Roles of Wnt ligands and receptors in oral squamous cell carcinoma

Muhammad TUFAIL; Caiyun HE; Canhua JIANG; Ning LI

doi:10.1631/jzus.B2400251

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Review | Updated：2026-02-06

Roles of Wnt ligands and receptors in oral squamous cell carcinoma
Roles of Wnt ligands and receptors in oral squamous cell carcinoma
Wnt配体和受体在口腔鳞状细胞癌中的作用
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 2, Pages: 105-128(2026)
Affiliations：

1.Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China
2.Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China
3.Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha 410008, China
4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
Funds：
DOI：10.1631/jzus.B2400251
CLC：
CSTR：
Received：20 May 2024，

Revised：2024-10-07，

Online First：21 November 2025，

Published：06 February 2026
Accepted：

穆罕默德·图法尔 ,何彩云,蒋灿华等.Wnt配体和受体在口腔鳞状细胞癌中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):105-128.

Muhammad TUFAIL, Caiyun HE, Canhua JIANG, et al. Roles of Wnt ligands and receptors in oral squamous cell carcinoma[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 105-128.
穆罕默德·图法尔 ,何彩云,蒋灿华等.Wnt配体和受体在口腔鳞状细胞癌中的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(02):105-128. DOI： 10.1631/jzus.B2400251.

Muhammad TUFAIL, Caiyun HE, Canhua JIANG, et al. Roles of Wnt ligands and receptors in oral squamous cell carcinoma[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(2): 105-128. DOI： 10.1631/jzus.B2400251.

摘要

口腔鳞状细胞癌（OSCC）具有较高发病率和死亡率，在临床诊断和治疗中面临重大挑战。最新研究证实Wnt配体及其受体在OSCC发病中具有关键作用。Wnt信号通路失调可通过促进细胞增殖和上皮-间质转化（EMT），以及维持癌症干细胞（CSC）干性，来驱动肿瘤的发生与发展，并导致其产生治疗抵抗。尽管靶向Wnt信号通路展现出潜在的治疗前景，但要实现有效干预，仍需对Wnt与其他信号通路的复杂相互作用展开进一步研究。本文对Wnt配体和受体在OSCC中作用的最新研究进行综述，强调其作为诊断生物标志物和治疗靶点的潜力。未来的研究方向包括阐明Wnt信号通路在特定背景下的动态变化，并探索联合疗法以提高OSCC患者的临床治疗效果。

Abstract

Oral squamous cell carcinoma (OSCC) poses significant challenges in terms of diagnosis and treatment

with high rates of morbidity and mortality. Emerging evidence highlights the critical involvement of Wingless/Int-1 (Wnt) ligands and receptors in OSCC pathogenesis. Dysregulated Wnt signaling pathways contribute to tumor initiation

progression

and therapy resistance by promoting cellular proliferation

epithelial‒mesenchymal transition (EMT)

and the maintenance of cancer stem cells (CSCs). Targeting Wnt signaling presents a promising therapeutic avenue

yet its complex interplay with other signaling pathways requires a deeper understanding to implement effective intervention. This study sheds light on the current knowledge of the roles of Wnt ligands and receptors in OSCC

emphasizing their potential as diagnostic biomarkers and therapeutic targets. Future research directions involve elucidating context-specific Wnt signaling dynamics and exploring combination therapies to improve clinical outcomes for OSCC patients.

关键词

Keywords

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Related Author

Yu LIU

Mengfei YU

Huiming WANG

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Tianyi GU

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Ziyu ZHU

Related Institution

The Second School of Clinical Medicine, Zhejiang Chinese Medical University

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University

Liangzhu Laboratory

Department of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine

Scientific Research Platform of Xinjiang Medical University Key Laboratory of Neurophysiology and Clinical Translation

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