Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer

Jiajie FANG; Ahmad ALHASKAWI; Yanzhao DONG; Cheng CHENG; Zhijie XU; Junjie TIAN; Sahar Ahmed ABDALBARY; Hui LU

doi:10.1631/jzus.B2300614

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Review | Updated：2025-02-25

Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer
Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer
前列腺癌精确诊断与治疗的分子成像探针技术的研究进展
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 2, Pages: 124-144(2025)
Affiliations：

1.Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
2.Department of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
3.Zhejiang Engineering Research Center for Urinary Bladder Carcinoma Innovation Diagnosis and Treatment, Hangzhou 310024, China
4.Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University, Beni Suef 62511, Egypt
5.Biomechanics and Microsurgery Labs, Nahda University, Beni Suef 62511, Egypt
6.Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, Hangzhou 310058, China
Funds：
DOI：10.1631/jzus.B2300614
CLC：
CSTR：
Received：29 August 2023，

Published Online：15 January 2025，

Published：25 February 2025
Accepted：

方家杰,Ahmad ALHASKAWI,董延钊等.前列腺癌精确诊断与治疗的分子成像探针技术的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):124-144.

Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, et al. Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 124-144.
方家杰,Ahmad ALHASKAWI,董延钊等.前列腺癌精确诊断与治疗的分子成像探针技术的研究进展[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):124-144. DOI： 10.1631/jzus.B2300614.

Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, et al. Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 124-144. DOI： 10.1631/jzus.B2300614.

摘要

前列腺癌是男性第二常见癌症，在2020年占新发癌症病例的14.1%。前列腺癌的侵袭性高度变异，取决于其在诊断时的分级和分期。尽管近年来前列腺癌治疗有所进步，但仍有一些患者在接受根治性治疗后会出现疾病的复发甚至进展的情况。精确的初始分期和复发监测决定了患者的治疗方案，进而影响患者的预后和生存率。相比传统影像学在前列腺癌的诊断和治疗中的局限性，新型分子探针的使用提高了前列腺癌检测的检出率、特异性和准确性。基于分子探针的影像学方式可以在活体系统中实现分子和细胞水平的生物学过程的可视化和定量测量。对前列腺癌肿瘤生物学的深入理解和新肿瘤生物标志物的发现，使得探索新的分子探针目标成为可能。新型配体的开发和基于纳米的传递技术的进步加速了分子探针的研究和开发。在此，我们总结了分子探针在正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）、磁共振成像（MRI）、光学成像和超声成像中的应用，并简述了前列腺癌中重要的靶分子。

Abstract

Prostate cancer is the second most common cancer in men

accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable

depending on its grade and stage at the time of diagnosis. Despite recent advances in prostate cancer treatment

some patients still experience recurrence or even progression after undergoing radical treatment. Accurate initial staging and monitoring for recurrence determine patient management

which in turn affect patient prognosis and survival. Classical imaging has limitations in the diagnosis and treatment of prostate cancer

but the use of novel molecular probes has improved the detection rate

specificity

and accuracy of prostate cancer detection. Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems. An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets. The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes. Here

we summarize the use of molecular probes in positron emission tomography (PET)

single-photon emission computed tomography (SPECT)

magnetic resonance imaging (MRI)

optical imaging

and ultrasound imaging

and provide a brief overview of important target molecules in prostate cancer.

关键词

Keywords

references

Adams JY , Johnson M , Sato M , et al. , 2002 . Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging . Nat Med , 8 ( 8 ): 891 - 896 . https://doi.org/10.1038/nm743 https://doi.org/10.1038/nm743

An Y , Chang W , Wang W , et al. , 2020 . A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn 2+ in healthy versus cancerous cells . J Adv Res , 24 : 363 - 370 . https://doi.org/10.1016/j.jare.2020.04.008 https://doi.org/10.1016/j.jare.2020.04.008

Asano Y , Inoue Y , Ikeda Y , et al. , 2011 . Phase I clinical study of NMK36: a new PET tracer with the synthetic amino acid analogue anti -[ 18 F ] FACBC . Ann Nucl Med , 25 ( 6 ): 414 - 418 . https://doi.org/10.1007/s12149-011-0477-z https://doi.org/10.1007/s12149-011-0477-z

Asim M , Massie CE , Orafidiya F , et al. , 2016 . Choline kinase alpha as an androgen receptor chaperone and prostate cancer therapeutic target . J Natl Cancer Inst , 108 ( 5 ): djv371 . https://doi.org/10.1093/jnci/djv371 https://doi.org/10.1093/jnci/djv371

Bai JW , Qiu SQ , Zhang GJ , 2023 . Molecular and functional imaging in cancer-targeted therapy: current applications and future directions . Signal Transduct Target Ther , 8 : 89 . https://doi.org/10.1038/s41392-023-01366-y https://doi.org/10.1038/s41392-023-01366-y

Banerjee SR , Kumar V , Lisok A , et al. , 2019 . Evaluation of 111 In-DOTA-5D3, a surrogate SPECT imaging agent for radioimmunotherapy of prostate-specific membrane antigen . J Nucl Med , 60 ( 3 ): 400 - 406 . https://doi.org/10.2967/jnumed.118.214403 https://doi.org/10.2967/jnumed.118.214403

Baratto L , Jadvar H , Iagaru A , 2018 . Prostate cancer theranostics targeting gastrin-releasing peptide receptors . Mol Imaging Biol , 20 ( 4 ): 501 - 509 . https://doi.org/10.1007/s11307-017-1151-1 https://doi.org/10.1007/s11307-017-1151-1

Basu S , Hess S , Nielsen Braad PE , et al. , 2014 . The basic principles of FDG-PET/CT imaging . PET Clin , 9 ( 4 ): 355 - 370 . https://doi.org/10.1016/j.cpet.2014.07.006 https://doi.org/10.1016/j.cpet.2014.07.006

Beattie BJ , Smith-Jones PM , Jhanwar YS , et al. , 2010 . Pharmacokinetic assessment of the uptake of 16β- 18 F-fluoro-5α- dihydrotestosterone (FDHT) in prostate tumors as measured by PET. J Nucl Med , 51 ( 2 ): 183 - 192 . https://doi.org/10.2967/jnumed.109.066159 https://doi.org/10.2967/jnumed.109.066159

Bénard F , Harsini S , Wilson D , et al. , 2022 . Intra-individual comparison of 18 F-sodium fluoride PET-CT and 99m Tc bone scintigraphy with SPECT in patients with prostate cancer or breast cancer at high risk for skeletal metastases (MITNEC-A1): a multicentre, phase 3 trial . Lancet Oncol , 23 ( 12 ): 1499 - 1507 . https://doi.org/10.1016/S1470-2045(22)00642-8 https://doi.org/10.1016/S1470-2045(22)00642-8

Bhatnagar A , Wang YC , Mease RC , et al. , 2014 . AEG-1 promoter-mediated imaging of prostate cancer . Cancer Res , 74 ( 20 ): 5772 - 5781 . https://doi.org/10.1158/0008-5472.Can-14-0018 https://doi.org/10.1158/0008-5472.Can-14-0018

Bianco FJ , Scardino PT , Eastham JA , 2005 . Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function (“trifecta”) . Urology , 66 (5 Suppl ): 83 - 94 . https://doi.org/10.1016/j.urology.2005.06.116 https://doi.org/10.1016/j.urology.2005.06.116

Bostwick DG , Pacelli A , Blute M , et al. , 1998 . Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases . Cancer , 82 ( 11 ): 2256 - 2261 . https://doi.org/10.1002/(sici)1097-0142(19980601)82:11<2256::aid-cncr22>3.0.co;2-s https://doi.org/10.1002/(sici)1097-0142(19980601)82:11<2256::aid-cncr22>3.0.co;2-s

Brawley OW , 2012 . Trends in prostate cancer in the United States . J Natl Cancer Inst Monogr , 2012 ( 45 ): 152 - 156 . https://doi.org/10.1093/jncimonographs/lgs035 https://doi.org/10.1093/jncimonographs/lgs035

Calais J , Cao MS , Nickols NG , 2018 . The utility of PET/CT in the planning of external radiation therapy for prostate cancer . J Nucl Med , 59 ( 4 ): 557 - 567 . https://doi.org/10.2967/jnumed.117.196444 https://doi.org/10.2967/jnumed.117.196444

Champagne A , Jain P , Vélot L , et al. , 2022 . A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy . Theranostics , 12 ( 2 ): 474 - 492 . https://doi.org/10.7150/thno.63744 https://doi.org/10.7150/thno.63744

Chandekar KR , Singh H , Kumar R , et al. , 2023 . Comparison of 18 F-PSMA-1007 PET/CT with 68 Ga-PSMA-11 PET/CT for initial staging in intermediate- and high-risk prostate cancer . Clin Nucl Med , 48 ( 1 ): e1 - e8 . https://doi.org/10.1097/rlu.0000000000004430 https://doi.org/10.1097/rlu.0000000000004430

Chatalic KL , Veldhoven-Zweistra J , Bolkestein M , et al. , 2015 . A novel ¹¹¹In-labeled anti-prostate-specific membrane antigen nanobody for targeted SPECT/CT imaging of prostate cancer . J Nucl Med , 56 ( 7 ): 1094 - 1099 . https://doi.org/10.2967/jnumed.115.156729 https://doi.org/10.2967/jnumed.115.156729

Chen YN , Xu CD , Zhang ZY , et al. , 2021 . Prostate cancer identification via photoacoustic spectroscopy and machine learning . Photoacoustics , 23 : 100280 . https://doi.org/10.1016/j.pacs.2021.100280 https://doi.org/10.1016/j.pacs.2021.100280

Cheng LY , Yang TS , Zhang J , et al. , 2023 . The application of radiolabeled targeted molecular probes for the diagnosis and treatment of prostate cancer . Korean J Radiol , 24 ( 6 ): 574 - 589 . https://doi.org/10.3348/kjr.2022.1002 https://doi.org/10.3348/kjr.2022.1002

Combes AD , Palma CA , Calopedos R , et al. , 2022 . PSMA PET-CT in the diagnosis and staging of prostate cancer . Diagnostics (Basel) , 12 ( 11 ): 2594 . https://doi.org/10.3390/diagnostics12112594 https://doi.org/10.3390/diagnostics12112594

Cook GJR , Wong WL , Sanghera B , et al. , 2023 . Eligibility for 177 Lu-PSMA therapy depends on the choice of companion diagnostic tracer: a comparison of 68 Ga-PSMA-11 and 99m Tc-MIP-1404 in metastatic castration-resistant prostate cancer . J Nucl Med , 64 ( 2 ): 227 - 231 . https://doi.org/10.2967/jnumed.122.264296 https://doi.org/10.2967/jnumed.122.264296

Cooperberg MR , Broering JM , Carroll PR , 2010 . Time trends and local variation in primary treatment of localized prostate cancer . J Clin Oncol , 28 ( 7 ): 1117 - 1123 . https://doi.org/10.1200/jco.2009.26.0133 https://doi.org/10.1200/jco.2009.26.0133

Crișan G , Moldovean-Cioroianu NS , Timaru DG , et al. , 2022 . Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade . Int J Mol Sci , 23 ( 9 ): 5023 . https://doi.org/10.3390/ijms23095023 https://doi.org/10.3390/ijms23095023

Dell'Oglio P , Meershoek P , Maurer T , et al. , 2021 . A DROP-IN gamma probe for robot-assisted radioguided surgery of lymph nodes during radical prostatectomy . Eur Urol , 79 ( 1 ): 124 - 132 . https://doi.org/10.1016/j.eururo.2020.10.031 https://doi.org/10.1016/j.eururo.2020.10.031

de Vincentis G , Gerritsen W , Gschwend JE , et al. , 2019 . Advances in targeted alpha therapy for prostate cancer . Ann Oncol , 30 ( 11 ): 1728 - 1739 . https://doi.org/10.1093/annonc/mdz270 https://doi.org/10.1093/annonc/mdz270

Dmochowska N , Milanova V , Mukkamala R , et al. , 2023 . Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumors . Small , 19 ( 21 ): 2204956 . https://doi.org/10.1002/smll.202204956 https://doi.org/10.1002/smll.202204956

Dong SL , Wang YH , Liu ZQ , et al. , 2020 . Beehive-inspired macroporous SERS probe for cancer detection through capturing and analyzing exosomes in plasma . ACS Appl Mater Interfaces , 12 ( 4 ): 5136 - 5146 . https://doi.org/10.1021/acsami.9b21333 https://doi.org/10.1021/acsami.9b21333

Dong YZ , Zhou HY , Alhaskawi A , et al. , 2023 . The superiority of fibroblast activation protein inhibitor (FAPI) PET/CT versus FDG PET/CT in the diagnosis of various malignancies . Cancers (Basel) , 15 ( 4 ): 1193 . https://doi.org/10.3390/cancers15041193 https://doi.org/10.3390/cancers15041193

Dorfinger J , Ponholzer A , Stolzlechner M , et al. , 2022 . MRI/ultrasound fusion biopsy of the prostate compared to systematic prostate biopsy—effectiveness and accuracy of a combined approach in daily clinical practice . Eur J Radiol , 154 : 110432 . https://doi.org/10.1016/j.ejrad.2022.110432 https://doi.org/10.1016/j.ejrad.2022.110432

Eder AC , Omrane MA , Stadlbauer S , et al. , 2021 . The PSMA-11-derived hybrid molecule PSMA-914 specifically identifies prostate cancer by preoperative PET/CT and intraoperative fluorescence imaging . Eur J Nucl Med Mol Imaging , 48 ( 6 ): 2057 - 2058 . https://doi.org/10.1007/s00259-020-05184-0 https://doi.org/10.1007/s00259-020-05184-0

Effert P , Beniers AJ , Tamimi Y , et al. , 2004 . Expression of glucose transporter 1 (Glut-1) in cell lines and clinical specimens from human prostate adenocarcinoma . Anticancer Res , 24 ( 5 A): 3057 - 3063 .

Eisenhauer EA , Therasse P , Bogaerts J , et al. , 2009 . New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) . Eur J Cancer , 45 ( 2 ): 228 - 247 . https://doi.org/10.1016/j.ejca.2008.10.026 https://doi.org/10.1016/j.ejca.2008.10.026

Evazalipour M , D'Huyvetter M , Tehrani BS , et al. , 2014 . Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer . Contrast Media Mol Imaging , 9 ( 3 ): 211 - 220 . https://doi.org/10.1002/cmmi.1558 https://doi.org/10.1002/cmmi.1558

Fan KL , Cao CQ , Pan YX , et al. , 2012 . Magnetoferritin nanoparticles for targeting and visualizing tumour tissues . Nat Nanotechnol , 7 ( 7 ): 459 - 464 . https://doi.org/10.1038/nnano.2012.90 https://doi.org/10.1038/nnano.2012.90

Ferro M , de Cobelli O , Vartolomei MD , et al. , 2021 . Prostate cancer radiogenomics-from imaging to molecular characterization . Int J Mol Sci , 22 ( 18 ): 9971 . https://doi.org/10.3390/ijms22189971 https://doi.org/10.3390/ijms22189971

Filippi L , Bagni O , Crisafulli C , et al. , 2022 . Detection rate and clinical impact of PET/CT with 18 F-FACBC in patients with biochemical recurrence of prostate cancer: a retrospective bicentric study . Biomedicines , 10 ( 1 ): 177 . https://doi.org/10.3390/biomedicines10010177 https://doi.org/10.3390/biomedicines10010177

Fortuin A , van Asten J , Veltien A , et al. , 2023 . Small suspicious lymph nodes detected on ultrahigh-field magnetic resonance imaging (MRI) in patients with prostate cancer with high risk of nodal metastases: the first in-patient study on ultrasmall superparamagnetic iron oxide-enhanced 7T MRI . Eur Urol , 83 ( 4 ): 375 - 377 . https://doi.org/10.1016/j.eururo.2023.01.002 https://doi.org/10.1016/j.eururo.2023.01.002

Fortuin AS , Brüggemann R , van der Linden J , et al. , 2018 . Ultra-small superparamagnetic iron oxides for metastatic lymph node detection: back on the block . WIREs Nanomed Nanobiotechnol , 10 ( 1 ): e1471 . https://doi.org/10.1002/wnan.1471 https://doi.org/10.1002/wnan.1471

Fosbøl MØ , Kurbegovic S , Johannesen HH , et al. , 2021 . Urokinase-type plasminogen activator receptor (uPAR) PET/MRI of prostate cancer for noninvasive evaluation of aggressiveness: comparison with gleason score in a prospective phase 2 clinical trial . J Nucl Med , 62 ( 3 ): 354 - 359 . https://doi.org/10.2967/jnumed.120.248120 https://doi.org/10.2967/jnumed.120.248120

Gai YK , Yuan LJ , Sun LY , et al. , 2020 . Comparison of Al 18 F- and 68 Ga-labeled NOTA-PEG 4 -LLP2A for PET imaging of very late antigen-4 in melanoma . J Biol Inorg Chem , 25 ( 1 ): 99 - 108 . https://doi.org/10.1007/s00775-019-01742-6 https://doi.org/10.1007/s00775-019-01742-6

García-Pérez FO , Davanzo J , López-Buenrostro S , et al. , 2018 . Head to head comparison performance of 99m Tc-EDDA/HYNIC-iPSMA SPECT/CT and 68 Ga-PSMA-11 PET/CT a prospective study in biochemical recurrence prostate cancer patients . Am J Nucl Med Mol Imaging , 8 ( 5 ): 332 - 340 .

Giesel FL , Hadaschik B , Cardinale J , et al. , 2017 . F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients . Eur J Nucl Med Mol Imaging , 44 ( 4 ): 678 - 688 . https://doi.org/10.1007/s00259-016-3573-4 https://doi.org/10.1007/s00259-016-3573-4

Gondoputro W , Scheltema MJ , Blazevski A , et al. , 2022 . Robot-assisted prostate-specific membrane antigen-radioguided surgery in primary diagnosed prostate cancer . J Nucl Med , 63 ( 11 ): 1659 - 1664 . https://doi.org/10.2967/jnumed.121.263743 https://doi.org/10.2967/jnumed.121.263743

Grover VPB , Tognarelli JM , Crossey MME , et al. , 2015 . Magnetic resonance imaging: principles and techniques: lessons for clinicians . J Clin Exp Hepatol , 5 ( 3 ): 246 - 255 . https://doi.org/10.1016/j.jceh.2015.08.001 https://doi.org/10.1016/j.jceh.2015.08.001

He YD , Xu WD , Xiao YT , et al. , 2022 . Targeting signaling pathways in prostate cancer: mechanisms and clinical trials . Signal Transduct Target Ther , 7 : 198 . https://doi.org/10.1038/s41392-022-01042-7 https://doi.org/10.1038/s41392-022-01042-7

Heesakkers RAM , Fütterer JJ , Hövels AM , et al. , 2006 . Prostate cancer evaluated with ferumoxtran-10‒enhanced T2*-weighted MR imaging at 1.5 and 3.0 T: early experience . Radiology , 239 ( 2 ): 481 - 487 . https://doi.org/10.1148/radiol.2392050411 https://doi.org/10.1148/radiol.2392050411

Hegde JV , Mulkern RV , Panych LP , et al. , 2013 . Multiparametric MRI of prostate cancer: an update on state-of-the-art techniques and their performance in detecting and localizing prostate cancer . J Magn Reson Imaging , 37 ( 5 ): 1035 - 1054 . https://doi.org/10.1002/jmri.23860 https://doi.org/10.1002/jmri.23860

Hernot S , Klibanov AL , 2008 . Microbubbles in ultrasound-triggered drug and gene delivery . Adv Drug Deliv Rev , 60 ( 10 ): 1153 - 1166 . https://doi.org/10.1016/j.addr.2008.03.005 https://doi.org/10.1016/j.addr.2008.03.005

Hernot S , van Manen L , Debie P , et al. , 2019 . Latest developments in molecular tracers for fluorescence image-guided cancer surgery . Lancet Oncol , 20 ( 7 ): e354 - e367 . https://doi.org/10.1016/S1470-2045(19)30317-1 https://doi.org/10.1016/S1470-2045(19)30317-1

Hintz HM , Gallant JP , Vander Griend DJ , et al. , 2020 . Imaging fibroblast activation protein alpha improves diagnosis of metastatic prostate cancer with positron emission tomography . Clin Cancer Res , 26 ( 18 ): 4882 - 4891 . https://doi.org/10.1158/1078-0432.Ccr-20-1358 https://doi.org/10.1158/1078-0432.Ccr-20-1358

Hong SH , Sun Y , Tang C , et al. , 2017 . Chelator-free and biocompatible melanin nanoplatform with facile-loading gadolinium and copper-64 for bioimaging . Bioconjugate Chem , 28 ( 7 ): 1925 - 1930 . https://doi.org/10.1021/acs.bioconjchem.7b00245 https://doi.org/10.1021/acs.bioconjchem.7b00245

Hope TA , Eiber M , Armstrong WR , et al. , 2021 . Diagnostic accuracy of 68 Ga-PSMA-11 PET for pelvic nodal metastasis detection prior to radical prostatectomy and pelvic lymph node dissection: a multicenter prospective phase 3 imaging trial . JAMA Oncol , 7 ( 11 ): 1635 - 1642 . https://doi.org/10.1001/jamaoncol.2021.3771 https://doi.org/10.1001/jamaoncol.2021.3771

Hricak H , Choyke PL , Eberhardt SC , et al. , 2007 . Imaging prostate cancer: a multidisciplinary perspective . Radiology , 243 ( 1 ): 28 - 53 . https://doi.org/10.1148/radiol.2431030580 https://doi.org/10.1148/radiol.2431030580

Huang YT , Tseng NC , Chen YK , et al. , 2022 . The detection performance of 18 F-prostate-specific membrane antigen-1007 PET/CT in primary prostate cancer: a systemic review and meta-analysis . Clin Nucl Med , 47 ( 9 ): 755 - 762 . https://doi.org/10.1097/rlu.0000000000004228 https://doi.org/10.1097/rlu.0000000000004228

Isik EG , Has-Simsek D , Sanli O , et al. , 2022 . Fibroblast activation protein‒targeted PET imaging of metastatic castration-resistant prostate cancer compared with 68 Ga-PSMA and 18 F-FDG PET/CT . Clin Nucl Med , 47 ( 1 ): e54 - e55 . https://doi.org/10.1097/rlu.0000000000003837 https://doi.org/10.1097/rlu.0000000000003837

Israel O , Pellet O , Biassoni L , et al. , 2019 . Two decades of SPECT/CT ‒ the coming of age of a technology: an updated review of literature evidence . Eur J Nucl Med Mol Imaging , 46 ( 10 ): 1990 - 2012 . https://doi.org/10.1007/s00259-019-04404-6 https://doi.org/10.1007/s00259-019-04404-6

Jadvar H , 2011 . Prostate cancer: PET with 18 F-FDG, 18 F- or 11 C-acetate, and 18 F- or 11 C-choline . J Nucl Med , 52 ( 1 ): 81 - 89 . https://doi.org/10.2967/jnumed.110.077941 https://doi.org/10.2967/jnumed.110.077941

Jadvar H , 2012 . Molecular imaging of prostate cancer: PET radiotracers . Am J Roentgenol , 199 ( 2 ): 278 - 291 . https://doi.org/10.2214/ajr.12.8816 https://doi.org/10.2214/ajr.12.8816

Jermyn M , Mok K , Mercier J , et al. , 2015 . Intraoperative brain cancer detection with Raman spectroscopy in humans . Sci Transl Med , 7 ( 274 ): 274ra19 . https://doi.org/10.1126/scitranslmed.aaa2384 https://doi.org/10.1126/scitranslmed.aaa2384

Kaskova ZM , Tsarkova AS , Yampolsky IV , 2016 . 1001 lights: luciferins, luciferases, their mechanisms of action and applications in chemical analysis, biology and medicine . Chem Soc Rev , 45 ( 21 ): 6048 - 6077 . https://doi.org/10.1039/c6cs00296j https://doi.org/10.1039/c6cs00296j

Kinoshita Y , Kuratsukuri K , Landas S , et al. , 2006 . Expression of prostate-specific membrane antigen in normal and malignant human tissues . World J Surg , 30 ( 4 ): 628 - 636 . https://doi.org/10.1007/s00268-005-0544-5 https://doi.org/10.1007/s00268-005-0544-5

Knipper S , Mehdi Irai M , Simon R , et al. , 2023 . Cohort study of oligorecurrent prostate cancer patients: oncological outcomes of patients treated with salvage lymph node dissection via prostate-specific membrane antigen-radioguided surgery . Eur Urol , 83 ( 1 ): 62 - 69 . https://doi.org/10.1016/j.eururo.2022.05.031 https://doi.org/10.1016/j.eururo.2022.05.031

Kothapalli SR , Sonn GA , Choe JW , et al. , 2019 . Simultaneous transrectal ultrasound and photoacoustic human prostate imaging . Sci Transl Med , 11 ( 507 ): eaav2169 . https://doi.org/10.1126/scitranslmed.aav2169 https://doi.org/10.1126/scitranslmed.aav2169

Kratochwil C , Flechsig P , Lindner T , et al. , 2019 . 68 Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer . J Nucl Med , 60 ( 6 ): 801 - 805 . https://doi.org/10.2967/jnumed.119.227967 https://doi.org/10.2967/jnumed.119.227967

Kularatne SA , Thomas M , Myers CH , et al. , 2019 . Evaluation of novel prostate-specific membrane antigen-targeted near-infrared imaging agent for fluorescence-guided surgery of prostate cancer . Clin Cancer Res , 25 ( 1 ): 177 - 187 . https://doi.org/10.1158/1078-0432.CCR-18-0803 https://doi.org/10.1158/1078-0432.CCR-18-0803

Kumar R , Singh SK , Mittal BR , et al. , 2022 . Safety and diagnostic yield of 68 Ga prostate-specific membrane antigen PET/CT-guided robotic-assisted transgluteal prostatic biopsy . Radiology , 303 ( 2 ): 392 - 398 . https://doi.org/10.1148/radiol.204066 https://doi.org/10.1148/radiol.204066

Kuten J , Fahoum I , Savin Z , et al. , 2020 . Head-to-head comparison of 68 Ga-PSMA-11 with 18 F-PSMA-1007 PET/CT in staging prostate cancer using histopathology and immunohistochemical analysis as a reference standard . J Nucl Med , 61 ( 4 ): 527 - 532 . https://doi.org/10.2967/jnumed.119.234187 https://doi.org/10.2967/jnumed.119.234187

Laudicella R , Albano D , Alongi P , et al. , 2019 . 18 F-FACBC in prostate cancer: a systematic review and meta-analysis . Cancers (Basel) , 11 ( 9 ): 1348 . https://doi.org/10.3390/cancers11091348 https://doi.org/10.3390/cancers11091348

Lawal IO , Ankrah AO , Mokgoro NP , et al. , 2017 . Diagnostic sensitivity of Tc-99m HYNIC PSMA SPECT/CT in prostate carcinoma: a comparative analysis with Ga-68 PSMA PET/CT . Prostate , 77 ( 11 ): 1205 - 1212 . https://doi.org/10.1002/pros.23379 https://doi.org/10.1002/pros.23379

Lawal IO , Marcus C , Schuster DM , et al. , 2023 . Impact of 18 F-fluciclovine PET/CT findings on failure-free survival in biochemical recurrence of prostate cancer following salvage radiation therapy . Clin Nucl Med , 48 ( 4 ): e153 - e159 . https://doi.org/10.1097/rlu.0000000000004590 https://doi.org/10.1097/rlu.0000000000004590

Lee C , Jeon M , Kim C , 2015 . Photoacoustic imaging in nanomedicine . In: Hamblin MR, Avci P (Eds.), Applications of Nanoscience in Photomedicine . Woodhead Publishing , Cambridge , p. 31 - 47 . https://doi.org/10.1533/9781908818782.31 https://doi.org/10.1533/9781908818782.31

Li SH , Li Q , Chen W , et al. , 2022 . A renal-clearable activatable molecular probe for fluoro-photacoustic and radioactive imaging of cancer biomarkers . Small , 18 ( 28 ): 2201334 . https://doi.org/10.1002/smll.202201334 https://doi.org/10.1002/smll.202201334

Lindenberg L , Ahlman M , Turkbey B , et al. , 2016 . Evaluation of prostate cancer with PET/MRI . J Nucl Med , 57 ( Suppl 3 ): 111S - 116S . https://doi.org/10.2967/jnumed.115.169763 https://doi.org/10.2967/jnumed.115.169763

Lindenberg L , Mena E , Turkbey B , et al. , 2020 . Evaluating biochemically recurrent prostate cancer: histologic validation of 18 F-DCFPyL PET/CT with comparison to multiparametric MRI . Radiology , 296 ( 3 ): 564 - 572 . https://doi.org/10.1148/radiol.2020192018 https://doi.org/10.1148/radiol.2020192018

Liu F , Qi L , Liu B , et al. , 2015 . Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis . PLoS ONE , 10 ( 3 ): e0116683 . https://doi.org/10.1371/journal.pone.0116683 https://doi.org/10.1371/journal.pone.0116683

Liu X , Jiang T , Gao CL , et al. , 2022 . Detection rate of fluorine-18 prostate-specific membrane antigen-1007 PET/CT for prostate cancer in primary staging and biochemical recurrence with different serum PSA levels: a systematic review and meta-analysis . Front Oncol , 12 : 911146 . https://doi.org/10.3389/fonc.2022.911146 https://doi.org/10.3389/fonc.2022.911146

Macheda ML , Rogers S , Best JD , 2005 . Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer . J Cell Physiol , 202 ( 3 ): 654 - 662 . https://doi.org/10.1002/jcp.20166 https://doi.org/10.1002/jcp.20166

Mansi R , Fleischmann A , Mäcke HR , et al. , 2013 . Targeting GRPR in urological cancers—from basic research to clinical application . Nat Rev Urol , 10 ( 4 ): 235 - 244 . https://doi.org/10.1038/nrurol.2013.42 https://doi.org/10.1038/nrurol.2013.42

Marcus C , Abiodun-Ojo OA , Jani AB , et al. , 2021 . Clinical utility of 18 F-fluciclovine PET/CT in recurrent prostate cancer with very low (≤0.3 ng/mL) prostate-specific antigen levels . Am J Nucl Med Mol Imaging , 11 ( 5 ): 406 - 414 .

Maurer T , Eiber M , Schwaiger M , et al. , 2016 . Current use of PSMA-PET in prostate cancer management . Nat Rev Urol , 13 ( 4 ): 226 - 235 . https://doi.org/10.1038/nrurol.2016.26 https://doi.org/10.1038/nrurol.2016.26

Mease RC , Kang CM , Kumar V , et al. , 2022 . An improved 211 At-labeled agent for PSMA-targeted α-therapy . J Nucl Med , 63 ( 2 ): 259 - 267 . https://doi.org/10.2967/jnumed.121.262098 https://doi.org/10.2967/jnumed.121.262098

Mena E , Black PC , Rais-Bahrami S , et al. , 2021 . Novel PET imaging methods for prostate cancer . World J Urol , 39 ( 3 ): 687 - 699 . https://doi.org/10.1007/s00345-020-03344-3 https://doi.org/10.1007/s00345-020-03344-3

Meng ZY , Zhang Y , Shen E , et al. , 2021 . Marriage of virus-mimic surface topology and microbubble-assisted ultrasound for enhanced intratumor accumulation and improved cancer theranostics . Adv Sci (Weinh) , 8 ( 13 ): 2004670 . https://doi.org/10.1002/advs.202004670 https://doi.org/10.1002/advs.202004670

Miller ET , Salmasi A , Reiter RE , 2018 . Anatomic and molecular imaging in prostate cancer . Cold Spring Harb Perspect Med , 8 ( 3 ): a030619 . https://doi.org/10.1101/cshperspect.a030619 https://doi.org/10.1101/cshperspect.a030619

Nanni C , Schiavina R , Brunocilla E , et al. , 2015 . 18 F-fluciclovine PET/CT for the detection of prostate cancer relapse: a comparison to 11 C-choline PET/CT . Clin Nucl Med , 40 ( 8 ): e386 - e391 . https://doi.org/10.1097/rlu.0000000000000849 https://doi.org/10.1097/rlu.0000000000000849

Nessler I , Khera E , Vance S , et al. , 2020 . Increased tumor penetration of single-domain antibody-drug conjugates improves in vivo efficacy in prostate cancer models . Cancer Res , 80 ( 6 ): 1268 - 1278 . https://doi.org/10.1158/0008-5472.Can-19-2295 https://doi.org/10.1158/0008-5472.Can-19-2295

O'Keefe DS , Su SL , Bacich DJ , et al. , 1998 . Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene . Biochim Biophys Acta , 1443 ( 1-2 ): 113 - 127 . https://doi.org/10.1016/s0167-4781(98)00200-0 https://doi.org/10.1016/s0167-4781(98)00200-0

O'Sullivan JM , Norman AR , Cook GJ , et al. , 2003 . Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital . BJU Int , 92 ( 7 ): 685 - 689 . https://doi.org/10.1046/j.1464-410x.2003.04480.x https://doi.org/10.1046/j.1464-410x.2003.04480.x

Papagiannopoulou D , 2017 . Technetium-99m radiochemistry for pharmaceutical applications . J Labelled Comp Radiopharm , 60 ( 11 ): 502 - 520 . https://doi.org/10.1002/jlcr.3531 https://doi.org/10.1002/jlcr.3531

Parker C , Castro E , Fizazi K , et al. , 2020 . Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up . Ann Oncol , 31 ( 9 ): 1119 - 1134 . https://doi.org/10.1016/j.annonc.2020.06.011 https://doi.org/10.1016/j.annonc.2020.06.011

Pathmanandavel S , Crumbaker M , Nguyen A , et al. , 2023 . The prognostic value of posttreatment 68 Ga-PSMA-11 PET/CT and 18 F-FDG PET/CT in metastatic castration-resistant prostate cancer treated with 177 Lu-PSMA-617 and NOX66 in a phase I/II trial (LuPIN) . J Nucl Med , 64 ( 1 ): 69 - 74 . https://doi.org/10.2967/jnumed.122.264104 https://doi.org/10.2967/jnumed.122.264104

Peltier A , Seban RD , Buvat I , et al. , 2022 . Fibroblast heterogeneity in solid tumors: from single cell analysis to whole-body imaging . Semin Cancer Biol , 86 : 262 - 272 . https://doi.org/10.1016/j.semcancer.2022.04.008 https://doi.org/10.1016/j.semcancer.2022.04.008

Perera M , Papa N , Christidis D , et al. , 2016 . Sensitivity, specificity, and predictors of positive 68 Ga-prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysis . Eur Urol , 70 ( 6 ): 926 - 937 . https://doi.org/10.1016/j.eururo.2016.06.021 https://doi.org/10.1016/j.eururo.2016.06.021

Perera RH , de Leon A , Wang XN , et al. , 2020 . Real time ultrasound molecular imaging of prostate cancer with PSMA-targeted nanobubbles . Nanomed Nanotechnol Biol Med , 28 : 102213 . https://doi.org/10.1016/j.nano.2020.102213 https://doi.org/10.1016/j.nano.2020.102213

Pernthaler B , Kulnik R , Gstettner C , et al. , 2019 . A prospective head-to-head comparison of 18 F-fluciclovine with 68 Ga-PSMA-11 in biochemical recurrence of prostate cancer in PET/CT . Clin Nucl Med , 44 ( 10 ): e566 - e573 . https://doi.org/10.1097/rlu.0000000000002703 https://doi.org/10.1097/rlu.0000000000002703

Persson M , Skovgaard D , Brandt-Larsen M , et al. , 2015 . First-in-human uPAR PET: imaging of cancer aggressiveness . Theranostics , 5 ( 12 ): 1303 - 1316 . https://doi.org/10.7150/thno.12956 https://doi.org/10.7150/thno.12956

Petersen LJ , Zacho HD , 2020 . PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review . Cancer Imaging , 20 : 10 . https://doi.org/10.1186/s40644-020-0290-9 https://doi.org/10.1186/s40644-020-0290-9

Prasad V , Steffen IG , Diederichs G , et al. , 2016 . Biodistribution of [ 68 Ga ] PSMA-HBED-CC in patients with prostate cancer: characterization of uptake in normal organs and tumour lesions . Mol Imaging Biol , 18 ( 3 ): 428 - 436 . https://doi.org/10.1007/s11307-016-0945-x https://doi.org/10.1007/s11307-016-0945-x

Ramya AN , Joseph MM , Nair JB , et al. , 2016 . New insight of tetraphenylethylene-based Raman signatures for targeted SERS nanoprobe construction toward prostate cancer cell detection . ACS Appl Mater Interfaces , 8 ( 16 ): 10220 - 10225 . https://doi.org/10.1021/acsami.6b01908 https://doi.org/10.1021/acsami.6b01908

Ratain MJ , Eckhardt SG , 2004 . Phase II studies of modern drugs directed against new targets: if you are fazed, too, then resist RECIST . J Clin Oncol , 22 ( 22 ): 4442 - 4445 . https://doi.org/10.1200/jco.2004.07.960 https://doi.org/10.1200/jco.2004.07.960

Rathkopf DE , Morris MJ , Fox JJ , et al. , 2013 . Phase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer . J Clin Oncol , 31 ( 28 ): 3525 - 3530 . https://doi.org/10.1200/jco.2013.50.1684 https://doi.org/10.1200/jco.2013.50.1684

Ren JY , Yuan LL , Wen GH , et al. , 2016 . The value of anti-1-amino-3- 18 F-fluorocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recurrent prostate carcinoma: a meta-analysis . Acta Radiol , 57 ( 4 ): 487 - 493 . https://doi.org/10.1177/0284185115581541 https://doi.org/10.1177/0284185115581541

Ross JS , Sheehan CE , Fisher HAG , et al. , 2003 . Correlation of primary tumor prostate-specific membrane antigen expression with disease recurrence in prostate cancer . Clin Cancer Res , 9 ( 17 ): 6357 - 6362 .

Rowe SP , Pomper MG , 2022 . Molecular imaging in oncology: current impact and future directions . CA Cancer J Clin , 72 ( 4 ): 333 - 352 . https://doi.org/10.3322/caac.21713 https://doi.org/10.3322/caac.21713

Sadeghi-Naini A , Falou O , Hudson JM , et al. , 2012 . Imaging innovations for cancer therapy response monitoring . Imaging Med , 4 ( 3 ): 311 - 327 . https://doi.org/10.2217/iim.12.23 https://doi.org/10.2217/iim.12.23

Sanchez-Crespo A , 2013 . Comparison of Gallium-68 and Fluorine-18 imaging characteristics in positron emission tomography . Appl Radiat Isot , 76 : 55 - 62 . https://doi.org/10.1016/j.apradiso.2012.06.034 https://doi.org/10.1016/j.apradiso.2012.06.034

Sathianathen NJ , Butaney M , Konety BR , 2019 . The utility of PET-based imaging for prostate cancer biochemical recurrence: a systematic review and meta-analysis . World J Urol , 37 ( 7 ): 1239 - 1249 . https://doi.org/10.1007/s00345-018-2403-7 https://doi.org/10.1007/s00345-018-2403-7

Schmuck S , Mamach M , Wilke F , et al. , 2017 . Multiple time-point 68 Ga-PSMA I & T PET/CT for characterization of primary prostate cancer: value of early dynamic and delayed imagin g . Clin Nucl Med , 42 ( 6 ): e286 - e293 . https://doi.org/10.1097/rlu.0000000000001589 https://doi.org/10.1097/rlu.0000000000001589

Schollhammer R , Robert G , Asselineau J , et al. , 2023 . Comparison of 68 Ga-PSMA-617 PET/CT and 68 Ga-RM2 PET/CT in patients with localized prostate cancer who are candidates for radical prostatectomy: a prospective, single-arm, single-center, phase II study . J Nucl Med , 64 ( 3 ): 379 - 385 . https://doi.org/10.2967/jnumed.122.263889 https://doi.org/10.2967/jnumed.122.263889

Schottelius M , Wurzer A , Wissmiller K , et al. , 2019 . Synthesis and preclinical characterization of the PSMA-targeted hybrid tracer PSMA-I&F for nuclear and fluorescence imaging of prostate cancer . J Nucl Med , 60 ( 1 ): 71 - 78 . https://doi.org/10.2967/jnumed.118.212720 https://doi.org/10.2967/jnumed.118.212720

Serkova NJ , Glunde K , Haney CR , et al. , 2021 . Preclinical applications of multi-platform imaging in animal models of cancer . Cancer Res , 81 ( 5 ): 1189 - 1200 . https://doi.org/10.1158/0008-5472.Can-20-0373 https://doi.org/10.1158/0008-5472.Can-20-0373

Shen CJ , Minn I , Hobbs RF , et al. , 2020 . Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen in a micrometastatic model of prostate cancer . Theranostics , 10 ( 7 ): 2888 - 2896 . https://doi.org/10.7150/thno.38882 https://doi.org/10.7150/thno.38882

Silver DA , Pellicer I , Fair WR , et al. , 1997 . Prostate-specific membrane antigen expression in normal and malignant human tissues . Clin Cancer Res , 3 ( 1 ): 81 - 85 .

Skovgaard D , Persson M , Brandt-Larsen M , et al. , 2017 . Safety, dosimetry, and tumor detection ability of 68 Ga-NOTA-AE105: first-in-human study of a novel radioligand for uPAR PET imaging . J Nucl Med , 58 ( 3 ): 379 - 386 . https://doi.org/10.2967/jnumed.116.178970 https://doi.org/10.2967/jnumed.116.178970

Sodee DB , Malguria N , Faulhaber P , et al. , 2000 . Multicenter ProstaScint imaging findings in 2154 patients with prostate cancer . Urology , 56 ( 6 ): 988 - 993 . https://doi.org/10.1016/s0090-4295(00)00824-4 https://doi.org/10.1016/s0090-4295(00)00824-4

Sung H , Ferlay J , Siegel RL , et al. , 2021 . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries . CA Cancer J Clin , 71 ( 3 ): 209 - 249 . https://doi.org/10.3322/caac.21660 https://doi.org/10.3322/caac.21660

Tan Y , Fang ZH , Tang YX , et al. , 2023 . Clinical advancement of precision theranostics in prostate cancer . Front Oncol , 13 : 1072510 . https://doi.org/10.3389/fonc.2023.1072510 https://doi.org/10.3389/fonc.2023.1072510

Tatar G , Baykal Koca S , Sevindir İ , et al. , 2023 . 68 Ga-FAPI-04 PET/CT in primary signet ring-like cell carcinoma of prostate with bone metastases . Clin Nucl Med , 48 ( 4 ): e188 - e189 . https://doi.org/10.1097/rlu.0000000000004550 https://doi.org/10.1097/rlu.0000000000004550

Tremblay S , Alhogbani M , Weickhardt A , et al. , 2023 . Influence of molecular imaging on patient selection for treatment intensification prior to salvage radiation therapy for prostate cancer: a post hoc analysis of the PROPS trial . Cancer Imaging , 23 : 57 . https://doi.org/10.1186/s40644-023-00570-x https://doi.org/10.1186/s40644-023-00570-x

Turpin A , Girard E , Baillet C , et al. , 2020 . Imaging for metastasis in prostate cancer: a review of the literature . Front Oncol , 10 : 55 . https://doi.org/10.3389/fonc.2020.00055 https://doi.org/10.3389/fonc.2020.00055

Vahrmeijer AL , Hutteman M , van der Vorst JR , et al. , 2013 . Image-guided cancer surgery using near-infrared fluorescence . Nat Rev Clin Oncol , 10 ( 9 ): 507 - 518 . https://doi.org/10.1038/nrclinonc.2013.123 https://doi.org/10.1038/nrclinonc.2013.123

Vallabhajosula S , Nikolopoulou A , Babich JW , et al. , 2014 . 99m Tc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer . J Nucl Med , 55 ( 11 ): 1791 - 1798 . https://doi.org/10.2967/jnumed.114.140426 https://doi.org/10.2967/jnumed.114.140426

Vargas HA , Wassberg C , Fox JJ , et al. , 2014 . Bone metastases in castration-resistant prostate cancer: associations between morphologic CT patterns, glycolytic activity, and androgen receptor expression on PET and overall survival . Radiology , 271 ( 1 ): 220 - 229 . https://doi.org/10.1148/radiol.13130625 https://doi.org/10.1148/radiol.13130625

Vargas HA , Kramer GM , Scott AM , et al. , 2018 . Reproducibility and repeatability of semiquantitative 18 F-fluorodihydrotestosterone uptake metrics in castration-resistant prostate cancer metastases: a prospective multicenter study . J Nucl Med , 59 ( 10 ): 1516 - 1523 . https://doi.org/10.2967/jnumed.117.206490 https://doi.org/10.2967/jnumed.117.206490

Varnosfaderani ZG , Emamzadeh R , Nazari M , et al. , 2019 . Detection of a prostate cancer cell line using a bioluminescent affiprobe: an attempt to develop a new molecular probe for ex vivo studies . Int J Biol Macromol , 138 : 755 - 763 . https://doi.org/10.1016/j.ijbiomac.2019.07.085 https://doi.org/10.1016/j.ijbiomac.2019.07.085

Vasalou C , Helmlinger G , Gomes B , 2015 . A mechanistic tumor penetration model to guide antibody drug conjugate design . PLoS ONE , 10 ( 3 ): e0118977 . https://doi.org/10.1371/journal.pone.0118977 https://doi.org/10.1371/journal.pone.0118977

Wang GC , Hong HY , Zang J , et al. , 2022 . Head-to-head comparison of [ 68 Ga ] Ga-P16-093 and [ 68 Ga ] Ga-PSMA-617 in dynamic PET/CT evaluation of the same group of recurrent prostate cancer patients . Eur J Nucl Med Mol Imaging , 49 ( 3 ): 1052 - 1062 . https://doi.org/10.1007/s00259-021-05539-1 https://doi.org/10.1007/s00259-021-05539-1

Wang R , Shen GH , Huang MX , et al. , 2021 . The diagnostic role of 18 F-choline, 18 F-fluciclovine and 18 F-PSMA PET/CT in the detection of prostate cancer with biochemical recurrence: a meta-analysis . Front Oncol , 11 : 684629 . https://doi.org/10.3389/fonc.2021.684629 https://doi.org/10.3389/fonc.2021.684629

Wang Y , de Leon AC , Perera R , et al. , 2021 . Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA . Sci Rep , 11 : 4726 . https://doi.org/10.1038/s41598-021-84072-5 https://doi.org/10.1038/s41598-021-84072-5

Weissleder R , Mahmood U , 2001 . Molecular imaging . Radiology , 219 ( 2 ): 316 - 333 . https://doi.org/10.1148/radiology.219.2.r01ma19316 https://doi.org/10.1148/radiology.219.2.r01ma19316

Wieser G , Mansi R , Grosu AL , et al. , 2014 . Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist—from mice to men . Theranostics , 4 ( 4 ): 412 - 419 . https://doi.org/10.7150/thno.7324 https://doi.org/10.7150/thno.7324

Xia L , Meng XX , Wen L , et al. , 2021 . A highly specific multiple enhancement theranostic nanoprobe for PET/MRI/PAI image-guided radioisotope combined photothermal therapy in prostate cancer . Small , 17 ( 21 ): 2100378 . https://doi.org/10.1002/smll.202100378 https://doi.org/10.1002/smll.202100378

Yin TH , Wang K , Qiu C , et al. , 2020 . Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer . Nanomed Nanotechnol Biol Med , 28 : 102229 . https://doi.org/10.1016/j.nano.2020.102229 https://doi.org/10.1016/j.nano.2020.102229

You HJ , Shang WT , Min XD , et al. , 2020 . Sight and switch off: nerve density visualization for interventions targeting nerves in prostate cancer . Sci Adv , 6 ( 6 ): eaax6040 . https://doi.org/10.1126/sciadv.aax6040 https://doi.org/10.1126/sciadv.aax6040

Yu WX , Zhao M , Deng YJ , et al. , 2023 . Meta-analysis of 18 F-PSMA-1007 PET/CT, 18 F-FDG PET/CT, and 68 Ga-PSMA PET/CT in diagnostic efficacy of prostate Cancer . Cancer Imaging , 23 ( 1 ): 77 . https://doi.org/10.1186/s40644-023-00599-y https://doi.org/10.1186/s40644-023-00599-y

Yuan M , Wu Y , Zhao CY , et al. , 2022 . Activated molecular probes for enzyme recognition and detection . Theranostics , 12 ( 3 ): 1459 - 1485 . https://doi.org/10.7150/thno.66676 https://doi.org/10.7150/thno.66676

Zare H , Rajabibazl M , Rasooli I , et al. , 2014 . Production of nanobodies against prostate-specific membrane antigen (PSMA) recognizing LnCaP cells . Int J Biol Markers , 29 ( 2 ): 169 - 179 . https://doi.org/10.5301/jbm.5000063 https://doi.org/10.5301/jbm.5000063

Zhang JL , Cheng DF , He JY , et al. , 2021 . Cargo loading within ferritin nanocages in preparation for tumor-targeted delivery . Nat Protoc , 16 ( 10 ): 4878 - 4896 . https://doi.org/10.1038/s41596-021-00602-5 https://doi.org/10.1038/s41596-021-00602-5

Zhao Y , Peng J , Yang JY , et al. , 2019 . Enhancing prostate-cancer-specific MRI by genetic amplified nanoparticle tumor homing . Adv Mater , 31 ( 30 ): 1900928 . https://doi.org/10.1002/adma.201900928 https://doi.org/10.1002/adma.201900928

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Xuehua ZHU

Lizhi SHAO

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Department of Urology, Peking University Third Hospital

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences

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Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University

Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China

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