为学检测揭示其探索行为的变化，表明GABRD可能与焦虑症相关疾病密切相关。综上所述，舒郁胶囊可通过激活dPAG脑区GABAergic神经元以及下调GABRD的表达水平，发挥对PMDD的抗抑郁样作用，这不仅为中医治疗PMDD的临床应用提供了理论依据，也为PMDD新型治疗药物的研发奠定了科学基础。
Abstract
Premenstrual dysphoric disorder (PMDD)
a subtype of premenstrual syndrome (PMS)
involves physical and emotional symptoms that impact patients’ daily lives and productivity. A reliable
side-effect-free clinical intervention is needed. Shuyu capsule is an effective traditional Chinese medicine preparation for PMDD used in the clinics
but its therapeutic mechanism remains unclear. Previous research has suggested that the γ-aminobutyric acidergic (GABAergic) system in the periaqueductal gray (PAG) may play a role in treating PMDD with traditional Chinese medicine
but there is a lack of functional verification. This study aims to reveal the potential mechanism of the Shuyu capsule in treating PMDD. The study employed an experimental design using female C57BL/6J and Vgat-Cre mice to assess the effects of Shuyu capsules on PMDD
with a focus on the GABAergic system in the dorsal PAG (dPAG). Assessments were conducted using the forced swimming test (FST) to gauge depression-like behaviors and western blot (WB) and immunofluorescence (IF) to measure the numbers of active GABAergic neurons and the γ-aminobutyric acid type A receptor
(GABA
A
R) δ subunit (GABRD) expression. Chemogenetic techniques and adeno-associated virus were specifically used to activate GABAergic neurons and knock down the expression of subunits
respectively
providing insights into the neurobiological mechanisms underpinning the therapeutic effects of Shuyu capsules in treating PMDD. After being stressed by FST
the immobility duration of PMDD mice in the late dioestrus (LD) phase decreased after the Shuyu capsule intervention
implying that it can improve the estrous cycle-dependent depression-like phenotype in PMDD mice. Additionally
the application of Shuyu capsule can downregulate the expression of GABRD and reverse the downtrend of activated GABAergic neurons in the dPAG of PMDD model mice. We also found that single-target manipulation was enough to improve the depression-like behavior of PMDD model mice. Transgenic mice with
GABRD
knockout were established
and their behaviors were tested
revealing changes in their exploratory behaviors
indicating that the GABRD may be closely related to anxiety disorders. Shuyu capsule plays an anti-PMDD role by activating GABAergic neurons and downregulating the expression of GABRD in the dPAG. This provides a theoretical basis for the clinical treatment of PMDD with traditional Chinese medicine and promotes the development of drugs for treating PMDD.
关键词
Keywords
references
Behbehani MM , 1995 . Functional characteristics of the midbrain periaqueductal gray . Prog Neurobiol , 46 ( 6 ): 575 - 605 . https://doi.org/10.1016/0301-0082(95)00009-k https://doi.org/10.1016/0301-0082(95)00009-k
Berlyne DE , 1966 . Curiosity and exploration: animals spend much of their time seeking stimuli whose significance raises problems for psychology . Science , 153 ( 3731 ): 25 - 33 . https://doi.org/10.1126/science.153.3731.25 https://doi.org/10.1126/science.153.3731.25
Brack KE , Lovick TA , 2007 . Neuronal excitability in the periaqueductal grey matter during the estrous cycle in female Wistar rats . Neuroscience , 144 ( 1 ): 325 - 335 . https://doi.org/10.1016/j.neuroscience.2006.08.058 https://doi.org/10.1016/j.neuroscience.2006.08.058
Campion KN , Saville KA , Morgan MM , 2016 . Relative contribution of the dorsal raphe nucleus and ventrolateral periaqueductal gray to morphine antinociception and tolerance in the rat . Eur J Neurosci , 44 ( 9 ): 2667 - 2672 . https://doi.org/10.1111/ejn.13378 https://doi.org/10.1111/ejn.13378
Carver CM , Reddy DS , 2013 . Neurosteroid interactions with synaptic and extrasynaptic GABA A receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability . Psychopharmacology (Berl) , 230 ( 2 ): 151 - 188 . https://doi.org/10.1007/s00213-013-3276-5 https://doi.org/10.1007/s00213-013-3276-5
Chung G , Shim HG , Kim CY , et al. , 2020 . Persistent activity of metabotropic glutamate receptor 5 in the periaqueductal gray constrains emergence of chronic neuropathic pain . Curr Biol , 30 ( 23 ): 4631 - 4642.e6 . https://doi.org/10.1016/j.cub.2020.09.008 https://doi.org/10.1016/j.cub.2020.09.008
Devall AJ , Lovick TA , 2010 . Differential activation of the periaqueductal gray by mild anxiogenic stress at different stages of the estrous cycle in female rats . Neuropsychopharmacology , 35 ( 5 ): 1174 - 1185 . https://doi.org/10.1038/npp.2009.222 https://doi.org/10.1038/npp.2009.222
Devall AJ , Liu ZW , Lovick TA , 2009 . Hyperalgesia in the setting of anxiety: sex differences and effects of the oestrous cycle in Wistar rats . Psychoneuroendocrinology , 34 ( 4 ): 587 - 596 . https://doi.org/10.1016/j.psyneuen.2008.10.021 https://doi.org/10.1016/j.psyneuen.2008.10.021
Devall AJ , Santos JM , Fry JP , et al. , 2015 . Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats . Eur Neuropsychopharmacol , 25 ( 1 ): 113 - 123 . https://doi.org/10.1016/j.euroneuro.2014.11.017 https://doi.org/10.1016/j.euroneuro.2014.11.017
Erika EC , López-Rubalcava C , 2022 . Can animal models resemble a premenstrual dysphoric condition? Front Neuroendocrinol , 66 : 101007 . https://doi.org/10.1016/j.yfrne.2022.101007 https://doi.org/10.1016/j.yfrne.2022.101007
Farrant M , Nusser Z , 2005 . Variations on an inhibitory theme: phasic and tonic activation of GABA A receptors . Nat Rev Neurosci , 6 ( 3 ): 215 - 229 . https://doi.org/10.1038/nrn1625 https://doi.org/10.1038/nrn1625
First MB , 2013 . Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility . J Nerv Ment Dis , 201 ( 9 ): 727 - 729 . https://doi.org/10.1097/NMD.0b013e3182a2168a https://doi.org/10.1097/NMD.0b013e3182a2168a
Gao XX , Sun P , Qiao MQ , et al. , 2014 . Shu-Yu capsule, a traditional Chinese medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint . Mol Med Rep , 10 ( 6 ): 2942 - 2948 . https://doi.org/10.3892/mmr.2014.2599 https://doi.org/10.3892/mmr.2014.2599
Geng XW , Wang XY , Liu K , et al. , 2024 . ShuYu capsule alleviates emotional and physical symptoms of premenstrual dysphoric disorder: impact on ALLO decline and GABA A receptor δ subunit in the PAG area . Phytomedicine , 130 : 155549 . https://doi.org/10.1016/j.phymed.2024.155549 https://doi.org/10.1016/j.phymed.2024.155549
Girdler SS , Straneva PA , Light KC , et al. , 2001 . Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder . Biol Psychiatry , 49 ( 9 ): 788 - 797 . https://doi.org/10.1016/s0006-3223(00)01044-1 https://doi.org/10.1016/s0006-3223(00)01044-1
Goldstein JM , Jerram M , Poldrack R , et al. , 2005 . Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging . J Neurosci , 25 ( 40 ): 9309 - 9316 . https://doi.org/10.1523/JNEUROSCI.2239-05.2005 https://doi.org/10.1523/JNEUROSCI.2239-05.2005
Griffiths J , Lovick T , 2005 . Withdrawal from progesterone increases expression of α4 , β1, and δ GABA A receptor subunits in neurons in the periaqueductal gray matter in female Wistar rats . J Comp Neurol, 486 : 89 - 97 . https://doi.org/10.1002/cne.20540 https://doi.org/10.1002/cne.20540
Gulinello M , Gong QH , Smith SS , 2002 . Progesterone withdrawal increases the α4 subunit of the GABA A receptor in male rats in association with anxiety and altered pharmacology—a comparison with female rats . Neuropharmacology , 43 ( 4 ): 701 - 714 . https://doi.org/10.1016/s0028-3908(02)00171-5 https://doi.org/10.1016/s0028-3908(02)00171-5
Holt RA , Bateson AN , Martin IL , 1996 . Chronic treatment with diazepam or abecarnil differentially affects the expression of GABA A receptor subunit mRNAs in the rat cortex . Neuropharmacology , 35 ( 9-10 ): 1457 - 1463 . https://doi.org/10.1016/s0028-3908(96)00064-0 https://doi.org/10.1016/s0028-3908(96)00064-0
Hsiung A , Poh JH , Huettel SA , et al. , 2023 . Curiosity evolves as information unfolds . Proc Natl Acad Sci USA , 120 ( 43 ): e2301974120 . https://doi.org/10.1073/pnas.2301974120 https://doi.org/10.1073/pnas.2301974120
Hu ZF , Mu YM , Huang L , et al. , 2022 . A visual circuit related to the periaqueductal gray area for the antinociceptive effects of bright light treatment . Neuron , 110 ( 10 ): 1712 - 1727.e7 . https://doi.org/10.1016/j.neuron.2022.02.009 https://doi.org/10.1016/j.neuron.2022.02.009
Ismaili E , Walsh S , O'Brien PMS , et al. , 2016 . Fourth consensus of the international society for premenstrual disorders (ISPMD): auditable standards for diagnosis and management of premenstrual disorder . Arch Womens Ment Health , 19 ( 6 ): 953 - 958 . https://doi.org/10.1007/s00737-016-0631-7 https://doi.org/10.1007/s00737-016-0631-7
Jensen ML , Timmermann DB , Johansen TH , et al. , 2002 . The β subunit determines the ion selectivity of the GABA A receptor . J Biol Chem , 277 ( 44 ): 41438 - 41447 . https://doi.org/10.1074/jbc.M205645200 https://doi.org/10.1074/jbc.M205645200
Kadian S , O'Brien S , 2012 . Classification of premenstrual disorders as proposed by the international society for premenstrual disorders . Menopause Int , 18 ( 2 ): 43 - 47 . https://doi.org/10.1258/mi.2012.012017 https://doi.org/10.1258/mi.2012.012017
Klatzkin RR , Morrow AL , Light KC , et al. , 2006 . Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesterone . Psychoneuroendocrinology , 31 ( 10 ): 1208 - 1219 . https://doi.org/10.1016/j.psyneuen.2006.09.002 https://doi.org/10.1016/j.psyneuen.2006.09.002
Koh W , Lee CJ , 2024 . Diagnostic and therapeutic potential of tonic gamma-aminobutyric acid from reactive astrocytes in brain diseases . Clin Transl Med , 14 ( 4 ): e1642 . https://doi.org/10.1002/ctm2.1642 https://doi.org/10.1002/ctm2.1642
Koh W , Kwak H , Cheong E , et al. , 2023 . GABA tone regulation and its cognitive functions in the brain . Nat Rev Neurosci , 24 ( 9 ): 523 - 539 . https://doi.org/10.1038/s41583-023-00724-7 https://doi.org/10.1038/s41583-023-00724-7
Kyzar EJ , Pham M , Roth A , et al. , 2012 . Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes . Brain Res Bull , 89 ( 5-6 ): 168 - 176 . https://doi.org/10.1016/j.brainresbull.2012.08.004 https://doi.org/10.1016/j.brainresbull.2012.08.004
Levy DR , Hunter N , Lin S , et al. , 2023 . Mouse spontaneous behavior reflects individual variation rather than estrous state . Curr Biol , 33 ( 7 ): 1358 - 1364.e4 . https://doi.org/10.1016/j.cub.2023.02.035 https://doi.org/10.1016/j.cub.2023.02.035
Li F , Feng J , Gao D , et al. , 2016 . Shuyu capsules relieve premenstrual syndrome depression by reducing 5-HT 3A R and 5-HT 3B R expression in the rat brain . Neural Plast , 2016 : 7950781 . https://doi.org/10.1155/2016/7950781 https://doi.org/10.1155/2016/7950781
Lovick TA , Griffiths JL , Dunn SM , et al. , 2005 . Changes in GABA A receptor subunit expression in the midbrain during the oestrous cycle in Wistar rats . Neuroscience , 131 ( 2 ): 397 - 405 . https://doi.org/10.1016/j.neuroscience.2004.11.010 https://doi.org/10.1016/j.neuroscience.2004.11.010
Lowery-Gionta EG , Diberto J , Mazzone CM , et al. , 2018 . GABA neurons of the ventral periaqueductal gray area modulate behaviors associated with anxiety and conditioned fear . Brain Struct Funct , 223 ( 8 ): 3787 - 3799 . https://doi.org/10.1007/s00429-018-1724-z https://doi.org/10.1007/s00429-018-1724-z
Maguire J , Mody I , 2008 . GABA A R plasticity during pregnancy: relevance to postpartum depression . Neuron , 59 ( 2 ): 207 - 213 . https://doi.org/10.1016/j.neuron.2008.06.019 https://doi.org/10.1016/j.neuron.2008.06.019
Marván ML , Santana S , Chávez Chávez L , et al. , 1997 . Inescapable shocks accentuate fluctuations of forced swimming immobility in different phases of the rat estrous cycle . Arch Med Res , 28 ( 3 ): 369 - 372 .
Mody I , Pearce RA , 2004 . Diversity of inhibitory neurotransmission through GABA A receptors . Trends Neurosci , 27 ( 9 ): 569 - 575 . https://doi.org/10.1016/j.tins.2004.07.002 https://doi.org/10.1016/j.tins.2004.07.002
Möhler H , 2006 . GABA A receptor diversity and pharmacology . Cell Tissue Res , 326 ( 2 ): 505 - 516 . https://doi.org/10.1007/s00441-006-0284-3 https://doi.org/10.1007/s00441-006-0284-3
Noble RE , 2005 . Depression in women . Metabolism , 54 ( 5 ): 49 - 52 . https://doi.org/10.1016/j.metabol.2005.01.014 https://doi.org/10.1016/j.metabol.2005.01.014
Osborne L , Yenokyan G , Sanyal A , et al. , 2019 . 37. The role of allopregnanolone in perinatal mood and anxiety disorders . Biol Psychiatry , 85 ( 10 ): S15 - S16 . https://doi.org/10.1016/j.biopsych.2019.03.051 https://doi.org/10.1016/j.biopsych.2019.03.051
Pinna G , Uzunova V , Matsumoto K , et al. , 2000 . Brain allopregnanolone regulates the potency of the GABA A receptor agonist muscimol . Neuropharmacology , 39 ( 3 ): 440 - 448 . https://doi.org/10.1016/s0028-3908(99)00149-5 https://doi.org/10.1016/s0028-3908(99)00149-5
Puia G , Mienville JM , Matsumoto K , et al. , 2003 . On the putative physiological role of allopregnanolone on GABA A receptor function . Neuropharmacology , 44 ( 1 ): 49 - 55 . https://doi.org/10.1016/s0028-3908(02)00341-6 https://doi.org/10.1016/s0028-3908(02)00341-6
Reichling DB , Basbaum AI , 1990 . Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus . J Comp Neurol , 302 ( 2 ): 370 - 377 . https://doi.org/10.1002/cne.903020213 https://doi.org/10.1002/cne.903020213
Reid RL , Soares CN , 2018 . Premenstrual dysphoric disorder: contemporary diagnosis and management . J Obstet Gynaecol Can , 40 ( 2 ): 215 - 223 . https://doi.org/10.1016/j.jogc.2017.05.018 https://doi.org/10.1016/j.jogc.2017.05.018
Rodgers RJ , Dalvi A , 1997 . Anxiety, defence and the elevated plus-maze . Neurosci Biobehav Rev , 21 ( 6 ): 801 - 810 . https://doi.org/10.1016/S0149-7634(96)00058-9 https://doi.org/10.1016/S0149-7634(96)00058-9
Roughan JV , Wright-Williams SL , Flecknell PA , 2009 . Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice . Lab Anim , 43 ( 1 ): 17 - 26 . https://doi.org/10.1258/la.2008.007156 https://doi.org/10.1258/la.2008.007156
Rudolph S , Guo C , Pashkovski SL , et al. , 2020 . Cerebellum-specific deletion of the GABA A receptor δ subunit leads to sex-specific disruption of behavior . Cell Rep , 33 ( 5 ): 108338 . https://doi.org/10.1016/j.celrep.2020.108338 https://doi.org/10.1016/j.celrep.2020.108338
Schneider T , Popik P , 2007 . Increased depressive-like traits in an animal model of premenstrual irritability . Horm Behav , 51 ( 1 ): 142 - 148 . https://doi.org/10.1016/j.yhbeh.2006.09.006 https://doi.org/10.1016/j.yhbeh.2006.09.006
Sekhon S , Gupta V , 2024 . Mood disorder . In: Statpearls . StatPearls Publishing, Treasure Island (FL).
Smith AJ , Oxley B , Malpas S , et al. , 2004 . Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acid A receptors . J Pharmacol Exp Ther , 311 ( 2 ): 601 - 609 . https://doi.org/10.1124/jpet.104.070342 https://doi.org/10.1124/jpet.104.070342
Smith SS , Ruderman Y , Frye C , et al. , 2006 . Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder . Psychopharmacology (Berl) , 186 ( 3 ): 323 - 333 . https://doi.org/10.1007/s00213-005-0168-3 https://doi.org/10.1007/s00213-005-0168-3
Spindelegger CJ , Papageorgiou K , Grohmann R , et al. , 2015 . Cardiovascular adverse reactions during antidepressant treatment: a drug surveillance report of German-speaking countries between 1993 and 2010 . Int J Neuropsychopharmacol , 18 ( 4 ): pyu080 . https://doi.org/10.1093/ijnp/pyu080 https://doi.org/10.1093/ijnp/pyu080
Sundström-Poromaa I , Comasco E , Sumner R , et al. , 2020 . Progesterone ‒ friend or foe? Front Neuroendocrinol , 59 : 100856 . https://doi.org/10.1016/j.yfrne.2020.100856 https://doi.org/10.1016/j.yfrne.2020.100856
Walz N , Mühlberger A , Pauli P , 2016 . A human open field test reveals thigmotaxis related to agoraphobic fear . Biol Psychiatry , 80 ( 5 ): 390 - 397 . https://doi.org/10.1016/j.biopsych.2015.12.016 https://doi.org/10.1016/j.biopsych.2015.12.016
Wang XL , Gao J , Wang XY , et al. , 2018 . Treatment with Shuyu capsule increases 5-HT1AR level and activation of cAMP-PKA-CREB pathway in hippocampal neurons treated with serum from a rat model of depression . Mol Med Rep , 17 ( 3 ): 3575 - 3582 . https://doi.org/10.3892/mmr.2017.8339 https://doi.org/10.3892/mmr.2017.8339
Wei S , Geng XW , Li ZF , et al. , 2020 . A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention . Aging (Albany NY) , 12 ( 23 ): 24357 - 24370 . https://doi.org/10.18632/aging.202249 https://doi.org/10.18632/aging.202249
Yankelevitch-Yahav R , Franko M , Huly A , et al. , 2015 . The forced swim test as a model of depressive-like behavior . J Vis Exp , ( 97 ): 52587 . https://doi.org/10.3791/52587 https://doi.org/10.3791/52587
Zhang H , Qiao MQ , Gao DM , et al. , 2023 . Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus . Asian J Psychiatr , 90 : 103800 . https://doi.org/10.1016/j.ajp.2023.103800 https://doi.org/10.1016/j.ajp.2023.103800
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