Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases

Xiaodan HUANG; Yue FANG; Jie SONG; Yuanjing HAO; Yuanyuan CAI; Pengfei WEI; Na ZHANG

doi:10.1631/jzus.B2400186

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Review | Updated：2025-09-22

Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases
Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases
通过纳米方法恢复溶酶体/自噬缺陷：对溶酶体/自噬缺陷相关疾病的意义
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 9, Pages: 813-842(2025)
Affiliations：

1.School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China
2.Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou Red Cross Hospital, Hangzhou 310003, China
Funds：
DOI：10.1631/jzus.B2400186
CLC：
CSTR：
Received：12 April 2024，

Revised：2024-06-04，

Published Online：19 August 2025，

Published：20 September 2025
Accepted：

黄晓丹,方悦,宋杰等.通过纳米方法恢复溶酶体/自噬缺陷：对溶酶体/自噬缺陷相关疾病的意义[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(09):813-842.

Xiaodan HUANG, Yue FANG, Jie SONG, et al. Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(9): 813-842.
黄晓丹,方悦,宋杰等.通过纳米方法恢复溶酶体/自噬缺陷：对溶酶体/自噬缺陷相关疾病的意义[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(09):813-842. DOI： 10.1631/jzus.B2400186.

Xiaodan HUANG, Yue FANG, Jie SONG, et al. Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(9): 813-842. DOI： 10.1631/jzus.B2400186.

摘要

溶酶体和自噬-溶酶体系统的功能障碍是神经退行性、代谢紊乱性、炎症性疾病和其他相关疾病的驱动力，影响疾病的发生和发展。因此，恢复溶酶体或自噬-溶酶体系统功能在上述疾病治疗中已成为日益重要的策略。本文对溶酶体的生物发生、结构和功能，以及自噬-溶酶体系统的生物学过程展开介绍；综述了与溶酶体/自噬功能障碍密切相关的各种疾病，揭示调节溶酶体或自噬-溶酶体系统功能在疾病治疗中的重要性；重点探讨了能够恢复溶酶体或自噬-溶酶体系统功能的工程化纳米材料，并对实现这一目标的不同策略和方法进行总结。本文旨在阐明纳米医学领域治疗溶酶体/自噬缺陷相关疾病的最新进展，并推动具有临床价值的创新纳米药物的开发。

Abstract

The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases

metabolic disorders

inflammatory conditions

and other related diseases

closely influencing their onset and progression. Therefore

restoring the function of the lysosome or autophagy-lysosome system has become an increasingly crucial therapeutic strategy in disease management. In this review

we will introduce the lysosomal biogenesis

structure

and function

as well as the biological process of the autophagy-lysosome system. Various diseases closely associated with lysosomal/autophagic dysfunction are also reviewed

emphasizing the significance of targeting the function of the lysosome or autophagy-lysosome system in disease treatment. Finally

we focus on engineered nanomaterials that have the capabilities to restore the function of the lysosome or autophagy-lysosome system

and summarize different strategies and methods for achieving this goal. This review aims to elucidate the latest progress in the field of nanomedicine for lysosomal/autophagic defect-related diseases and inspire the development of innovative and clinically valuable nanomedicines.

关键词

Keywords

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