Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment

Shihua ZHANG; Jianmin GUO; Yuting HE; Zhi’ang SU; Yao FENG; Lan ZHANG; Jun ZOU; Xiquan WENG; Yu YUAN

doi:10.1631/jzus.B2300607

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Review | Updated：2025-02-25

Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment
Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment
LncRNA对骨微环境中的骨生成和血管生成耦联的作用
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 2, Pages: 107-123(2025)
Affiliations：

1.School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China
2.School of Life Sciences, South University of Science and Technology, Shenzhen 518055, China
3.College of Sports and Health, Shandong Sport University, Jinan 250102, China
4.School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China
Funds：
DOI：10.1631/jzus.B2300607
CLC：
CSTR：
Received：29 August 2023，

Revised：16 January 2024，

Published：25 February 2025
Accepted：

张士花,郭健民,何玉婷等.LncRNA对骨微环境中的骨生成和血管生成耦联的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):107-123.

Shihua ZHANG, Jianmin GUO, Yuting HE, et al. Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 107-123.
张士花,郭健民,何玉婷等.LncRNA对骨微环境中的骨生成和血管生成耦联的作用[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(02):107-123. DOI： 10.1631/jzus.B2300607.

Shihua ZHANG, Jianmin GUO, Yuting HE, et al. Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(2): 107-123. DOI： 10.1631/jzus.B2300607.

摘要

骨骼是一种高度钙化和血管化的组织。血管系统在支持骨骼生长和修复方面发挥着重要作用，如提供营养和生长因子以及转移代谢废物。此外，骨血管的其他功能，如分泌各种因子和调节骨相关信号通路，对骨骼健康的维持同样有着不可或缺的作用。在骨微环境中，骨髓间充质干细胞（BMSCs）、成骨细胞及破骨细胞等骨组织细胞在血管生成的调控中发挥着关键作用。骨生成和骨血管生成密切相关。衰老导致骨生成和骨血管生成能力减弱，从而诱发骨质疏松症。长链非编码RNA（lncRNA）能够参与骨生成和血管生成等多种生理过程的调控。最近的研究表明，lncRNA可介导血管生成和骨生成之间的耦联，但其具体的机制仍不清楚。这篇综述描述了lncRNA如何调控成骨与血管生成之间的耦联以促进骨骼健康，旨在为lncRNA调控骨代谢机制的研究提供新的方向。

Abstract

Bone is a highly calcified and vascularized tissue. The vascular system plays a vital role in supporting bone growth and repair

such as the provision of nutrients

growth factors

and metabolic waste transfer. Moreover

the additional functions of the bone vasculature

such as the secretion of various factors and the regulation of bone-related signaling pathways

are essential for maintaining bone health. In the bone microenvironment

bone tissue cells play a critical role in regulating angiogenesis

including osteoblasts

bone marrow mesenchymal stem cells (BMSCs)

and osteoclasts. Osteogenesis and bone angiogenesis are closely linked. The decrease in osteogenesis and bone angiogenesis caused by aging leads to osteoporosis. Long noncoding RNAs (lncRNAs) are involved in various physiological processes

including osteogenesis and angiogenesis. Recent studies have shown that lncRNAs could mediate the crosstalk between angiogenesis and osteogenesis. However

the mechanism by which lncRNAs regulate angiogenesis‒osteogenesis crosstalk remains unclear. In this review

we describe in detail the ways in which lncRNAs regulate the crosstalk between osteogenesis and angiogenesis to promote bone health

aiming to provide new directions for the study of the mechanism by which lncRNAs regulate bone metabolism.

关键词

Keywords

references

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