Recent research advances in the biological function and molecular mechanism of methylmalonic acid

Zi’ang WANG; Wenhui CHENG; Teng WANG; Yidi ZHANG; Xin’e SHI; Yuqi LV; Jianjun JIN

doi:10.1631/jzus.B2400202

Your Location：

Home >

Browse articles >

Recent research advances in the biological function and molecular mechanism of methylmalonic acid

Scan QR Code

Alert me when the article has been cited

Submit

Review | Updated：2026-03-18

Recent research advances in the biological function and molecular mechanism of methylmalonic acid
Recent research advances in the biological function and molecular mechanism of methylmalonic acid
甲基丙二酸生物学功能和分子机制的研究进展
Journal of Zhejiang University-SCIENCE B Vol. 27, Issue 3, Pages: 225-235(2026)
Affiliations：

1.Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
2.College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
Funds：
DOI：10.1631/jzus.B2400202
CLC：
CSTR：
Received：22 April 2024，

Revised：2024-11-02，

Online First：21 November 2025，

Published：18 March 2026
Accepted：

王子昂,程文荟,王腾等.甲基丙二酸生物学功能和分子机制的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(03):225-235.

Zi’ang WANG, Wenhui CHENG, Teng WANG, et al. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(3): 225-235.
王子昂,程文荟,王腾等.甲基丙二酸生物学功能和分子机制的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2026,27(03):225-235. DOI： 10.1631/jzus.B2400202.

Zi’ang WANG, Wenhui CHENG, Teng WANG, et al. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University-SCIENCE B, 2026, 27(3): 225-235. DOI： 10.1631/jzus.B2400202.

摘要

甲基丙二酸（MMA）的异常积累是导致甲基丙二酸血症的主要原因，可对大脑、肾脏和心血管系统造成不可逆的损害。此外，已有研究发现血液中MMA的积累与癌症、身体运动受限和生长发育迟缓有关。本综述总结了近年来MMA代谢异常与疾病发生之间关系的研究，涉及脑、肾、心血管系统、癌症和骨骼肌等方面，为进一步研究和治疗与MMA相关的病理生理学变化提供理论依据和参考。

Abstract

The abnormal accumulation of methylmalonic acid (MMA)

the leading cause of methylmalonic acidemia

can cause irreversible damage to the brain

kidney

and cardiovascular system. In addition

the accumulation of MMA in the blood has recently been associated with the occurrence of cancer

restricted bodily movement

and growth retardation. In this review

recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized

concerning the brain

kidney

cardiovascular system

cancer

and skeletal muscles. It provides a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

关键词

Keywords

references

Andrade VM , dal Pont HS , Leffa DD , et al. , 2014 . Methylmalonic acid administration induces DNA damage in rat brain and kidney . Mol Cell Biochem , 391 : 137 - 145 . https://doi.org/10.1007/s11010-014-1996-4 https://doi.org/10.1007/s11010-014-1996-4

Arbab M , Matuszek Z , Kray KM , et al. , 2023 . Base editing rescue of spinal muscular atrophy in cells and in mice . Science , 380 ( 6642 ): eadg6518 . https://doi.org/10.1126/science.adg6518 https://doi.org/10.1126/science.adg6518

Atkuri KR , Cowan TM , Kwan T , et al. , 2009 . Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia . Proc Natl Acad Sci USA , 106 ( 10 ): 3941 - 3945 . https://doi.org/10.1073/pnas.0813409106 https://doi.org/10.1073/pnas.0813409106

Baumgartner MR , Hörster F , Dionisi-Vici C , et al. , 2014 . Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia . Orphanet J Rare Dis , 9 : 130 . https://doi.org/10.1186/s13023-014-0130-8 https://doi.org/10.1186/s13023-014-0130-8

Bednarska-Makaruk M , Graban A , Sobczyńska-Malefora A , et al. , 2016 . Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia . Exp Gerontol , 81 : 83 - 91 . https://doi.org/10.1016/j.exger.2016.05.002 https://doi.org/10.1016/j.exger.2016.05.002

Brismar J , Ozand PT , 1994 . CT and MR of the brain in disorders of the propionate and methylmalonate metabolism . AJNR Am J Neuroradiol , 15 ( 8 ): 1459 - 1473 .

Brusque AM , Rotta L , Pettenuzzo LF , et al. , 2001 . Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuraminic acid concentration in cerebrum of young rats . Braz J Med Biol Res , 34 ( 2 ): 227 - 231 . https://doi.org/10.1590/s0100-879x2001000200010 https://doi.org/10.1590/s0100-879x2001000200010

Chandler RJ , Sloan J , Fu H , et al. , 2007 . Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle . BMC Med Genet , 8 : 64 . https://doi.org/10.1186/1471-2350-8-64 https://doi.org/10.1186/1471-2350-8-64

Chen L , Liu S , Tao YG , 2020 . Regulating tumor suppressor genes: post-translational modifications . Sig Transduct Target Ther , 5 : 90 . https://doi.org/10.1038/s41392-020-0196-9 https://doi.org/10.1038/s41392-020-0196-9

Cheng AL , Yao R , Cao WJ , et al. , 2019 . The value of 1H-MRS and MRI in combined methylmalonic aciduria and homocystinuria . J Comput Assist Tomogr , 43 ( 4 ): 559 - 562 . https://doi.org/10.1097/rct.0000000000000854 https://doi.org/10.1097/rct.0000000000000854

Cudré-Cung HP , Zavadakova P , do Vale-Pereira S , et al. , 2016 . Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria . Mol Genet Metab , 119 ( 1-2 ): 57 - 67 . https://doi.org/10.1016/j.ymgme.2016.07.013 https://doi.org/10.1016/j.ymgme.2016.07.013

da Costa RT , Dos Santos MB , Silva ICS , et al. , 2021 . Methylmalonic acid compromises respiration and reduces the expression of differentiation markers of SH-SY5Y human neuroblastoma cells . ACS Chem Neurosci , 12 ( 14 ): 2608 - 2618 . https://doi.org/10.1021/acschemneuro.1c00119 https://doi.org/10.1021/acschemneuro.1c00119

de Keyzer Y , Valayannopoulos V , Benoist JF , et al. , 2009 . Multiple OXPHOS deficiency in the liver, kidney, heart, and skeletal muscle of patients with methylmalonic aciduria and propionic aciduria . Pediatr Res , 66 : 91 - 95 . https://doi.org/10.1203/PDR.0b013e3181a7c270 https://doi.org/10.1203/PDR.0b013e3181a7c270

Delgado JA , García MIP , Jiménez NM , et al. , 2023 . Functional vitamin B12 deficiency: improving methylmalonic acid reference intervals in urine . Clin Chim Acta , 544 : 117334 . https://doi.org/10.1016/j.cca.2023.117334 https://doi.org/10.1016/j.cca.2023.117334

Dhar I , Lysne V , Ulvik A , et al. , 2023 . Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: a prospective 2-cohort study . J Intern Med , 293 ( 4 ): 508 - 519 . https://doi.org/10.1111/joim.13610 https://doi.org/10.1111/joim.13610

Dilber B , Eyüboğlu İ , 2022 . Cranial magnetic resonance imaging findings in hypotonic infants with cobalamin deficiency and combined methylmalonic aciduria and homocystinuria . Klin Padiatr , 234 ( 2 ): 105 - 112 . https://doi.org/10.1055/a-1749-6008 https://doi.org/10.1055/a-1749-6008

el Hasbaoui B , Mebrouk N , Saghir S , et al. , 2021 . Vitamin B12 deficiency: case report and review of literature . Pan Afr Med J , 38 : 237 . https://doi.org/10.11604/pamj.2021.38.237.20967 https://doi.org/10.11604/pamj.2021.38.237.20967

Figtree GA , Adamson PD , Antoniades C , et al. , 2022 . Noninvasive plaque imaging to accelerate coronary artery disease drug development . Circulation , 146 ( 22 ): 1712 - 1727 . https://doi.org/10.1161/CIRCULATIONAHA.122.060308 https://doi.org/10.1161/CIRCULATIONAHA.122.060308

Filomeni G , de Zio D , Cecconi F , 2015 . Oxidative stress and autophagy: the clash between damage and metabolic needs . Cell Death Differ , 22 : 377 - 388 . https://doi.org/10.1038/cdd.2014.150 https://doi.org/10.1038/cdd.2014.150

Forny P , Schumann A , Mustedanagic M , et al. , 2016 . Novel mouse models of methylmalonic aciduria recapitulate phenotypic traits with a genetic dosage effect . J Biol Chem , 291 ( 39 ): 20563 - 20573 . https://doi.org/10.1074/jbc.M116.747717 https://doi.org/10.1074/jbc.M116.747717

Gomes AP , Ilter D , Low V , et al. , 2020 . Age-induced accumulation of methylmalonic acid promotes tumour progression . Nature , 585 : 283 - 287 . https://doi.org/10.1038/s41586-020-2630-0 https://doi.org/10.1038/s41586-020-2630-0

Gomes AP , Ilter D , Low V , et al. , 2022 . Altered propionate metabolism contributes to tumour progression and aggressiveness . Nat Metab , 4 : 435 - 443 . https://doi.org/10.1038/s42255-022-00553-5 https://doi.org/10.1038/s42255-022-00553-5

Guo JC , Liu XX , Wang Z , et al. , 2023 . Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study . Nutr J , 22 : 63 . https://doi.org/10.1186/s12937-023-00900-6 https://doi.org/10.1186/s12937-023-00900-6

Guo JC , Wang SJ , Wan X , et al. , 2024 . Mitochondria-derived methylmalonic acid aggravates ischemia‒reperfusion injury by activating reactive oxygen species-dependent ferroptosis . Cell Commun Signal , 22 : 53 . https://doi.org/10.1186/s12964-024-01479-z https://doi.org/10.1186/s12964-024-01479-z

Halperin ML , Schiller CM , Fritz IB , 1971 . The inhibition by methylmalonic acid of malate transport by the dicarboxylate carrier in rat liver mitochondria: a possible explantation for hypoglycemia in methylmalonic aciduria . J Clin Invest , 50 ( 11 ): 2276 - 2282 . https://doi.org/10.1172/jci106725 https://doi.org/10.1172/jci106725

Hannibal L , DiBello PM , Yu M , et al. , 2011 . The MMACHC proteome: hallmarks of functional cobalamin deficiency in humans . Mol Genet Metab , 103 ( 3 ): 226 - 239 . https://doi.org/10.1016/j.ymgme.2011.03.008 https://doi.org/10.1016/j.ymgme.2011.03.008

He RX , Dong H , Zhang HW , et al. , 2021 . Clinical and genetic studies on 76 patients with hydrocephalus caused by methylmalonic acidemia combined with homocysteinuria . Chin J Pediatr , 59 ( 6 ): 459 - 465 (in Chinese) . https://doi.org/10.3760/cma.j.cn112140-20210311-00204 https://doi.org/10.3760/cma.j.cn112140-20210311-00204

Hu CH , Ye MJ , Bai JN , et al. , 2023 . Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial‒mesenchymal transition . Cancer Cell Int , 23 : 131 . https://doi.org/10.1186/s12935-023-02973-z https://doi.org/10.1186/s12935-023-02973-z

Indo HP , Davidson M , Yen HC , et al. , 2007 . Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage . Mitochondrion , 7 ( 1-2 ): 106 - 118 . https://doi.org/10.1016/j.mito.2006.11.026 https://doi.org/10.1016/j.mito.2006.11.026

Kölker S , Ahlmeyer B , Krieglstein J , et al. , 2000 . Methylmalonic acid induces excitotoxic neuronal damage in vitro . J Inherit Metab Dis , 23 ( 4 ): 355 - 358 . https://doi.org/10.1023/a:1005631230455 https://doi.org/10.1023/a:1005631230455

Kölker S , Sauer SW , Surtees RAH , et al. , 2006 . The aetiology of neurological complications of organic acidaemias—a role for the blood‒brain barrier . J Inherit Metab Dis , 29 ( 6 ): 701 - 704 . https://doi.org/10.1007/s10545-006-0415-8 https://doi.org/10.1007/s10545-006-0415-8

Lash LH , 2006 . Mitochondrial glutathione transport: physiological, pathological and toxicological implications . Chem Biol Interact , 163 ( 1-2 ): 54 - 67 . https://doi.org/10.1016/j.cbi.2006.03.001 https://doi.org/10.1016/j.cbi.2006.03.001

Li ZC , Low V , Luga V , et al. , 2022 . Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression . Nat Commun , 13 : 6239 . https://doi.org/10.1038/s41467-022-33862-0 https://doi.org/10.1038/s41467-022-33862-0

Liu Y , Huang ZM , Qiu HB , et al. , 2024 . The association between serum methylmalonic acid, cobalamin-related biomarkers, and long-term mortality risk in cancer survivors: a prospective cohort study . Am J Clin Nutr , 119 ( 5 ): 1122 - 1132 . https://doi.org/10.1016/j.ajcnut.2024.02.009 https://doi.org/10.1016/j.ajcnut.2024.02.009

Martinelli D , Deodato F , Dionisi-Vici C , 2011 . Cobalamin C defect: natural history, pathophysiology, and treatment . J Inherit Metab Dis , 34 ( 1 ): 127 - 135 . https://doi.org/10.1007/s10545-010-9161-z https://doi.org/10.1007/s10545-010-9161-z

McAuley GE , Yiu G , Chang PC , et al. , 2023 . Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing . Cell , 186 ( 7 ): 1398 - 1416.e23 . https://doi.org/10.1016/j.cell.2023.02.027 https://doi.org/10.1016/j.cell.2023.02.027

Morath MA , Okun JG , Müller IB , et al. , 2008 . Neurodegeneration and chronic renal failure in methylmalonic aciduria—a pathophysiological approach . J Inherit Metab Dis , 31 ( 1 ): 35 - 43 . https://doi.org/10.1007/s10545-007-0571-5 https://doi.org/10.1007/s10545-007-0571-5

Nielsen S , Parkner T , Arendt JFH , 2022 . Vitamin B12 deficiency: correction of P-methylmalonic acid for estimated glomerular filtration rate to improve diagnostic value ‒ a confirmatory study . Scand J Clin Lab Invest , 82 ( 4 ): 323 - 328 . https://doi.org/10.1080/00365513.2022.2092898 https://doi.org/10.1080/00365513.2022.2092898

Okun JG , Hörster F , Farkas LM , et al. , 2002 . Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity . J Biol Chem , 277 ( 17 ): 14674 - 14680 . https://doi.org/10.1074/jbc.M200997200 https://doi.org/10.1074/jbc.M200997200

Østergaard E , Wibrand F , Ørngreen MC , et al. , 2005 . Impaired energy metabolism and abnormal muscle histology in mut - methylmalonic aciduria . Neurology , 65 ( 6 ): 931 - 933 . https://doi.org/10.1212/01.wnl.0000176065.80560.26 https://doi.org/10.1212/01.wnl.0000176065.80560.26

Pannérec A , Migliavacca E , de Castro A , et al. , 2018 . Vitamin B12 deficiency and impaired expression of amnionless during aging . J Cachexia Sarcopenia Muscle , 9 : 41 - 52 . https://doi.org/10.1002/jcsm.12260 https://doi.org/10.1002/jcsm.12260

Pascoe MC , Linden T , 2016 . Folate and MMA predict cognitive impairment in elderly stroke survivors: a cross sectional study . Psychiat Res , 243 : 49 - 52 . https://doi.org/10.1016/j.psychres.2016.06.008 https://doi.org/10.1016/j.psychres.2016.06.008

Polytarchou K , Dimitroglou Y , Varvarousis D , et al. , 2020 . Methylmalonic acid and vitamin B12 in patients with heart failure . Hell J Cardiol , 61 ( 5 ): 330 - 337 . https://doi.org/10.1016/j.hjc.2019.10.010 https://doi.org/10.1016/j.hjc.2019.10.010

Proctor EC , Turton N , Boan EJ , et al. , 2020 . The effect of methylmalonic acid treatment on human neuronal cell coenzyme Q 10 status and mitochondrial function . Int J Mol Sci , 21 ( 23 ): 9137 . https://doi.org/10.3390/ijms21239137 https://doi.org/10.3390/ijms21239137

Refsum H , Smith AD , 2003 . Low vitamin B-12 status in confirmed Alzheimer’s disease as revealed by serum holotranscobalamin . J Neurol Neurosurg Psychiatry , 74 ( 7 ): 959 - 961 . https://doi.org/10.1136/jnnp.74.7.959 https://doi.org/10.1136/jnnp.74.7.959

Ribes A , Vilaseca MA , Briones P , et al. , 1984 . Methylmalonic aciduria with homocystinuria . In: Addison GM, Chalmers RA, Divry P, et al. (Eds.), Organic Acidurias . Springer, Dordrecht , p. 129 - 130 . https://doi.org/10.1007/978-94-009-5612-4_39 https://doi.org/10.1007/978-94-009-5612-4_39

Rosenberg LE , Lilljeqvist AC , Hsia YE , 1968 . Methylmalonic aciduria—an inborn error leading to metabolic acidosis, long-chain ketonuria and intermittent hyperglycinemia . N Engl J Med , 278 ( 24 ): 1319 - 1322 . https://doi.org/10.1056/nejm196806132782404 https://doi.org/10.1056/nejm196806132782404

Rossi A , Cerone R , Biancheri R , et al. , 2001 . Early-onset combined methylmalonic aciduria and homocystinuria: neuroradiologic findings . AJNR Am J Neuroradiol , 22 ( 3 ): 554 - 563 .

Santamaría G , Naude N , Bennett I , et al. , 2023 . In vivo assignment of methylmalonic acid in breast tissue using 2D MRS and relationship with breast density, menopausal status and cancer risk . NMR Biomed , 36 ( 3 ): e4851 . https://doi.org/10.1002/nbm.4851 https://doi.org/10.1002/nbm.4851

Serot JM , Barbé F , Arning E , et al. , 2005 . Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer’s disease . J Neurol Neurosurg Psychiatry , 76 ( 11 ): 1585 - 1587 . https://doi.org/10.1136/jnnp.2004.056119 https://doi.org/10.1136/jnnp.2004.056119

Shu F , Xiao H , Li QN , et al. , 2023 . Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets . Signal Transduct Target Ther , 8 : 32 . https://doi.org/10.1038/s41392-022-01300-8 https://doi.org/10.1038/s41392-022-01300-8

Singh NP , McCoy MT , Tice RR , et al. , 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp Cell Res , 175 : 184 - 191 . https://doi.org/10.1016/0014-4827(88)90265-0 https://doi.org/10.1016/0014-4827(88)90265-0

Smith AD , Refsum H , 2009 . Vitamin B-12 and cognition in the elderly . Am J Clin Nutr , 89 ( 2 ): 707S - 711S . https://doi.org/10.3945/ajcn.2008.26947D https://doi.org/10.3945/ajcn.2008.26947D

Souza DG , Almeida RF , Souza DO , et al. , 2019 . The astrocyte biochemistry . Semin Cell Dev Biol , 95 : 142 - 150 . https://doi.org/10.1016/j.semcdb.2019.04.002 https://doi.org/10.1016/j.semcdb.2019.04.002

Stein J , Geisel J , Obeid R , 2021 . Association between neuropathy and B-vitamins: a systematic review and meta-analysis . Eur J Neurol , 28 ( 6 ): 2054 - 2064 . https://doi.org/10.1111/ene.14786 https://doi.org/10.1111/ene.14786

Stepien KM , Heaton R , Rankin S , et al. , 2017 . Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders . J Clin Med , 6 ( 7 ): 71 . https://doi.org/10.3390/jcm6070071 https://doi.org/10.3390/jcm6070071

Takahashi-Iñiguez T , García-Hernandez E , Arreguín-Espinosa R , et al. , 2012 . Role of vitamin B 12 on methylmalonyl-CoA mutase activity . J Zhejiang Univ-Sci B (Biomed & Biotechnol) , 13 ( 6 ): 423 - 437 . https://doi.org/10.1631/jzus.B1100329 https://doi.org/10.1631/jzus.B1100329

Tang F , Qiu HB , Liu Y , et al. , 2024 . Decreased cobalamin sensitivity and biological aging acceleration in the general population . J Nutr Health Aging , 28 ( 7 ): 100262 . https://doi.org/10.1016/j.jnha.2024.100262 https://doi.org/10.1016/j.jnha.2024.100262

Tejero J , Lazure F , Gomes AP , 2024 . Methylmalonic acid in aging and disease . Trends Endocrinol Metab , 35 ( 3 ): 188 - 200 . https://doi.org/10.1016/j.tem.2023.11.001 https://doi.org/10.1016/j.tem.2023.11.001

Vermorken AJM , Zhu JJ , Holvoet P , et al. , 2021 . The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure . Redox Biol , 44 : 102011 . https://doi.org/10.1016/j.redox.2021.102011 https://doi.org/10.1016/j.redox.2021.102011

Viegas CM , Zanatta Â , Grings M , et al. , 2014 . Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats . Free Radic Res , 48 ( 6 ): 659 - 669 . https://doi.org/10.3109/10715762.2014.898842 https://doi.org/10.3109/10715762.2014.898842

Wajner M , Coelho JC , 1997 . Neurological dysfunction in methylmalonic acidaemia is probably related to the inhibitory effect of methylmalonate on brain energy production . J Inherit Metab Dis , 20 ( 6 ): 761 - 768 . https://doi.org/10.1023/a:1005359416197 https://doi.org/10.1023/a:1005359416197

Wang J , Tang YL , Liu Y , et al. , 2022 . Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes . Front Nutr , 9 : 974938 . https://doi.org/10.3389/fnut.2022.974938 https://doi.org/10.3389/fnut.2022.974938

Wang SJ , Liu YG , Liu JX , et al. , 2020 . Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population . Redox Biol , 37 : 101741 . https://doi.org/10.1016/j.redox.2020.101741 https://doi.org/10.1016/j.redox.2020.101741

Wang XY , Li WD , Xiang MX , 2022 . Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases . Front Cardiovasc Med , 9 : 966543 . https://doi.org/10.3389/fcvm.2022.966543 https://doi.org/10.3389/fcvm.2022.966543

Wang YX , Christopher BA , Wilson KA , et al. , 2018 . Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l -carnitine . Am J Physiol Endocrinol Metab , 315 ( 4 ): E622 - E633 . https://doi.org/10.1152/ajpendo.00081.2018 https://doi.org/10.1152/ajpendo.00081.2018

Wu Q , Hatse S , Kenis C , et al. , 2024 . Serum methylmalonic acid concentrations at breast cancer diagnosis significantly correlate with clinical frailty . Geroscience , 46 ( 2 ): 1489 - 1498 . https://doi.org/10.1007/s11357-023-00908-0 https://doi.org/10.1007/s11357-023-00908-0

Yang LF , Guo B , Li X , et al. , 2020 . Brain MRI features of methylmalonic acidemia in children: the relationship between neuropsychological scores and MRI findings . Sci Rep , 10 : 13099 . https://doi.org/10.1038/s41598-020-70113-y https://doi.org/10.1038/s41598-020-70113-y

Yuan YJ , Ma Y , Wu Q , et al. , 2024 . Clinical and electroencephalogram characteristics of methylmalonic acidemia with MMACHC and MUT gene mutations . BMC Pediatr , 24 : 119 . https://doi.org/10.1186/s12887-024-04559-8 https://doi.org/10.1186/s12887-024-04559-8

Zhu X , Tang Y , Cheang I , et al. , 2023 . Nonlinear associations of serum cobalamin with risk of all-cause and cardiovascular mortality in hypertensive adults . Hypertens Res , 46 ( 5 ): 1276 - 1286 . https://doi.org/10.1038/s41440-023-01218-w https://doi.org/10.1038/s41440-023-01218-w

Zsengellér ZK , Aljinovic N , Teot LA , et al. , 2014 . Methylmalonic acidemia: a megamitochondrial disorder affecting the kidney . Pediatr Nephrol , 29 ( 11 ): 2139 - 2146 . https://doi.org/10.1007/s00467-014-2847-y https://doi.org/10.1007/s00467-014-2847-y

Views

Downloads

CSCD

Tools

Publicity Resources

NRF2 nuclear translocation and interaction with DUSP1 regulate the osteogenic differentiation of murine mandibular osteoblasts stimulated with Porphyromonas gingivalis lipopolysaccharide

Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis

Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

Ceria nanoparticles: biomedical applications and toxicity

Related Author

Xufei YU

Jiaqi BAO

Yingming WEI

Yuting YANG

Wenlin YUAN

Lili CHEN

Zhongxiu WANG

Yiyan YANG

Related Institution

Cancer Institute, The Second Affiliated Hospital, School of Medicine, Zhejiang University

Department of Periodontology, The Second Affiliated Hospital, School of Medicine, Zhejiang University

School of Food Science and Biotechnology, Zhejiang Gongshang University

Department of Oncology, Shanghai Medical College, Fudan University

Department of Critical Care Medicine, Fudan University Shanghai Cancer Center

Address：Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou, China Postal code：310027
Tel：+86-571-87952783 Email：cjzhang@zju.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰