Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives

Xiaoyu HAN; Peijun LI; Meiling JIANG; Yuanyuan CAO; Yingqi WANG; Linhong JIANG; Xiaodan LIU; Weibing WU

doi:10.1631/jzus.B2300680

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Review | Updated：2025-03-13

Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives
Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives
自噬在慢性阻塞性肺疾病骨骼肌功能障碍中的作用、机制和展望
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 3, Pages: 227-239(2025)
Affiliations：

1.Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China
2.School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3.Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China
4.Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai 201203, China
Funds：
DOI：10.1631/jzus.B2300680
CLC：
CSTR：
Received：19 September 2023，

Revised：22 December 2023，

Published Online：01 March 2025，

Published：13 March 2025
Accepted：

韩晓雨,李培君,姜美玲等.自噬在慢性阻塞性肺疾病骨骼肌功能障碍中的作用、机制和展望[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(03):227-239.

Xiaoyu HAN, Peijun LI, Meiling JIANG, et al. Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(3): 227-239.
韩晓雨,李培君,姜美玲等.自噬在慢性阻塞性肺疾病骨骼肌功能障碍中的作用、机制和展望[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(03):227-239. DOI： 10.1631/jzus.B2300680.

Xiaoyu HAN, Peijun LI, Meiling JIANG, et al. Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(3): 227-239. DOI： 10.1631/jzus.B2300680.

摘要

骨骼肌功能障碍是慢性阻塞性肺疾病（COPD）患者常见的肺外共病，与患者生活质量和存活率相关。自噬溶酶体途径作为机体蛋白水解系统，影响骨骼肌结构和功能。然而，促进和抑制自噬均被发现可显著改善COPD骨骼肌的结构和功能，但其中机制尚未可知。本文首先综述巨自噬和线粒体自噬对COPD骨骼肌结构和功能的作用，并进一步探究自噬介导COPD骨骼肌功能障碍的机制。结果表明，巨自噬和线粒体自噬相关蛋白在COPD骨骼肌中显著升高，促进巨自噬可显著提高COPD肌卫星细胞的肌生成和复制能力，而体外抑制COPD肌管巨自噬可增加肌管直径。线粒体自噬有助于通过清除COPD受损线粒体来维持线粒体稳态。综上，自噬作为改善COPD骨骼肌功能障碍的潜在靶点，仍需进一步研究其在调节COPD骨骼肌功能的具体机制，以加深对该领域的理解。

Abstract

Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease (COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathway is one of the proteolytic systems that significantly affect skeletal muscle structure and function. Intriguingly

both promoting and inhibiting autophagy have been observed to improve COPD skeletal muscle dysfunction

yet the mechanism is unclear. This paper first reviewed the effects of macroautophagy and mitophagy on the structure and function of skeletal muscle in COPD

and then explored the mechanism of autophagy mediating the dysfunction of skeletal muscle in COPD. The results showed that macroautophagy- and mitophagy-related proteins were significantly increased in COPD skeletal muscle. Promoting macroautophagy in COPD improves myogenesis and replication capacity of muscle satellite cells

while inhibiting macroautophagy in COPD myotubes increases their diameters. Mitophagy helps to maintain mitochondrial homeostasis by removing impaired mitochondria in COPD. Autophagy is a promising target for improving COPD skeletal muscle dysfunction

and further research should be conducted to elucidate the specific mechanisms by which autophagy mediates COPD skeletal muscle dysfunction

with the aim of enhancing our understanding in this field.

关键词

Keywords

references

Baechler BL , Bloemberg D , Quadrilatero J , 2019 . Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation . Autophagy , 15 ( 9 ): 1606 - 1619 . https://doi.org/10.1080/15548627.2019.1591672 https://doi.org/10.1080/15548627.2019.1591672

Balnis J , Drake LA , Singer DV , et al. , 2022 . Deaccelerated myogenesis and autophagy in genetically induced pulmonary emphysema . Am J Respir Cell Mol Biol , 66 ( 6 ): 623 - 637 . https://doi.org/10.1165/rcmb.2021-0351OC https://doi.org/10.1165/rcmb.2021-0351OC

Bellot G , Garcia-Medina R , Gounon P , et al. , 2009 . Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains . Mol Cell Biol , 29 ( 10 ): 2570 - 2581 . https://doi.org/10.1128/mcb.00166-09 https://doi.org/10.1128/mcb.00166-09

Benz E , Trajanoska K , Lahousse L , et al. , 2019 . Sarcopenia in COPD: a systematic review and meta-analysis . Eur Respir Rev , 28 ( 154 ): 190049 . https://doi.org/10.1183/16000617.0049-2019 https://doi.org/10.1183/16000617.0049-2019

Bernard S , Leblanc P , Whittom F , et al. , 1998 . Peripheral muscle weakness in patients with chronic obstructive pulmonary disease . Am J Respir Crit Care Med , 158 ( 2 ): 629 - 634 . https://doi.org/10.1164/ajrccm.158.2.9711023 https://doi.org/10.1164/ajrccm.158.2.9711023

Bujak AL , Crane JD , Lally JS , et al. , 2015 . AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging . Cell Metab , 21 ( 6 ): 883 - 890 . https://doi.org/10.1016/j.cmet.2015.05.016 https://doi.org/10.1016/j.cmet.2015.05.016

Ceelen JJM , Schols AMWJ , van Hoof SJ , et al. , 2017 . Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation . Respir Res , 18 ( 1 ): 75 . https://doi.org/10.1186/s12931-017-0531-z https://doi.org/10.1186/s12931-017-0531-z

Chen M , Chen ZH , Wang YY , et al. , 2016 . Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy . Autophagy , 12 ( 4 ): 689 - 702 . https://doi.org/10.1080/15548627.2016.1151580 https://doi.org/10.1080/15548627.2016.1151580

Chen W , Chen YS , Liu YX , et al. , 2022 . Autophagy in muscle regeneration: potential therapies for myopathies . J Cachexia Sarcopenia Muscle , 13 ( 3 ): 1673 - 1685 . https://doi.org/10.1002/jcsm.13000 https://doi.org/10.1002/jcsm.13000

Christenson SA , Smith BM , Bafadhel M , et al. , 2022 . Chronic obstructive pulmonary disease . Lancet , 399 ( 10342 ): 2227 - 2242 . https://doi.org/10.1016/s0140-6736(22)00470-6 https://doi.org/10.1016/s0140-6736(22)00470-6

Debigaré R , Côté CH , Hould FS , et al. , 2003 . In vitro and in vivo contractile properties of the vastus lateralis muscle in males with COPD . Eur Respir J , 21 ( 2 ): 273 - 278 . https://doi.org/10.1183/09031936.03.00036503 https://doi.org/10.1183/09031936.03.00036503

Eldeeb MA , Thomas RA , Ragheb MA , et al. , 2022 . Mitochondrial quality control in health and in Parkinson’s disease . Physiol Rev , 102 ( 4 ): 1721 - 1755 . https://doi.org/10.1152/physrev.00041.2021 https://doi.org/10.1152/physrev.00041.2021

Evans RA , Kaplovitch E , Beauchamp MK , et al. , 2015 . Is quadriceps endurance reduced in COPD?: a systematic review . Chest , 147 ( 3 ): 673 - 684 . https://doi.org/10.1378/chest.14-1079 https://doi.org/10.1378/chest.14-1079

Faucher M , Steinberg JG , Barbier D , et al. , 2004 . Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans . Clin Physiol Funct Imaging , 24 ( 2 ): 75 - 84 . https://doi.org/10.1111/j.1475-097X.2004.00533.x https://doi.org/10.1111/j.1475-097X.2004.00533.x

Fermont JM , Masconi KL , Jensen MT , et al. , 2019 . Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis . Thorax , 74 ( 5 ): 439 - 446 . https://doi.org/10.1136/thoraxjnl-2018-211855 https://doi.org/10.1136/thoraxjnl-2018-211855

Fiacco E , Castagnetti F , Bianconi V , et al. , 2016 . Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles . Cell Death Differ , 23 ( 11 ): 1839 - 1849 . https://doi.org/10.1038/cdd.2016.70 https://doi.org/10.1038/cdd.2016.70

Fivenson EM , Lautrup S , Sun N , et al. , 2017 . Mitophagy in neurodegeneration and aging . Neurochem Int , 109 : 202 - 209 . https://doi.org/10.1016/j.neuint.2017.02.007 https://doi.org/10.1016/j.neuint.2017.02.007

Franssen FME , Broekhuizen R , Janssen PP , et al. , 2005 . Limb muscle dysfunction in COPD: effects of muscle wasting and exercise training . Med Sci Sports Exerc , 37 ( 1 ): 2 - 9 . https://doi.org/10.1249/01.mss.0000150082.59155.4f https://doi.org/10.1249/01.mss.0000150082.59155.4f

García-Prat L , Martínez-Vicente M , Perdiguero E , et al. , 2016 . Autophagy maintains stemness by preventing senescence . Nature , 529 ( 7584 ): 37 - 42 . https://doi.org/10.1038/nature16187 https://doi.org/10.1038/nature16187

Gifford JR , Trinity JD , Kwon OS , et al. , 2018 . Altered skeletal muscle mitochondrial phenotype in COPD: disease vs . disuse. J Appl Physiol , 124 ( 4 ): 1045 - 1053 . https://doi.org/10.1152/japplphysiol.00788.2017 https://doi.org/10.1152/japplphysiol.00788.2017

Global Initiatives for Chronic Obstructive Lung Disease , 2023 . Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2023 Report) . https://goldcopd.org/2023-gold-report-2 https://goldcopd.org/2023-gold-report-2

Gouzi F , Blaquière M , Catteau M , et al. , 2018 . Oxidative stress regulates autophagy in cultured muscle cells of patients with chronic obstructive pulmonary disease . J Cell Physiol , 233 ( 12 ): 9629 - 9639 . https://doi.org/10.1002/jcp.26868 https://doi.org/10.1002/jcp.26868

Guo YT , Gosker HR , Schols AMWJ , et al. , 2013 . Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease . Am J Respir Crit Care Med , 188 ( 11 ): 1313 - 1320 . https://doi.org/10.1164/rccm.201304-0732OC https://doi.org/10.1164/rccm.201304-0732OC

He CC , Bassik MC , Moresi V , et al. , 2012 . Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis . Nature , 481 ( 7382 ): 511 - 515 . https://doi.org/10.1038/nature10758 https://doi.org/10.1038/nature10758

Henrot P , Blervaque L , Dupin I , et al. , 2023 . Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models . J Cachexia Sarcopenia Muscle , 14 ( 2 ): 745 - 757 . https://doi.org/10.1002/jcsm.13103 https://doi.org/10.1002/jcsm.13103

Hussain SNA , Sandri M , 2013 . Role of autophagy in COPD skeletal muscle dysfunction . J Appl Physiol , 114 ( 9 ): 1273 - 1281 . https://doi.org/10.1152/japplphysiol.00893.2012 https://doi.org/10.1152/japplphysiol.00893.2012

Ito A , Hashimoto M , Tanihata J , et al. , 2022 . Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia . J Cachexia Sarcopenia Muscle , 13 ( 3 ): 1864 - 1882 . https://doi.org/10.1002/jcsm.12988 https://doi.org/10.1002/jcsm.12988

Jaitovich A , Barreiro E , 2018 . Skeletal muscle dysfunction in chronic obstructive pulmonary disease . What we know and can do for our patients. Am J Respir Crit Care Med , 198 ( 2 ): 175 - 186 . https://doi.org/10.1164/rccm.201710-2140CI https://doi.org/10.1164/rccm.201710-2140CI

Jakobsson P , Jorfeldt L , Henriksson J , 1995 . Metabolic enzyme activity in the quadriceps femoris muscle in patients with severe chronic obstructive pulmonary disease . Am J Respir Crit Care Med , 151 ( 2 ): 374 - 377 . https://doi.org/10.1164/ajrccm.151.2.7842194 https://doi.org/10.1164/ajrccm.151.2.7842194

Jeong SJ , Zhang XY , Rodriguez-Velez A , et al. , 2019 . p62/ SQSTM1 and selective autophagy in cardiometabolic diseases . Antioxid Redox Signal , 31 ( 6 ): 458 - 471 . https://doi.org/10.1089/ars.2018.7649 https://doi.org/10.1089/ars.2018.7649

Kim J , Kundu M , Viollet B , et al. , 2011 . AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 . Nat Cell Biol , 13 ( 2 ): 132 - 141 . https://doi.org/10.1038/ncb2152 https://doi.org/10.1038/ncb2152

Kim KH , Jeong YT , Oh H , et al. , 2013 . Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine . Nat Med , 19 ( 1 ): 83 - 92 . https://doi.org/10.1038/nm.3014 https://doi.org/10.1038/nm.3014

Klionsky DJ , Abdel-Aziz AK , Abdelfatah S , et al. , 2021 . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . Autophagy , 17 ( 1 ): 1 - 382 . https://doi.org/10.1080/15548627.2020.1797280 https://doi.org/10.1080/15548627.2020.1797280

Kneppers AEM , Langen RCJ , Gosker HR , et al. , 2017 . Increased myogenic and protein turnover signaling in skeletal muscle of chronic obstructive pulmonary disease patients with sarcopenia . J Am Med Dir Assoc , 18 ( 7 ): 637.e1 - 637.e11 . https://doi.org/10.1016/j.jamda.2017.04.016 https://doi.org/10.1016/j.jamda.2017.04.016

Laker RC , Drake JC , Wilson RJ , et al. , 2017 . AMPK phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy . Nat Commun , 8 : 548 . https://doi.org/10.1038/s41467-017-00520-9 https://doi.org/10.1038/s41467-017-00520-9

Lazarou M , Sliter DA , Kane LA , et al. , 2015 . The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy . Nature , 524 ( 7565 ): 309 - 314 . https://doi.org/10.1038/nature14893 https://doi.org/10.1038/nature14893

Leermakers PA , Schols AMWJ , Kneppers AEM , et al. , 2018 . Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) . Sci Rep , 8 : 15007 . https://doi.org/10.1038/s41598-018-33471-2 https://doi.org/10.1038/s41598-018-33471-2

Leermakers PA , Remels AHV , Langen RCJ , et al. , 2020 . Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle . BMC Pulm Med , 20 : 20 . https://doi.org/10.1186/s12890-020-1047-8 https://doi.org/10.1186/s12890-020-1047-8

Lemire BB , Debigaré R , Dubé A , et al. , 2012 . MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease . J Appl Physiol , 113 ( 1 ): 159 - 166 . https://doi.org/10.1152/japplphysiol.01518.2011 https://doi.org/10.1152/japplphysiol.01518.2011

Lin A , Yao J , Zhuang L , et al. , 2014 . The FoxO‒BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress . Oncogene , 33 ( 24 ): 3183 - 3194 . https://doi.org/10.1038/onc.2013.273 https://doi.org/10.1038/onc.2013.273

Mador MJ , Bozkanat E , 2001 . Skeletal muscle dysfunction in chronic obstructive pulmonary disease . Respir Res , 2 ( 4 ): 216 . https://doi.org/10.1186/rr60 https://doi.org/10.1186/rr60

Maltais F , Decramer M , Casaburi R , et al. , 2014 . An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease . Am J Respir Crit Care Med , 189 ( 9 ): e15 - e62 . https://doi.org/10.1164/rccm.201402-0373ST https://doi.org/10.1164/rccm.201402-0373ST

Mano Y , Tsukamoto M , Wang KY , et al. , 2022 . Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model . J Bone Miner Metab , 40 ( 6 ): 927 - 939 . https://doi.org/10.1007/s00774-022-01371-1 https://doi.org/10.1007/s00774-022-01371-1

Mao J , Li Y , Feng SX , et al. , 2020 . Bufei Jianpi formula improves mitochondrial function and suppresses mitophagy in skeletal muscle via the adenosine monophosphate-activated protein kinase pathway in chronic obstructive pulmonary disease . Front Pharmacol , 11 : 587176 . https://doi.org/10.3389/fphar.2020.587176 https://doi.org/10.3389/fphar.2020.587176

Mason SE , Moreta-Martinez R , Labaki WW , et al. , 2022 . Longitudinal association between muscle loss and mortality in ever smokers . Chest , 161 ( 4 ): 960 - 970 . https://doi.org/10.1016/j.chest.2021.10.047 https://doi.org/10.1016/j.chest.2021.10.047

Mathur S , Brooks D , Carvalho CRF , 2014 . Structural alterations of skeletal muscle in COPD . Front Physiol , 5 : 104 . https://doi.org/10.3389/fphys.2014.00104 https://doi.org/10.3389/fphys.2014.00104

Mizushima N , Yoshimori T , 2007 . How to interpret LC3 immunoblotting . Autophagy , 3 ( 6 ): 542 - 545 . https://doi.org/10.4161/auto.4600 https://doi.org/10.4161/auto.4600

Mizushima N , Levine B , Cuervo AM , et al. , 2008 . Autophagy fights disease through cellular self-digestion . Nature , 451 ( 7182 ): 1069 - 1075 . https://doi.org/10.1038/nature06639 https://doi.org/10.1038/nature06639

Natanek SA , Riddoch-Contreras J , Marsh GS , et al. , 2013 . MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD . COPD J Chronic Obstruct Pulm Dis , 10 ( 5 ): 618 - 624 . https://doi.org/10.3109/15412555.2013.781577 https://doi.org/10.3109/15412555.2013.781577

Paré MF , Baechler BL , Fajardo VA , et al. , 2017 . Effect of acute and chronic autophagy deficiency on skeletal muscle apoptotic signaling, morphology, and function . Biochim Biophys Acta Mol Cell Res , 1864 ( 4 ): 708 - 718 . https://doi.org/10.1016/j.bbamcr.2016.12.015 https://doi.org/10.1016/j.bbamcr.2016.12.015

Pomiès P , Rodriguez J , Blaquière M , et al. , 2015 . Reduced myotube diameter, atrophic signalling and elevated oxidative stress in cultured satellite cells from COPD patients . J Cell Mol Med , 19 ( 1 ): 175 - 186 . https://doi.org/10.1111/jcmm.12390 https://doi.org/10.1111/jcmm.12390

Puente-Maestu L , Pérez-Parra J , Godoy R , et al. , 2009 . Abnormal mitochondrial function in locomotor and respiratory muscles of COPD patients . Eur Respir J , 33 ( 5 ): 1045 - 1052 . https://doi.org/10.1183/09031936.00112408 https://doi.org/10.1183/09031936.00112408

Puente-Maestu L , Tejedor A , Lázaro A , et al. , 2012 . Site of mitochondrial reactive oxygen species production in skeletal muscle of chronic obstructive pulmonary disease and its relationship with exercise oxidative stress . Am J Respir Cell Mol Biol , 47 ( 3 ): 358 - 362 . https://doi.org/10.1165/rcmb.2011-0382OC https://doi.org/10.1165/rcmb.2011-0382OC

Puente-Maestu L , Lázaro A , Humanes B , 2013 . Metabolic derangements in COPD muscle dysfunction . J Appl Physiol , 114 ( 9 ): 1282 - 1290 . https://doi.org/10.1152/japplphysiol.00815.2012 https://doi.org/10.1152/japplphysiol.00815.2012

Puig-Vilanova E , Rodriguez DA , Lloreta J , et al. , 2015 . Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer . Free Radic Biol Med , 79 : 91 - 108 . https://doi.org/10.1016/j.freeradbiomed.2014.11.006 https://doi.org/10.1016/j.freeradbiomed.2014.11.006

Rikka S , Quinsay MN , Thomas RL , et al. , 2011 . Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover . Cell Death Differ , 18 ( 4 ): 721 - 731 . https://doi.org/10.1038/cdd.2010.146 https://doi.org/10.1038/cdd.2010.146

Roig M , Eng JJ , Macintyre DL , et al. , 2011 . Deficits in muscle strength, mass, quality, and mobility in people with chronic obstructive pulmonary disease . J Cardiopulm Rehabil Prev , 31 ( 2 ): 120 - 124 . https://doi.org/10.1097/HCR.0b013e3181f68ae4 https://doi.org/10.1097/HCR.0b013e3181f68ae4

Romanello V , Sandri M , 2016 . Mitochondrial quality control and muscle mass maintenance . Front Physiol , 6 : 422 . https://doi.org/10.3389/fphys.2015.00422 https://doi.org/10.3389/fphys.2015.00422

Seymour JM , Ward K , Sidhu PS , et al. , 2009 . Ultrasound measurement of rectus femoris cross-sectional area and the relationship with quadriceps strength in COPD . Thorax , 64 ( 5 ): 418 - 423 . https://doi.org/10.1136/thx.2008.103986 https://doi.org/10.1136/thx.2008.103986

Shrikrishna D , Patel M , Tanner RJ , et al. , 2012 . Quadriceps wasting and physical inactivity in patients with COPD . Eur Respir J , 40 ( 5 ): 1115 - 1122 . https://doi.org/10.1183/09031936.00170111 https://doi.org/10.1183/09031936.00170111

Singh AK , Kashyap MP , Tripathi VK , et al. , 2017 . Neuroprotection through rapamycin-induced activation of autophagy and PI3K/Akt1/mTOR/CREB signaling against amyloid-βinduced oxidative stress, synaptic/neurotransmission dysfunction, and neurodegeneration in adult rats . Mol Neurobiol , 54 ( 8 ): 5815 - 5828 . https://doi.org/10.1007/s12035-016-0129-3 https://doi.org/10.1007/s12035-016-0129-3

Spositon T , Oliveira JM , Rodrigues A , et al. , 2022 . Quadriceps weakness associated with mortality in individuals with chronic obstructive pulmonary disease . Ann Phys Rehabil Med , 65 ( 5 ): 101587 . https://doi.org/10.1016/j.rehab.2021.101587 https://doi.org/10.1016/j.rehab.2021.101587

Su LJ , Zhang JH , Gomez H , et al. , 2023 . Mitochondria ROS and mitophagy in acute kidney injury . Autophagy , 19 ( 2 ): 401 - 414 . https://doi.org/10.1080/15548627.2022.2084862 https://doi.org/10.1080/15548627.2022.2084862

Suzuki K , Akioka M , Kondo-Kakuta C , et al. , 2013 . Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae . J Cell Sci , 126 ( 11 ): 2534 - 2544 . https://doi.org/10.1242/jcs.122960 https://doi.org/10.1242/jcs.122960

Swallow EB , Reyes D , Hopkinson NS , et al. , 2007 . Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease . Thorax , 62 ( 2 ): 115 - 120 . https://doi.org/10.1136/thx.2006.062026 https://doi.org/10.1136/thx.2006.062026

Tashiro H , Takahashi K , Tanaka M , et al. , 2021 . Skeletal muscle is associated with exercise tolerance evaluated by cardiopulmonary exercise testing in Japanese patients with chronic obstructive pulmonary disease . Sci Rep , 11 : 15862 . https://doi.org/10.1038/s41598-021-95413-9 https://doi.org/10.1038/s41598-021-95413-9

Thériault ME , Paré MÈ , Lemire BB , et al. , 2014 . Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease . Respir Res , 15 : 35 . https://doi.org/10.1186/1465-9921-15-35 https://doi.org/10.1186/1465-9921-15-35

Torres SH , de Oca MM , Loeb E , et al. , 2011 . Gender and skeletal muscle characteristics in subjects with chronic obstructive pulmonary disease . Respir Med , 105 ( 1 ): 88 - 94 . https://doi.org/10.1016/j.rmed.2010.05.010 https://doi.org/10.1016/j.rmed.2010.05.010

Vermeeren MAP , Creutzberg EC , Schols AMWJ , et al. , 2006 . Prevalence of nutritional depletion in a large out-patient population of patients with COPD . Respir Med , 100 ( 8 ): 1349 - 1355 . https://doi.org/10.1016/j.rmed.2005.11.023 https://doi.org/10.1016/j.rmed.2005.11.023

Vestbo J , Prescott E , Almdal T , et al. , 2006 . Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study . Am J Respir Crit Care Med , 173 ( 1 ): 79 - 83 . https://doi.org/10.1164/rccm.200506-969OC https://doi.org/10.1164/rccm.200506-969OC

Wang P , Shao BZ , Deng ZQ , et al. , 2018 . Autophagy in ischemic stroke . Prog Neurobiol , 163 - 164 : 98 - 117 . https://doi.org/10.1016/j.pneurobio.2018.01.001 https://doi.org/10.1016/j.pneurobio.2018.01.001

World Health Organization , 2019 . Chronic obstructive pulmonary disease (COPD) . https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd) https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd)

Zhang LC , Gong HY , Sun QW , et al. , 2018 . Spermidine-activated satellite cells are associated with hypoacetylation in ACVR2B and Smad3 binding to myogenic genes in mice . J Agric Food Chem , 66 ( 2 ): 540 - 550 . https://doi.org/10.1021/acs.jafc.7b04482 https://doi.org/10.1021/acs.jafc.7b04482

Zorov DB , Juhaszova M , Sollott SJ , 2014 . Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release . Physiol Rev , 94 ( 3 ): 909 - 950 . https://doi.org/10.1152/physrev.00026.2013 https://doi.org/10.1152/physrev.00026.2013

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