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1.Department of Infectious Diseases, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou 310006, China
2.Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Received:26 February 2024,
Revised:2024-06-05,
Published Online:28 August 2025,
Published:20 October 2025
周琦惠,岑盼盼,陈智等.Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2025,26(10):972-994.
Qihui ZHOU, Panpan CEN, Zhi CHEN, et al. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of zhejiang university-science b, 2025, 26(10): 972-994.
周琦惠,岑盼盼,陈智等.Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2025,26(10):972-994. DOI: 10.1631/jzus.B2400053.
Qihui ZHOU, Panpan CEN, Zhi CHEN, et al. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of zhejiang university-science b, 2025, 26(10): 972-994. DOI: 10.1631/jzus.B2400053.
核因子E2相关因子2(Nrf2)是一种细胞内转录因子,在病理条件下有助于保护不同类型细胞免受氧化应激。线粒体参与机体内多种代谢过程,包括氧化还原反应、脂质代谢和细胞死亡等。线粒体自噬是自噬的一种特殊形式,专门负责清除受损的线粒体,在肝脏疾病病理生理机制中起着重要作用。本综述详细阐述了Nrf2信号通路和线粒体自噬在各种肝脏疾病(非酒精性脂肪性肝病、病毒性肝炎、酒精性肝病、药物性肝损伤、自身免疫性肝炎、肝缺血再灌注损伤和肝癌)中的作用及其相互关系,同时提供了一些临床应用相关的潜在见解和治疗方法。
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles that function in diverse metabolic processes in the body
including redox reactions
lipid metabolism
and cell death. Mitophagy
a specific form of autophagy for damaged mitochondria
plays a critical role in the pathophysiology of liver diseases. In this review
we explain in detail the roles of the Nrf2 signaling pathway and mitophagy
and the relationship between them
in various hepatic diseases (nonalcoholic fatty liver disease
viral hepatitis
alcoholic liver disease
drug-induced liver injury
autoimmune hepatitis
hepatic ischemia‒reperfusion injury
and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.
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