Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis

Huiya FANG; Jin LIN; Yiwu QIU; Zijian CHENG; Weiqian CHEN

doi:10.1631/jzus.B2300519

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Review | Updated：2025-05-28

Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis
Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis
类风湿关节炎与牙周炎在流行病学及发病机制上的关联
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) Vol. 26, Issue 5, Pages: 448-460(2025)
Affiliations：

1.Division of Rheumatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
3.Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310000, China
Funds：
DOI：10.1631/jzus.B2300519
CLC：
CSTR：
Received：18 July 2023，

Revised：13 December 2023，

Published Online：01 March 2025，

Published：28 May 2025
Accepted：

方惠雅,林进,邱一吾等.类风湿关节炎与牙周炎在流行病学及发病机制上的关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(05):448-460.

Huiya FANG, Jin LIN, Yiwu QIU, et al. Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(5): 448-460.
方惠雅,林进,邱一吾等.类风湿关节炎与牙周炎在流行病学及发病机制上的关联[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2025,26(05):448-460. DOI： 10.1631/jzus.B2300519.

Huiya FANG, Jin LIN, Yiwu QIU, et al. Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis[J]. Journal of zhejiang university-science b (biomedicine & biotechnology), 2025, 26(5): 448-460. DOI： 10.1631/jzus.B2300519.

摘要

类风湿关节炎（rheumatoid arthritis，RA）是一种以慢性滑膜炎为特征的自身免疫性疾病，分为抗瓜氨酸蛋白抗体（ACPA）阳性/阴性两种亚型。目前对ACPA阳性RA致病机制已有充分了解，但对ACPA阴性RA病因学的研究仍较为有限。RA和牙周炎（periodontitis，PD）间的关联自20世纪初被发现，他们具有共同的遗传和环境风险因素，可导致骨骼和结缔组织的进行性破坏。然而，RA两种亚型与PD间可能存在不同的联系。本文旨在通过对RA与PD间在流行病学关联上最新的研究结果进行综述，并探讨两种疾病间潜在的致病机制，同时强调RA两种亚型间的关键区别及其与PD的相关性。此外，本文提出早期干预或治疗这两种疾病的可能性，以期为该领域未来研究和临床工作提供有效见解。

Abstract

Rheumatoid arthritis (RA)

an autoimmune disease characterized by chronic inflammation of synovial tissue

is divided into two subtypes—anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. While the pathogenic mechanisms of ACPA-positive RA are well-understood

the etiology of ACPA-negative RA remains largely unknown. The association between RA and periodontitis (PD) has been observed since the early 1900s

with the two diseases sharing common genetic and environmental risk factors that lead to the progressive destruction of bone and connective tissue. However

the associations between PD and the two subtypes of RA differ. This comprehensive review aims to provide an updated understanding of the epidemiological association between RA and PD

explore potential pathogenic mechanisms linking the two diseases

and highlight the key distinctions between the subtypes of RA and their respective associations with PD. We also discuss the possibility of early intervention or the treatment of the two diseases. Ultimately

this review aims to provide valuable insights for future research in this field.

关键词

Keywords

references

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