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1.Molecular Genetics and Microbiomics Laboratory, BIOTROF+ Ltd., Pushkin, St. Petersburg 196602, Russia
2.Federal State Budgetary Educational Institution of Higher Education “St. Petersburg State Agrarian University,” Pushkin, St. Petersburg 196605, Russia
3.School of Natural Sciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
4.Animal Genomics and Bioresource Research Unit (AGB Research Unit), Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand
5.L. K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk, Moscow Oblast 142132, Russia
Received:25 October 2023,
Revised:07 February 2024,
Published:25 February 2025
Georgi Yu. LAPTEV,Daria G. TIURINA,Elena A. YILDIRIM等.草甘膦、抗生素和抗球虫药物对肉鸡胰腺基因表达和血液生理的影响[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2025,26(02):185-199.
Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, et al. Effects of glyphosate, antibiotics, and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 185-199.
Georgi Yu. LAPTEV,Daria G. TIURINA,Elena A. YILDIRIM等.草甘膦、抗生素和抗球虫药物对肉鸡胰腺基因表达和血液生理的影响[J].浙江大学学报(英文版)(B辑:生物医学和生物技术),2025,26(02):185-199. DOI: 10.1631/jzus.B2300767.
Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, et al. Effects of glyphosate, antibiotics, and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 185-199. DOI: 10.1631/jzus.B2300767.
肉鸡饲料中的药物和农药残留可能会影响抗生素(ANT)的治疗和生产效益,进而影响基因表达。在本研究中,我们分析了在施用最大残留限量的除草剂草甘膦(GLY)、两种ANT和一种抗球虫药物(AD)后,13个关键胰腺基因的表达和血液生理参数的变化。将260只1~40日龄的Ross 308肉鸡分为以下四组,每组65只:(1)对照组,饲喂基础日粮(MD);(2)GLY组,饲喂添加GLY的MD;(3)GLY+ANTs组,饲喂添加GLY和ANT的MD;(4)GLY+AD组,饲喂添加GLY和AD的MD。结果显示,添加GLY、GLY+ANTs和GLY+AD会导致多个具有生理和经济意义的基因表达发生显著变化。特别是,与炎症和凋亡相关的基因(如白细胞介素6(
IL6
)、前列腺素内过氧化物合酶2(
PTGS2
)和半胱天冬酶6(
CASP6
))的表达下调高达99.1%,而与抗氧化保护相关的基因(如过氧化氢酶(
CAT
)、超氧化物歧化酶1(
SOD1
)和过氧化还原酶6(
PRDX6
))的表达下调高达98.6%。实验组中还观察到血清免疫学特性值显著下降,某些基因表达的变化与胰腺功能和血液变化一致。GLY、ANT和AD引起的基因表达和血液指标变化揭示了这些物质在分子水平上的可能作用机制,同时也表明肉鸡克服GLY、GLY+ANT和GLY+AD负面影响的生理机制。
Drugs and pesticide residues in broiler feed can compromise the therapeutic and production benefits of antibiotic (ANT) application and affect gene expression. In this study
we analyzed the expression of 13 key pancreatic genes and blood physiology parameters after administering one maximum residue limit of herbicide glyphosate (GLY)
two ANTs
and one anticoccidial drug (AD). A total of 260 Ross 308 broilers aged 1–40 d were divided into the following four groups of 65 birds each: control group
which was fed the main diet (MD)
and three experimental groups
which were fed MD supplemented with GLY
GLY+ANTs (enrofloxacin and colistin methanesulfonate)
and GLY+AD (ammonium maduramicin)
respectively. The results showed that the addition of GLY
GLY+ANTs
and GLY+AD caused significant changes in the expression of several genes of physiological and economic importance. In particular
genes related to inflammation and apoptosis (interleukin 6 (
IL6
)
prostaglandin-endoperoxide synthase 2 (
PTGS2
)
and caspase 6 (
CASP6
)) were downregulated by up to 99.1%
and those related to antioxid
ant protection (catalase (
CAT
)
superoxide dismutase 1 (
SOD1
) and peroxiredoxin 6 (
PRDX6
)) by up to 98.6%
compared to controls. There was also a significant decline in the values of immunological characteristics in the blood serum observed in the experimental groups
and certain changes in gene expression were concordant with changes in the functioning of the pancreas and blood. The changes revealed in gene expression and blood indices in response to GLY
ANTs
and AD provide insights into the possible mechanisms of action of these agents at the molecular level. Specifically
these changes may be indicative of physiological mechanisms to overcome the negative effects of GLY
GLY+ANTs
and GLY+AD in broilers.
Adedosu O , Badmus A , Adeleke G , et al. , 2017 . Telfairia occidentalis seed extract protects against oxidative stress, inflammation and some haematological disorders associated with atrazine-induced prostate cancer in rats . Eur J Cancer , 72 ( Suppl 1 ): S94 . https://doi.org/10.1016/S0959-8049(17)30393-3 https://doi.org/10.1016/S0959-8049(17)30393-3
Attia Y , El-Kelawy M , Al-Harthi M , et al. , 2020 . Impact of multienzymes dose supplemented continuously or intermittently in drinking water on growth performance, nutrient digestibility, and blood constituents of broiler chickens . Animals , 10 ( 3 ): 375 . https://doi.org/10.3390/ani10030375 https://doi.org/10.3390/ani10030375
Attia YA , El-Tahawy WS , El-Hamid A , et al. , 2014 . Effect of feed form, pellet diameter and enzymes supplementation on growth performance and nutrient digestibility of broiler during days 21-37 of age . Arch Anim Breed , 57 : 34 . https://doi.org/10.7482/0003-9438-57-034 https://doi.org/10.7482/0003-9438-57-034
Attia YA , Al-Harthi MA , El-Shafey AS , 2020 . Influence of different time and frequency of multienzyme application on the efficiency of broiler chicken rearing and some selected metabolic indicators . Animals , 10 ( 3 ): 450 . https://doi.org/10.3390/ani10030450 https://doi.org/10.3390/ani10030450
Aviagen , 2002 . Ross Broiler Management Manual . Aviagen , Newbridge, UK .
Aviagen , 2014 . Ross 308 Broiler: Nutrition Specifications . Aviagen , Newbridge, UK .
Ballmer PE , 2001 . Causes and mechanisms of hypoalbuminaemia . Clin Nutr , 20 ( 3 ): 271 - 273 . https://doi.org/10.1054/clnu.2001.0439 https://doi.org/10.1054/clnu.2001.0439
Banerjee S , Sar A , Misra A , et al. , 2018 . Increased productivity in poultry birds by sub-lethal dose of antibiotics is arbitrated by selective enrichment of gut microbiota, particularly short-chain fatty acid producers . Microbiology , 164 ( 2 ): 142 - 153 . https://doi.org/10.1099/mic.0.000597 https://doi.org/10.1099/mic.0.000597
Bondarenko YV , Ostapenko VI , Bulchenko IA , et al. , 2013 . Sexual dimorphism and sex determination of broilers of the Ross 308 cross . Ptakhivnytstvo , 69 : 51 - 54 (in Russian) .
Cattani D , Cesconetto PA , Tavares MK , et al. , 2017 . Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: implication of glutamate excitotoxicity and oxidative stress . Toxicology , 387 : 67 - 80 . https://doi.org/10.1016/j.tox.2017.06.001 https://doi.org/10.1016/j.tox.2017.06.001
Chapman HD , Jeffers TK , Williams RB , 2010 . Forty years of monensin for the control of coccidiosis in poultry . Poult Sci , 89 ( 9 ): 1788 - 1801 . https://doi.org/10.3382/ps.2010-00931 https://doi.org/10.3382/ps.2010-00931
Choi JH , Lee K , Kim DW , et al. , 2018 . Influence of dietary avilamycin on ileal and cecal microbiota in broiler chickens . Poult Sci , 97 ( 3 ): 970 - 979 . https://doi.org/10.3382/ps/pex360 https://doi.org/10.3382/ps/pex360
Clemente JC , Ursell LK , Parfrey LW , et al. , 2012 . The impact of the gut microbiota on human health: an integrative view . Cell , 148 ( 6 ): 1258 - 1270 . https://doi.org/10.1016/j.cell.2012.01.035 https://doi.org/10.1016/j.cell.2012.01.035
Costas-Ferreira C , Durán R , Faro LRF , 2022 . Toxic effects of glyphosate on the nervous system: a systematic review . Int J Mol Sci , 23 ( 9 ): 4605 . https://doi.org/10.3390/ijms23094605 https://doi.org/10.3390/ijms23094605
Cray C , Zaias J , Altman NH , 2009 . Acute phase response in animals: a review . Comp Med , 59 ( 6 ): 517 - 526 .
Dagli AJ , Shaikh WA , 1983 . Pancreatic involvement in malathion-anticholinesterase insecticide intoxication a study of 75 cases . Br J Clin Pract , 37 ( 7-8 ): 270 - 272 . https://doi.org/10.1111/j.1742-1241.1983.tb07199.x https://doi.org/10.1111/j.1742-1241.1983.tb07199.x
Dayan FE , Barker A , Bough R , et al. , 2019 . 4.04 - Herbicide mechanisms of action and resistance . Compr Biotechnol , 4 : 36 - 48 . https://doi.org/10.1016/B978-0-444-64046-8.00211-1 https://doi.org/10.1016/B978-0-444-64046-8.00211-1
Degterev A , Boyce M , Yuan JY , 2003 . A decade of caspases . Oncogene , 22 ( 53 ): 8543 - 8567 . https://doi.org/10.1038/sj.onc.1207107 https://doi.org/10.1038/sj.onc.1207107
Duke SO , 2018 . The history and current status of glyphosate . Pest Manag Sci , 74 ( 5 ): 1027 - 1034 . https://doi.org/10.1002/ps.4652 https://doi.org/10.1002/ps.4652
Duong HQ , You KS , Oh S , et al. , 2017 . Silencing of NRF2 reduces the expression of ALDH1A1 and ALDH3A1 and sensitizes to 5-FU in pancreatic cancer cells . Antioxidants , 6 ( 3 ): 52 . https://doi.org/10.3390/antiox6030052 https://doi.org/10.3390/antiox6030052
Egorov IA , Manukyan VA , Lenkova TN , et al. , 2013 . Methodology for scientific and production research on poultry feeding. molecular genetic methods for determining gut microflora . In: Fisinin VI (Ed.), Russian Academy of Agricultural Sciences . State Scientific Institution All-Russian Research and Technological Institute of Poultry Farming of the Russian Agricultural Academy, Sergiev Posad, Russia (in Russian).
Eleiwa NZ , El-Shabrawi AA , Ibrahim D , et al. , 2023 . Dietary curcumin modulating effect on performance, antioxidant status, and immune-related response of broiler chickens exposed to imidacloprid insecticide . Animals , 13 ( 23 ): 3650 . https://doi.org/10.3390/ani13233650 https://doi.org/10.3390/ani13233650
Evan GI , Vousden KH , 2001 . Proliferation, cell cycle and apoptosis in cancer . Nature , 411 ( 6835 ): 342 - 348 . https://doi.org/10.1038/35077213 https://doi.org/10.1038/35077213
Evrard E , Marchand J , Theron M , et al. , 2010 . Impacts of mixtures of herbicides on molecular and physiological responses of the European flounder Platichthys flesus . Comp Biochem Physiol Part C Toxicol Pharmacol , 152 ( 3 ): 321 - 331 . https://doi.org/10.1016/j.cbpc.2010.05.009 https://doi.org/10.1016/j.cbpc.2010.05.009
Fisinin VI , Egorov IA , Draganov IF , 2011 . Feeding of Poultry: A Textbook . GEOTAR-Media , Moscow , Russia (in Russian).
Gao MC , Zhu HJ , Guo JM , et al. , 2022a . Tannic acid through ROS/TNF-α/TNFR 1 antagonizes atrazine induced apoptosis, programmed necrosis and immune dysfunction of grass carp hepatocytes . Fish Shellfish Immunol , 131 : 312 - 322 . https://doi.org/10.1016/j.fsi.2022.09.062 https://doi.org/10.1016/j.fsi.2022.09.062
Gao MC , Yang NX , Lei YT , et al. , 2022b . Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function . Fish Shellfish Immunol , 131 : 1075 - 1084 . https://doi.org/10.1016/j.fsi.2022.11.024 https://doi.org/10.1016/j.fsi.2022.11.024
Grozina AA , Ilina LA , Laptev GY , et al. , 2023 . Probiotics as an alternative to antibiotics in modulating the intestinal microbiota and performance of broiler chickens . J Appl Microbiol , 134 ( 9 ): lxad213 . https://doi.org/10.1093/jambio/lxad213 https://doi.org/10.1093/jambio/lxad213
Haiser HJ , Turnbaugh PJ , 2013 . Developing a metagenomic view of xenobiotic metabolism . Pharmacol Res , 69 ( 1 ): 21 - 31 . https://doi.org/10.1016/j.phrs.2012.07.009 https://doi.org/10.1016/j.phrs.2012.07.009
Halper J , Burt DW , Romanov MN , 2004 . On reassessment of the chicken TGFB4 gene as TGFB1 . Growth Factors , 22 ( 2 ): 121 - 122 . https://doi.org/10.1080/08977190410001712878 https://doi.org/10.1080/08977190410001712878
Hengartner MO , 2000 . The biochemistry of apoptosis . Nature , 407 ( 6805 ): 770 - 776 . https://doi.org/10.1038/35037710 https://doi.org/10.1038/35037710
Johnstone RW , Ruefli AA , Lowe SW , 2002 . Apoptosis: a link between cancer genetics and chemotherapy . Cell , 108 ( 2 ): 153 - 164 . https://doi.org/10.1016/S0092-8674(02)00625-6 https://doi.org/10.1016/S0092-8674(02)00625-6
Kaiser JT , Clausen T , Bourenkow GP , et al. , 2000 . Crystal structure of a NifS-like protein from Thermotoga maritima : implications for iron sulphur cluster assembly . J Mol Biol , 297 ( 2 ): 451 - 464 . https://doi.org/10.1006/jmbi.2000.3581 https://doi.org/10.1006/jmbi.2000.3581
Kammon AM , Brar RS , Sodhi S , et al. , 2011 . Chlorpyrifos chronic toxicity in broilers and effect of vitamin C . Open Vet J , 1 ( 1 ): 21 - 27 .
Karaffová V , Bobíková K , Husáková E , et al. , 2015 . Interaction of TGF-β4 and IL-17 with IgA secretion in the intestine of chickens fed with E . faecium AL41 and challenged with S. Enteritidis. Res Vet Sci , 100 : 75 - 79 . https://doi.org/10.1016/j.rvsc.2015.04.005 https://doi.org/10.1016/j.rvsc.2015.04.005
Karput IM , 1993 . Immunology and Immunopathology of Diseases of Young Animals . Urajay , Minsk, Belarus (in Russian).
Klümper W , Qaim M , 2014 . A meta-analysis of the impacts of genetically modified crops . PLoS ONE , 9 ( 11 ): e111629 . https://doi.org/10.1371/journal.pone.0111629 https://doi.org/10.1371/journal.pone.0111629
Kochish II , Brazhnik EA , Vorobyov NI , et al. , 2023a . Features of fractal conformity and bioconsolidation in the early myogenesis gene expression and their relationship to the genetic diversity of chicken breeds . Animals , 13 ( 3 ): 521 . https://doi.org/10.3390/ani13030521 https://doi.org/10.3390/ani13030521
Kochish II , Titov VY , Nikonov IN , et al. , 2023b . Unraveling signatures of chicken genetic diversity and divergent selection in breed-specific patterns of early myogenesis, nitric oxide metabolism and post-hatch growth . Front Genet , 13 : 1092242 . https://doi.org/10.3389/fgene.2022.1092242 https://doi.org/10.3389/fgene.2022.1092242
Kolyakov YE , 1990 . Veterinary Immunology . Agropromizdat , Moscow , R ussia (in Russian).
Kostyna MA , 1983 . Determination of classes of immunoglobulins by the method of discrete sedimentation . Problems of Increasing the Resistance of Newborn Animals: Collection of Scientific Papers of VNIINBZh , p. 76 - 80 (in Russian) .
Kreutz LC , Pavan TR , Alves AG , et al. , 2014 . Increased immunoglobulin production in silver catfish ( Rhamdia quelen ) exposed to agrichemicals . Braz J Med Biol Res , 47 ( 6 ): 499 - 504 . https://doi.org/10.1590/1414-431X20143890 https://doi.org/10.1590/1414-431X20143890
Krishnan J , Selvarajoo K , Tsuchiya M , et al. , 2007 . Toll-like receptor signal transduction . Exp Mol Med , 39 ( 4 ): 421 - 438 . https://doi.org/10.1038/emm.2007.47 https://doi.org/10.1038/emm.2007.47
Laptev G , Turina D , Yildirim E , et al. , 2023 . Analysis of changes in broiler microbiome biodiversity parameters due to intake of glyphosate and probiotic Bacillus sp. GL-8 using next-generation sequencing . In: Ronzhin A, Kostyaev A (Eds.), Agriculture Digitalization and Organic Production . Proceedings of the Third International Conference on Agriculture Digitalization and Organic Production, Springer , Singapore , p. 161 - 170 . https://doi.org/10.1007/978-981-99-4165-0_15 https://doi.org/10.1007/978-981-99-4165-0_15
Laptev GY , Filippova VA , Kochish II , et al. , 2019 . Examination of the expression of immunity genes and bacterial profiles in the caecum of growing chickens infected with Salmonella Enteritidis and fed a phytobiotic . Animals , 9 ( 9 ): 615 . https://doi.org/10.3390/ani9090615 https://doi.org/10.3390/ani9090615
Laptev GY , Yildirim EA , Ilina LA , et al. , 2021 . Effects of essential oils-based supplement and Salmonella infection on gene expression, blood parameters, cecal microbiome, and egg production in laying hens . Animals , 11 ( 2 ): 360 . https://doi.org/10.3390/ani11020360 https://doi.org/10.3390/ani11020360
Levitt DG , Levitt MD , 2016 . Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements . Int J Gen Med , 9 : 229 - 255 . https://doi.org/10.2147/IJGM.S102819 https://doi.org/10.2147/IJGM.S102819
Liu RH , Jia TT , Cui Y , et al. , 2018 . The protective effect of selenium on the chicken pancreas against cadmium toxicity via alleviating oxidative stress and autophagy . Biol Trace Elem Res , 184 ( 1 ): 240 - 246 . https://doi.org/10.1007/s12011-017-1186-9 https://doi.org/10.1007/s12011-017-1186-9
Livak KJ , Schmittgen TD , 2001 . Analysis of relative gene expression data using real-time quantitative PCR and the <math id="M2"><msup><mrow><mn mathvariant="normal">2</mn></mrow><mrow><mo>-</mo><mi mathvariant="normal">Δ</mi><mi mathvariant="normal">Δ</mi><msub><mrow><mi mathvariant="normal">C</mi></mrow><mrow><mi mathvariant="normal">T</mi></mrow></msub></mrow></msup></math> https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=74187818&type= 2.53999996 https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=74187826&type= 6.68866634 method . Methods , 25 ( 4 ): 402 - 408 . https://doi.org/10.1006/meth.2001.1262 https://doi.org/10.1006/meth.2001.1262
Lovaković BT , Pizent A , Kašuba V , et al. , 2017 . Effects of sub-chronic exposure to terbuthylazine on DNA damage, oxidative stress and parent compound/metabolite levels in adult male rats . Food Chem Toxicol , 108 : 93 - 103 . https://doi.org/10.1016/j.fct.2017.07.046 https://doi.org/10.1016/j.fct.2017.07.046
Lowe SW , Lin AW , 2000 . Apoptosis in cancer . Carcinogenesis , 21 ( 3 ): 485 - 495 . https://doi.org/10.1093/carcin/21.3.485 https://doi.org/10.1093/carcin/21.3.485
Ma JG , Li XY , 2015 . Alteration in the cytokine levels and histopathological damage in common carp induced by glyphosate . Chemosphere , 128 : 293 - 298 . https://doi.org/10.1016/j.chemosphere.2015.02.017 https://doi.org/10.1016/j.chemosphere.2015.02.017
Ma JG , Bu YZ , Li XY , 2015 . Immunological and histopathological responses of the kidney of common car p ( Cyprinus carpio L .) sublethally exposed to glyphosate. Environ Toxicol Pharmacol , 39 ( 1 ): 1 - 8 . https://doi.org/10.1016/j.etap.2014.11.004 https://doi.org/10.1016/j.etap.2014.11.004
Maggi F , la Cecilia D , Tang FHM , et al. , 2020 . The global environmental hazard of glyphosate use . Sci Total Environ , 717 : 137167 . https://doi.org/10.1016/j.scitotenv.2020.137167 https://doi.org/10.1016/j.scitotenv.2020.137167
Manne V , Handa P , Kowdley KV , 2018 . Pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis . Clin Liver Dis , 22 ( 1 ): 23 - 37 . https://doi.org/10.1016/j.cld.2017.08.007 https://doi.org/10.1016/j.cld.2017.08.007
Martínez MA , Ares I , Rodríguez JL , et al. , 2018 . Neurotransmitter changes in rat brain regions following glyphosate exposure . Environ Res , 161 : 212 - 219 . https://doi.org/10.1016/j.envres.2017.10.051 https://doi.org/10.1016/j.envres.2017.10.051
Menshikov VV , 1997 . Clinical Diagnosis – Laboratory Basics . Labinform , Moscow , Russia (in Russian).
Meza Cerda MIM , Gray R , Higgins DP , 2020 . Cytokine RT-qPCR and ddPCR for immunological investigations of the endangered Australian sea lion ( Neophoca cinerea ) and other mammals . PeerJ , 8 : e10306 . https://doi.org/10.7717/peerj.10306 https://doi.org/10.7717/peerj.10306
Morikawa K , Watabe H , Araake M , et al. , 1996 . Modulatory effect of antibiotics on cytokine production by human monocytes in vitro . Antimicrob. Agents Chemother , 40 ( 6 ): 1366 - 1370 . https://doi.org/10.1128/aac.40.6.1366 https://doi.org/10.1128/aac.40.6.1366
Nikolaienko VM , Tsynovyi OV , Tereschenko OV , 2011 . Method for Determination of Percent Ratio of Protein Fractions in Blood Serum of Broiler Chick . UA Patent 57682 (in Ukrainian with English information) .
Noack S , Chapman HD , Selzer PM , 2019 . Anticoccidial drugs of the livestock industry . Parasitol Res , 118 ( 7 ): 2009 - 2026 . https://doi.org/10.1007/s00436-019-06343-5 https://doi.org/10.1007/s00436-019-06343-5
Ognjanović BI , Marković SD , Pavlović SZ , et al. , 2008 . Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium . Physiol Res , 57 ( 3 ): 403 - 411 . https://doi.org/10.33549/physiolres.931197 https://doi.org/10.33549/physiolres.931197
Palomino DCT , Marti LC , 2015 . Chemokines and immunity . Einstein (Sao Paulo) , 13 ( 3 ): 469 - 473 . https://doi.org/10.1590/S1679-45082015RB3438 https://doi.org/10.1590/S1679-45082015RB3438
Pandey A , Dabhade P , Kumarasamy A , 2019 . Inflammatory effects of subacute exposure of Roundup in rat liver and adipose tissue . Dose Response , 17 ( 2 ): 1559325819843380 . https://doi.org/10.1177/1559325819843380 https://doi.org/10.1177/1559325819843380
Park JH , Hong S , Jun DW , et al. , 2021 . Prevalence and clinical characteristics of antibiotics associated drug induced liver injury . Ann Transl Med , 9 ( 8 ): 642 . https://doi.org/10.21037/atm-20-5144 https://doi.org/10.21037/atm-20-5144
Patreva LS , Kovalenko VP , Tereshchenko OV , et al. , 2010 . Poultry Meat Production: Textbook . MDAU , Mykolaiv, Ukraine (in Ukrainian).
Peillex C , Pelletier M , 2020 . The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity . J Immunotoxicol , 17 ( 1 ): 163 - 174 . https://doi.org/10.1080/1547691X.2020.1804492 https://doi.org/10.1080/1547691X.2020.1804492
Pradeep M , 2014 . Application of acute phase proteins as biomarkers in modern veterinary practice . Ind J Vet Anim Sci Res , 43 ( 1 ): 1 - 13 .
Reato G , Cuffini AM , Tullio V , et al. , 2004 . Immunomodulating effect of antimicrobial agents on cytokine production by human polymorphonuclear neutrophils . Int J Antimicrob Agents , 23 ( 2 ): 150 - 154 . https://doi.org/10.1016/j.ijantimicag.2003.07.006 https://doi.org/10.1016/j.ijantimicag.2003.07.006
Rodes L , Khan A , Paul A , et al. , 2013 . Effect of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharides and inflammatory cytokines: an in vitro study using a human colonic microbiota model . J Microbiol Biotechnol , 23 ( 4 ): 518 - 526 . https://doi.org/10.4014/jmb.1205.05018 https://doi.org/10.4014/jmb.1205.05018
Romanov MN , Kochish II , Titov VY , et al. , 2022a . Breed-specific patterns of early myogenesis, nitric oxide metabolism, and post-hatch growth in relation to genetic diversity and divergent selection in chickens . Life of Genomes : Abstracts of the International Conference, Kazan, Russia , p. 43 .
Romanov MN , Grozina AA , Ilina LA , et al. , 2022b . From feed regulation to regulated feeding: intestinal microbiome and performance optimization in broiler chickens in response to antibiotic and probiotic treatment . Life of Genomes : Abstracts of the International Conference, Kazan, Russia , p. 44 - 45 .
Rostami S , Akhlaghi A , Ahangari YJ , et al. , 2020 . Effects in broiler hens of genetic lines differing in fertility, biotin supplementation, and age on relative abundance of oviductal transforming growth factor-β and carbonic anhydrase mRNA transcripts . Anim Reprod Sci , 219 : 106480 . https://doi.org/10.1016/j.anireprosci.2020.106480 https://doi.org/10.1016/j.anireprosci.2020.106480
Sadovnikov NV , Pridybailo ND , Vereshchak NA , 2009 . General and Special Methods of Blood Testing of Birds of Industrial Crosses . Ural State Agricultural Academy , NPP “AVIVAC” , Yekaterinburg – St. Petersburg, Russia (in Russian).
SanPiN , 2021 . Sanitary Rules and Norms: SanPiN 1.2 . 3685 - 21 “Hygienic Standards and Requirements for Ensuring the Safety and (or) Harmlessness of Environmental Factors for Humans”, Registration No . 62296 . National Standards of Russian Federation (in Russian).
Santos T , Cancian G , Neodini DNR , et al. , 2015 . Toxicological evaluation of ametryn effects in Wistar rats . Exp Toxicol Pathol , 67 ( 10 ): 525 - 532 . https://doi.org/10.1016/j.etp.2015.08.001 https://doi.org/10.1016/j.etp.2015.08.001
Slack JMW , 1995 . Developmental biology of the pancreas . Development , 121 ( 6 ): 1569 - 1580 . https://doi.org/10.1242/dev.121.6.1569 https://doi.org/10.1242/dev.121.6.1569
Štefanac T , Grgas D , Dragičević TL , 2021 . Xenobiotics—division and methods of detection: a review . J Xenobiot , 11 ( 4 ): 130 - 141 . https://doi.org/10.3390/jox11040009 https://doi.org/10.3390/jox11040009
Streltsov VA , Ryabicheva AE , 2018 . Results of raising broilers at different slaughter dates . Current Problems of Intensive Development of Livestock Farming : Collection of Scientific Papers , p. 325 - 332 (in Russian) .
Surai PF , 2002 . Natural Antioxidants in Avian Nutrition and Reproduction . Nottingham University Press , Nottingham , UK .
Surai PF , 2006 . Selenium in Nutrition and Health . Nottingham University Press , Nottingham , UK .
Temperley ND , Berlin S , Paton IR , et al. , 2008 . Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss . BMC Genomics , 9 : 62 . https://doi.org/10.1186/1471-2164-9-62 https://doi.org/10.1186/1471-2164-9-62
Tereshchenko OV , Ryabinin SV , 2009 . Method of enzyme immunoassay and its use in practice . Ptakhivnytstvo , 63 : 274 - 278 (in Ukrainian with English summary) .
Titsa NW , 1997 . Encyclopedia of Clinical Laboratory Tests . Labinform , Moscow , Russia (in Russian).
Tizhe E , Ibrahim N , Fatihu M , et al. , 2018 . Pancreatic function and histoarchitecture in Wistar rats following chronic exposure to Bushfire®: the mitigating role of zinc . J Int Med Res , 46 ( 8 ): 3296 - 3305 . https://doi.org/10.1177/0300060518778640 https://doi.org/10.1177/0300060518778640
Tizhe EV , Ibrahim NDG , Fatihu MY , et al. , 2014 . Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate . Comp Clin Pathol , 23 ( 5 ): 1535 - 1543 . https://doi.org/10.1007/s00580-013-1818-1 https://doi.org/10.1007/s00580-013-1818-1
Tyurina DG , Laptev GY , Yildirim EA , et al. , 2022 . Influence of antibiotics, glyphosate and a Bacillus sp . strain on productivity performance and gene expression in cross Ross 308 broiler chickens (Gallus gallus L. ). Sel’skokhozyaistvennaya Biol, 57 ( 6 ): 1147 - 1165 . https://doi.org/10.15389/agrobiology.2022.6.1147eng https://doi.org/10.15389/agrobiology.2022.6.1147eng
Vleeming W , Rambali B , Opperhuizen A , 2002 . The role of nitric oxide in cigarette smoking and nicotine addiction . Nicotine Tob Res , 4 ( 3 ): 341 - 348 . https://doi.org/10.1080/14622200210142724 https://doi.org/10.1080/14622200210142724
Wang M , Wang L , Shabbir S , et al. , 2023 . Effects of thiram exposure on liver metabolism of chickens . Front Vet Sci , 10 : 1139815 . https://doi.org/10.3389/fvets.2023.1139815 https://doi.org/10.3389/fvets.2023.1139815
Wu GY , Fang YZ , Yang S , et al. , 2004 . Glutathione metabolism and its implications for health . J Nutr , 134 ( 3 ): 489 - 492 . https://doi.org/10.1093/jn/134.3.489 https://doi.org/10.1093/jn/134.3.489
Yildirim EA , Laptev GY , Tiurina DG , et al. , 2024 . Investigating adverse effects of chronic dietary exposure to herbicide glyphosate on zootechnical characteristics and clinical, biochemical and immunological blood parameters in broiler chickens . Vet Res Commun , 48 ( 1 ): 153 - 164 . https://doi.org/10.1007/s11259-023-10195-x https://doi.org/10.1007/s11259-023-10195-x
Yoo HH , Kim IS , Yoo DH , et al. , 2016 . Effects of orally administered antibiotics on the bioavailability of amlodipine: gut microbiota-mediated drug interaction . J Hypertens , 34 ( 1 ): 156 - 162 . https://doi.org/10.1097/HJH.0000000000000773 https://doi.org/10.1097/HJH.0000000000000773
Yue H , Lei XW , Yang FL , et al. , 2010 . Reference gene selection for normalization of PCR analysis in chicken embryo fibroblast infected with H5N1 AIV . Virol Sin , 25 ( 6 ): 425 - 431 . https://doi.org/10.1007/s12250-010-3114-4 https://doi.org/10.1007/s12250-010-3114-4
Zeka F , Vanderheyden K , de Smet E , et al. , 2016 . Straightforward and sensitive RT-qPCR based gene expression analysis of FFPE samples . Sci Rep , 6 : 21418 . https://doi.org/10.1038/srep21418 https://doi.org/10.1038/srep21418
Zhan J , Liang YR , Liu DH , et al. , 2018 . Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota . Microbiome , 6 : 224 . https://doi.org/10.1186/s40168-018-0602-5 https://doi.org/10.1186/s40168-018-0602-5
Zhang H , Mehmood K , Li K , et al. , 2018 . Icariin ameliorate thiram-induced tibial dyschondroplasia via regulation of WNT4 and VEGF expression in broiler chickens . Front Pharmacol , 9 : 123 . https://doi.org/10.3389/fphar.2018.00123 https://doi.org/10.3389/fphar.2018.00123
Zhang M , Nii T , Isobe N , et al. , 2012 . Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters . Poult Sci , 91 ( 8 ): 1997 - 2003 . https://doi.org/10.3382/ps.2012-02236 https://doi.org/10.3382/ps.2012-02236
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