Potential role of FNDC5 in exercise-induced improvement of cognitive function

Ruobing ZHAO; Xuchang ZHOU; Dongxue WANG; Haifeng TANG; Guoxin NI

doi:10.1631/jzus.B2400016

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Review | Updated：2025-06-24

Potential role of FNDC5 in exercise-induced improvement of cognitive function
Potential role of FNDC5 in exercise-induced improvement of cognitive function
FNDC5在运动介导的认知功能改善中的潜在作用
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 6, Pages: 557-572(2025)
Affiliations：

1.School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China
2.Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China
Funds：
DOI：10.1631/jzus.B2400016
CLC：
CSTR：
Received：12 January 2024，

Revised：06 March 2024，

Published Online：23 May 2025，

Published：24 June 2025
Accepted：

赵若兵,周绪昌,王冬雪等.FNDC5在运动介导的认知功能改善中的潜在作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(06):557-572.

Ruobing ZHAO, Xuchang ZHOU, Dongxue WANG, et al. Potential role of FNDC5 in exercise-induced improvement of cognitive function[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(6): 557-572.
赵若兵,周绪昌,王冬雪等.FNDC5在运动介导的认知功能改善中的潜在作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(06):557-572. DOI： 10.1631/jzus.B2400016.

Ruobing ZHAO, Xuchang ZHOU, Dongxue WANG, et al. Potential role of FNDC5 in exercise-induced improvement of cognitive function[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(6): 557-572. DOI： 10.1631/jzus.B2400016.

摘要

认知功能障碍常出现在阿尔茨海默病、帕金森病、脑血管疾病以及其他神经退行性疾病中，严重影响患者的生活质量，给患者及其家庭带来严重的社会、心理和经济负担。大量研究证实，运动可以通过多种途径延缓认知功能的下降，在此过程中Ⅲ型纤连蛋白结构域5（FNDC5）扮演着重要的角色，但目前对于运动调控FNDC5改善认知功能的研究尚缺乏系统和全面的认识。因此，本文围绕运动介导的FNDC5在认知功能中的最新研究进展，系统地梳理了FNDC5在各种原因导致的认知功能障碍中的积极作用，明确了运动诱导的FNDC5通过抑制神经炎症、改善海马神经发生以及海马突触可塑性等改善认知功能的具体机制，并根据现有文献提出了领域内仍需深入研究的问题，为运动预防和改善认知功能障碍提供了理论依据。

Abstract

Cognitive dysfunction often occurs in Alzheimer’s disease

Parkinson’s disease

cerebrovascular disease

or other neurodegenerative diseases

and can significantly impact the life quality of patients and create serious social

psychological

and economic burdens for individuals and their families. Numerous studies have confirmed that exercise can slow the decline in cognitive function through multiple pathways

in which fibronectin type III domain-containing protein 5 (FNDC5) plays an important role. However

the current research on the modulation of FNDC5 by exercise and its ability to improve hippocampal cognitive function lacks a systematic and comprehensive understanding. Therefore

this review focuses on the latest research progress regarding the role of exercise-induced FNDC5 in cognitive function

systematically reviews the positive effects of FNDC5 on cognitive function impairment caused by various factors

and clarifies the specific mechanisms by which exercise-induced FNDC5 improves cognitive function by inhibiting neuroinflammation and improving hippocampal neurogenesis and hippocampal synaptic plasticity. Based on the existing literature

we also identify the areas that require further research in this field. Overall

this review provides a theoretical basis for exercise-based prevention and improvement of cognitive function impairment.

关键词

Keywords

references

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