Epigenetic factors associated with peri-implantitis: a review

Qianhui LI; Hongye LU; Mengyuan ZHANG; Yuting YE; Qianming CHEN; Ping SUN

doi:10.1631/jzus.B2400032

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Review | Updated：2025-07-25

Epigenetic factors associated with peri-implantitis: a review
Epigenetic factors associated with peri-implantitis: a review
与种植体周炎相关的表观遗传因素：综述
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 7, Pages: 657-674(2025)
Affiliations：

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China
Funds：
DOI：10.1631/jzus.B2400032
CLC：
CSTR：
Received：24 January 2024，

Revised：09 July 2024，

Published Online：04 July 2025，

Published：15 July 2025
Accepted：

李千慧,卢洪叶,章梦媛等.与种植体周炎相关的表观遗传因素：综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):657-674.

Qianhui LI, Hongye LU, Mengyuan ZHANG, et al. Epigenetic factors associated with peri-implantitis: a review[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 657-674.
李千慧,卢洪叶,章梦媛等.与种植体周炎相关的表观遗传因素：综述[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(07):657-674. DOI： 10.1631/jzus.B2400032.

Qianhui LI, Hongye LU, Mengyuan ZHANG, et al. Epigenetic factors associated with peri-implantitis: a review[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(7): 657-674. DOI： 10.1631/jzus.B2400032.

摘要

种植体周病是一类以硬组织吸收和软组织炎症为特征的病症。表观遗传学是指不在DNA序列中编码的基因表达的改变，影响免疫反应、炎症和骨代谢在内的多种生理活动。表观遗传修饰导致个体间组织特异性基因表达的差异，可能引发或加剧炎症和疾病易感性，然而其对种植体周炎的影响尚无定论。为了填补这一空白，我们在PubMed、Web of Science、Scopus和Google Scholar上使用“epigenetics”“peri-implantitis”“DNA methylation”和“microRNA”等关键词进行文献搜索，探讨表观遗传机制与种植体周炎之间的关系，并特别关注DNA甲基化和microRNAs（miRNAs或miRs）。DNA甲基化和miRNAs在种植体周围形成了一种动态的表观遗传机制。与炎症和成骨相关的基因表观遗传修饰为理解局部和环境因素如何影响种植体周炎的发病机制提供了新的视角。此外，我们评估了DNA甲基化和miRNAs在种植体周炎预防、诊断和治疗中的潜在应用，旨在为未来探索潜在治疗靶点并开发更有效的管理策略提供基础。这些发现对于理解其他口腔炎症性疾病（如牙周炎）的发病机制也具有更广泛的意义。

Abstract

Peri-implant diseases are characterized by the resorption of hard tissue and the inflammation of soft tissue. Epigenetics refers to alterations in the expression of genes that are not encoded in the DNA sequence

influencing diverse physiological activities

including immune response

inflammation

and bone metabolism. Epigenetic modifications can lead to tissue-specific gene expression variations among individuals and may initiate or exacerbate inflammation and disease predisposition. However

the impact of these factors on peri-implantitis remains inconclusive. To address this gap

we conducted a comprehensive review to investigate the associations between epigenetic mechanisms and peri-implantitis

specifically focusing on DNA methylation and microRNAs (miRNAs or miRs). We searched for relevant literature on PubMed

Web of Science

Scopus

and Google Scholar with keywords including “epigenetics

” “peri-implantitis

” “DNA methylation

” and “microRNA.” DNA methylation and miRNAs present a dynamic epigenetic mechanism operating around implants. Epigenetic modifications of genes related to inflammation and osteogenesis provide a new perspective for understanding how local and environmental factors influence the pathogenesis of peri-implantitis. In addition

we assessed the potential application of DNA methylation and miRNAs in the prevention

diagnosis

and treatment of peri-implantitis

aiming to provide a foundation for future studies to explore potential therapeutic targets and develop more effective management strategies for this condition. These findings also have broader implications for understanding the pathogenesis of other inflammation-related oral diseases like periodontitis.

关键词

Keywords

references

Alves CH , Russi KL , Rocha NC , et al. , 2022 . Host-microbiome interactions regarding peri-implantitis and dental implant loss . J Transl Med , 20 : 425 . https://doi.org/10.1186/s12967-022-03636-9 https://doi.org/10.1186/s12967-022-03636-9

Amirhosseini M , Madsen RV , Escott KJ , et al. , 2018 . GSK-3β inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation . J Cell Physiol , 233 ( 3 ): 2398 - 2408 . https://doi.org/10.1002/jcp.26111 https://doi.org/10.1002/jcp.26111

Astolfi V , Ríos-Carrasco B , Gil-Mur FJ , et al. , 2022 . Incidence of peri-implantitis and relationship with different conditions: a retrospective study . Int J Environ Res Public Health , 19 ( 7 ): 4147 . https://doi.org/10.3390/ijerph19074147 https://doi.org/10.3390/ijerph19074147

Berglundh T , Armitage G , Araujo MG , et al. , 2018 . Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions . J Clin Periodontol , 45 ( S20 ): S286 - S291 . https://doi.org/10.1111/jcpe.12957 https://doi.org/10.1111/jcpe.12957

Berglundh T , Mombelli A , Schwarz F , et al. , 2024 . Etiology, pathogenesis and treatment of peri-implantitis: a European perspective . Periodontol 2000 , in press . https://doi.org/10.1111/prd.12549 https://doi.org/10.1111/prd.12549

Bommarito PA , Fry RC , 2019 . The role of DNA methylation in gene regulation . In: McCullough SD, Dolinoy DC (Eds.), Toxicoepigenetics . Academic Press , London , p. 127 - 151 . https://doi.org/10.1016/B978-0-12-812433-8.00005-8 https://doi.org/10.1016/B978-0-12-812433-8.00005-8

Cavalli G , Heard E , 2019 . Advances in epigenetics link genetics to the environment and disease . Nature , 571 ( 7766 ): 489 - 499 . https://doi.org/10.1038/s41586-019-1411-0 https://doi.org/10.1038/s41586-019-1411-0

Chaparro A , Atria P , Realini O , et al. , 2021 . Diagnostic potential of peri-implant crevicular fluid microRNA-21-3p and microRNA-150-5p and extracellular vesicles in peri-implant diseases . J Periodontol , 92 ( 6 ): e11 - e21 . https://doi.org/10.1002/JPER.20-0372 https://doi.org/10.1002/JPER.20-0372

Chen RS , Liao X , Chen FR , et al. , 2018 . Circulating microRNAs, miR-10b-5p, miR-328-3p, miR-100 and let-7, are associated with osteoblast differentiation in osteoporosis . Int J Clin Exp Pathol , 11 ( 3 ): 1383 - 1390 .

Cheng L , Fan YL , Cheng J , et al. , 2022 . Long non-coding RNA ZFY-AS1 represses periodontitis tissue inflammation and oxidative damage via modulating microRNA-129-5p/DEAD-Box helicase 3 X-linked axis . Bioengineered , 13 ( 5 ): 12691 - 12705 . https://doi.org/10.1080/21655979.2021.2019876 https://doi.org/10.1080/21655979.2021.2019876

Cho YD , Kim PJ , Kim HG , et al. , 2020 . Transcriptome and methylome analysis of periodontitis and peri-implantitis with tobacco use . Gene , 727 : 144258 . https://doi.org/10.1016/j.gene.2019.144258 https://doi.org/10.1016/j.gene.2019.144258

Cho YD , Kim WJ , Kim S , et al. , 2021 . Surface topography of titanium affects their osteogenic potential through DNA methylation . Int J Mol Sci , 22 ( 5 ): 2406 . https://doi.org/10.3390/ijms22052406 https://doi.org/10.3390/ijms22052406

Choi SW , Braun T , Henig I , et al. , 2017 . Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT . Blood , 130 ( 15 ): 1760 - 1767 . https://doi.org/10.1182/blood-2017-06-790469 https://doi.org/10.1182/blood-2017-06-790469

Choudhuri S , 2011 . From Waddington’s epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research . Toxicol Mech Methods , 21 ( 4 ): 252 - 274 . https://doi.org/10.3109/15376516.2011.559695 https://doi.org/10.3109/15376516.2011.559695

Daubert DM , Pozhitkov AE , Safioti LM , et al. , 2019 . Association of global DNA methylation to titanium and peri-implantitis: a case-control study . JDR Clin Trans Res , 4 ( 3 ): 284 - 291 . https://doi.org/10.1177/2380084418822831 https://doi.org/10.1177/2380084418822831

de la Rica L , García-Gómez A , Comet NR , et al. , 2015 . NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation . Genome Biol , 16 : 2 . https://doi.org/10.1186/s13059-014-0561-5 https://doi.org/10.1186/s13059-014-0561-5

Derks J , Ichioka Y , Dionigi C , et al. , 2023 . Prevention and management of peri-implant mucositis and peri-implantitis: a systematic review of outcome measures used in clinical studies in the last 10 years . J Clin Periodontol , 50 ( S25 ): 55 - 66 . https://doi.org/10.1111/jcpe.13608 https://doi.org/10.1111/jcpe.13608

Dumitrescu RG , 2018 . Early epigenetic markers for precision medicine . In: Dumitrescu RG, Verma M (Eds.), Cancer Epigenetics for Precision Medicine . Humana Press , New York , p. 3 - 17 . https://doi.org/10.1007/978-1-4939-8751-1_1 https://doi.org/10.1007/978-1-4939-8751-1_1

Farsetti A , Illi B , Gaetano C , 2023 . How epigenetics impacts on human diseases . Eur J Intern Med , 114 : 15 - 22 . https://doi.org/10.1016/j.ejim.2023.05.036 https://doi.org/10.1016/j.ejim.2023.05.036

Ganesan SM , Dabdoub SM , Nagaraja HN , et al. , 2022 . Biome-microbiome interactions in peri-implantitis: a pilot investigation . J Periodontol , 93 ( 6 ): 814 - 823 . https://doi.org/10.1002/JPER.21-0423 https://doi.org/10.1002/JPER.21-0423

Gao CS , Ren CM , Liu ZX , et al. , 2019 . GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis . Artif Cells Nanomed Biotechnol , 47 ( 1 ): 3985 - 3993 . https://doi.org/10.1080/21691401.2019.1670189 https://doi.org/10.1080/21691401.2019.1670189

Geng Z , Wang XG , Zhao J , et al. , 2018 . The synergistic effect of strontium-substituted hydroxyapatite and microRNA-21 on improving bone remodeling and osseointegration . Biomater Sci , 6 ( 10 ): 2694 - 2703 . https://doi.org/10.1039/c8bm00716k https://doi.org/10.1039/c8bm00716k

Geng Z , Yu YM , Li ZY , et al. , 2020 . miR-21 promotes osseointegration and mineralization through enhancing both osteogenic and osteoclastic expression . Mater Sci Eng C Mater Biol Appl , 111 : 110785 . https://doi.org/10.1016/j.msec.2020.110785 https://doi.org/10.1016/j.msec.2020.110785

Guan HB , Fan DP , Mrelashvili D , et al. , 2013 . MicroRNA let-7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis . Eur J Immunol , 43 ( 1 ): 104 - 114 . https://doi.org/10.1002/eji.201242702 https://doi.org/10.1002/eji.201242702

Guglielmotti MB , Olmedo DG , Cabrini RL , 2019 . Research on implants and osseointegration . Periodontol 2000 , 79 ( 1 ): 178 - 189 . https://doi.org/10.1111/prd.12254 https://doi.org/10.1111/prd.12254

Hiers NM , Li TQ , Traugot CM , et al. , 2024 . Target-directed microRNA degradation: mechanisms, significance, and functional implications . WIREs RNA , 15 ( 2 ): e1832 . https://doi.org/10.1002/wrna.1832 https://doi.org/10.1002/wrna.1832

Ho PTB , Clark IM , Le LTT , 2022 . MicroRNA-based diagnosis and therapy . Int J Mol Sci , 23 ( 13 ): 7167 . https://doi.org/10.3390/ijms23137167 https://doi.org/10.3390/ijms23137167

Hodges AJ , Hudson NO , Buck-Koehntop BA , 2020 . Cys 2 His 2 zinc finger methyl-CpG binding proteins: getting a handle on methylated DNA . J Mol Biol , 432 ( 6 ): 1640 - 1660 . https://doi.org/10.1016/j.jmb.2019.09.012 https://doi.org/10.1016/j.jmb.2019.09.012

Hogg SJ , Beavis PA , Dawson MA , et al. , 2020 . Targeting the epigenetic regulation of antitumour immunity . Nat Rev Drug Discov , 19 ( 11 ): 776 - 800 . https://doi.org/10.1038/s41573-020-0077-5 https://doi.org/10.1038/s41573-020-0077-5

Holliday R , Pugh JE , 1975 . DNA modification mechanisms and gene activity during development . Science , 187 ( 4173 ): 226 - 232 . https://doi.org/10.1126/science.187.4173.226 https://doi.org/10.1126/science.187.4173.226

Isola G , Tartaglia GM , Santonocito S , et al. , 2023 . Impact of N-terminal pro-B-type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: an explorative human randomized-controlled clinical trial . J Periodontol , 94 ( 12 ): 1414 - 1424 . https://doi.org/10.1002/JPER.23-0063 https://doi.org/10.1002/JPER.23-0063

Jiang SY , Xue D , Xie YF , et al. , 2015 . The negative feedback regulation of microRNA-146a in human periodontal ligament cells after Porphyromonas gingivalis lipopolysaccharide stimulation . Inflamm Res , 64 ( 6 ): 441 - 451 . https://doi.org/10.1007/s00011-015-0824-y https://doi.org/10.1007/s00011-015-0824-y

Jiang SY , Hu Y , Deng S , et al. , 2018 . miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6 . Biochim Biophys Acta Mol Basis Dis , 1864 ( 3 ): 925 - 933 . https://doi.org/10.1016/j.bbadis.2017.12.035 https://doi.org/10.1016/j.bbadis.2017.12.035

Jin YC , Hong FL , Bao QY , et al. , 2020 . MicroRNA-145 suppresses osteogenic differentiation of human jaw bone marrow mesenchymal stem cells partially via targeting semaphorin 3A . Connect Tissue Res , 61 ( 6 ): 577 - 585 . https://doi.org/10.1080/03008207.2019.1643334 https://doi.org/10.1080/03008207.2019.1643334

Jurdziński KT , Potempa J , Grabiec AM , 2020 . Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential . Clin Epigenet , 12 : 186 . https://doi.org/10.1186/s13148-020-00982-7 https://doi.org/10.1186/s13148-020-00982-7

Kadkhodazadeh M , Jafari AR , Amid R , et al. , 2013 . MiR146a and MiR499 gene polymorphisms in Iranian periodontitis and peri-implantitis patients . J Long-Term Eff Med Implants , 23 ( 1 ): 9 - 16 . https://doi.org/10.1615/JLongTermEffMedImplants.2013007073 https://doi.org/10.1615/JLongTermEffMedImplants.2013007073

Kaur P , Kotru S , Singh S , et al. , 2022 . Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions . Mol Neurobiol , 59 ( 3 ): 1836 - 1849 . https://doi.org/10.1007/s12035-021-02662-w https://doi.org/10.1007/s12035-021-02662-w

Khalid M , Petroianu G , Adem A , 2022 . Advanced glycation end products and diabetes mellitus: mechanisms and perspectives . Biomolecules , 12 ( 4 ): 542 . https://doi.org/10.3390/biom12040542 https://doi.org/10.3390/biom12040542

Khouly I , Pardiñas López S , Díaz Prado SM , et al. , 2022 . Global DNA methylation in dental implant failure due to peri-implantitis: an exploratory clinical pilot study . Int J Environ Res Public Health , 19 ( 2 ): 1020 . https://doi.org/10.3390/ijerph19021020 https://doi.org/10.3390/ijerph19021020

Larsson L , 2017 . Current concepts of epigenetics and its role in periodontitis . Curr Oral Health Rep , 4 ( 4 ): 286 - 293 . https://doi.org/10.1007/s40496-017-0156-9 https://doi.org/10.1007/s40496-017-0156-9

Li Y , Zheng JN , Gong CJ , et al. , 2020 . Development of an immunogenomic landscape for the competing endogenous RNAs network of peri-implantitis . BMC Med Genet , 21 : 208 . https://doi.org/10.1186/s12881-020-01145-4 https://doi.org/10.1186/s12881-020-01145-4

Li YF , Du ZB , Xie XT , et al. , 2021 . Epigenetic changes caused by diabetes and their potential role in the development of periodontitis . J Diabetes Investig , 12 ( 8 ): 1326 - 1335 . https://doi.org/10.1111/jdi.13477 https://doi.org/10.1111/jdi.13477

Li YM , Chen GH , He Y , et al. , 2021 . Selenomethionine-modified polyethylenimine-based nanoparticles loaded with miR-132-3p inhibitor-biofunctionalized titanium implants for improved osteointegration . ACS Biomater Sci Eng , 7 ( 10 ): 4933 - 4945 . https://doi.org/10.1021/acsbiomaterials.1c00880 https://doi.org/10.1021/acsbiomaterials.1c00880

Liu HM , Liu P , 2021 . Kartogenin promotes the BMSCs chondrogenic differentiation in osteoarthritis by down-regulation of miR-145-5p targeting Smad4 pathway . Tissue Eng Regen Med , 18 ( 6 ): 989 - 1000 . https://doi.org/10.1007/s13770-021-00390-9 https://doi.org/10.1007/s13770-021-00390-9

Liu XM , Su K , Kuang SJ , et al. , 2020 . miR-16-5p and miR-145-5p trigger apoptosis in human gingival epithelial cells by down-regulating BACH2 . Int J Clin Exp Pathol , 13 ( 5 ): 901 - 911 .

Liu Y , Wang XX , Yang DP , et al. , 2014 . MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts . Plast Reconstr Surg , 134 ( 4 ): 561e - 573 e. https://doi.org/10.1097/PRS.0000000000000577 https://doi.org/10.1097/PRS.0000000000000577

Luan X , Zhou X , Trombetta-Esilva J , et al. , 2017 . MicroRNAs and periodontal homeostasis . J Dent Res , 96 ( 5 ): 491 - 500 . https://doi.org/10.1177/0022034516685711 https://doi.org/10.1177/0022034516685711

Matarese G , Isolal G , Anastasp GP , et al. , 2013 . Transforming growth factor beta 1 and vascular endothelial growth factor levels in the pathogenesis of periodontal disease . Eur J Inflamm , 11 ( 2 ): 479 - 488 . https://doi.org/10.1177/1721727X1301100217 https://doi.org/10.1177/1721727X1301100217

Mazziotta C , Badiale G , Cervellera CF , et al. , 2024 . Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation . Theranostics , 14 ( 1 ): 143 - 158 . https://doi.org/10.7150/thno.89066 https://doi.org/10.7150/thno.89066

Meng YB , Li X , Li ZY , et al. , 2016 . Surface functionalization of titanium alloy with miR-29b nanocapsules to enhance bone regeneration . ACS Appl Mater Interfaces , 8 ( 9 ): 5783 - 5793 . https://doi.org/10.1021/acsami.5b10650 https://doi.org/10.1021/acsami.5b10650

Menini M , Dellepiane E , Baldi D , et al. , 2017 . Microarray expression in peri-implant tissue next to different titanium implant surfaces predicts clinical outcomes: a split-mouth study . Clin Oral Implants Res , 28 ( 9 ): e121 - e134 . https://doi.org/10.1111/clr.12943 https://doi.org/10.1111/clr.12943

Menini M , Pesce P , Baldi D , et al. , 2019 . Prediction of titanium implant success by analysis of microRNA expression in peri-implant tissue. A 5-year follow-up study . J Clin Med , 8 ( 6 ): 888 . https://doi.org/10.3390/jcm8060888 https://doi.org/10.3390/jcm8060888

Menini M , Pesce P , Pera F , et al. , 2021 . MicroRNAs in peri-implant crevicular fluid can predict peri-implant bone resorption: clinical trial with a 5-year follow-up . Int J Oral Maxillofac Implants , 36 ( 6 ): 1148 - 1157 . https://doi.org/10.11607/jomi.9040 https://doi.org/10.11607/jomi.9040

Meteran H , Knudsen AØ , Jørgensen TL , et al. , 2024 . Carboplatin plus paclitaxel in combination with the histone deacetylate inhibitor, vorinostat, in patients with recurrent platinum-sensitive ovarian cancer . J Clin Med , 13 ( 3 ): 897 . https://doi.org/10.3390/jcm13030897 https://doi.org/10.3390/jcm13030897

Michou L , 2018 . Epigenetics of bone diseases . Joint Bone Spine , 85 ( 6 ): 701 - 707 . https://doi.org/10.1016/j.jbspin.2017.12.003 https://doi.org/10.1016/j.jbspin.2017.12.003

Mijiritsky E , Ferroni L , Gardin C , et al. , 2019 . Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence . J Clin Med , 9 ( 1 ): 38 . https://doi.org/10.3390/jcm9010038 https://doi.org/10.3390/jcm9010038

Millán-Zambrano G , Burton A , Bannister AJ , et al. , 2022 . Histone post-translational modifications‒cause and consequence of genome function . Nat Rev Genet , 23 ( 9 ): 563 - 580 . https://doi.org/10.1038/s41576-022-00468-7 https://doi.org/10.1038/s41576-022-00468-7

Mohr AM , Mott JL , 2015 . Overview of microRNA biology . Semin Liver Dis , 35 ( 1 ): 3 - 11 . https://doi.org/10.1055/s-0034-1397344 https://doi.org/10.1055/s-0034-1397344

Nibali L , Gkranias N , Mainas G , et al. , 2022 . Periodontitis and implant complications in diabetes . Periodontol 2000 , 90 ( 1 ): 88 - 105 . https://doi.org/10.1111/prd.12451 https://doi.org/10.1111/prd.12451

Oh JM , Kim Y , Son H , et al. , 2024 . Comparative transcriptome analysis of periodontitis and peri-implantitis in human subjects . J Periodontol , 95 ( 4 ): 337 - 349 . https://doi.org/10.1002/JPER.23-0289 https://doi.org/10.1002/JPER.23-0289

Oton-Gonzalez L , Mazziotta C , Iaquinta MR , et al. , 2022 . Genetics and epigenetics of bone remodeling and metabolic bone diseases . Int J Mol Sci , 23 ( 3 ): 1500 . https://doi.org/10.3390/ijms23031500 https://doi.org/10.3390/ijms23031500

Pan KQ , Hu Y , Wang YF , et al. , 2020 . RANKL blockade alleviates peri-implant bone loss and is enhanced by anti-inflammatory microRNA-146a through TLR2/4 signaling . Int J Implant Dent , 6 : 15 . https://doi.org/10.1186/s40729-020-00210-0 https://doi.org/10.1186/s40729-020-00210-0

Schwarz F , Derks J , Monje A , et al. , 2018 . Peri-implantitis . J Clin Periodontol , 45 ( S20 ): S246 - S266 . https://doi.org/10.1111/jcpe.12954 https://doi.org/10.1111/jcpe.12954

Sczepanik FSC , Grossi ML , Casati M , et al. , 2020 . Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way . Periodontol 2000 , 84 ( 1 ): 45 - 68 . https://doi.org/10.1111/prd.12342 https://doi.org/10.1111/prd.12342

Selbach M , Schwanhäusser B , Thierfelder N , et al. , 2008 . Widespread changes in protein synthesis induced by microRNAs . Nature , 455 ( 7209 ): 58 - 63 . https://doi.org/10.1038/nature07228 https://doi.org/10.1038/nature07228

Shang RF , Lee S , Senavirathne G , et al. , 2023 . microRNAs in action: biogenesis, function and regulation . Nat Rev Genet , 24 ( 12 ): 816 - 833 . https://doi.org/10.1038/s41576-023-00611-y https://doi.org/10.1038/s41576-023-00611-y

Shao D , Wang CF , Sun YP , et al. , 2018 . Effects of oral implants with miR-122-modified cell sheets on rat bone marrow mesenchymal stem cells . Mol Med Rep , 17 ( 1 ): 1537 - 1544 . https://doi.org/10.3892/mmr.2017.8094 https://doi.org/10.3892/mmr.2017.8094

Shen GY , Ren H , Shang Q , et al. , 2020 . miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss . Theranostics , 10 ( 10 ): 4334 - 4348 . https://doi.org/10.7150/thno.42982 https://doi.org/10.7150/thno.42982

Strauss FJ , Stähli A , Kobatake R , et al. , 2020 . miRNA-21 deficiency impairs alveolar socket healing in mice . J Periodontol , 91 ( 12 ): 1664 - 1672 . https://doi.org/10.1002/JPER.19-0567 https://doi.org/10.1002/JPER.19-0567

Subramaniam R , Vijakumaran U , Shanmuganantha L , et al. , 2023 . The role and mechanism of microRNA 21 in osteogenesis: an update . Int J Mol Sci , 24 ( 14 ): 11330 . https://doi.org/10.3390/ijms241411330 https://doi.org/10.3390/ijms241411330

Sun L , Girnary M , Wang LF , et al. , 2020 . IL-10 dampens an IL-17-mediated periodontitis-associated inflammatory network . J Immunol , 204 ( 8 ): 2177 - 2191 . https://doi.org/10.4049/jimmunol.1900532 https://doi.org/10.4049/jimmunol.1900532

Tanaka U , Kajioka S , Finoti LS , et al. , 2021 . Decitabine inhibits bone resorption in periodontitis by upregulating anti-inflammatory cytokines and suppressing osteoclastogenesis . Biomedicines , 9 ( 2 ): 199 . https://doi.org/10.3390/biomedicines9020199 https://doi.org/10.3390/biomedicines9020199

Urvasizoglu G , Kilic A , Barlak N , et al. , 2021 . MiR-4484 acts as a potential saliva biomarker for early detection of peri-implantitis . Int J Oral Maxillofac Implants , 36 ( 1 ): 115 - 121 . https://doi.org/10.11607/jomi.8470 https://doi.org/10.11607/jomi.8470

Urvasizoglu G , Kilic A , Capik O , et al. , 2024 . CXCL14 and miR-4484 serves as potential salivary biomarkers for early detection of peri-implantitis . Odontology , 112 ( 3 ): 864 - 871 . https://doi.org/10.1007/s10266-023-00876-z https://doi.org/10.1007/s10266-023-00876-z

Vojinovic J , Damjanov N , D'Urzo C , et al. , 2011 . Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis . Arthritis Rheum , 63 ( 5 ): 1452 - 1458 . https://doi.org/10.1002/art.30238 https://doi.org/10.1002/art.30238

Wachi T , Shuto T , Shinohara Y , et al. , 2015 . Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption . Toxicology , 327 : 1 - 9 . https://doi.org/10.1016/j.tox.2014.10.016 https://doi.org/10.1016/j.tox.2014.10.016

Waddington CH , 2012 . The epigenotype . Int J Epidemiol , 41 ( 1 ): 10 - 13 . https://doi.org/10.1093/ije/dyr184 https://doi.org/10.1093/ije/dyr184

Wang Q , Wang XY , Valverde P , et al. , 2021 . Osteogenic effects of microRNA-335-5p/lipidoid nanoparticles coated on titanium surface . Arch Oral Biol , 129 : 105207 . https://doi.org/10.1016/j.archoralbio.2021.105207 https://doi.org/10.1016/j.archoralbio.2021.105207

Wang QN , Yan YZ , Zhang XZ , et al. , 2022 . Rescuing effects of periostin in advanced glycation end-products (AGEs) caused osteogenic and oxidative damage through AGE receptor mediation and DNA methylation of the CALCA promoter . Chem Biol Interact , 354 : 109835 . https://doi.org/10.1016/j.cbi.2022.109835 https://doi.org/10.1016/j.cbi.2022.109835

Wang SM , Wu WY , 2018 . DNA methylation alterations in human cancers . In: Tollefsbol TO (Ed.), Epigenetics in Human Disease , 2nd Ed . Academic Press , SanDiego, p. 109 - 139 . https://doi.org/10.1016/B978-0-12-812215-0.00005-4 https://doi.org/10.1016/B978-0-12-812215-0.00005-4

Wang YF , Liu HM , Wu JM , et al. , 2020 . 5-Aza-2-deoxycytidine inhibits osteolysis induced by titanium particles by regulating RANKL/OPG ratio . Biochem Biophys Res Commun , 529 ( 3 ): 629 - 634 . https://doi.org/10.1016/j.bbrc.2020.05.192 https://doi.org/10.1016/j.bbrc.2020.05.192

Wang ZL , Wu XF , Hou XW , et al. , 2020 . miR-548b-3p functions as a tumor suppressor in lung cancer . Lasers Med Sci , 35 ( 4 ): 833 - 839 . https://doi.org/10.1007/s10103-019-02865-7 https://doi.org/10.1007/s10103-019-02865-7

Wang ZS , Wu GS , Feng ZH , et al. , 2015 . Microarc-oxidized titanium surfaces functionalized with microRNA-21-loaded chitosan/hyaluronic acid nanoparticles promote the osteogenic differentiation of human bone marrow mesenchymal stem cells . Int J Nanomedicine , 10 : 6675 - 6687 . https://doi.org/10.2147/IJN.S94689 https://doi.org/10.2147/IJN.S94689

Wang ZS , Wu GS , Yang ZJ , et al. , 2022 . Chitosan/hyaluronic acid/microRNA-21 nanoparticle-coated smooth titanium surfaces promote the functionality of human gingival fibroblasts . Int J Nanomedicine , 17 : 3793 - 3807 . https://doi.org/10.2147/IJN.S375180 https://doi.org/10.2147/IJN.S375180

Wu XL , Chen XP , Mi WX , et al. , 2017 . MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs . Biosci Rep , 37 ( 5 ): BSR20170768 . https://doi.org/10.1042/BSR20170768 https://doi.org/10.1042/BSR20170768

Wu XL , Gu QH , Chen XP , et al. , 2019 . MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis . J Bone Miner Res , 34 ( 1 ): 123 - 134 . https://doi.org/10.1002/jbmr.3575 https://doi.org/10.1002/jbmr.3575

Xie N , Cui HC , Banerjee S , et al. , 2014 . miR-27a regulates inflammatory response of macrophages by targeting IL-10 . J Immunol , 193 ( 1 ): 327 - 334 . https://doi.org/10.4049/jimmunol.1400203 https://doi.org/10.4049/jimmunol.1400203

Xu C , Wang ZD , Liu YJ , et al. , 2023 . Extracellular vesicles derived from bone marrow mesenchymal stem cells loaded on magnetic nanoparticles delay the progression of diabetic osteoporosis via delivery of miR-150-5p . Cell Biol Toxicol , 39 ( 4 ): 1257 - 1274 . https://doi.org/10.1007/s10565-022-09744-y https://doi.org/10.1007/s10565-022-09744-y

Yadalam PK , Thiyagaraj A , 2020 . An immune interaction network driven approach for identifying biomarkers for peri‐implantitis . Clin Oral Implants Res , 31 ( S20 ): 70 . https://doi.org/10.1111/clr.11_13644 https://doi.org/10.1111/clr.11_13644

Yan J , Chang B , Hu XX , et al. , 2018 . Titanium implant functionalized with antimiR-138 delivered cell sheet for enhanced peri-implant bone formation and vascularization . Mater Sci Eng C Mater Biol Appl , 89 : 52 - 64 . https://doi.org/10.1016/j.msec.2018.03.011 https://doi.org/10.1016/j.msec.2018.03.011

Zhang HM , Yuan Y , Xue HX , et al. , 2022 . MicroRNA sequence and function analysis in peri-implantitis and periodontitis: an animal study . J Periodontal Res , 57 ( 5 ): 1043 - 1055 . https://doi.org/10.1111/jre.13045 https://doi.org/10.1111/jre.13045

Zhang HM , Yuan Y , Xue HX , et al. , 2023 . Reprogramming mitochondrial metabolism of macrophages by miRNA-released microporous coatings to prevent peri-implantitis . J Nanobiotechnol , 21 : 485 . https://doi.org/10.1186/s12951-023-02244-z https://doi.org/10.1186/s12951-023-02244-z

Zhou HL , Chen DH , Xie GF , et al. , 2020 . LncRNA-mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high-throughput sequencing . Clin Implant Dent Relat Res , 22 ( 3 ): 424 - 450 . https://doi.org/10.1111/cid.12911 https://doi.org/10.1111/cid.12911

Zhou W , Su L , Duan XY , et al. , 2018 . MicroRNA-21 down-regulates inflammation and inhibits periodontitis . Mol Immunol , 101 : 608 - 614 . https://doi.org/10.1016/j.molimm.2018.05.008 https://doi.org/10.1016/j.molimm.2018.05.008

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