Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies

Xueni ZHANG; Yidi MO; Chunbin LU; Zhijian SU; Xiaokun LI

doi:10.1631/jzus.B2300830

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Review | Updated：2025-06-24

Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies
Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies
成纤维细胞生长因子与子宫内膜蜕膜化：模型、机制和相关病理学
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 6, Pages: 573-588(2025)
Affiliations：

1.Department of Developmental Biology and Regenerative Medicine, Jinan University, Guangzhou 510632, China
2.Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China
3.National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China
4.State Key Laboratory for Macromolecule Drugs and Large-scale Preparation, Wenzhou Medical University, Wenzhou 325035, China
Funds：
DOI：10.1631/jzus.B2300830
CLC：
CSTR：
Received：14 November 2023，

Revised：12 March 2024，

Published Online：02 June 2025，

Published：24 June 2025
Accepted：

张雪妮,莫一迪,芦春斌等.成纤维细胞生长因子与子宫内膜蜕膜化：模型、机制和相关病理学[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(06):573-588.

Xueni ZHANG, Yidi MO, Chunbin LU, et al. Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(6): 573-588.
张雪妮,莫一迪,芦春斌等.成纤维细胞生长因子与子宫内膜蜕膜化：模型、机制和相关病理学[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(06):573-588. DOI： 10.1631/jzus.B2300830.

Xueni ZHANG, Yidi MO, Chunbin LU, et al. Fibroblast growth factors and endometrial decidualization: models, mechanisms, and related pathologies[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(6): 573-588. DOI： 10.1631/jzus.B2300830.

摘要

受精卵的形成代表妊娠的开始，胎儿的分娩则代表妊娠的结束。成功怀孕需要一系列精心策划的阶段：胚胎植入、子宫持续蜕膜化、胎盘形成和分娩。蜕膜化是妊娠期间子宫内膜发生的重要事件，需要性激素和细胞因子精确调节。其中，成纤维细胞生长因子（FGFs），尤其是FGF2，在这一生理过程中发挥着至关重要的作用。FGF的表达失调可导致蜕膜化不足，进而引发包括先兆子痫、反复着床失败和流产等多种不良妊娠结局。此外，与大多数哺乳动物物种不同，人类子宫内膜的蜕膜化具有规律性的形成和脱落周期，与胚胎是否存在无关。在这篇综述中，我们全面比较各种研究蜕膜化的模型，同时总结子宫内膜FGFs在月经周期中的变化趋势以及由FGF失调引发的子宫内膜疾病。

Abstract

The onset of pregnancy is marked by the formation of a zygote

while the culmination of gestation is manifested by the delivery of a fetus. Meanwhile

a successful pregnancy entails a meticulously coordinated sequence of events from embryo implantation to sustained decidualization of the uterus to placental development and childbirth. The decidual reaction

a pivotal process occurring within the endometrium during pregnancy

is finely regulated by sex steroids and cytokines. Notably

fibroblast growth factors (FGFs)

particularly FGF2

play a critical role in this physiological cascade. Dysregulated FGF expression may trigger inadequate decidualization

precipitating a spectrum of adverse pregnancy outcomes

including preeclampsia

recurrent implantation failure

and miscarriage. Furthermore

the human decidua

distinct from most mammalian species and similar to great apes

undergoes regular cycles of formation and shedding

independent of the presence of the embryo in the endometrium. This process is also tightly controlled by various FGFs. In this review

we comprehensively compare diverse research decidualization models

delineate the trend of endometrial FGFs during the menstrual cycle

and provide a synopsis of endometrial diseases triggered by FGF dysregulation.

关键词

Keywords

references

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