Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation

Liwen WANG; Huimei LIU; Lanfang LI

doi:10.1631/jzus.B2300853

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Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation

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Correspondence | Updated：2024-12-27

Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
自噬受体激发嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器去除的新方法
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 25, Issue 12, Pages: 1115-1119(2024)
Affiliations：

1.Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang421001, China
2.Hengyang Medical School, University of South China, Hengyang421001, China
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DOI：10.1631/jzus.B2300853
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CSTR：
Published： 15 December 2024 ，

Published Online： 25 September 2024 ，

Received： 26 November 2023 ，

Revised： 26 March 2024 ，
Accepted：

王丽雯,刘惠美,李兰芳.自噬受体激发嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器去除的新方法[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(12):1115-1119.

LIWEN WANG, HUIMEI LIU, LANFANG LI. Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(12): 1115-1119.
王丽雯,刘惠美,李兰芳.自噬受体激发嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器去除的新方法[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2024,25(12):1115-1119. DOI： 10.1631/jzus.B2300853.

LIWEN WANG, HUIMEI LIU, LANFANG LI. Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation. [J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2024, 25(12): 1115-1119. DOI： 10.1631/jzus.B2300853.

摘要

Abstract

神经退行性疾病作为中枢神经系统的遗传性疾病，其主要特征是错误折叠的蛋白质聚集体在大脑神经元中缓慢积累。虽然自噬在降解蛋白质聚集体中发挥着至关重要的作用，但目前尚无有效且广泛适用的方法来降解哺乳动物细胞中的蛋白质聚集体。最新研究表明，合成的自噬受体启发的靶向嵌合体（AceTAC）作为降解剂可将选择性自噬受体-p62的LC3相互作用区（LIR）结构域与抗体结合，AceTAC降解剂可选择性靶向分解不同的蛋白质聚集体（例如mHTT、TDP-43和Tau）。此外，这些降解剂可靶向包括线粒体、过氧化物酶体和内质网在内的细胞器。综上，基于自噬的靶向降解剂AceTAC可作为一种有效治疗神经退行性疾病的新方法。

关键词

合成自噬受体自噬p62蛋白质聚集：细胞器

Keywords

references

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